Detalhe da pesquisa
1.
Discovery of 4-phenyl-1H-indazole derivatives as novel small-molecule inhibitors targeting the PD-1/PD-L1 interaction.
Bioorg Chem
; 147: 107376, 2024 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38640722
2.
Discovery and Computational Studies of Potent Covalent Kinase Inhibitors with α-Substituent Electrophiles Targeting Cysteine.
J Chem Inf Model
; 63(2): 493-506, 2023 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36632804
3.
Discovery of conformationally constrained c-Abl inhibitors with potential neuroprotective effects against Parkinson's disease.
Bioorg Med Chem
; 96: 117532, 2023 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38006642
4.
Discovery and Characterization of Moracin C as an Anti-Gouty Arthritis/Hyperuricemia Candidate by Docking-Based Virtual Screening and Pharmacological Evaluation.
J Nat Prod
; 86(9): 2091-2101, 2023 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37625387
5.
Discovery of novel resorcinol biphenyl ether-based macrocyclic small molecules as PD-1/PD-L1 inhibitors with favorable pharmacokinetics for cancer immunotherapy.
Bioorg Chem
; 139: 106740, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37478546
6.
Discovery of 4-methyl-3-(pyridin-2-ylamino)benzamide derivatives as C-Abl inhibitors with potential neuroprotective effect.
Bioorg Med Chem
; 74: 117069, 2022 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36283251
7.
Design, synthesis, and bioevaluation of imidazo [1,2-a] pyrazine derivatives as tubulin polymerization inhibitors with potent anticancer activities.
Bioorg Med Chem
; 76: 117098, 2022 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36455508
8.
Discovery of KRas G12C-IN-3 and Pomalidomide-based PROTACs as degraders of endogenous KRAS G12C with potent anticancer activity.
Bioorg Chem
; 117: 105447, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34715575
9.
Identification of imidazo[4,5-c]pyridin-2-one derivatives as novel Src family kinase inhibitors against glioblastoma.
J Enzyme Inhib Med Chem
; 36(1): 1541-1552, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34238111
10.
The anti-parasitic drug suramin potently inhibits formation of seminal amyloid fibrils and their interaction with HIV-1.
J Biol Chem
; 294(37): 13740-13754, 2019 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31346035
11.
Discovery of [1,2,4]triazolo[4,3-a]pyridines as potent Smoothened inhibitors targeting the Hedgehog pathway with improved antitumor activity in vivo.
Bioorg Med Chem
; 28(16): 115584, 2020 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32690258
12.
ADS-J1 disaggregates semen-derived amyloid fibrils.
Biochem J
; 476(6): 1021-1035, 2019 03 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-30877194
13.
Scandoside Exerts Anti-Inflammatory Effect Via Suppressing NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages.
Int J Mol Sci
; 19(2)2018 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29401674
14.
Molecular Dynamics Study to Investigate the Dimeric Structure of the Full-Length α-Synuclein in Aqueous Solution.
J Chem Inf Model
; 57(9): 2281-2293, 2017 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28796507
15.
The Effect of the Aqueous Extract of Bidens Pilosa L. on Androgen Deficiency Dry Eye in Rats.
Cell Physiol Biochem
; 39(1): 266-77, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27337217
16.
Largely Improved Creep Resistance and Thermal-Aging Stability of Eco-Friendly Polypropylene High-Voltage Insulation by Long-Chain Branch-Induced Interfacial Constraints.
ACS Macro Lett
; : 592-598, 2024 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38683051
17.
Discovery of Novel Small-Molecule-Based Potential PD-L1/EGFR Dual Inhibitors with High Druggability for Glioblastoma Immunotherapy.
J Med Chem
; 2024 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38739112
18.
Discovery of Novel Potent and Fast BTK PROTACs for the Treatment of Osteoclasts-Related Inflammatory Diseases.
J Med Chem
; 67(4): 2438-2465, 2024 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38321747
19.
Lithium-sulfur battery cathode enabled by lithium-nitrile interaction.
J Am Chem Soc
; 135(2): 763-7, 2013 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23234561
20.
X-ray Crystal Structure-Guided Discovery of Novel Indole Analogues as Colchicine-Binding Site Tubulin Inhibitors with Immune-Potentiating and Antitumor Effects against Melanoma.
J Med Chem
; 66(10): 6697-6714, 2023 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-37145846