Synthesis of (Furyl)Methyl Disulfides via Tandem Reaction of Conjugated Ene-Yne-Ketones with Acetyl-Masked Disulfide Nucleophiles.

In this study, we outline a general method for the construction of various (furyl)methyl disulfides from acetyl-masked disulfide nucleophiles and ene-yne-ketones. This protocol is feathered by metal-free, simple experimental conditions, high efficiency, and scalable potential, which make it attractive and practical.

Transition-Metal-Free Disulfuration of Amides with Trisulfide Dioxides via Formation of Unaccessible S-S-N Bonds.

Under transition-metal-free conditions, trisulfide dioxides were used as disulfurating reagents to react with a wide range of amides, affording various substituted N-disulfanyl amides in good yields. Furthermore, the gram-scale experiment has confirmed the practicability of this approach.

Value of Procalcitonin in Neonatal Infection within 24 Hours after Birth: a Retrospective Cohort Study.

BACKGROUND: Neonatal infections, especially neonatal pneumonia, are clinically common and have a high mortality rate. Early diagnosis and the duration of appropriate antibiotic treatment are critical. PCT is an indication of infection and may be valuable. METHODS: This is a retrospective cohort of 269 neonates within 24 hours after birth, analyzing the value of procalcitonin, C-reactive protein, and white blood cell count in neonatal infections, especially neonatal pneumonia, and antibiotic therapy. RESULTS: The median of PCT, CRP, and WBC in the severely infected group, neonatal pneumonia group, neonatal infection group, and non-infectious disease group were (1.76, 5.25, 15.8), (0.20, 0.53, 13.8), (0.22, 3.64, 10.4), and (0.15, 0.39, 10.6), respectively. In ROC curves, PCT had an area under the curve (AUC) of 0.64 (95% CI, 0.49 - 0.0.79); CRP had an AUC of 0.61 (95% CI, 0.49 - 0.74); WBC had an AUC of 0.78 (95% CI, 0.67 - 0.88). There was a significant difference between the neonatal pneumonia with PCT results group and the neonatal pneumonia without PCT results group, p < 0.001. The median of antibiotic treatment was 4.0 d (95% CI 3.7 - 4.8) in the neonatal pneumonia with PCT results group vs. 4.9 d (95% CI 4.5 - 5.6) in the standard group; p < 0.001. CONCLUSIONS: PCT helps identify neonate infections and grades of infections and assists pediatricians in deciding when to stop antibiotic treatment; PCT and WBC help improve the accuracy of neonatal pneumonia diagnosis.

Construction of ß-Acetoxy or ß-Hydroxyl Disulfides via Highly Regioselective Ring-Opening of Epoxides with Acetyl Masked Disulfide Nucleophiles.

In the organic or water phase, acetyl masked disulfide nucleophiles were used as the disulfide source to react with a wide range of epoxides, affording various ß-acetoxy or ß-hydroxyl disulfides in good yields with high regioselectivity. This method features transition-metal-free, simple experimental conditions, high atom economy, and scalable potential, which make it attractive and practical.

Visible-light-induced synthesis of N-disulfanyl indoles, pyrroles or carbazoles via the construction of stable S-S-N bonds.

A simple and efficient visible-light-induced approach for the formation of stable S-S-N bonds has been developed. Through these photocatalytic reactions, a series of N-disulfanyl indoles, pyrroles and carbazoles were afforded with good to excellent yields. Moreover, the gram-scale experiment has confirmed the practicability of this approach.