RESUMO
A pigmented choroidal lesion was observed 41 years prior to enucleation. The patient, with a clinical diagnosis of malignant melanoma in an eye with good visual function, was followed up for the last 25 years by one of the authors. Sudden growth of the lesion and loss of vision led to enucleation and allowed histologic confirmation of the diagnosis of malignant melanoma. A pigmented iris lesion in the same eye was also present for 25 years and showed no notable growth under observation. The patient died of metastatic disease approximately one year after enucleation.
Assuntos
Neoplasias da Coroide/cirurgia , Melanoma/cirurgia , Idoso , Neoplasias da Coroide/diagnóstico , Neoplasias da Coroide/patologia , Feminino , Humanos , Melanoma/diagnóstico , Melanoma/patologia , Fatores de TempoRESUMO
Fifteen owl monkeys (30 eyes) that received proton irradiation of discrete areas of the retina and choroid have been observed for 3 1/2 years or more after irradiation. The dose delivered to the retina varied from a single dose of 1,600 to 4,750 proton rads and from 10,250 to 18,250 rads delivered in five fractions over a period of one month. Fundus examination, fluorescein angiography, and light and electron microscopy revealed chorioretinal changes at the area of irradiation. The part of the retina adjacent to the chorioretinal scar showed preservation of normal retinal vascular architecture on trypsin digest studies of the retina and on electron microscopic examination, even 1 mm from the edge of the scar. The results of this study suggest that proton beam irradiation may markedly reduce delayed ocular complications, especially radiation retinopathy, which is common to other forms of radiotherapy in the treatment of intraocular tumors.
Assuntos
Olho/efeitos da radiação , Prótons , Animais , Câmara Anterior/patologia , Aotus trivirgatus , Corioide/patologia , Traumatismos Oculares , Angiofluoresceinografia , Haplorrinos , Epitélio Pigmentado Ocular/patologia , Lesões Experimentais por Radiação/diagnóstico , Lesões Experimentais por Radiação/patologia , Retina/patologiaRESUMO
Twenty-three untreated patients (14 men and nine women ranging in age from 31 to 74 years) with partial occlusion of the central retinal vein were followed up prospectively for a minimum of 12 months. Seventeen had systemic vascular disease. At the conclusion of the study, 12 patients had visual acuities of 20/40 or better and eight had visual acuities of 20/100 or worse. Eleven patients had complete resolution of the retinopathy and had final visual acuities of 20/30 or better. Five eyes progressed to complete occlusion with final visual acuities of 20/300 or less. Seven eyes had chronic macular edema and visual acuities ranging from 20/40 to 20/200. One eye with background diabetic retinopathy developed optic disk neovascularization. None of the patients developed neovascular glaucoma.