RESUMO
A convenient zinc-promoted [4+3] cycloaddition of a carbonyl ene-yne with simple dienes was first achieved. This reaction provided an efficient strategy to prepare various cyclohepta[b]furan rings by cascade cycloadditions. Additionally, a multicomponent reaction of dione, alkynal, and diene was also reported, which exhibited a novel strategy for selective creations of C-O bonds and C-C bonds.
Assuntos
Furanos/síntese química , Compostos Heterocíclicos/síntese química , Zinco/química , Catálise , Reação de Cicloadição , Furanos/química , Compostos Heterocíclicos/químicaRESUMO
Brønsted acid catalyzed tandem cyclization was found to be highly effective for the preparation of a series of polysubstituted 4-pyrones from diynones (yield up to 99%). 4-Pyridone and 3-pyrrolone derivatives were also selectively synthesized by employing NIS and/or Brønsted acid. NIS as an electrophilic reagent could promote these reactions efficiently and rapidly under very mild reaction conditions.
Assuntos
Ácidos/química , Cetonas/química , Piridonas/síntese química , Pironas/síntese química , Pirróis/síntese química , Catálise , Ciclização , Estrutura Molecular , Piridonas/química , Pironas/química , Pirróis/químicaRESUMO
A Bi(III)-catalyzed method for the synthesis of highly conjugated aromatic multisubstituted fluorene with (Z)-pent-2-en-4-yl acetates and ethynylarenes via domino reaction is described. In this process, the reaction appears to be very general and suitable for a variety of multisubstituted fluorene.
RESUMO
An efficient approach for the synthesis of tetrasubstituted cyclopentadienes through Pd-catalyzed reactions of (Z)-2-en-4-yn acetates with substituted indoles was developed. This methodology has the advantages of broad scope, simple conditions and easily accessible starting materials.
RESUMO
A new and efficient synthesis of substituted indene has been achieved via copper(I)-catalyzed domino three-component coupling and cyclization reaction in moderate to good yield.
Assuntos
Cobre/química , Indenos/síntese química , Aminas/química , Catálise , Ciclização , Formaldeído/química , Indenos/química , Malonatos/química , Estrutura Molecular , Polímeros/químicaRESUMO
An intermolecular condensation reaction of 1,3,5-triarylenynols catalyzed by copper is developed. This reaction is a straightforward method for the synthesis of highly conjugated 1H-cyclopenta[b]naphthalene. Fluorescent properties have been determined for some of the products.
Assuntos
Alcinos/química , Cobre/química , Ciclopentanos/síntese química , Naftalenos/química , Compostos Organometálicos/química , Catálise , Ciclização , Ciclopentanos/química , Estrutura Molecular , EstereoisomerismoRESUMO
A strategy for the synthesis of spiroketal compounds through a tandem iodocyclization of 1-(2-ethynylphenyl)-4-hydroxybut-2-yn-1-one derivatives is presented. This reaction could proceed under very mild conditions in a short time and avoid the use of expensive and toxic metal catalysts. Moreover, the resulting halides can be further exploited by subsequent palladium-catalyzed coupling reactions, which act as the important intermediates for building other valuable compounds.
RESUMO
Palladium-catalyzed carbene migratory insertion-cyclization reactions were reported, delivering dihydronaphthalene and indene derivatives in moderate to good yields. A three-component cross-coupling was also developed. The reactions are easy to handle, under mild conditions and various functional groups are tolerated.
Assuntos
Carbono/química , Hidrazonas/química , Paládio/química , Compostos de Tosil/química , Catálise , Indenos/química , Estrutura Molecular , Naftalenos/químicaRESUMO
A novel and efficient synthetic approach to substituted 2-iodo-spiro[indene-1,1'-isobenzofuran]-3'-ones has been developed via an iodine-promoted cascade cyclization of 2-(3-hydroxy-3,3-diarylprop-1-yn-1-yl)benzoates. This sequential cascade process is concisely conducted at room temperature. Subsequent palladium-catalyzed Sonogashira, Suzuki, and Heck reactions of the resulting iodides proceed smoothly in good yields.