Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

A Bright Future for Antibiotics?

Matzov, Donna; Bashan, Anat; Yonath, Ada.

Annu Rev Biochem ; 86: 567-583, 2017 06 20.

Artigo em Inglês | MEDLINE | ID: mdl-28654325

2.

Origin of life: protoribosome forms peptide bonds and links RNA and protein dominated worlds.

Bose, Tanaya; Fridkin, Gil; Davidovich, Chen; Krupkin, Miri; Dinger, Nikita; Falkovich, Alla H; Peleg, Yoav; Agmon, Ilana; Bashan, Anat; Yonath, Ada.

Nucleic Acids Res ; 50(4): 1815-1828, 2022 02 28.

Artigo em Inglês | MEDLINE | ID: mdl-35137169

3.

Cryo-EM structure of the ancient eukaryotic ribosome from the human parasite Giardia lamblia.

Hiregange, Disha-Gajanan; Rivalta, Andre; Bose, Tanaya; Breiner-Goldstein, Elinor; Samiya, Sarit; Cimicata, Giuseppe; Kulakova, Liudmila; Zimmerman, Ella; Bashan, Anat; Herzberg, Osnat; Yonath, Ada.

Nucleic Acids Res ; 50(3): 1770-1782, 2022 02 22.

Artigo em Inglês | MEDLINE | ID: mdl-35100413

4.

Rational prioritization strategy allows the design of macrolide derivatives that overcome antibiotic resistance.

König, Gerhard; Sokkar, Pandian; Pryk, Niclas; Heinrich, Sascha; Möller, David; Cimicata, Giuseppe; Matzov, Donna; Dietze, Pascal; Thiel, Walter; Bashan, Anat; Bandow, Julia Elisabeth; Zuegg, Johannes; Yonath, Ada; Schulz, Frank; Sanchez-Garcia, Elsa.

Proc Natl Acad Sci U S A ; 118(46)2021 11 16.

Artigo em Inglês | MEDLINE | ID: mdl-34750269

5.

Ribosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida.

Breiner-Goldstein, Elinor; Eyal, Zohar; Matzov, Donna; Halfon, Yehuda; Cimicata, Giuseppe; Baum, Moti; Rokney, Assaf; Ezernitchi, Analia V; Lowell, Andrew N; Schmidt, Jennifer J; Rozenberg, Haim; Zimmerman, Ella; Bashan, Anat; Valinsky, Lea; Anzai, Yojiro; Sherman, David H; Yonath, Ada.

Nucleic Acids Res ; 49(16): 9560-9573, 2021 09 20.

Artigo em Inglês | MEDLINE | ID: mdl-34417608

6.

Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis.

Matzov, Donna; Taoka, Masato; Nobe, Yuko; Yamauchi, Yoshio; Halfon, Yehuda; Asis, Nofar; Zimermann, Ella; Rozenberg, Haim; Bashan, Anat; Bhushan, Shashi; Isobe, Toshiaki; Gray, Michael W; Yonath, Ada; Shalev-Benami, Moran.

Nucleic Acids Res ; 48(20): 11750-11761, 2020 11 18.

Artigo em Inglês | MEDLINE | ID: mdl-33091122

7.

Structure of Pseudomonas aeruginosa ribosomes from an aminoglycoside-resistant clinical isolate.

Halfon, Yehuda; Jimenez-Fernandez, Alicia; La Rosa, Ruggero; Espinosa Portero, Rocio; Krogh Johansen, Helle; Matzov, Donna; Eyal, Zohar; Bashan, Anat; Zimmerman, Ella; Belousoff, Matthew; Molin, Søren; Yonath, Ada.

Proc Natl Acad Sci U S A ; 116(44): 22275-22281, 2019 10 29.

Artigo em Inglês | MEDLINE | ID: mdl-31611393

8.

Structural insights of lincosamides targeting the ribosome of Staphylococcus aureus.

Matzov, Donna; Eyal, Zohar; Benhamou, Raphael I; Shalev-Benami, Moran; Halfon, Yehuda; Krupkin, Miri; Zimmerman, Ella; Rozenberg, Haim; Bashan, Anat; Fridman, Micha; Yonath, Ada.

Nucleic Acids Res ; 45(17): 10284-10292, 2017 Sep 29.

Artigo em Inglês | MEDLINE | ID: mdl-28973455

9.

Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding.

Krupkin, Miri; Wekselman, Itai; Matzov, Donna; Eyal, Zohar; Diskin Posner, Yael; Rozenberg, Haim; Zimmerman, Ella; Bashan, Anat; Yonath, Ada.

Proc Natl Acad Sci U S A ; 113(44): E6796-E6805, 2016 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-27791159

10.

Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus.

Eyal, Zohar; Matzov, Donna; Krupkin, Miri; Wekselman, Itai; Paukner, Susanne; Zimmerman, Ella; Rozenberg, Haim; Bashan, Anat; Yonath, Ada.

Proc Natl Acad Sci U S A ; 112(43): E5805-14, 2015 Oct 27.

Artigo em Inglês | MEDLINE | ID: mdl-26464510

11.

Protoribosome by quantum kernel energy method.

Huang, Lulu; Krupkin, Miri; Bashan, Anat; Yonath, Ada; Massa, Lou.

Proc Natl Acad Sci U S A ; 110(37): 14900-5, 2013 Sep 10.

Artigo em Inglês | MEDLINE | ID: mdl-23980159

12.

A Recombinant Collagen-mRNA Platform for Controllable Protein Synthesis.

Sun, Liping; Xiong, Yunjing; Bashan, Anat; Zimmerman, Ella; Shulman Daube, Shirley; Peleg, Yoav; Albeck, Shira; Unger, Tamar; Yonath, Hagith; Krupkin, Miri; Matzov, Donna; Yonath, Ada.

Chembiochem ; 16(10): 1415-9, 2015 Jul 06.

Artigo em Inglês | MEDLINE | ID: mdl-25930950

13.

Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunit.

Belousoff, Matthew J; Shapira, Tal; Bashan, Anat; Zimmerman, Ella; Rozenberg, Haim; Arakawa, Kenji; Kinashi, Haruyasu; Yonath, Ada.

Proc Natl Acad Sci U S A ; 108(7): 2717-22, 2011 Feb 15.

Artigo em Inglês | MEDLINE | ID: mdl-21282615

14.

Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.

Rajan, K Shanmugha; Aryal, Saurav; Hiregange, Disha-Gajanan; Bashan, Anat; Madmoni, Hava; Olami, Mika; Doniger, Tirza; Cohen-Chalamish, Smadar; Pescher, Pascal; Taoka, Masato; Nobe, Yuko; Fedorenko, Aliza; Bose, Tanaya; Zimermann, Ella; Prina, Eric; Aharon-Hefetz, Noa; Pilpel, Yitzhak; Isobe, Toshiaki; Unger, Ron; Späth, Gerald F; Yonath, Ada; Michaeli, Shulamit.

Cell Rep ; 43(5): 114203, 2024 May 28.

Artigo em Inglês | MEDLINE | ID: mdl-38722744

15.

The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics.

Auerbach, Tamar; Mermershtain, Inbal; Davidovich, Chen; Bashan, Anat; Belousoff, Matthew; Wekselman, Itai; Zimmerman, Ella; Xiong, Liqun; Klepacki, Dorota; Arakawa, Kenji; Kinashi, Haruyasu; Mankin, Alexander S; Yonath, Ada.

Proc Natl Acad Sci U S A ; 107(5): 1983-8, 2010 Feb 02.

Artigo em Inglês | MEDLINE | ID: mdl-20080686

16.

A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.

Rajan, K Shanmugha; Madmoni, Hava; Bashan, Anat; Taoka, Masato; Aryal, Saurav; Nobe, Yuko; Doniger, Tirza; Galili Kostin, Beathrice; Blumberg, Amit; Cohen-Chalamish, Smadar; Schwartz, Schraga; Rivalta, Andre; Zimmerman, Ella; Unger, Ron; Isobe, Toshiaki; Yonath, Ada; Michaeli, Shulamit.

Nat Commun ; 14(1): 7462, 2023 Nov 20.

Artigo em Inglês | MEDLINE | ID: mdl-37985661

17.

Systematic Exploration of Functional Group Relevance for Anti-Leishmanial Activity of Anisomycin.

Nguyen, Anh Minh Thao; Shalev-Benami, Moran; Rosa-Teijeiro, Chloé; Ibarra-Meneses, Ana Victoria; Yonath, Ada; Bashan, Anat; Jaffe, Charles L; Olivier, Martin; Fernandez-Prada, Christopher; Lubell, William D.

Biomedicines ; 11(9)2023 Sep 15.

Artigo em Inglês | MEDLINE | ID: mdl-37760981

18.

Tough science.

Yonath, Ada Etil.

Nature ; 478(7368): S6-7, 2011 Oct 12.

Artigo em Inglês | MEDLINE | ID: mdl-21993826

19.

Mutations in RPS19 may affect ribosome function and biogenesis in Diamond Blackfan anemia.

Hiregange, Disha-Gajanan; Rivalta, Andre; Yonath, Ada; Zimmerman, Ella; Bashan, Anat; Yonath, Hagith.

FEBS Open Bio ; 12(7): 1419-1434, 2022 07.

Artigo em Inglês | MEDLINE | ID: mdl-35583751

20.

Structural Studies Reveal the Role of Helix 68 in the Elongation Step of Protein Biosynthesis.

Cimicata, Giuseppe; Fridkin, Gil; Bose, Tanaya; Eyal, Zohar; Halfon, Yehuda; Breiner-Goldstein, Elinor; Fox, Tara; Zimmerman, Ella; Bashan, Anat; de Val, Natalia; Wlodawer, Alexander; Yonath, Ada.

mBio ; 13(2): e0030622, 2022 04 26.

Artigo em Inglês | MEDLINE | ID: mdl-35348349

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