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INTRODUCTION: Perioperative risk stratification is an essential component of preoperative planning for cancer surgery. While frailty has gained attention for its utility in risk stratification, no studies have directly compared it to existing risk calculators. Therefore, the objective of this study was to compare the risk stratification of the American College of Surgeons Surgical Risk Calculator (ACS-SRC), the Revised Risk Analysis Index (RAI-rev), and the Modified Frailty Index (5-mFI). The primary outcomes were 30-day postoperative morbidity, 30-day postoperative mortality, unplanned readmission, unplanned reoperation, and discharge disposition other-than-home. METHODS: Patients undergoing anatomic lung resection for primary, non-small cell lung cancer were identified within the American College of Surgeons National Quality Improvement Program (ACS NSQIP) database. The ACS-SRC, RAI-rev, and 5-mFI tools were used to predict adverse postoperative events. Tools were compared for discrimination in the primary outcomes. RESULTS: 9663 patients undergoing anatomic lung resection for cancer between 2012 and 2014 were included. The cohort was 53.1% female. Median age at diagnosis was 67 (interquartile range = 59-74) years. Cardiothoracic surgeons performed 89% and general surgeons performed 11.0% of the operations. Perioperative morbidity and mortality rates were 10.9% (n = 1048) and 1.6% (n = 158). Rates of 30-day postoperative unplanned readmission and reoperation were 7.5% (n = 725) and 4.8% (n = 468). The ACS-SRC had the highest discrimination for all measured outcomes, as measured by the area under the receiver operating curve (AUC) and corresponding confidence interval (95% confidence interval [CI]). This included perioperative mortality (AUC = 0.74, 95% CI = 0.71-0.78), compared to RAI-rev (AUC = 0.66, 95% CI = 0.62-0.69) and 5-mFI (AUC = 0.61, 95% CI = 0.57-0.65; p < 0.001). The RAI-rev and 5-mFI had similar discrimination for all measured outcomes. CONCLUSION: ACS-SRC was the perioperative risk stratification tool with the highest predictive discrimination for adverse, 30-day, postoperative events for patients with cancer treated with anatomic lung resection.
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BACKGROUND: Participation of women at national surgery conferences is an important aspect of achieving gender equity; however, participation has to be meaningful and representative of scientific and clinical achievement. We hypothesized that the presence of women on planning committees would increase the number of women speakers and the presence of women as moderators would increase the number of women panelists. Furthermore, we hypothesized that although women may be included as speakers, they are less likely to speak on clinical and technical surgical topics than men. METHODS: Four 2018 national surgery conferences were chosen for investigation: Eastern Association for the Surgery of Trauma, Society of American Gastrointestinal and Endoscopic Surgeons, Academic Surgical Conference, and the American Society of Breast Surgeons because of varied subject matter. The published online conference programs were reviewed and participant gender, presentation role, type, and topic were recorded. Submitted abstract and scientific articles were excluded from analysis; moderators of these sessions were included. Statistical analyses were performed using chi-squared tests and t-tests where appropriate. RESULTS: The overall mean percentage of female speakers was 28%. The percentage of women on the program committees positively correlated with the number of women speaking at the conference (Eastern Association for the Surgery of Trauma, 15.4% women on committee vs 18.92% speakers; Society of American Gastrointestinal and Endoscopic Surgeons, 27% versus 22%; Academic Surgical Conference, 38.5% versus 32%; and the American Society of Breast Surgeons, 50% versus 58.55 %; P < 0.001). Panels with greater than 50% female moderators were more likely to have female panelists than those with less than 50% female moderators (23.6% versus 14.8%; P < 0.001). Women were most likely to present awards, introductions, and keynote speeches, then most likely to speak on professionalism (54.84% and 36.29%; P < 0.001). They were significantly less likely to present on a clinical topic, technical skill, or moderate a scientific presentation (25.68% and 26.75%; P < 0.001). CONCLUSION: Despite increasing attention on improving diversity at surgical conferences, disparities continue to persist. As demonstrated in nonsurgical literature, planning committee gender diversity positively correlated with speaker diversity, and moderator diversity positively correlated with panel diversity. Women were more likely to speak on topics considered "soft sciences", such as professionalism and advocacy, and less likely to present on clinical topics, technical skill, or scientific research.
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Congressos como Assunto/estatística & dados numéricos , Equidade de Gênero , Cirurgia Geral/organização & administração , Feminino , Humanos , MasculinoRESUMO
Precision medicine and targeted therapies have a long history in the treatment of breast cancer and continue to show promise for further specialized and individualized care for this disease. From the discovery of endocrine and HER2 targeted therapies, to multigene arrays in chemotherapy for more specific patient selection, to radiomics and genetic subtyping, targeted therapies and precision medicine continue to push the management of breast cancer toward more individualized care. This article describes the foundation and future of targeted therapy and precision medicine in breast cancer.