Heart Rate Reactivity to Acute Psychological Stress Predicts Higher Levels of Posttraumatic Stress Disorder Symptoms During the COVID-19 Pandemic.

OBJECTIVE: Increased autonomic arousal is a proposed risk factor for posttraumatic stress disorder (PTSD). Few studies have prospectively examined the association between physiological responses to acute psychological stress before a traumatic event and later PTSD symptoms. The present prospective study examined whether cardiovascular responses to an acute psychological stress task before the COVID-19 global pandemic predicted PTSD symptoms related to the ongoing pandemic. METHODS: Participants (n = 120) were a subsample of an ongoing research study. Phase 1 consisted of a 10-minute baseline and 4-minute acute psychological stress task with blood pressure and heart rate recorded throughout. Phase 2 was initiated 2 weeks after the COVID-19 pandemic declaration. Participants completed the Impact of Event Scale-Revised (IES-R) with respect to the ongoing pandemic. Hierarchical linear regression analyses were used to examine whether cardiovascular stress reactivity predicted COVID-19 PTSD symptoms. RESULTS: Heart rate reactivity significantly predicted IES intrusion (ß = -0.208, t = -2.28, p = .025, ΔR2 = 0.041, confidence interval = -0.021 to -0.001) and IES hyperarousal (ß = -0.224, t = -2.54, p = .012, ΔR2 = 0.047, confidence interval = -0.22 to - 0.003), but not IES avoidance (p = .077). These results remained statistically significant after adjustment for sex, socioeconomic status, baseline cardiovascular activity, neuroticism, race, ethnicity, body mass index, and adverse childhood experiences. There were no statistically significant associations between blood pressure and any of the Impact of Event Scale-Revised subscales (p values > .12). CONCLUSIONS: Diminished heart rate responses (i.e., lower physiological arousal) to acute psychological stress before the COVID-19 pandemic significantly predicted reported PTSD symptoms during the crisis.

Physiological reactivity and habituation to acute psychological stress: The influence of trait extraversion.

BACKGROUND AND AIMS: Adaptive physiological responses to stress have been suggested as a potential mechanism facilitating the association between extraversion and positive health outcomes. The present study examined the influence of extraversion on physiological reactivity and habituation to a standardized psychological stress task presented as two separate laboratory sessions approximately 48 days apart. METHODS: The present study utilized data from the Pittsburgh Cold Study 3. Participants in the study (N = 213, mean age = 30.13, SD = 10.85 years; female = 42.3 %) completed a standardized stress testing protocol twice, at two separate laboratory sessions. The stress protocol consisted of a speech preparation period (5-minutes), a public specking task (5-minutes), and a mental arithmetic task with observation (5-minutes). Trait extraversion was assessed using 10-items from the international personality item pool (IPIP). Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR) and salivary cortisol (SC) were assessed throughout a baseline phase and the stress task phase. RESULTS: Extraversion was statistically significantly associated with larger DBP and HR reactivity in response to the initial stress exposure, as well as greater habituation of DBP, MAP and HR on repeated stress exposure. No statistically significant associations emerged between extraversion and SBP responses, SC responses or self-reported state affective responses. CONCLUSION: Extraversion is associated with greater cardiovascular reactivity, as well as pronounced cardiovascular habituation to acute social stress. These findings may indicate an adaptive response pattern amongst highly extraverted individuals and a potential mechanism leading to positive health outcomes.

Disordered eating is associated with blunted blood pressure reactivity and poorer habituation to acute psychological stress.

Psychological stress has been shown to influence the development and progression of disordered eating. Psychophysiological studies have reported that individuals with disordered eating behavior exhibit atypical cardiovascular reactions to acute psychological stress. However, prior studies have been limited by small sample sizes and have examined cardiovascular responses to a singular stress exposure. The current study examined the association between disordered eating and cardiovascular reactivity, as well as cardiovascular habituation to acute psychological stress. A mixed-sex sample (N = 450) of undergraduate students were categorized into a disordered eating or non-disordered eating group using a validated disordered eating screening questionnaire and attended a laboratory stress testing session. The testing session included two identical stress-testing protocols, each consisting of a 10-minute baseline and 4-minute stress task. Cardiovascular parameters including heart rate, systolic/diastolic blood pressure and mean arterial pressure (MAP) were recorded throughout the testing session. Post task measures of self-reported stress, as well as positive affect and negative affect (NA) reactivity were used to assess psychological reactions to stress. The disordered eating group exhibited greater increases in NA reactivity in response to both stress exposures. Additionally, in comparison to the control group, those in the disordered eating group exhibited blunted MAP reactivity to the initial stress exposure and less MAP habituation across both stress exposures. These findings indicate that disordered eating is characterized by dysregulated hemodynamic stress responsivity, which may constitute a physiological mechanism leading to poor physical health outcomes.

Emotion regulation tendencies and cardiovascular responses to repeated acute psychological stress.

Poor emotion regulation has been associated with cardiovascular disease (CVD) through maladaptive cardiovascular responses to psychological stress. However, there has been scant research examining the relationship between emotion regulation and habituation of cardiovascular responses to recurrent stress, which may be more directly applicable to the experience of stress in everyday life. The aims of the current study were to examine the associations between emotion regulation tendencies and cardiovascular stress reactivity, as well as habituation of cardiovascular reactivity across repeated stressors. A sample of 453 participants (mean (SD) age = 19.5 (1.3) years; 62 % women) completed a repeated stress paradigm, which consisted of two 10-minute baselines and two identical 4-minute stress tasks, separated by a 10-minute recovery period. Heart rate (HR) was measured continuously; systolic/diastolic blood pressures (SBP/DBP) were measured every 2 min. At the end of the visit, participants completed the Emotion Regulation Questionnaire (ERQ) and Difficulties in Emotion Regulation Scale (DERS). Results indicate that impulse control difficulties when distressed (a DERS subscale) were significantly associated with blunted SBP, DBP, and HR reactivity to both stressors, as well as impaired HR habituation across the stressors. None of the ERQ subscales (cognitive reappraisal, expressive suppression) were found to be associated with cardiovascular stress reactivity or habituation. The outcomes of this study demonstrate a potential underlying physiological pathway through which impulse control difficulties when distressed may contribute to CVD risk. This study also reveals the importance of extending traditional cardiovascular stress reactivity protocols to include multiple exposures of the same stress task.

Cardiovascular stress reactivity, habituation, and adiposity.

The relationship between adiposity and cardiovascular disease morbidity and mortality is complex. One pathway through which adiposity may influence future health outcomes is by altering how biological systems respond to stress. The current study aimed to examine the association between two metrics of adiposity (body mass index and waist-hip ratio) and two indices of cardiovascular stress responses (reactivity and habituation). A sample of 455 participants (Mean age = 19.47, SD = 1.25 years; BMI = 24.32, SD = 5.04 kg/m2 ; 62% female; 17.9% Hispanic/Latino; 65.2% White, 18.7% Asian, 7.9% Black, 0.2% American Indian/Alaska Native, and 7% other) completed two acute psychosocial stress tasks. Heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were recorded throughout each stressor. In unadjusted and adjusted models, there were no statistically significant associations between adiposity and HR, SBP, or DBP stress reactivity or habituation. The current data do not support the hypothesis that adiposity influences health by altering cardiovascular responses to acute psychological stress. Results are at odds with prior population-level studies and the single prior study examining adiposity and habituation. At the same time, results are in line with mounting evidence that adiposity itself does not drive poor cardiovascular outcomes seen in people classified as overweight or obese.

Extraversion is associated with lower cardiovascular reactivity to acute psychological stress.

BACKGROUND AND AIMS: Extraversion has been associated with positive physical health outcomes, with adaptive cardiovascular responses to stress being one potential physiological mechanism. The present study examined the influence of extraversion on both cardiovascular reactivity and cardiovascular habituation to an acute psychological stress task (Paced Auditory Serial Addition Test (PASAT)) in a sample of healthy undergraduate students. METHODS: A sample of 467 undergraduate students completed the Big Five Inventory (BFI) to assess trait extraversion and attended a single stress testing session. The testing session included two identical stress-testing protocols, each consisting of a 10-minute baseline and 4-minute PASAT. Cardiovascular parameters including heart rate (HR), systolic/diastolic blood pressure (S/DBP) and mean arterial pressure (MAP) were recorded throughout the testing session. State measures of positive affect (PA) and negative affect (NA), as well as post task measures of self-reported stress were used to assess psychological experiences of the stress task. RESULTS: Extraversion was significantly associated with lower self-reported stress in response to the initial stress exposure, but not the second stress exposure. Higher levels of extraversion were associated with lower SBP, DBP, MAP and HR reactivity in responses to both exposures to the stressor. However, no significant associations were observed between extraversion and cardiovascular habituation to recurring psychological stress. CONCLUSION: Extraversion is associated with lower cardiovascular reactivity to acute psychological stress and this relationship persists upon repeated exposures to the same stressor. Cardiovascular responses to stress may indicate a potential mechanism facilitating the association between extraversion and positive physical health outcomes.

Effects of arousal reappraisal on the anxiety responses to stress: Breaking the cycle of negative arousal intensity and arousal interpretation.

Arousal reappraisal has been shown to be an effective strategy during stress to improve anxiety. However, the exact psychological mechanism through which arousal reappraisal improves anxiety is unknown. In a large, cross-sectional study (Study 1, N = 455) participants engaged in an acute psychological stress task and rated their levels of physiological arousal, cognitive anxiety, and somatic anxiety, and whether they perceived this physiological arousal, cognitive anxiety, and somatic anxiety as helpful or hurtful (i.e., interpretation). Structural equation models supported a previously hypothesized model demonstrating that higher levels of physiological arousal were interpreted more negatively and this negative interpretation was associated with higher levels of anxiety intensity and more negative interpretations of anxiety. In an independent sample (Study 2, N = 155), participants were randomly assigned to an arousal reappraisal intervention or control condition prior to engaging in the psychological stress task. Results indicated that arousal reappraisal resulted in more positive interpretations of physiological arousal and anxiety. Results also supported a previously hypothesized model demonstrating that arousal reappraisal 'broke' the connection between physiological arousal intensity and physiological arousal interpretation. The present studies suggest that arousal reappraisal could possibly be acting through improving interpretations of physiological arousal symptoms.

Cardiovascular reactions to acute psychological stress and academic achievement.

Cardiovascular reactions to acute psychological stress have been associated with cognitive function. However, previous work has assessed cardiovascular reactions and cognitive function in the laboratory at the same time. The present study examined the association between cardiovascular reactions to acute psychological stress in the laboratory and academic performance in final year high school students. Heart rate, blood pressure, stroke volume, and cardiac output reactions to an acute psychological stress task were measured in 131 participants during their final year of high school. Performance on high school A-levels were obtained the following year. Higher heart rate and cardiac output reactivity were associated with better A-level performance. These associations were still statistically significant after adjusting for a wide range of potentially confounding variables. The present results are consistent with a body of literature suggesting that higher heart rate reactions to acute psychological stress are associated with better cognitive performance across a variety of domains.

Boosting nitric oxide in stress and respiratory infection: Potential relevance for asthma and COVID-19.

Nitric oxide (NO) is a ubiquitous signaling molecule that is critical for supporting a plethora of processes in biological organisms. Among these, its role in the innate immune system as a first line of defense against pathogens has received less attention. In asthma, levels of exhaled NO have been utilized as a window into airway inflammation caused by allergic processes. However, respiratory infections count among the most important triggers of disease exacerbations. Among the multitude of factors that affect NO levels are psychological processes. In particular, longer lasting states of psychological stress and depression have been shown to attenuate NO production. The novel SARS-CoV-2 virus, which has caused a pandemic, and with that, sustained levels of psychological stress globally, also adversely affects NO signaling. We review evidence on the role of NO in respiratory infection, including COVID-19, and stress, and argue that boosting NO bioavailability may be beneficial in protection from infections, thus benefitting individuals who suffer from stress in asthma or SARS-CoV-2 infection.

Adverse childhood experiences, sex, and cardiovascular habituation to repeated stress.

Adverse childhood experiences (ACEs) are robustly associated with later cardiovascular disease. Alterations in cardiovascular responses to stress may be an underlying mechanism. The present study examined whether ACEs predicted habituation of cardiovascular responses across two acute laboratory stress tasks, and whether this differed between men and women. During a single laboratory visit, 453 healthy young adults completed two identical stress-inducing protocols, each involving a 10-minute baseline and 4-minute acute psychological stress task. Heart rate (HR) and systolic/diastolic blood pressure (S/DBP) were recorded throughout. Participants also completed the Adverse Childhood Experiences scale. Cardiovascular responses habituated from the first to second stress task on average across the entire sample. However, women-but not men-with higher self-reported ACEs displayed less habituation of HR and DBP, but not SBP, across the stress tasks. Results suggest that ACEs may alter the body's ability to adaptively respond to stress exposures in adulthood, specifically in women.

Diminished cardiovascular stress reactivity is associated with higher levels of behavioral disengagement.

Blunted cardiovascular responses to stress have been associated with poor behavioral regulation. The present study examined the relationship between cardiovascular stress reactivity and an established measure behavioral disengagement. Blood pressure and heart rate were measured during rest and stress task in 452 participants. Behavioral disengagement was measured using the Brief Coping Orientation to Problems Experienced Scale (Brief COPE). Regression models adjusting for baseline cardiovascular values, age, gender, race, ethnicity, SES, depressive symptomology, self-report stress task stressfulness, self-report stress task demandingness, and objective stress task performance demonstrated that lower levels of cardiovascular reactivity were associated with behavioral disengagement, ß = -.114, t = -2.36, p = .019, ΔR2 = .017. There were no statistically significant associations between blood pressure reactivity and behavioral disengagement (p's > .077) in fully adjusted models. The results are consistent with the hypothesis that low reactivity may be a marker of motivational dysregulation.

Frequency and perceptions of life stress are associated with reduced cardiovascular stress-response adaptation.

Psychological stress is a risk factor for cardiovascular disease. Individual differences in cardiovascular responses to stress may be an underlying mechanism. The literature examining the relationships between frequency and perceptions of life stress with cardiovascular reactivity to acute stress in the laboratory is inconclusive. Recent work highlights the need to measure cardiovascular reactivity across multiple stress exposures to obtain more comprehensive profiles of reactivity by assessing adaptation over time. The aims of the current study were to examine the relationships between frequency and perceptions of stressful life events with cardiovascular reactivity, as well as adaptation of cardiovascular reactivity over time. Four hundred and fifty-three healthy, young adults (mean (SD) age = 19.5 (1.3) years, 62% female, 66.2% Caucasian, 17.7% Hispanic) completed a single laboratory visit, which included two identical, stress-testing protocols, each consisting of a 10-minute baseline and 4-minute stress task. Heart rate (HR) and systolic/diastolic blood pressure (S/DBP) were recorded throughout. Participants completed the Undergraduate Stress Questionnaire (USQ) and Perceived Stress Scale (PSS). Results indicate that greater frequency and perceptions of life stress were independently associated with blunted HR and DBP reactivity at the first stress exposure and less habituation of HR and DBP reactivity across both exposures, even after controlling for confounding variables. The present study suggests that higher frequency and perceptions of stress in daily life may harm the body's ability to respond effectively to short-term stress and also disrupt healthy adaptation of stress responses over repeated exposures, thus increasing risk of cardiovascular disease outcomes.

State gratitude is associated with lower cardiovascular responses to acute psychological stress: A replication and extension.

Positive affect is associated with more adaptive responses to psychological stress. However, few studies have examined the association between gratitude, a specific type of positive affect, with physiological responses to acute psychological stress. The current study aimed to replicate and extend on previous work examining the associations between state and trait gratitude and cardiovascular stress reactivity in 324 (59.9% female, 67.0% Caucasian, 17.9% Hispanic) healthy participants. State gratitude was measured at the beginning of the laboratory session using the Gratitude Adjective Checklist-Three Items. Trait gratitude was measured using the Gratitude Questionnaire-Six Items. Blood pressure and heart rate reactions to an acute mental arithmetic task were measured. In regression models that adjusted for baseline cardiovascular activity, body mass index, sex, depressive symptomology, performance on the acute mental arithmetic task, and state positive affect, state gratitude was associated with lower systolic blood pressure reactivity. There were no associations between trait gratitude and any of the cardiovascular variables. Results support previous work demonstrating that state, but not trait, gratitude is related to cardiovascular stress reactivity. Higher levels of state gratitude immediately preceding a stressful encounter may be protective.