Two-dimensional heterojunction layered graphene oxide/graphitic carbon nitride photocatalyst for removal of toxic environmental dye methylene blue.

The direct thermal polymerization techniques were applied to prepare the graphene oxide (GO)-graphitic carbon nitride (gCN) hybrid structure. The prepared hybrid heterojunction GO-gCN nanosheets were utilized as a photocatalyst to remove model pollutants methylene blue (MB) dye. The basic physio-chemical properties of GO-gCN layered materials have been analyzed by various characterization techniques. In addition, the proposed materials have a higher photocatalytic ability toward the degradation of aqueous solution of MB dye under visible light irradiation within a short treatment time. This is because it's the synergistic effects of GO-gCN layer-by-layer structures produced by π─π stacking with charge-transfer interactions. The gCN with GO composite can able to enhance the charge transfer and light-harvesting properties. Under the influence of photocatalyst, the surface of Graphene oxide undergoes the separation and combination of carbonyl radicals, hydroxyl radicals, epoxy radicals, and electron-hole pairs. This enhances the absorption of visible light and improves the degradation of MB, when GO is incorporated into gCN. The removal efficiency of MB reached up to 82.311% within the short treatment time.

Improving the p-Type CuCrO2 Thin Film's Electrical and Optical Properties.

In this research, we studied the functional properties of CuCrO2, which is the most promising p-type transparent conductive oxide (TCO). The thin films were fabricated using a spin coating technique. The diffraction patterns were obtained with the help of X-ray diffractions, and the optical properties of absorption characteristics were studied using UV-visible absorption. The physical properties of film formation and surface morphology were analyzed using FESEM analysis. The aging properties were also analyzed with the help of various precursors with different aging times. The CuCrO2 thin films' functional properties were determined by using chelating agent and precursor solution aging times. The CuCrO2 thin films have better transmittance, resistance, figure of merit (FOM), and electrical conductivity. Moreover, the resistivity values of the CuCrO2 thin films are 7.01, 9.90, 12.54, 4.10, 2.42, and 0.35 Ω cm. The current research article covers the preparation of copper chromium delafossite thin films. These thin films can be suitable for hole transport layers in transparent optoelectronic devices.

SIRGs score may be a predictor of prognosis and immunotherapy response for esophagogastric junction adenocarcinoma.

Background: Esophagogastric junction adenocarcinoma (EGJA) is a special malignant tumor with unknown biological behavior. PD-1 checkpoint inhibitors have been recommended as first-line treatment for advanced EGJA patients. However, the biomarkers for predicting immunotherapy response remain controversial. Methods: We identified stromal immune-related genes (SIRGs) by ESTIMATE from the TCGA-EGJA dataset and constructed a signature score. In addition, survival analysis was performed in both the TCGA cohort and GEO cohort. Subsequently, we explored the differences in tumor-infiltrating immune cells, immune subtypes, immune-related functions, tumor mutation burden (TMB), immune checkpoint gene expression, immunophenoscore (IPS) between the high SIRGs score and low SIRGs score groups. Finally, two validation cohorts of patients who had accepted immunotherapy was used to verify the value of SIRGs score in predicting immunotherapy response. Results: Eight of the SIRGs were selected by LASSO regression to construct a signature score (SIRGs score). Univariate and multivariate analyses in the TCGA and GEO cohort suggested that SIRGs score was an independent risk factor for the overall survival (OS) and it could increase the accuracy of clinical prediction models for survival. However, in the high SIRGs score group, patients had more immune cell infiltration, more active immune-related functions, higher immune checkpoint gene expression and higher IPS-PD1 and IPS-PD1-CTLA4 scores, which indicate a better response to immunotherapy. The external validation illustrated that high SIRGs score was significantly associated with immunotherapy response and immune checkpoint inhibitors (ICIs) can improve OS in patients with high SIRGs score. Conclusion: The SIRGs score may be a predictor of the prognosis and immune-therapy response for esophagogastric junction adenocarcinoma.