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J Microbiol Immunol Infect ; 50(2): 183-188, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-26220305

RESUMO

BACKGROUND/PURPOSE: We conducted a case series study to review the epidemiology of human influenza A(H7N9) infection reported in Hong Kong. METHODS: We reviewed case records of confirmed human cases of influenza A(H7N9) infection reported in Hong Kong in the 2013-2014 winter season. We compared the median viral shedding duration and interval from illness onset to initiation of oseltamivir treatment between severe and mild cases. We estimated the incubation period of influenza A(H7N9) virus from cases with a single known date of poultry exposure. RESULTS: A total of 10 cases were reported and all were imported infection from Mainland China. Four patients died and the cause of death was related to influenza A(H7N9) infection in two patients. The median interval from illness onset to initiation of oseltamivir treatment for the severe cases (4.5 days) was significantly longer than the mild cases (2 days; p = 0.025). Severe cases had a significantly longer viral shedding duration than mild cases (p = 0.028). The median incubation period for cases with a single known exposure date was 4 days. Nasopharyngeal aspirate taken from the 88 close contacts of the 10 patients all tested negative for influenza A virus using reverse transcription polymerase chain reaction. CONCLUSION: Delayed administration of antiviral treatment may be associated with a more severe illness for influenza A(H7N9) infection. Despite our aggressive contact tracing policy with laboratory testing of all close contacts, no secondary case was identified which implied that the potential of human-to-human transmission of the circulating influenza A(H7N9) virus remains low.


Assuntos
Subtipo H7N9 do Vírus da Influenza A/isolamento & purificação , Influenza Humana/epidemiologia , Influenza Humana/virologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Animais , Antivirais/uso terapêutico , Criança , Pré-Escolar , Surtos de Doenças , Feminino , Hong Kong/epidemiologia , Humanos , Lactente , Subtipo H7N9 do Vírus da Influenza A/genética , Influenza Aviária/epidemiologia , Influenza Aviária/transmissão , Influenza Humana/tratamento farmacológico , Influenza Humana/transmissão , Masculino , Pessoa de Meia-Idade , Oseltamivir/uso terapêutico , Aves Domésticas/virologia , Reação em Cadeia da Polimerase Via Transcriptase Reversa/métodos , Estações do Ano , Eliminação de Partículas Virais , Adulto Jovem , Zoonoses/epidemiologia
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