Detalhe da pesquisa
1.
N-BAR and F-BAR proteins-endophilin-A3 and PSTPIP1-control clathrin-independent endocytosis of L1CAM.
Traffic
; 24(4): 190-212, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36843549
2.
Defining the mechanism of galectin-3-mediated TGF-ß1 activation and its role in lung fibrosis.
J Biol Chem
; 300(6): 107300, 2024 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38641066
3.
Anti-Angiogenic and Anti-Scarring Dual Effect of Galectin-3 Inhibition in Mouse Models of Corneal Wound Healing.
Am J Pathol
; 194(3): 447-458, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38159722
4.
Galectin-8 Downmodulates TLR4 Activation and Impairs Bacterial Clearance in a Mouse Model of Pseudomonas aeruginosa Keratitis.
J Immunol
; 210(4): 398-407, 2023 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36603009
5.
Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis.
Eur Respir J
; 57(5)2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33214209
6.
Crosstalk between WNT and STAT3 is mediated by galectin-3 in tumor progression.
Gastric Cancer
; 24(5): 1050-1062, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33834359
7.
3-Substituted 1-Naphthamidomethyl-C-galactosyls Interact with Two Unique Sub-sites for High-Affinity and High-Selectivity Inhibition of Galectin-3.
Molecules
; 24(24)2019 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31842451
8.
Quinoline-galactose hybrids bind selectively with high affinity to a galectin-8 N-terminal domain.
Org Biomol Chem
; 16(34): 6295-6305, 2018 08 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-30117507
9.
State of affairs: Design and structure-activity relationships of reversible P2Y12 receptor antagonists.
Bioorg Med Chem Lett
; 26(12): 2739-2754, 2016 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27133596
10.
Optimization of ketone-based P2Y(12) receptor antagonists as antithrombotic agents: pharmacodynamics and receptor kinetics considerations.
Bioorg Med Chem Lett
; 24(13): 2963-8, 2014 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24835983
11.
Myocardin related transcription factor and galectin-3 drives lipid accumulation in human blood vessels.
Vascul Pharmacol
; : 107383, 2024 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38830455
12.
Interplay of halogen bonding and solvation in protein-ligand binding.
iScience
; 27(4): 109636, 2024 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38633000
13.
Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer.
J Med Chem
; 2024 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38804039
14.
Discovery of Selective and Orally Available Galectin-1 Inhibitors.
J Med Chem
; 66(24): 16980-16990, 2023 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38059452
15.
Resistance to anti-PD-1/anti-PD-L1: galectin-3 inhibition with GB1211 reverses galectin-3-induced blockade of pembrolizumab and atezolizumab binding to PD-1/PD-L1.
Front Immunol
; 14: 1250559, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37701441
16.
Safety and pharmacokinetics of GB1211, an oral galectin-3 inhibitor: a single- and multiple-dose first-in-human study in healthy participants.
Cancer Chemother Pharmacol
; 91(3): 267-280, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36914828
17.
Evaluating the affinity and kinetics of small molecule glycomimetics for human and mouse galectin-3 using surface plasmon resonance.
SLAS Discov
; 28(5): 233-239, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36990319
18.
Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease.
J Med Chem
; 65(19): 12626-12638, 2022 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36154172
19.
A novel series of piperazinyl-pyridine ureas as antagonists of the purinergic P2Y12 receptor.
Bioorg Med Chem Lett
; 21(10): 2877-81, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21507636
20.
Benzimidazole-galactosides bind selectively to the Galectin-8 N-Terminal domain: Structure-based design and optimisation.
Eur J Med Chem
; 223: 113664, 2021 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34225180