Detalhe da pesquisa
1.
Hsp70-Bim interaction facilitates mitophagy by recruiting parkin and TOMM20 into a complex.
Cell Mol Biol Lett
; 28(1): 46, 2023 May 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37237369
2.
The chaperone Hsp70 is a BH3 receptor activated by the pro-apoptotic Bim to stabilize anti-apoptotic clients.
J Biol Chem
; 295(37): 12900-12909, 2020 09 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32651234
3.
Hsp70-Bim incoherent feedforward loop contributes to cell-fate heterogeneity and fractional killing.
Br J Pharmacol
; 181(5): 659-669, 2024 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37706555
4.
Exploring the binding mechanism of a small molecular Hsp70-Bim PPI inhibitor through molecular dynamic simulation.
J Mol Model
; 30(3): 71, 2024 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38351232
5.
An updated patent review of Mcl-1 inhibitors (2020-2022).
Expert Opin Ther Pat
; 33(5): 371-383, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37293764
6.
Exploiting the "Hot-Spots" of Hsp70-Bim Protein-Protein Interaction to Optimize the 1-Oxo-1H-phenalene-2,3-dicarbonitrile Analogues as Specific Hsp70-Bim Inhibitors.
J Med Chem
; 66(23): 16377-16387, 2023 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38011535
7.
A novel Hsp70 inhibitor specifically targeting the cancer-related Hsp70-Bim protein-protein interaction.
Eur J Med Chem
; 220: 113452, 2021 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33906046
8.
Small-molecule inhibitor targeting the Hsp70-Bim protein-protein interaction in CML cells overcomes BCR-ABL-independent TKI resistance.
Leukemia
; 35(10): 2862-2874, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34007045
9.
Targeting the Allosteric Pathway That Interconnects the Core-Functional Scaffold and the Distal Phosphorylation Sites for Specific Dephosphorylation of Bcl-2.
J Med Chem
; 63(22): 13733-13744, 2020 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33197310