Detalhe da pesquisa
1.
Lysophosphatidylglycerol (LPG) phospholipase D maintains membrane homeostasis in Staphylococcus aureus by converting LPG to lysophosphatidic acid.
J Biol Chem
; 299(7): 104863, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37236358
2.
Pantothenate Kinase Activation Restores Brain Coenzyme A in a Mouse Model of Pantothenate Kinase-Associated Neurodegeneration.
J Pharmacol Exp Ther
; 388(1): 171-180, 2024 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37875310
3.
Relief of CoA sequestration and restoration of mitochondrial function in a mouse model of propionic acidemia.
J Inherit Metab Dis
; 46(1): 28-42, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36251252
4.
LipE guided discovery of isopropylphenyl pyridazines as pantothenate kinase modulators.
Bioorg Med Chem
; 52: 116504, 2021 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34814071
5.
Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs.
Angew Chem Int Ed Engl
; 60(51): 26663-26670, 2021 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34614283
6.
Allosteric Regulation of Mammalian Pantothenate Kinase.
J Biol Chem
; 291(42): 22302-22314, 2016 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27555321
7.
Structural polymorphism in the N-terminal oligomerization domain of NPM1.
Proc Natl Acad Sci U S A
; 111(12): 4466-71, 2014 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24616519
8.
Pterin-sulfa conjugates as dihydropteroate synthase inhibitors and antibacterial agents.
Bioorg Med Chem Lett
; 26(16): 3950-4, 2016 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27423480
9.
PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis.
Nat Chem Biol
; 9(3): 163-8, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23340338
10.
Structural and biochemical basis for development of influenza virus inhibitors targeting the PA endonuclease.
PLoS Pathog
; 8(8): e1002830, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22876176
11.
The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg Med Chem
; 22(7): 2157-65, 2014 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24613625
12.
SB226, an inhibitor of tubulin polymerization, inhibits paclitaxel-resistant melanoma growth and spontaneous metastasis.
Cancer Lett
; 555: 216046, 2023 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36596380
13.
Design, Synthesis, and Biological Evaluation of Pyrimidine Dihydroquinoxalinone Derivatives as Tubulin Colchicine Site-Binding Agents That Displayed Potent Anticancer Activity Both In Vitro and In Vivo.
ACS Pharmacol Transl Sci
; 6(4): 526-545, 2023 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37082747
14.
Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma.
Sci Transl Med
; 14(653): eabq2096, 2022 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35857643
15.
Development of a pterin-based fluorescent probe for screening dihydropteroate synthase.
Bioconjug Chem
; 22(10): 2110-7, 2011 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21916405
16.
Synthesis of bi-substrate state mimics of dihydropteroate synthase as potential inhibitors and molecular probes.
Bioorg Med Chem
; 19(3): 1298-305, 2011 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21216602
17.
Design, Synthesis, and Biological Evaluation of Stable Colchicine-Binding Site Tubulin Inhibitors 6-Aryl-2-benzoyl-pyridines as Potential Anticancer Agents.
J Med Chem
; 64(16): 12049-12074, 2021 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34378386
18.
Pantothenate kinase activation relieves coenzyme A sequestration and improves mitochondrial function in mice with propionic acidemia.
Sci Transl Med
; 13(611): eabf5965, 2021 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34524863
19.
X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor.
J Med Chem
; 64(17): 13072-13095, 2021 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34406768
20.
17-DMAG dually inhibits Hsp90 and histone lysine demethylases in alveolar rhabdomyosarcoma.
iScience
; 24(1): 101996, 2021 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33490904