1.
Chem Commun (Camb)
; 56(1): 157-160, 2019 Dec 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31799975
RESUMO
Modular polyketide synthases (PKSs) are enzymatic assembly lines that fuse carbon fragments into complex chiral products. Here, their synthetic logic is employed to chemoenzymatically generate two-stereocenter triketides. Each of the four stereoisomers was constructed in a stereocontrolled manner using C-acylation and two PKS ketoreductases possessing opposite stereoselectivities.