Detalhe da pesquisa
1.
The genomic landscape of response to EGFR blockade in colorectal cancer.
Nature
; 526(7572): 263-7, 2015 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26416732
2.
Systems analysis of protein signatures predicting cetuximab responses in KRAS, NRAS, BRAF and PIK3CA wild-type patient-derived xenograft models of metastatic colorectal cancer.
Int J Cancer
; 147(10): 2891-2901, 2020 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32700762
3.
The "Magnificent Seven" in Oral and Systemic Health against COVID-19.
Endocr Metab Immune Disord Drug Targets
; 2024 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38798209
4.
Synthetic Lethal Interaction with BCL-XL Blockade Deepens Response to Cetuximab in Patient-Derived Models of Metastatic Colorectal Cancer.
Clin Cancer Res
; 29(6): 1102-1113, 2023 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36622698
5.
Phosphoproteomics of patient-derived xenografts identifies targets and markers associated with sensitivity and resistance to EGFR blockade in colorectal cancer.
Sci Transl Med
; 15(709): eabm3687, 2023 08 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-37585503
6.
Towards precision oncology with patient-derived xenografts.
Nat Rev Clin Oncol
; 19(11): 719-732, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36151307
7.
Chromatin Velocity reveals epigenetic dynamics by single-cell profiling of heterochromatin and euchromatin.
Nat Biotechnol
; 40(2): 235-244, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34635836
8.
Molecular Subtyping Combined with Biological Pathway Analyses to Study Regorafenib Response in Clinically Relevant Mouse Models of Colorectal Cancer.
Clin Cancer Res
; 27(21): 5979-5992, 2021 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34426441
9.
Implementing Systems Modelling and Molecular Imaging to Predict the Efficacy of BCL-2 Inhibition in Colorectal Cancer Patient-Derived Xenograft Models.
Cancers (Basel)
; 12(10)2020 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33066609
10.
Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell-like phenotype.
Sci Transl Med
; 12(555)2020 08 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32759276
11.
Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer.
Clin Cancer Res
; 25(20): 6243-6259, 2019 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31375513
12.
Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer.
Nat Commun
; 8: 15107, 2017 05 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-28561063
13.
Sustained Inhibition of HER3 and EGFR Is Necessary to Induce Regression of HER2-Amplified Gastrointestinal Carcinomas.
Clin Cancer Res
; 21(24): 5519-31, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26296355
14.
IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies.
Sci Transl Med
; 7(272): 272ra12, 2015 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-25632036
15.
Inhibition of MEK and PI3K/mTOR suppresses tumor growth but does not cause tumor regression in patient-derived xenografts of RAS-mutant colorectal carcinomas.
Clin Cancer Res
; 18(9): 2515-25, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22392911