The mechanisms related to fibroblasts in burn surface.

PURPOSE: Mesenchymal stem cells (MSCs) can promote burn wound healing, skin appearance, and function recovery by promoting the differentiation and migration of fibroblasts of a wound. The burn environment can activate the autophagy of MSCs. However, it is not clear whether this autophagy can affect the proliferation and migration of fibroblasts. METHODS: In this study, pretreated MSCs with rapamycin and 3-methyladenine modulated autophagy and co-cultured with fibroblasts of burn. Cell migration was detected by immunofluorescence chemical staining. Western blot analysis and enzyme-linked immunosorbent assay were performed to detect 2,3-Dioxygenase (IDO), cytokine synthesis inhibitory factor 10 (IL-10), cytokine synthesis inhibitory factor 6 (IL-6), prostaglandin E2 (PGE2), transforming growth factor beta 1 (TGF-ß1) proteins levels, and the autophagy proteins p62 and microtubule-associated protein LC3-II/I. RESULTS: We demonstrated that autophagy regulates MSCs survival and proliferation in burn wound transplants and found that autophagy inhibition with 3-methyladenine reduced MSCs-mediated, fibroblast proliferation and migration in burn environment. However, rapamycin-induced autophagy had the opposite effect and increased the TGF-ß1 expression. Therefore, we speculate that MSCs may promote fibroblast proliferation and migration by secreting TGF-ß1 via the AKT/mTOR (RAC-alpha serine/threonine-protein kinase/mammalian target of rapamycin) pathway. CONCLUSION: Autophagy of MSCs regulates burn wound fibroblast proliferation and migration by affecting TGF-ß1 and prostaglandin E2 production adjacent to MSCs transplanted on the burn wound. The results of this study provide a potential strategy for promoting MSCs treatment of burns.

5 V Compatible Two-Axis PZT Driven MEMS Scanning Mirror with Mechanical Leverage Structure for Miniature LiDAR Application.

The MEMS (Micro-Electronical Mechanical System) scanning mirror is an optical MEMS device that can scan laser beams across one or two dimensions. MEMS scanning mirrors can be applied in a variety of applications, such as laser display, bio-medical imaging and Light Detection and Ranging (LiDAR). These commercial applications have recently created a great demand for low-driving-voltage and low-power MEMS mirrors. However, no reported two-axis MEMS scanning mirror is available for usage in a universal supplying voltage such as 5 V. In this paper, we present an ultra-low voltage driven two-axis MEMS scanning mirror which is 5 V compatible. In order to realize low voltage and low power, a two-axis MEMS scanning mirror with mechanical leverage driven by PZT (Lead zirconate titanate) ceramic is designed, modeled, fabricated and characterized. To further decrease the power of the MEMS scanning mirror, a new method of impedance matching for PZT ceramic driven by a two-frequency mixed signal is established. As experimental results show, this MEMS scanning mirror reaches a two-axis scanning angle of 41.9° × 40.3° at a total driving voltage of 4.2 Vpp and total power of 16 mW. The effective diameter of reflection of the mirror is 2 mm and the operating frequencies of two-axis scanning are 947.51 Hz and 1464.66 Hz, respectively.

Image Quality Analysis and Optical Performance Requirement for Micromirror-Based Lissajous Scanning Displays.

Micromirror-based scanning displays have been the focus of a variety of applications. Lissajous scanning displays have advantages in terms of power consumption; however, the image quality is not good enough. The main reason for this is the varying size and the contrast ratio of pixels at different positions of the image. In this paper, the Lissajous scanning trajectory is analyzed and a new method based on the diamond pixel is introduced to Lissajous displays. The optical performance of micromirrors is discussed. A display system demonstrator is built, and tests of resolution and contrast ratio are conducted. The test results show that the new Lissajous scanning method can be used in displays by using diamond pixels and image quality remains stable at different positions.

Design and experimental evaluation on an advanced multisource energy harvesting system for wireless sensor nodes.

An effective multisource energy harvesting system is presented as power supply for wireless sensor nodes (WSNs). The advanced system contains not only an expandable power management module including control of the charging and discharging process of the lithium polymer battery but also an energy harvesting system using the maximum power point tracking (MPPT) circuit with analog driving scheme for the collection of both solar and vibration energy sources. Since the MPPT and the power management module are utilized, the system is able to effectively achieve a low power consumption. Furthermore, a super capacitor is integrated in the system so that current fluctuations of the lithium polymer battery during the charging and discharging processes can be properly reduced. In addition, through a simple analog switch circuit with low power consumption, the proposed system can successfully switch the power supply path according to the ambient energy sources and load power automatically. A practical WSNs platform shows that efficiency of the energy harvesting system can reach about 75-85% through the 24-hour environmental test, which confirms that the proposed system can be used as a long-term continuous power supply for WSNs.

Fault diagnosis of landing gear retraction system with bond graph under uncertain conditions.

Given the lack of sufficient historical data for aircraft landing gear retractor systems, a model-based fault diagnosis approach is needed to overcome this data deficiency. Meanwhile, inherent uncertainties are inevitable in engineering practice, and it is a great challenge to construct a model that accurately reflects the complexity of the actual system under uncertain conditions. Due to the urgent need for reliable model-based diagnostic methods and the need to cope with inherent uncertainties, this paper proposes an improved fault diagnostic method aimed at increasing the diagnostic efficiency of the landing gear retractor system, a critical component in aircraft take-off and landing operations. Due to a lack of historical data, the model-based fault diagnosis method can solve the problem of lack of data. The proposed uncertainty method addresses the challenge of multiple sources of uncertainty by using subsystems to reduce complexity. Fault diagnosis is achieved by comparing residuals with thresholds derived from a diagnostic bond graph (DBG) model. To address the problem of limited fault data, we modeled and simulated the landing gear retractor system using AMESim®. In addition, the linear fractional transform (LFT) approach has been used to resolve parametric uncertainties, but is unable to resolve system structural uncertainties. Therefore, we also analyzed the comparative fault diagnosis results derived from the linear fractional transformation-DBG (LFT-DBG) and the subsystem-DBG approaches. The experimental results support the effectiveness of the subsystem approach in improving fault diagnosis accuracy and reliability, highlighting its potential as a viable diagnostic strategy in aerospace engineering applications.

A motion characteristics modeled angular position sensor by nonlinear transfer of differential capacitance for miniaturized scanning mirrors.

In this paper, an angular position sensor (APS) designed for a resonant miniaturized scanning mirror (M-SM) is presented. The APS operates based on the principle of differential variable capacitance, significantly expanding the detectable bandwidth from a few hertz to several kilohertz. By modeling the motion characteristics, the sampling rates of the biaxial scanning angles are 1473.6 times and 539.4 times higher than those of conventional sensors. Initially, the motion characteristics model is presented as a simple harmonic motion, converting sampled capacitance into continuous capacitance. Subsequently, the nonparallel state of the M-SM and sensor is transformed into a parallel state through the space coordinate system transformation. Furthermore, a 2D nonlinear angle transfer function is developed to convert the differential capacitance into an angle, thereby mitigating the nonlinear errors resulting from large angles. Achieving an accuracy better than 0.014°, the measuring range expands from ±0.5729° (±10 mrad) to ±5.026° ( ± 87 mrad). Additionally, the capturing mode and tracking mode are proposed to monitor real-time angular changes of the M-SM with an accuracy of 0.017°. High-precision APSs have enhanced beam pointing accuracy and resolution and can thereby be used to advance the development of laser components, including light detection and ranging (LiDAR).

Improved sampling scheme for LiDAR in Lissajous scanning mode.

MEMS light detection and ranging (LiDAR) is becoming an indispensable sensor in vehicle environment sensing systems due to its low cost and high performance. The beam scanning trajectory, sampling scheme and gridding are the key technologies of MEMS LiDAR imaging. In Lissajous scanning mode, this paper improves the sampling scheme, through which a denser Cartesian grid of point cloud data at the same scanning frequency can be obtained. By summarizing the rules of the Cartesian grid, a general sampling scheme independent of the beam scanning trajectory patterns is proposed. Simulation and experiment results show that compared with the existing sampling scheme, the resolution and the number of points per frame are both increased by 2 times with the same hardware configuration and scanning frequencies for a MEMS scanning mirror (MEMS-SM). This is beneficial for improving the point cloud imaging performance of MEMS LiDAR.

Identification of key genes related to skin burns based on bioinformatics analysis.

To further understand the regulatory network and molecular mechanisms of gene expression after skin burns, we performed bioinformatics analysis of gene expression profiles of skin burn samples and identified key genes associated with skin burns. The GSE8056 dataset and GSE139028 dataset was downloaded from the Gene Expression Omnibus (GEO) database for analysis and validation. The limma package was used to screen for differentially expressed genes (DEGs). Gene ontology (GO) and pathway enrichment analyses (KEGG) were then performed. Subsequently, LASSO regression analysis was performed on DEGs and a regulatory network map of skin burn-related genes was constructed. Finally, the infiltration of immune cells was calculated and co-expression network maps of immune-related key genes and skin regeneration genes were constructed. Analysis of the GSE8056 dataset showed that 432 genes were upregulated and 351 genes were downregulated. The DEGs were mainly focused on immune response and skin regeneration. Meanwhile, these two groups of pivotal genes were significantly associated with abnormal infiltration of 9 immune cells. GSE139028 validation revealed that 3 hub genes associated with skin burn immunity were differentially expressed, except for S100A8, while only the DPT gene was differentially expressed among the seven hub genes associated with skin regeneration. In short, the effect of skin burn on patients is to regulate the expression of immune-related genes UPP1, MMP1, MMP3 and skin regeneration-related gene DPT, which may be the key target for the treatment of skin burn.

Dermal Toxicity Influence of Gold Nanomaterials after Embedment in Cosmetics.

Gold nanomaterials (Au NMs) have been widely used in cosmetic products for improving the brightening, and reducing the wrinkling of, skin, etc.; however, the dermal safety of Au NMs is rarely concerned. A previous study found that cosmetics could enhance the toxicity of Au nanosheets, but different physicochemical properties of Au NMs will induce different interaction modes with ingredients of cosmetics, potentially leading to different toxicity profiles. In the present study, spherical and rodlike Au NMs were first found in commercial cosmetics, and then Au nanospheres (NSs) with different sizes and Au nanorods (NRs) with different aspect ratios were prepared to simulate these Au NMs in cosmetics and further investigate their toxicity before and after embedment in cosmetics. It was found that the primary sizes, morphologies, and optical absorptions of these Au NSs and NRs before and after embedment were similar; however, their hydrodynamic sizes and zeta potentials were noticeably different. Then, these Au NSs and NRs presented weak or no cytotoxicity against HaCaT keratinocytes, while cosmetic cream could alleviate their cytotoxicity. Moreover, the cream could enhance the accumulation of Au NSs and NRs in the skin of hairless mice, but it also alleviated the toxicological responses of Au NSs and NRs in terms of superoxide dismutase (SOD) elevation and malondialdehyde (MDA) reduction. Therefore, the embedment of Au NSs and NRs into cosmetics can alleviate the in vitro and in vivo dermal toxicities of Au NSs and NRs.

A novel multi-aperture based sun sensor based on a fast multi-point MEANSHIFT (FMMS) algorithm.

With the current increased widespread interest in the development and applications of micro/nanosatellites, it was found that we needed to design a small high accuracy satellite attitude determination system, because the star trackers widely used in large satellites are large and heavy, and therefore not suitable for installation on micro/nanosatellites. A Sun sensor + magnetometer is proven to be a better alternative, but the conventional sun sensor has low accuracy, and cannot meet the requirements of the attitude determination systems of micro/nanosatellites, so the development of a small high accuracy sun sensor with high reliability is very significant. This paper presents a multi-aperture based sun sensor, which is composed of a micro-electro-mechanical system (MEMS) mask with 36 apertures and an active pixels sensor (APS) CMOS placed below the mask at a certain distance. A novel fast multi-point MEANSHIFT (FMMS) algorithm is proposed to improve the accuracy and reliability, the two key performance features, of an APS sun sensor. When the sunlight illuminates the sensor, a sun spot array image is formed on the APS detector. Then the sun angles can be derived by analyzing the aperture image location on the detector via the FMMS algorithm. With this system, the centroid accuracy of the sun image can reach 0.01 pixels, without increasing the weight and power consumption, even when some missing apertures and bad pixels appear on the detector due to aging of the devices and operation in a harsh space environment, while the pointing accuracy of the single-aperture sun sensor using the conventional correlation algorithm is only 0.05 pixels.

Neuraminidase inhibitory terpenes from endophytic Cochliobolus sp.

The chemical study of endophytic fungus of Cochliobolus led to the isolation of 10 terpenes (1-10), including one new compound named isocochlioquinone B (1). Their structures were elucidated on the basis of spectroscopic methods, including 2D NMR techniques. Compounds 5-7 showed significant neuraminidase inhibitory activity with IC(50) values of 0.79-1.75 µM.

Efficacy and safety of blood purification in the treatment of deep burns: A systematic review and meta-analysis.

INTRODUCTION: This meta-analysis aimed to systematically review and evaluate randomized controlled trials (RCTs) and cohort studies examining the efficacy and safety of blood purification in the treatment of patients with deep burns. METHODS: The PubMed, Cochrane Library, and Embase databases and relevant references were systematically searched for RCTs and cohort studies published until the end of September 2020 to investigate the potential of blood purification in improving the prognosis of severely burned patients. The primary outcome of this systematic review was overall patient mortality; secondary outcomes included the incidence of sepsis and infection prevention (vital signs and routine blood tests). RESULTS: A total of 6 RCTs and 1 cohort study were included, with a total of 538 burn patients (274 patients who received blood purification and 264 control patients). Compared with patients who received conventional treatment, those treated with blood purification displayed significant 2-day reduction in mortality and sepsis with relative risks of 0.62 and 0.41, respectively (95% confidence intervals [CIs], 0.74-0.82 and 0.25-0.67, respectively; P < .05). In terms of vital signs and blood biochemistry, the respiratory rates and blood urea nitrogen levels of patients in the blood purification group 3 days post-treatment were significantly higher than those in the control group (randomized standard deviations (SMDs), 0.78 and 0.77, respectively; 95% CIs, 0.33-1.23 and 1.22-0.31, respectively; P < .05). However, there were no significant differences between groups on day 3 with regard to temperature (P = .32), heart rate (P = .26), white blood cell count (P = .54), or neutrophil count (P = .74), potentially owing to the small sample size or the relatively short intervention time. Heterogeneous differences existed between the groups with respect to blood urea nitrogen (SMD = -1.22; 95% CI, -2.16 to -0.40; P < .00001) and Cr (SMD = -3.13; 95% CI, -4.92 to -1.33; P < .00001) on day 7. No systematic adverse events occurred. CONCLUSIONS: Blood purification treatment for deep burn patients can significantly reduce the mortality rate and the incidence of complications.

Design rules for dense and rapid Lissajous scanning.

Lissajous microscanners are very popular in compact laser-scanning applications, such as solid-state light detection and ranging (LIDAR), owing to their high-quality factor and low power consumption. In the Lissajous scanner driven by a two-axis micro-electro-mechanical system scanning mirror (MEMS-SM), the design theory is insufficient to meet the temporal and spatial resolution at the same time. In this paper, the greatest common divisor of the two-axis driving frequency is used as the temporal resolution, the concept of the fill factor (FF) is used to describe the spatial resolution of the scanner, and a general algorithm for calculating the FF is presented. Combined with the characteristics of the Lissajous trajectory, three design rules of the general Lissajous scanner are proposed, and the design theory of the Lissajous scanner enabling MEMS LIDAR is perfected. Experimental results show that the proposed design rules can effectively meet the LIDAR design requirements.

A two-dimensional micro scanner integrated with a piezoelectric actuator and piezoresistors.

A compact two-dimensional micro scanner with small volume, large deflection angles and high frequency is presented and the two-dimensional laser scanning is achieved by specular reflection. To achieve large deflection angles, the micro scanner excited by a piezoelectric actuator operates in the resonance mode. The scanning frequencies and the maximum scanning angles of the two degrees of freedom are analyzed by modeling and simulation of the structure. For the deflection angle measurement, piezoresistors are integrated in the micro scanner. The appropriate directions and crystal orientations of the piezoresistors are designed to obtain the large piezoresistive coefficients for the high sensitivities. Wheatstone bridges are used to measure the deflection angles of each direction independently and precisely. The scanner is fabricated and packaged with the piezoelectric actuator and the piezoresistors detection circuits in a size of 28 mm×20 mm×18 mm. The experiment shows that the two scanning frequencies are 216.8 Hz and 464.8 Hz, respectively. By an actuation displacement of 10 µm, the scanning range of the two-dimensional micro scanner is above 26° × 23°. The deflection angle measurement sensitivities for two directions are 59 mV/deg and 30 mV/deg, respectively.

Post-traumatic psychological intervention in college athletes / Intervenção psicológica pós-traumática em atletas universitários / Intervención psicológica postraumática en deportistas universitarios

ABSTRACT Introduction: Injuries will always be with an athlete throughout their career. When analyzing the factors that cause athletic injuries, their coaches usually consider environmental and physical training factors, ignoring psychological factors. Objective: Investigate the mental health status of college athletes after serious injuries during competition, discussing the impact of sports injuries on athletes' mental health. Methods: Twelve college athletes were selected as research volunteers. They were divided into two groups by randomization. The control group was followed by traditional psychotherapy while the experimental group received the post-traumatic mental intervention. A comparison was carried out and mainly the general situation of sports injuries and the effect of intervention treatment were analyzed. The impact of psychological intervention methods on athletes' mental health after injuries were also studied using mathematical statistics to analyze the data. Results: There were significant differences in STAI scores in the experimental group before and after the intervention. BFS scores in the experimental group were significantly higher than those in the control group before and after an intervention. There was no significant difference in the indicators in the control group. Conclusion: Post-traumatic psychological intervention positively affects the mental health recovery of college athletes. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.

RESUMO Introdução: Os ferimentos estarão sempre com um atleta durante toda a sua carreira. Ao analisar os fatores que causam as lesões atléticas, seus treinadores geralmente consideram fatores ambientais e de treinamento físico, ignorando os fatores psicológicos. Objetivo: Investigar o estado de saúde mental dos atletas universitários após as lesões graves durante as competições, discutindo o impacto das lesões esportivas sobre a saúde mental dos atletas. Métodos: Foram selecionados 12 atletas universitários como voluntários de pesquisa. Eles foram divididos em dois grupos por randomização. O grupo de controle foi acompanhado pela psicoterapia tradicional enquanto o grupo experimental recebeu intervenção mental pós-traumática. Foi efetuada a comparação e analisada principalmente a situação geral das lesões esportivas e o efeito do tratamento de intervenção. O impacto dos métodos de intervenção psicológica sobre a saúde mental dos atletas após lesões também foi estudado utilizando o método de estatística matemática que é usado para analisar os dados. Resultados: Houve diferenças significativas na pontuação do STAI no grupo experimental antes e depois da intervenção. Os índices de BFS no grupo experimental foram significativamente maiores do que os do grupo de controle antes e depois de uma intervenção. Não houve diferença significativa nos indicadores do grupo de controle. Conclusão: A intervenção psicológica pós-traumática tem um efeito positivo sobre a recuperação da saúde mental dos atletas universitários. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

RESUMEN Introducción: Las lesiones siempre acompañarán a un deportista a lo largo de su carrera. Al analizar los factores que causan las lesiones deportivas, los entrenadores suelen tener en cuenta los factores ambientales y de entrenamiento físico, ignorando los factores psicológicos. Objetivo: Investigar el estado de salud mental de los atletas universitarios después de sufrir lesiones graves durante las competiciones, analizando el impacto de las lesiones deportivas en la salud mental de los atletas. Métodos: Se seleccionaron doce atletas universitarios como voluntarios para la investigación. Se dividieron en dos grupos de forma aleatoria. El grupo de control recibió una psicoterapia tradicional, mientras que el grupo experimental recibió una intervención mental postraumática. Se realizó una comparación y se analizó principalmente la situación general de las lesiones deportivas y el efecto del tratamiento de intervención. También se estudió el impacto de los métodos de intervención psicológica en la salud mental de los deportistas después de las lesiones, utilizando el método de la estadística matemática para analizar los datos. Resultados: Hubo diferencias significativas en las puntuaciones del STAI en el grupo experimental antes y después de la intervención. Las puntuaciones del BFS en el grupo experimental fueron significativamente más altas que las del grupo de control antes y después de la intervención. No hubo diferencias significativas en los indicadores del grupo de control. Conclusión: La intervención psicológica postraumática tiene un efecto positivo en la recuperación de la salud mental de los deportistas universitarios. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento.

Optimization Design and Simulation of a Multi-Source Energy Harvester Based on Solar and Radioisotope Energy Sources.

A novel multi-source energy harvester based on solar and radioisotope energy sources is designed and simulated in this work. We established the calculation formulas for the short-circuit current and open-circuit voltage, and then studied and analyzed the optimization thickness of the semiconductor, doping concentration, and junction depth with simulation of the transport process of ß particles in a semiconductor material using the Monte Carlo simulation program MCNP (version 5, Radiation Safety Information Computational Center, Oak Ridge, TN, USA). In order to improve the efficiency of converting solar light energy into electric power, we adopted PC1D (version 5.9, University of New South Wales, Sydney, Australia) to optimize the parameters, and selected the best parameters for converting both the radioisotope energy and solar energy into electricity. The results concluded that the best parameters for the multi-source energy harvester are as follows: Na is 1 × 1019 cm-3, Nd is 3.8 × 1016 cm-3, a PN junction depth of 0.5 µm (using the 147Pm radioisotope source), and so on. Under these parameters, the proposed harvester can achieve a conversion efficiency of 5.05% for the 147Pm radioisotope source (with the activity of 9.25 × 108 Bq) and 20.8% for solar light radiation (AM1.5). Such a design and parameters are valuable for some unique micro-power fields, such as applications in space, isolated terrestrial applications, and smart dust in battlefields.

The effect of physical fitness to change human health and improve the quality of life / O efeito da aptidão física para mudar a saúde humana e melhorar a qualidade de vida / El efecto de la aptitud física para cambiar la salud humana y mejorar la calidad de vida

ABSTRACT Introduction People need to strengthen their bodies through leisure sports to prevent diseases. Physical fitness exercise is conducive to maintaining a good physical and mental state and establishing a good interpersonal relationship. Exercise can keep people happy. Object According to the actual needs of people's physical fitness exercises, this article uses the correlation analysis method to carry out an empirical analysis on the effect of physical fitness exercises on the quality of life. Method The paper puts forward a model based on indicators combined with correlation analysis by constructing a hypothetical model of the effect of physical fitness exercise. We analyzed the reasons and influencing factors of people participating in physical fitness exercises. Results The influencing indicators of people's participation in sports to improve the quality of life are gender, age, and disposable income. Conclusion People playing sports can enhance the quality and quality of life. Level of evidence II; Therapeutic studies - investigation of treatment results.

RESUMO Introdução As pessoas precisam fortalecer seus corpos por meio de esportes de lazer para prevenir doenças. O exercício de aptidão física contribui para a manutenção de um bom estado físico e mental e para o estabelecimento de um bom relacionamento interpessoal. O exercício pode manter as pessoas felizes. Objetivo De acordo com as reais necessidades de exercícios de aptidão física das pessoas, este artigo utiliza o método de análise de correlação para realizar uma análise empírica sobre o efeito dos exercícios de aptidão física na qualidade de vida. Método O artigo propõe um modelo baseado em indicadores combinados com análise de correlação por meio da construção de um modelo hipotético do efeito do exercício de aptidão física. Analisamos os motivos e fatores que influenciam as pessoas que participam de exercícios de aptidão física. Resultados Os indicadores que influenciam a participação das pessoas no esporte para melhorar a qualidade de vida são gênero, idade e renda disponível. Conclusão Pessoas que praticam esportes podem melhorar a qualidade de vida. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento.

RESUMEN Introducción Las personas necesitan fortalecer su cuerpo a través de deportes recreativos para prevenir enfermedades. El ejercicio físico favorece el mantenimiento de un buen estado físico y mental y el establecimiento de una buena relación interpersonal. El ejercicio puede hacer felices a las personas. Objeto De acuerdo con las necesidades reales de los ejercicios de aptitud física de las personas, este artículo utiliza el método de análisis de correlación para realizar un análisis empírico sobre el efecto de los ejercicios de aptitud física en la calidad de vida. Método El trabajo propone un modelo basado en indicadores combinados con análisis de correlación mediante la construcción de un modelo hipotético del efecto del ejercicio físico. Analizamos los motivos y factores de influencia de las personas que realizan ejercicios de acondicionamiento físico. Resultados Los indicadores que influyen en la participación de las personas en el deporte para mejorar la calidad de vida son el género, la edad y la renta disponible. Conclusión las personas que practican deportes pueden mejorar la calidad de vida. Nivel de evidencia II; Estudios terapéuticos: investigación de los resultados del tratamiento.

Separation and structural elucidation of a new tadalafil analogue diethylaminopretadalafil included as an adulterant in a dietary supplement.

A new tadalafil analogue was detected and isolated from a dietary supplement, the structure was elucidated by means of nuclear magnetic resonance (NMR) and mass spectroscopy. The compound was determined to be diethylaminopretadalafil, which might be derived from a precursor in the synthesis of tadalafil.