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As one of the most instrumental components in the architecture of advanced nanomedicines, plasmonic nanostructures (mainly gold and silver nanomaterials) have been paid a lot of attention. This type of nanomaterial can absorb light photons with a specific wavelength and generate heat or excited electrons through surface resonance, which is a unique physical property. In innovative biomaterials, a significant number of theranostic (therapeutic and diagnostic) materials are produced through the conjugation of thiol-containing ingredients with gold and silver nanoparticles (Au and Ag NPs). Hence, it is essential to investigate Au/Ag-S interfaces precisely and determine the exact bonding states in the active nanobiomaterials. This study intends to provide useful insights into the interactions between Au/Ag NPs and thiol groups that exist in the structure of biomaterials. In this regard, the modeling of Au/Ag-S bonding in active biological ingredients is precisely reviewed. Then, the physiological stability of Au/Ag-based plasmonic nanobioconjugates in real physiological environments (pharmacokinetics) is discussed. Recent experimental validation and achievements of plasmonic theranostics and radiolabelled nanomaterials based on Au/Ag-S conjugation are also profoundly reviewed. This study will also help researchers working on biosensors in which plasmonic devices deal with the thiol-containing biomaterials (e.g., antibodies) inside blood serum and living cells.
Assuntos
Ouro , Nanopartículas Metálicas , Prata , Enxofre , Ouro/química , Prata/química , Nanopartículas Metálicas/química , Enxofre/química , Humanos , Nanomedicina Teranóstica , Materiais Biocompatíveis/química , Animais , Compostos de Sulfidrila/química , Nanoestruturas/químicaRESUMO
This study presents a novel photocatalytic system for photocatalytic degradation of Eriochrome black-T (EBT) dye via green light-emitting diode (LED) light exposure. This photocatalyst is comprised of nanoscale components, i.e., poly(vinyl alcohol) (PVA), magnetic iron oxide nanoparticles (Fe3O4 NPs), gold NPs (Au NPs), and zinc oxide nanorods (ZnO NRs), rendering an active high surface area. The most highlighted property from the structural facet is the superparamagnetic behavior of Fe3O4 NPs, which provides a facile collection of magnetic photocatalyst NPs from the reaction flask and is successfully recycled eight times without considerable reduction in catalytic behavior. Briefly, the photocatalytic degradation at its highest efficiency reached 51.4% (10 ppm dye solution, 5.0 mL) and 64.75% (8 ppm dye solution, 5.0 mL) utilizing 10 mg of the designed photocatalyst (formulated as Fe3O4@PVA-Au/ZnO), a magnetic photocatalytic system under green LED light (7 W, 526 nm) exposure for 60 min. Besides, the photocatalytic degradation mechanism of the EBT dye by the as-prepared photocatalyst was proposed. Based on the obtained results, the presented photocatalytic method was recommended for scaling up and large-scale exploitation for the purification of the water resources.
Assuntos
Óxido de Zinco , Fotólise , Óxido de Zinco/química , Álcool de Polivinil , Catálise , Fenômenos Magnéticos , ZincoRESUMO
Triazoles are biologically important compounds that play a crucial role in biomedical applications. In this study, we present an innovative and eco-friendly nanocatalyst system for synthesizing compounds via the click reaction. The system is composed of Arabic gum (AG), iron oxide magnetic nanoparticles (Fe3O4 MNPs), (3-chloropropyl) trimethoxysilane (CPTMS), 2-aminopyridine (AP), and Cu(i) ions. Using AP as an anchor for Cu(i) ions and Fe3O4 MNPs allows facile separation using an external magnet. The hydrophilic nature of the Fe3O4@AG/AP-Cu(i) nanocomposite makes it highly efficient in water as a green solvent. The highest reaction efficiency (95.0%) was achieved in H2O solvent with 50.0 mg of nanocatalyst for 60 min at room temperature. The reaction yield remained consistent for six runs, demonstrating the stability and effectiveness of the catalyst.
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In the current study, we introduce a hybrid magnetic nanocomposite comprised of curcumin (Cur), iron oxide magnetic nanoparticles (Fe3O4 MNPs), melamine linker (Mel), and silver nanoparticles (Ag NPs). Initially, a facile in situ route is administrated for preparing the Fe3O4@Cur/Mel-Ag effectual magnetic catalytic system. In addition, the advanced catalytic performance of the nanocomposite to reduce the nitrobenzene (NB) derivatives as hazardous chemical substances were assessed. Nevertheless, a high reaction yield of 98% has been achieved in short reaction times 10 min. Moreover, the Fe3O4@Cur/Mel-Ag magnetic nanocomposite was conveniently collected by an external magnet and recycled 5 times without a noticeable diminish in catalytic performance. Therefore, the prepared magnetic nanocomposite is a privileged substance for NB derivatives reduction since it achieved notable catalytic activity.
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In the current project, magnetic Bio-MOF-13 was used as an efficient carrier for the targeted delivery and controlled release of doxorubicin (DOX) to MDA-MB-231 cells. Magnetic Bio-MOF-13 was prepared by two strategies and compared to determine the optimal state of the structure. In the first path, Bio-MOF-13 was grown in situ on the surface of Fe3O4 nanoparticles (core/shell structure), while in the second method, the two presynthesized materials were mixed together (surface composite). Core/shell structure, among prepared nanocomposites, was chosen for biological evaluation due to its favorable structural features like a high accessible surface area and pore volume. Also, it is highly advantageous for drug release due to its ability to selectively release DOX in the acidic pH of breast cancer cells, while preventing any premature release in the neutral pH of the blood. Drug release from the carrier structure is precisely controlled not only by pH but also by an external magnetic field, guaranteeing accurate drug delivery at the intended location. Confocal microscopy and flow cytometry assay clearly confirms the increase in drug concentration in the MDA-MB-231 cell line after external magnet applying. This point, along with the low toxicity of the carrier components, makes it a suitable candidate for injectable medicine. According to MTT results, the percentage of viable MDA-MB-231 cells after treatment with 10 µL of DOX@Fe3O4/Bio-MOF-13 core/shell composite in different concentrations, in the presence and absence of magnetic field is 0.87 ± 0.25 and 2.07 ± 0.15, respectively. As a result, the DOX@Fe3O4/Bio-MOF-13 core/shell composite was performed and approved for targeted drug delivery and magnetic field-assisted controlled release of DOX to the MDA-MB-231 cell line.
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Photothermal therapy (PTT) has developed in recent decades as a relatively safe method for the treatment of cancers. Recently, various species of gold and silver (Au and Ag) nanostructures have been developed and investigated to achieve PTT due to their highly localized surface plasmon resonance (LSPR) effect. Concisely, the collective oscillation of electrons on the surface of Au and Ag nanostructures upon exposure to a specific wavelength (depending on their size and shape) and further plasmonic resonance leads to the heating of the surface of these particles. Hence, porous species can be equipped with tiny plasmonic ingredients that add plasmonic properties to therapeutic cargoes. In this case, a precise review of the recent achievements is very important to figure out to what extent plasmonic photothermal therapy (PPTT) by Au/Ag-based plasmonic porous nanomedicines successfully treated cancers with satisfactory biosafety. Herein, we classify the various species of LSPR-active micro- and nano-materials. Moreover, the routes for the preparation of Ag/Au-plasmonic porous cargoes and related bench assessments are carefully reviewed. Finally, as the main aim of this study, principal requirements for the clinicalization of Ag/Au-plasmonic porous cargoes and their further challenges are discussed, which are critical for specialists in this field.
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An efficient strategy for cancer therapy is presented, in which a tumor mass is initially pretreated with calcium hydroxide, then treated with Taxotere (TXT). In this regard, an advanced delivery system based on iron oxide nanoparticles has been designed. The surface of nanoparticles was functionalized with sortilin (SORT-1, a human IgG1 monoclonal antibody) that specifically encodes caov-4 ovarian cancerous cells. Plasmonic heating of the incorporated gold nanoparticles in polyvinyl alcohol (PVA) has been exploited to control the release process of TXT. The in vitro, ex vivo and in vivo experiments have exhibited high efficacy of a seven-day pretreatment by Ca(OH)2 plus 14 days treatment program by Ca(OH)2@Fe3O4/PVA/Au-SORT nano-therapeutics, where more penetration ratio resulted in tumor growth inhibition by ca. 78.3%. As a result, due to showing high values of the anti-tumor properties and biosafety, the presented pretreatment strategy is suggested for more effective treatment on the aged tumors.
Assuntos
Nanopartículas Metálicas , Neoplasias Ovarianas , Idoso , Anticorpos Monoclonais , Hidróxido de Cálcio , Docetaxel , Feminino , Ouro , Humanos , Imunoglobulina G , Fenômenos Magnéticos , Álcool de PolivinilRESUMO
Herein, a concise review of the latest developments in catalytic processes involving organic reactions is presented, focusing on magnetic catalytic systems (MCSs). In recent years, various micro- and nanoscale magnetic catalysts have been prepared through different methods based on optimized reaction conditions and utilized in complex organic synthesis or degradation reactions of pharmaceutical compounds. These biodegradable, biocompatible and eco-benign MCSs have achieved the principles of green chemistry, and thus their usage is highly advocated. In addition, MCSs can shorten the reaction time, effectively accelerate reactions, and significantly upgrade both pharmaceutical synthesis and degradation mechanisms by preventing unwanted side reactions. Moreover, the other significant benefits of MCSs include their convenient magnetic separation, high stability and reusability, inexpensive raw materials, facile preparation routes, and surface functionalization. In this review, our aim is to present at the recent improvements in the structure of versatile MCSs and their characteristics, i.e., magnetization, recyclability, structural stability, turnover number (TON), and turnover frequency (TOF). Concisely, different hybrid and multifunctional MCSs are discussed. Additionally, the applications of MCSs for the synthesis of different pharmaceutical ingredients and degradation of organic wastewater contaminants such as toxic dyes and drugs are demonstrated.
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Today, various drug delivery systems (DDS) are utilized to carry and deliver the desired drugs to the targeted action area to reduce potential side effects and negative interactions. Nanomaterials are an excellent candidate for the delivery of potent drugs, as they enhance pharmacokinetic and pharmacodynamic properties. Herein, we present a new ciprofloxacin (CPFX) delivery system based on a polymeric nanocarrier (ß-cyclodextrin) conjugated to a cell-adhesive dipeptide structure. Cyclodextrin (CD) is an inexpensive, easily accessible, biodegradable, and biocompatible material. Also, the conjugation of cysteine-arginine (CR) dipeptide to the CPFX/ß-CD particles is carried out to enhance cell adhesion growth. Through accurate analysis, the drug content and release for a final product have been estimated to be ca. 32%. Overall, the antimicrobial effects of CPFX were considerably raised through a low dose of CPFX. The growth zone inhibition of CPFX/ß-CD-CR particles on the staphylococcus aureus and the Escherichia coli bacterial cells was 5.5 ± 0.2 cm and 3.5 ± 0.2 cm, respectively. Hence, this therapeutic nano bioconjugate is an excellent candidate to be applied in antimicrobial applications with the minimum incorporated CPFX.
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In the field of targeted drug delivery, the effects of size and morphology of drug nanocarriers are of great importance and need to be discussed in depth. To be concise, among all the various shapes of nanocarriers, rods and tubes with a narrow cross-section are the most preferred shapes for the penetration of a cell membrane. In this regard, several studies have focused on methods to produce nanorods and nanotubes with controlled optimized size and aspect ratio (AR). Additionally, a non-spherical orientation could affect the cellular uptake process while a tangent angle of less than 45° is better at penetrating the membrane, and Ω = 90° is beneficial. Moreover, these nanocarriers show different behaviors when confronting diverse cells whose fields should be investigated in future studies. In this survey, a comprehensive classification based on carrier shape is first submitted. Then, the most commonly used methods for control over the size and shape of the carriers are reviewed. Finally, influential factors on the cellular uptake and internalization processes and related analytical methods for evaluating this process are discussed.
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Herein, a novel designed antimicrobial therapeutic drug delivery system is presented, in which halloysite nanotubes (HNTs) encapsulate a determined dosage of levofloxacin (lvx). Moreover, gold nanoparticles (AuNPs) have been embedded into the structure for plasmonic heating under irradiation of the green LED light (7 W, 526 nm). It was revealed that the plasmonic heating of the AuNPs leads to a controlled trend in the lvx release process. Also, a synergistic effect on the antimicrobial activity of the prepared therapeutic system has been observed through photothermal heating of the structure. To enhance the cell adhesion, a cell-penetrating peptide sequence (CPP) is conjugated to the surfaces. This CPP has led to quick co-localization of the prepared nano-cargo (denoted as lvx@HNT/Au-CPP) with the bacterial living cells and further attachment (confirmed by confocal microscopy). Concisely, the structure of the designed nano-cargo has been investigated by various methods, and the in vitro cellular experiments (zone of inhibition and colony-counting) have disclosed that the antimicrobial activity of the lvx is significantly enhanced through incorporation into the HNT/Au-CPP delivery system (drug content: 16 wt%), in comparison with the individual lvx with the same dosage. Hence, it can be stated that the bacterial resistance against antibiotics and the toxic effects of the chemical medications are reduced through the application of the presented strategy.