Detalhe da pesquisa
1.
A PRC2-Kdm5b axis sustains tumorigenicity of acute myeloid leukemia.
Proc Natl Acad Sci U S A
; 119(9)2022 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35217626
2.
USP7-Based Deubiquitinase-Targeting Chimeras Stabilize AMPK.
J Am Chem Soc
; 2024 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38597345
3.
A cryptic transactivation domain of EZH2 binds AR and AR's splice variant, promoting oncogene activation and tumorous transformation.
Nucleic Acids Res
; 50(19): 10929-10946, 2022 10 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36300627
4.
Chemically induced degradation of epigenetic targets.
Chem Soc Rev
; 52(13): 4313-4342, 2023 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37314393
5.
TF-DUBTACs Stabilize Tumor Suppressor Transcription Factors.
J Am Chem Soc
; 144(28): 12934-12941, 2022 07 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35786952
6.
Structure-activity relationships and docking studies of synthetic 2-arylindole derivatives determined with aromatase and quinone reductase 1.
Bioorg Med Chem Lett
; 27(24): 5393-5399, 2017 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29153737
7.
Discovery of a novel, highly potent EZH2 PROTAC degrader for targeting non-canonical oncogenic functions of EZH2.
Eur J Med Chem
; 267: 116154, 2024 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38295690
8.
Targeting G9a translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae.
bioRxiv
; 2024 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38496599
9.
Macrocyclic drugs and synthetic methodologies toward macrocycles.
Molecules
; 18(6): 6230-68, 2013 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-23708234
10.
Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degrader.
Oncogene
; 42(13): 994-1009, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36747009
11.
Discovery of novel BTK PROTACs with improved metabolic stability via linker rigidification strategy.
Eur J Med Chem
; 255: 115403, 2023 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37119666
12.
Chemical Epigenetic Regulation of Adeno-Associated Virus Delivered Transgenes.
Hum Gene Ther
; 34(17-18): 947-957, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37624737
13.
Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization.
Cell Chem Biol
; 30(7): 753-765.e8, 2023 07 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37354907
14.
Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer.
J Med Chem
; 66(23): 16168-16186, 2023 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38019706
15.
Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation.
Cell Chem Biol
; 30(12): 1525-1541.e7, 2023 12 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37858336
16.
WNTinib is a multi-kinase inhibitor with specificity against ß-catenin mutant hepatocellular carcinoma.
Nat Cancer
; 4(8): 1157-1175, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37537299
17.
Synthesis of 2-arylindole derivatives and evaluation as nitric oxide synthase and NFκB inhibitors.
Org Biomol Chem
; 10(44): 8835-47, 2012 Nov 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23044819
18.
Exploring Degradation of Mutant and Wild-Type Epidermal Growth Factor Receptors Induced by Proteolysis-Targeting Chimeras.
J Med Chem
; 65(12): 8416-8443, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35675209
19.
Novel Allosteric Inhibitor-Derived AKT Proteolysis Targeting Chimeras (PROTACs) Enable Potent and Selective AKT Degradation in KRAS/BRAF Mutant Cells.
J Med Chem
; 65(20): 14237-14260, 2022 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36197750
20.
Discovery of Potent, Selective, and In Vivo Efficacious AKT Kinase Protein Degraders via Structure-Activity Relationship Studies.
J Med Chem
; 65(4): 3644-3666, 2022 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35119851