Detalhe da pesquisa
1.
Synthesis of 1-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl)-2-morpholinoethane-1,2-dione analogues and their inhibitory activities with reduced cytotoxicity in lipopolysaccharide-induced BV2 cells.
Bioorg Med Chem Lett
; 79: 129061, 2023 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36371018
2.
Synthesis of 1-(4-(dimethylamino)phenyl)-3,4-diphenyl-1H-pyrrole-2,5-dione analogues and their anti-inflammatory activities in lipopolysaccharide-induced BV2 cells.
Bioorg Med Chem Lett
; 92: 129408, 2023 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37429500
3.
Synthesis of 4-(3-oxo-3-phenylpropyl)morpholin-4-ium chloride analogues and their inhibitory activities of nitric oxide production in lipopolysaccharide-induced BV2 cells.
Bioorg Med Chem Lett
; 36: 127780, 2021 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33422605
4.
Synthesis and Biological Evaluation of Salicylic Acid Analogues of Celecoxib as a New Class of Selective Cyclooxygenase-1 Inhibitor.
Biol Pharm Bull
; 44(9): 1230-1238, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34471051
5.
A novel peripheral cannabinoid 1 receptor antagonist, AJ5012, improves metabolic outcomes and suppresses adipose tissue inflammation in obese mice.
FASEB J
; 33(3): 4314-4326, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30566396
6.
2-Hydroxy-4-Methylbenzoic Anhydride Inhibits Neuroinflammation in Cellular and Experimental Animal Models of Parkinson's Disease.
Int J Mol Sci
; 21(21)2020 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33147699
7.
Synthesis of Clovamide Analogues That Inhibit NO Production in Activated BV-2 Microglial Cells.
Biol Pharm Bull
; 40(9): 1475-1482, 2017 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28592715
8.
EOP, a newly synthesized ethyl pyruvate derivative, attenuates the production of inflammatory mediators via p38, ERK and NF-κB pathways in lipopolysaccharide-activated BV-2 microglial cells.
Molecules
; 19(12): 19361-75, 2014 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-25429561
9.
Anti-neuroinflammatory activity of a novel cannabinoid derivative by inhibiting the NF-κB signaling pathway in lipopolysaccharide-induced BV-2 microglial cells.
J Pharmacol Sci
; 121(2): 119-30, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23370667
10.
Cannabinoid receptor type 1 protects nigrostriatal dopaminergic neurons against MPTP neurotoxicity by inhibiting microglial activation.
J Immunol
; 187(12): 6508-17, 2011 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22079984
11.
Simultaneous measurement of serotonin, dopamine and their metabolites in mouse brain extracts by high-performance liquid chromatography with mass spectrometry following derivatization with ethyl chloroformate.
Biol Pharm Bull
; 36(2): 252-8, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23196426
12.
AD-1 Small Molecule Improves Learning and Memory Function in Scopolamine-Induced Amnesic Mice Model through Regulation of CREB/BDNF and NF-κB/MAPK Signaling Pathway.
Antioxidants (Basel)
; 12(3)2023 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36978896
13.
Robust protective effects of a novel multimodal neuroprotectant oxopropanoyloxy benzoic acid (a salicylic acid/pyruvate ester) in the postischemic brain.
Mol Pharmacol
; 79(2): 220-8, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21036874
14.
Simplified heterocyclic analogues of fluoxetine inhibit inducible nitric oxide production in lipopolysaccharide-induced BV2 cells.
Biol Pharm Bull
; 34(4): 538-44, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21467642
15.
The growth of brain tumors can be suppressed by multiple transplantation of mesenchymal stem cells expressing cytosine deaminase.
Int J Cancer
; 127(8): 1975-83, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20473873
16.
2-(5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl)-N-(2-hydroxyethyl)-2-oxoacetamide (CDMPO) has anti-inflammatory properties in microglial cells and prevents neuronal and behavioral deficits in MPTP mouse model of Parkinson's disease.
Neuropharmacology
; 166: 107928, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31887307
17.
Fluoxetine affords robust neuroprotection in the postischemic brain via its anti-inflammatory effect.
J Neurosci Res
; 87(4): 1037-45, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18855941
18.
Anti-Inflammatory and Neuroprotective Effects of DIPOPA (N,N-Diisopropyl-2-Oxopropanamide), an Ethyl Pyruvate Bioisoster, in the Postischemic Brain.
Neurotherapeutics
; 16(2): 523-537, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30680637
19.
Marked prevention of ischemic brain injury by Neu2000, an NMDA antagonist and antioxidant derived from aspirin and sulfasalazine.
J Cereb Blood Flow Metab
; 27(6): 1142-51, 2007 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17106444
20.
Neuroprotective effect of triflusal and its main metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid (HTB), in the postischemic brain.
Neurosci Lett
; 643: 59-64, 2017 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28189746