Detalhe da pesquisa
1.
Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes.
Molecules
; 27(12)2022 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-35745067
2.
Correction: Clua et al. Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes. Molecules 2022, 27, 3944.
Molecules
; 28(1)2022 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36615657
3.
Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression.
Mol Ther
; 26(1): 105-114, 2018 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28988716
4.
Hepatocyte-specific delivery of siRNAs conjugated to novel non-nucleosidic trivalent N-acetylgalactosamine elicits robust gene silencing in vivo.
Chembiochem
; 16(6): 903-8, 2015 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25786782
5.
Metabolically Stable Anomeric Linkages Containing GalNAc-siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways.
J Med Chem
; 66(4): 2506-2523, 2023 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36757090
6.
Investigational RNAi Therapeutic Targeting C5 Is Efficacious in Pre-clinical Models of Myasthenia Gravis.
Mol Ther Methods Clin Dev
; 13: 484-492, 2019 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31193726
7.
siRNA conjugates carrying sequentially assembled trivalent N-acetylgalactosamine linked through nucleosides elicit robust gene silencing in vivo in hepatocytes.
ACS Chem Biol
; 10(5): 1181-7, 2015 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25730476
8.
A rapid two-step method for isolation of functional primary mouse hepatocytes: cell characterization and asialoglycoprotein receptor based assay development.
Cytotechnology
; 64(2): 187-95, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22105762
9.
Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells.
Mol Ther Nucleic Acids
; 1: e4, 2012 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-23344621