The evaluation of the nutritional status in Parkinson's disease: geriatric nutritional risk index comparison with mini nutritional assessment questionnaire.

OBJECTIVE: The symptoms associated with Parkinson's disease may lead to reduced food consumption and in turn, malnutrition. It is therefore important to apply a reliable nutrition screening tool to evaluate the nutritional status of individuals with Parkinson's disease. This cross-sectional study aims to compare the Mini Nutritional Assessment (MNA) questionnaire and the Geriatric Nutrition Risk Index (GNRI) in the assessment of the nutritional status of individuals with Parkinson's disease, and to evaluate the usability of the GNRI in cases of Parkinson's disease. METHODS: The study was conducted with 89 individuals over the age of 60 who were diagnosed with Parkinson's disease. Study data were collected using a questionnaire form administered through face-to-face interviews, the MNA-Long Form (MNA-LF), and the GNRI was calculated. RESULTS: The mean GNRI scores were significantly lower in the participants with malnutrition (106.5 ± 19.4) than in the participants at risk of malnutrition (121.0 ± 10.3) and the participants with no malnutrition (125.3 ± 9.6) according to the MNA-LF (p < 0.001). Although there was a positive correlation between the MNA-LF and the GNRI scores, this correlation was not significant (p = 0.095). CONCLUSIONS: This is the first study to research the nutritional status of individuals with Parkinson's disease using the GNRI. The malnutrition rate detected by GNRI was found to be lower than MNA in Parkinson's patients receiving outpatient treatment. Similar studies are recommended to determine the usability of GNRI on inpatients.

The nutritional status of relapsing-remitting multiple sclerosis (RRMS) patients compared to that of healthy people: a Turkish hospital-based study.

OBJECTIVE: This study compares the nutritional status and physical activity levels of relapsing-remitting multiple sclerosis (RRMS) patients and healthy people. METHOD: The study included 120 participants: 60 multiple sclerosis (MS) patients and 60 controls. RRMS diagnoses were made based on the 2017 McDonald criteria. The food intake frequency questionnaire was administered to the participants, their threeday food intake records were collected, their activity levels were determined, and anthropometric measurements were made. The differences between the groups were analyzed using the Mann-Whitney U test and Pearson's exact chi-squared test. RESULTS: The participants with MS (46.7%) had a significantly lower rate of shopping for their own food compared to the control group (68.3%) (p = 0.002). The MS group (3.3%) had a lower rate of intake of green leafy vegetables 5 times weekly or more frequently than the control group (20.0%) (p < 0.05); and the control group (35.0%) had a higher consumption rate of pastry more than 1 to 2 times monthly than the MS group (13.3%) (p < 0.05). The participants with MS had a higher intake of fiber, insoluble fiber, and omega 3 fatty acid than the control group (p < 0.05). Expanded Disability Status Scale (EDSS) scores indicates that a positive correlation was found between daily intake of fiber and insoluble fiber (p < 0.05). The patients with MS in the inactive group had a higher EDSS median [2.00(0.00 -5.00)] than the minimal active group [1.25(0.00 -4.00)] (p = 0.034). CONCLUSION: With the increase in disability in MS patients, their physical activity levels decrease and it becomes difficult for them to shop on their own. In addition, the consumption frequency of green leafy vegetables, which take time to prepare and a source of fiber, is also decreasing. It has been shown that fiber intake decreases when the disability increase. Therefore, preventing the progression of disability in MS patients is very important in ensuring diversity in food consumption.

Potential low-cost carbon-based adsorbent from gold mine tailings for anionic dye removal.

In this study, a mesoporous carbon (CMK-3) was successfully synthesized using mesoporous silica (SBA-15) prepared from gold mine tailings (sample CGMT) for removal of anionic dye from aqueous solution. For comparison, CMK-3 was prepared by the same method from pure silica (sample CT), and the other CMK-3 sample was prepared by a one-pot route mixing with Pluronic P123 (sample CP). The effect of the carbonization time on the synthesis of all CMK-3 samples was investigated, and the samples were characterized by X-ray diffraction and N2 adsorption-desorption. The sample with the highest surface area was chosen as an adsorbent, for each CMK-3 obtained from different methods. Batch adsorption experiments were studied to determine the influence of pH, contact time, and initial dye concentration. The adsorption kinetics obeyed the pseudo-second-order model. All carbon-based adsorbents were observed to be quite effective for the removal of dye with adsorption percentage in the order of CP > CT > CGMT. The maximum adsorption capacities were 188.99 and 204.57 mg·g-1 for CT and CGMT, respectively. The comparative results of all carbon-based adsorbents show that CGMT can be applied as a low-cost alternative to CT for dye removal.

Synthesis of nanoporous carbon from Ulva lactuca activated by eggshell for CO2 capture: a novel approach to waste valorization.

Facing the daunting challenge of climate change, driven by escalating greenhouse gas concentrations, our research introduces an innovative solution for CO2 capture. We explore a novel nanoporous carbon derived from Ulva lactuca, activated with eggshell waste, spotlighting waste valorization in mitigating atmospheric CO2. Through a systematic methodology encompassing variable carbonization temperatures (700-900 °C) and nitrogen flow rates (2-4 ml/min), complemented by a suite of characterization techniques, we unveil the synthesis of this pioneering adsorbent. Our study not only presents a novel, sustainable pathway for CO2 capture but also demonstrates superior performance, particularly with the NC800-4 sample, achieving a CO2 capture capacity of 1.40 mmol/g at 30 °C, alongside demonstrating consistent adsorption efficiency over four successive adsorption/desorption cycles. This breakthrough underscores the potential of leveraging waste for environmental remediation, offering a dual solution to waste management and carbon capture, utilization, and storage (CCUS) applications.

Exploring the structural characteristics and dye removal capabilities of powder-, granule- and film- shaped magnetic activated carbon derived from Oleaster seed.

Dye pollution in water caused by excessive discharge of industrial effluent has become a major environmental problem in recent decades because of its irreversible effects on human health. In this study, low-cost carbon-based adsorbents synthesized from Oleaster seed (OS) were prepared in three forms of powder (PAC), film (FAC), and granule (GAC) and used for the removal of methylene blue dye. The properties of the synthesized adsorbents were characterized by SEM-EDX, BET, XPS and FTIR analyses. The maximum adsorption capacity (qmax) of PAC, FAC, and GAC adsorbents were obtained as 68.49, 32.25, and 15.10 mg/g, respectively at the optimum experimental conditions of pH = 10, adsorbent dosages of 0.5, 1, and 2 g/l, contact times of 60, 90, and 120 min, dye concentration of 10 mg/L, and temperature of 25°C. The Langmuir isotherm well described the equilibrium data for all three adsorbents. The pseudo-second-order kinetic model provided the best fit with the adsorption data obtained from all three adsorbents. Adsorption occurred spontaneously through a combination of chemical and physical mechanisms, with a thermodynamically exothermic process. The desorption experiments demonstrated that all the adsorbents have substantial potential for recovery. The novel activated carbon/alginate composite films are proposed as more promising biosorbents to remove MB dye from the aquatic environment compared to GAC adsorbents.

A hybrid nanocomposite based on CuFe layered double hydroxide coated graphene oxide for photocatalytic degradation of trimethoprim.

Photocatalytic activation of persulfate (PS) has recently been considered an effective and environmentally friendly approach for antibiotic decomposition due to its high treatment efficiency, low energy consumption, and high reliability. The development of safe and high-performance catalysts is important for PS-based advanced oxidation processes. In this study, a CuFe-layered double hydroxide (LDH) coated graphene oxide (CuFe-LDH/GO) composite was constructed as a photocatalyst for trimethoprim (TMP) decomposition. The CuFe-LDH/GO catalyst was prepared via the co-precipitation method and characterized through Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), high-resolution transmission electron microscopy (HR-TEM), and X-ray electron microscopy (XPS) techniques. Characterization results revealed that GO was entirely covered by LDH platelets which also kept its hydrotalcite structure in the as-prepared nanocomposite. The average crystallite size of CuFe-LDH/GO was 28.22 nm. The results confirmed that CuFe-LDH/GO exhibited excellent performance for the PS activation with a TMP removal efficiency of 90.8% under UV-light irradiation. Compared with pristine CuFe-LDH, the rate constant of TMP degradation of CuFe-LDH/GO was doubled. The results also indicated that acidic and alkaline conditions were not favorable for TMP degradation, and the catalytic activity of the used photocatalyst has not decreased significantly after 720 h of continuous recycling. Overall, CuFe-LDH/GO could be a promising photocatalyst for the treatment of wastewater containing antibiotics.

Design of PEI and Amine Modified Metakaolin-Brushite Hybrid Polymeric Composite Materials for CO2 Capturing.

In this paper, the properties of organic-inorganic hybrid polymer materials, which were synthesized from an aluminosilicate inorganic matrix with the addition of brushite and aminosilane grafted on one side and PEI covalently bonded composites on the other side, were examined. The synthesized organic-inorganic hybrid polymers were examined in terms of a structural, morphological, thermo-gravimetric, and adsorption-desorption analysis and also as potential CO2 capturers. The structural and phase properties as well as the percentage contents of the crystalline and amorphous phase were determined by the X-ray diffraction method. The higher content of the amorphous phase in the structure of hybrid polymers was proven in metakaolin and metakaolin-brushite hybrid samples with the addition of amino silane and with 1,000,000 PEI in a structure. The DRIFT method showed the main band changes with the addition of an organic phase and inorganic matrix. Microstructural studies with the EDS analysis showed a uniform distribution of organic and inorganic phases in the hybrid geopolymers. The thermo-gravimetric analysis showed that organic compounds are successfully bonded to inorganic polymer matrix, while adsorption-desorption analysis confirmed that the organic phase completely covered the surface of the inorganic matrix. The CO2 adsorption experiments showed that the amine-modified composites have the higher capture capacity, which is 0.685 mmol·g-1 for the GM10 sample and 0.581 mmol·g-1 for the BGM10 sample, with 1,000,000 PEI in the structure.

Prognostic nutritional index as a novel marker for diabetic retinopathy in individuals with type 2 diabetes mellitus.

PURPOSE: In recent years, the prognostic nutritional index (PNI), an easily obtainable nutritional inflammatory marker, has been introduced as an independent prognostic indicator for various types of cancers and cardiovascular diseases. However, its clinical importance in the area of ophthalmology is not well known yet. We aimed to elucidate the association between the PNI and the occurrence of diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM). METHODS: In this cross-sectional study, the PNI was applied to 128 consecutive patients with T2DM. The relationship between the PNI and the occurrence of DR was examined. PNI was calculated as 10× (serum albumin) + 0.005 × (total lymphocyte count). The risk factors for DR were evaluated using multivariate logistic regression analysis. A receiver operating characteristic (ROC) curve analysis of PNI for predicting DR was performed. RESULTS: Patients with DR had significantly lower levels of PNI than those without DR (41.20 ± 4.81 and 44.49 ± 3.10, respectively,P< 0.001). Multivariate regression analysis indicated that PNI, together with the duration of diabetes and creatinine, was an independent factor for DR occurrence (odds ratio, 0.885; 95% confidence interval: 0.735-0.971;P= 0.017). ROC curve analysis revealed that the best cutoff value of PNI was 43 (area under the curve: 0.713; sensitivity: 74%; specificity: 64%). CONCLUSION: A lower PNI value is common among T2DM patients with DR and is strongly associated with the occurrence of DR. The PNI might be a useful biomarker for identifying DR to improve the risk stratification and management of T2DM patients.

Metabolic bone diseases in sickle cell anemia patients and evaluation of associated factors.

BACKGROUND: Metabolic or non-metabolic many bone diseases can be distinguished in sickle cell anemia. Patients with sickle cell anemia have a high risk of osteopenia and osteoporosis. The aim of this study is to reveal bone mineral density abnormalities and related factors in patients with sickle cell anemia. METHODS: A total of 70 patients with sickle cell anemia were retrospectively included in our study. Complete blood count (CBC) parameters, serum creatinine, lactate dehydrogenase (LDH), total bilirubin, direct bilirubin, uric acid, calcium, phosphorus, parathormone, alkaline phosphatase, 25 (OH) vitamin D, ferritin, C reactive protein (CRP) and calculated bone mineral densitometry measurements by Dual-Energy X-ray Absorptiometry (DEXA) were assessed and recorded to the statistics program. We diagnosed osteopenia and osteoporosis according to World Health Organization (WHO) criteria. To determine the status of avascular necrosis and bone fracture, we examined x-ray and magnetic resonance imaging reports and epicrisis reports of patients from the records. RESULTS: The average age was 30.01 ± 8.64 years. Eighteen (26.5%) of the 68 patients whose Z-score was evaluated by DEXA had bone mass below the expected age-related range according to the Z score, while 50 (73.5%) had bone mass within the expected age-related range. Of the patients whose T score was evaluated by DEXA, 46.8% were normal (n=29), 45.1% were osteopenic (n=28) and 8.1% were osteoporotic (n=5). CONCLUSIONS: Patients with sickle cell anemia are at increased risk for osteoporosis, osteopenia, and osteomalacia. Bone health should be emphasized in these patients.

The effect of breastfeeding training on exclusive breastfeeding: a randomized controlled trial.

INTRODUCTION: Although exclusive breastfeeding is very beneficial for children's and mothers' health, a limited number of infants are exclusively breastfed for 6 months. AIM: This randomized controlled intervention study aims to determine the effect of breastfeeding training on mothers' knowledge, behaviors, and exclusive breastfeeding for 6 months. MATERIALS AND METHODS: The participants were selected randomly for training (n = 60) and control groups (n = 60) among the pregnant women admitted to the obstetrics and gynecology polyclinics of a baby-friendly hospital. The training group received breastfeeding training during the prenatal and postnatal periods. The data were collected using a questionnaire during admission and at the postpartum 1st and 24th weeks through face-to-face interviews. The study was completed with 34 and 30 mother-infant pairs in the training and control groups, respectively. Analyzed using the chi-square, Student t, Mann-Whitney U, and Wilcoxon t-tests. RESULTS: The difference between the number of correct answers in pre- and posttest was higher in the training group (four questions) than in the control group (two questions) (p < .001). The number of mothers exclusively breastfeeding for 6 months was significantly higher in the training group (26.5%) than in the control group (3.3%) (p = .015). The median of the exclusive breastfeeding period was longer in the training group (5 months) than in the control group (4 months) (p = .013). CONCLUSION: Training and supporting pregnant women and breastfeeding mothers on breastfeeding increased their knowledge, the period of exclusive breastfeeding, and the rate of 6-month exclusive breastfeeding.

A Comparison of Cognitive Functions and Nutritional Status in Nursing Home Residents and Community-Dwelling Elderly.

Objective: This descriptive and comparative study was conducted to determine the cognitive functions and nutritional status of nursing-home-residing and community-dwelling elderly. Methods: The study was carried out with a total of 204 elderly people who were community dwelling (n = 104) and nursing home residents (n = 100). Data were collected with the Mini Nutritional Assessment (MNA) and standardized with the Mini Mental State Examination (MMSE). Results: Mean age of the nursing home residents and community-dwelling elderly people was 77.4 (SD = 6.7) years and 76.5 (SD = 7.4) years, respectively. Mean MMSE score was significantly different between nursing home residents (18.5 [SD = 4.5]) and community-dwelling elderly (22.1 [SD = 4.7]) (P < .05). Mean MNA score of nursing home residents (23.0 [SD = 3.7]) and community-dwelling elderly (24.6 [SD = 3.1]) was significantly different (P < .05). Conclusion: Nursing home residents were at risk of malnutrition and cognitive impairment. Precautions for the protection of the residents for maintaining nutritional status and cognitive functions were recommended.

Evaluation of the structure, autoimmunity, and functions of the thyroid gland in familial Mediterranean fever patients.

Objective Familial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory disorder that is frequently seen in the eastern Mediterranean region. The thyroid gland can be affected in FMF patients through autoimmunity or amyloidosis. Here, we aimed to evaluate the structure and functions of the thyroid gland in addition to possible autoimmunity in FMF patients. Subjects and methods The study was conducted by the Endocrinology and Metabolism and Internal Medicine Departments. Thirty FMF patients and 30 age and gender-matched healthy controls were enrolled in the study. Free thyroxin (fT4), free triiodothyronine (fT3), thyroid-stimulating hormone (TSH), and anti-thyroid peroxidase (anti-TPO) autoantibodies were investigated. Detailed thyroid grayscale and Doppler Ultrasonography examinations and shear-wave elastosonography (SWE) were performed in the patient and control groups. Results Anti-TPO was detected in 24% (n = 7) of the patients. On the grayscale US, mean thyroid volumes were similar between the FMF and the control groups (p > 0.05). By Doppler US, thyroid vascularity observed was detected in 10.3% (n = 3) of the patients. SWE revealed that the mean velocity value of right vs. left lobe in the patient group was 1.77 ± 0.45 m/s and 1.95 ± 0.51 m/s, respectively. Compared to the control group, the mean velocity values were significantly higher in the right (p = 0.004) and left (p = 0.01) lobes of the patient group. The mean stiffness value in the patient group was also significantly higher in the right and left lobes [10.13 ± 5.65 kPa (p = 0.005) and 12.24 ± 6.17 kPa (p = 0.02), respectively]. Conclusion Recognizing the complications of FMF early in the course of the disease is as important as the early diagnosis of the disorder. Based on this, thyroid functions and changes in its structure should be evaluated carefully for early diagnosis of a possible coexisting thyroid disorder. Arch Endocrinol Metab. 2020;64(1):66-70.

Dual antimicrobial effects induced by hydrogel incorporated with UV-curable quaternary ammonium polyethyleneimine and AgNO3.

This study presents a simple method for fabricating a highly potent dual effect antibacterial hydrogel consisting of a UV-curable cationic polyethyleneimine (QUV-PEI) and embedded silver nitrate (AgNO3). In the first part of this study, polyethyleneimine (PEI) was reacted with 3-(acryloyloxy)-2-hydroxypropyl methacrylate (ACOM) to introduce methacryl functionality onto the backbone. UV-curable PEI was further quaternized by N-methylation with methyl iodate. Hydrogels based on QUV-PEI and AgNO3were found to have impressive biocidal properties. The antibacterial properties were assessed by spraying aqueous suspensions of bacterial cells on the surface, followed by air drying and counting the number of remaining viable cells (i.e. capable of growing into colonies). In a manner depending on the QUV-PEI content in the gel formulation, up to 99±1% of Escherichia coli and Staphylococcus aureus cells sprayed on the resulting hydrogel surfaces were killed. The inclusion of AgNO3 in the QUV-PEI based hydrogel not only enhanced the antimicrobial property against adherent bacteria but also led to the inhibition of bacterial growth in suspended culture via the long-term release of Ag/Ag(+) to the surrounding media. Cytotoxicity studies on human umbilical vein endothelial cells and MTS cell lines were also performed with hydrogels. These findings confirm that hydrogels are potentially useful as antimicrobial agents in a wide variety of applications.

Evaluation of the structure, autoimmunity, and functions of the thyroid gland in familial Mediterranean fever patients

ABSTRACT Objective Familial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory disorder that is frequently seen in the eastern Mediterranean region. The thyroid gland can be affected in FMF patients through autoimmunity or amyloidosis. Here, we aimed to evaluate the structure and functions of the thyroid gland in addition to possible autoimmunity in FMF patients. Subjects and methods The study was conducted by the Endocrinology and Metabolism and Internal Medicine Departments. Thirty FMF patients and 30 age and gender-matched healthy controls were enrolled in the study. Free thyroxin (fT4), free triiodothyronine (fT3), thyroid-stimulating hormone (TSH), and anti-thyroid peroxidase (anti-TPO) autoantibodies were investigated. Detailed thyroid grayscale and Doppler Ultrasonography examinations and shear-wave elastosonography (SWE) were performed in the patient and control groups. Results Anti-TPO was detected in 24% (n = 7) of the patients. On the grayscale US, mean thyroid volumes were similar between the FMF and the control groups (p > 0.05). By Doppler US, thyroid vascularity observed was detected in 10.3% (n = 3) of the patients. SWE revealed that the mean velocity value of right vs. left lobe in the patient group was 1.77 ± 0.45 m/s and 1.95 ± 0.51 m/s, respectively. Compared to the control group, the mean velocity values were significantly higher in the right (p = 0.004) and left (p = 0.01) lobes of the patient group. The mean stiffness value in the patient group was also significantly higher in the right and left lobes [10.13 ± 5.65 kPa (p = 0.005) and 12.24 ± 6.17 kPa (p = 0.02), respectively]. Conclusion Recognizing the complications of FMF early in the course of the disease is as important as the early diagnosis of the disorder. Based on this, thyroid functions and changes in its structure should be evaluated carefully for early diagnosis of a possible coexisting thyroid disorder. Arch Endocrinol Metab. 2020;64(1):66-70

Obesity prevalence, waist-to-height ratio and associated factors in adult Turkish males.

SUMMARY: This study was performed to determine the obesity prevalence and associated risk factors in aged 20 and over years old males living in 11 towns in Kayseri, Turkey between July and August 2007. 1530 men were recruited, of which 6 were excluded because of incomplete information. Data were collected by a questionnaire. Body weight, height, waist and hip circumferences were measured. Body mass index (BMI) of 25.0-29.9 kg/m(2) was accepted as overweight and above 30 kg/m(2) as obesity, waist-to-hip ratio (WHpR) > 1.0 and waist-to-height ratio (WHtR) ≥ 0.5 were accepted as abdominal obesity. Chi-square and logistic regression tests were performed. According to BMI, overweight and obesity prevalences were 39.6% and 16.9%, respectively. Obesity prevalence was 29.9% (50-59 years) according to WHpR, 50.4% (60-69 years) according to waist circumference (WC) and 24.8% (40-49 years) according to WHtR. The logistic regression analysis revealed age of 60-69 years, being a graduate from university, being widowed and having positive familial history of obesity as risk factors of having BMI ≥ 25 kg/m(2). In conclusion, obesity is a serious issue for the males residing in Kayseri and among the anthropometric measurements WHtR is a simple and effective index to identify health related risks even in male of younger ages.: