Detalhe da pesquisa
1.
Mass Balance, Metabolic Pathways, Absolute Bioavailability, And Pharmacokinetics of Giredestrant In Healthy Subjects.
Drug Metab Dispos
; 2024 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38834357
2.
Industry Perspective on the Pharmacokinetic and Absorption, Distribution, Metabolism, and Excretion Characterization of Heterobifunctional Protein Degraders.
Drug Metab Dispos
; 51(7): 792-803, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37041086
3.
Identification of a Discrete Diglucuronide of GDC-0810 in Human Plasma after Oral Administration.
Drug Metab Dispos
; 51(10): 1284-1294, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37349116
4.
Smarca2 genetic ablation is phenotypically benign in a safety assessment of tamoxifen-inducible conditional knockout rats.
Toxicol Appl Pharmacol
; 475: 116627, 2023 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37453479
5.
An Integrated Strategy for Assessing the Metabolic Stability and Biotransformation of Macrocyclic Peptides in Drug Discovery toward Oral Delivery.
Anal Chem
; 94(4): 2032-2041, 2022 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35041378
6.
Biotransformation novel advances - 2021 year in review.
Drug Metab Rev
; 54(3): 207-245, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35815654
7.
Bioactivation and reactivity research advances - 2021 year in review.
Drug Metab Rev
; 54(3): 246-281, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35876116
8.
Comparative assessment for rat strain differences in metabolic profiles of 14 drugs in Wistar Han and Sprague Dawley hepatocytes.
Xenobiotica
; 51(1): 15-23, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-32713280
9.
Novel advances in biotransformation and bioactivation research-2019 year in review.
Drug Metab Rev
; 52(3): 333-365, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32645275
10.
NADPH-Independent Inactivation of CYP2B6 and NADPH-Dependent Inactivation of CYP3A4/5 by PBD: Potential Implication for Assessing Covalent Modulators for Time-Dependent Inhibition.
Drug Metab Dispos
; 48(8): 655-661, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32482757
11.
Novel Homodimer Metabolites of GDC-0994 via Cytochrome P450-Catalyzed Radical Coupling.
Drug Metab Dispos
; 48(6): 521-527, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32234735
12.
Bioactivation of α,ß-Unsaturated Carboxylic Acids Through Acyl Glucuronidation.
Drug Metab Dispos
; 48(9): 819-829, 2020 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32616543
13.
Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα).
Bioorg Med Chem Lett
; 30(4): 126907, 2020 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31902710
14.
Biotransformation and bioactivation reactions - 2018 literature highlights.
Drug Metab Rev
; 51(2): 121-161, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31170851
15.
Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo.
Bioconjug Chem
; 30(5): 1356-1370, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30966735
16.
Carfilzomib Is Not an Appropriate Payload of Antibody-Drug Conjugates Due to Rapid Inactivation by Lysosomal Enzymes.
Drug Metab Dispos
; 47(8): 884-889, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31072822
17.
Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues.
Drug Metab Dispos
; 47(10): 1146-1155, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31358513
18.
A Novel Depurination Methodology to Assess DNA Alkylation of Chloro-Bis-Seco-Cyclopropylbenzoindoles Allowed for Comparison of Minor-Groove Reactivity.
Drug Metab Dispos
; 47(5): 547-555, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30858239
19.
Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody-Drug Conjugates.
Drug Metab Dispos
; 47(10): 1156-1163, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31085544
20.
Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities.
Drug Metab Dispos
; 47(10): 1122-1135, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31266753