Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Phenolic compounds prevent amyloid ß-protein oligomerization and synaptic dysfunction by site-specific binding.

Ono, Kenjiro; Li, Lei; Takamura, Yusaku; Yoshiike, Yuji; Zhu, Lijun; Han, Fang; Mao, Xian; Ikeda, Tokuhei; Takasaki, Jun-ichi; Nishijo, Hisao; Takashima, Akihiko; Teplow, David B; Zagorski, Michael G; Yamada, Masahito.

J Biol Chem ; 287(18): 14631-43, 2012 Apr 27.

Artigo em Inglês | MEDLINE | ID: mdl-22393064

2.

Negatively charged gold nanoparticles inhibit Alzheimer's amyloid-ß fibrillization, induce fibril dissociation, and mitigate neurotoxicity.

Liao, Yi-Hung; Chang, Yu-Jen; Yoshiike, Yuji; Chang, Yun-Chorng; Chen, Yun-Ru.

Small ; 8(23): 3631-9, 2012 Dec 07.

Artigo em Inglês | MEDLINE | ID: mdl-22915547

3.

Aggregation of detergent-insoluble tau is involved in neuronal loss but not in synaptic loss.

Kimura, Tetsuya; Fukuda, Tetsuya; Sahara, Naruhiko; Yamashita, Shunji; Murayama, Miyuki; Mizoroki, Tatsuya; Yoshiike, Yuji; Lee, Boyoung; Sotiropoulos, Ioannis; Maeda, Sumihiro; Takashima, Akihiko.

J Biol Chem ; 285(49): 38692-9, 2010 Dec 03.

Artigo em Inglês | MEDLINE | ID: mdl-20921222

4.

Hyperphosphorylated tau in parahippocampal cortex impairs place learning in aged mice expressing wild-type human tau.

Kimura, Tetsuya; Yamashita, Shunji; Fukuda, Tetsuya; Park, Jun-Mi; Murayama, Miyuki; Mizoroki, Tatsuya; Yoshiike, Yuji; Sahara, Naruhiko; Takashima, Akihiko.

EMBO J ; 26(24): 5143-52, 2007 Dec 12.

Artigo em Inglês | MEDLINE | ID: mdl-18007595

5.

Pore-forming proteins share structural and functional homology with amyloid oligomers.

Yoshiike, Yuji; Kayed, Rakez; Milton, Saskia C; Takashima, Akihiko; Glabe, Charles G.

Neuromolecular Med ; 9(3): 270-5, 2007.

Artigo em Inglês | MEDLINE | ID: mdl-17914185

6.

[GABAergic neurotransmission].

Yoshiike, Yuji.

Nihon Rinsho ; 69 Suppl 8: 219-23, 2011 Oct.

Artigo em Japonês | MEDLINE | ID: mdl-22787785

7.

Nontoxic singlet oxygen generator as a therapeutic candidate for treating tauopathies.

Sheik Mohideen, Sahabudeen; Yamasaki, Yasutoyo; Omata, Yasuhiro; Tsuda, Leo; Yoshiike, Yuji.

Sci Rep ; 5: 10821, 2015 Jun 01.

Artigo em Inglês | MEDLINE | ID: mdl-26027742

8.

Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups.

Soeda, Yoshiyuki; Yoshikawa, Misato; Almeida, Osborne F X; Sumioka, Akio; Maeda, Sumihiro; Osada, Hiroyuki; Kondoh, Yasumitsu; Saito, Akiko; Miyasaka, Tomohiro; Kimura, Tetsuya; Suzuki, Masaaki; Koyama, Hiroko; Yoshiike, Yuji; Sugimoto, Hachiro; Ihara, Yasuo; Takashima, Akihiko.

Nat Commun ; 6: 10216, 2015 Dec 16.

Artigo em Inglês | MEDLINE | ID: mdl-26671725

9.

Adaptive responses to alloxan-induced mild oxidative stress ameliorate certain tauopathy phenotypes.

Yoshiike, Yuji; Yamashita, Shunji; Mizoroki, Tatsuya; Maeda, Sumihiro; Murayama, Miyuki; Kimura, Tetsuya; Sahara, Naruhiko; Soeda, Yoshiyuki; Takashima, Akihiko.

Aging Cell ; 11(1): 51-62, 2012 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-21981382

10.

Vitamin A has anti-oligomerization effects on amyloid-ß in vitro.

Takasaki, Junichi; Ono, Kenjiro; Yoshiike, Yuji; Hirohata, Mie; Ikeda, Tokuhei; Morinaga, Akiyoshi; Takashima, Akihiko; Yamada, Masahito.

J Alzheimers Dis ; 27(2): 271-80, 2011.

Artigo em Inglês | MEDLINE | ID: mdl-21811022

11.

Amyloid oligomer conformation in a group of natively folded proteins.

Yoshiike, Yuji; Minai, Ryoichi; Matsuo, Yo; Chen, Yun-Ru; Kimura, Tetsuya; Takashima, Akihiko.

PLoS One ; 3(9): e3235, 2008 Sep 18.

Artigo em Inglês | MEDLINE | ID: mdl-18800165

12.

GABA(A) receptor-mediated acceleration of aging-associated memory decline in APP/PS1 mice and its pharmacological treatment by picrotoxin.

Yoshiike, Yuji; Kimura, Tetsuya; Yamashita, Shunji; Furudate, Hiroyuki; Mizoroki, Tatsuya; Murayama, Miyuki; Takashima, Akihiko.

PLoS One ; 3(8): e3029, 2008 Aug 21.

Artigo em Inglês | MEDLINE | ID: mdl-18716656

13.

GSK-3beta is required for memory reconsolidation in adult brain.

Kimura, Tetsuya; Yamashita, Shunji; Nakao, Shinobu; Park, Jung-Mi; Murayama, Miyuki; Mizoroki, Tatsuya; Yoshiike, Yuji; Sahara, Naruhiko; Takashima, Akihiko.

PLoS One ; 3(10): e3540, 2008.

Artigo em Inglês | MEDLINE | ID: mdl-18958152

14.

Surface structure of amyloid-beta fibrils contributes to cytotoxicity.

Yoshiike, Yuji; Akagi, Takumi; Takashima, Akihiko.

Biochemistry ; 46(34): 9805-12, 2007 Aug 28.

Artigo em Inglês | MEDLINE | ID: mdl-17676931

15.

Granular tau oligomers as intermediates of tau filaments.

Maeda, Sumihiro; Sahara, Naruhiko; Saito, Yuko; Murayama, Miyuki; Yoshiike, Yuji; Kim, Hyonchol; Miyasaka, Tomohiro; Murayama, Shigeo; Ikai, Atsushi; Takashima, Akihiko.

Biochemistry ; 46(12): 3856-61, 2007 Mar 27.

Artigo em Inglês | MEDLINE | ID: mdl-17338548

16.

Vitamin A exhibits potent antiamyloidogenic and fibril-destabilizing effects in vitro.

Ono, Kenjiro; Yoshiike, Yuji; Takashima, Akihiko; Hasegawa, Kazuhiro; Naiki, Hironobu; Yamada, Masahito.

Exp Neurol ; 189(2): 380-92, 2004 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-15380488

17.

Specific compositions of amyloid-beta peptides as the determinant of toxic beta-aggregation.

Yoshiike, Yuji; Chui, De-Hua; Akagi, Takumi; Tanaka, Nobuo; Takashima, Akihiko.

J Biol Chem ; 278(26): 23648-55, 2003 Jun 27.

Artigo em Inglês | MEDLINE | ID: mdl-12716908

18.

Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease.

Ono, Kenjiro; Yoshiike, Yuji; Takashima, Akihiko; Hasegawa, Kazuhiro; Naiki, Hironobu; Yamada, Masahito.

J Neurochem ; 87(1): 172-81, 2003 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-12969264

19.

Nordihydroguaiaretic acid potently breaks down pre-formed Alzheimer's beta-amyloid fibrils in vitro.

Ono, Kenjiro; Hasegawa, Kazuhiro; Yoshiike, Yuji; Takashima, Akihiko; Yamada, Masahito; Naiki, Hironobu.

J Neurochem ; 81(3): 434-40, 2002 May.

Artigo em Inglês | MEDLINE | ID: mdl-12065652

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