Detalhe da pesquisa
1.
Combinatorial metabolic engineering of Streptomyces sp. CB03234-S for the enhanced production of anthraquinone-fused enediyne tiancimycins.
Microb Cell Fact
; 23(1): 128, 2024 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38704580
2.
Combined transcriptomic and pangenomic analyses guide metabolic amelioration to enhance tiancimycins production.
Appl Microbiol Biotechnol
; 108(1): 18, 2024 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-38170317
3.
Chalkophomycin Biosynthesis Revealing Unique Enzyme Architecture for a Hybrid Nonribosomal Peptide Synthetase and Polyketide Synthase.
Molecules
; 29(9)2024 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38731473
4.
Discovery and Biosynthetic Studies of a Highly Reduced Cinnamoyl Lipid, Tripmycin A, from an Endophytic Streptomyces sp.
J Nat Prod
; 86(7): 1870-1877, 2023 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37462318
5.
Lipopeptide surfactin ameliorates the cell uptake of platensimycin and enhances its therapeutic effect on treatment of MRSA skin infection.
J Antimicrob Chemother
; 77(10): 2840-2849, 2022 09 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-35848795
6.
Characterization and application of a thermophilic Argonaute from archaeon Thermococcus thioreducens.
Biotechnol Bioeng
; 119(9): 2388-2398, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35661137
7.
Liposome-Encapsulated Tiancimycin A Is Active against Melanoma and Metastatic Breast Tumors: The Effect of cRGD Modification of the Liposomal Carrier and Tiancimycin A Dose on Drug Activity and Toxicity.
Mol Pharm
; 19(4): 1078-1090, 2022 04 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35290067
8.
Deciphering the pathway-specific regulatory network for production of ten-membered enediyne Tiancimycins in Streptomyces sp. CB03234-S.
Microb Cell Fact
; 21(1): 188, 2022 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36088456
9.
Characterization of Chalkophomycin, a Copper(II) Metallophore with an Unprecedented Molecular Architecture.
J Am Chem Soc
; 143(49): 20579-20584, 2021 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34851100
10.
Genome mining of Streptomyces sp. CB00271 as a natural high-producer of ß-rubromycin and the resulting discovery of ß-rubromycin acid.
Biotechnol Bioeng
; 118(6): 2243-2254, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33629382
11.
Genome mining of novel rubiginones from Streptomyces sp. CB02414 and characterization of the post-PKS modification steps in rubiginone biosynthesis.
Microb Cell Fact
; 20(1): 192, 2021 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34600534
12.
Platensimycin-Encapsulated Poly(lactic-co-glycolic acid) and Poly(amidoamine) Dendrimers Nanoparticles with Enhanced Anti-Staphylococcal Activity in Vivo.
Bioconjug Chem
; 31(5): 1425-1437, 2020 05 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32286051
13.
Surfactin Ameliorated the Internalization and Inhibitory Performances of Bleomycin Family Compounds in Tumor Cells.
Mol Pharm
; 17(6): 2125-2134, 2020 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32348151
14.
The Isolation of Pyrroloformamide Congeners and Characterization of Their Biosynthetic Gene Cluster.
J Nat Prod
; 83(2): 202-209, 2020 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32049520
15.
Antitubercular Ilamycins from Marine-Derived Streptomyces atratus SCSIO ZH16 ΔilaR.
J Nat Prod
; 83(5): 1646-1657, 2020 05 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32324401
16.
Genome shuffling based on different types of ribosome engineering mutants for enhanced production of 10-membered enediyne tiancimycin-A.
Appl Microbiol Biotechnol
; 104(10): 4359-4369, 2020 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-32236679
17.
Discovery of the leinamycin family of natural products by mining actinobacterial genomes.
Proc Natl Acad Sci U S A
; 114(52): E11131-E11140, 2017 12 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29229819
18.
A 3-hydroxy-3-methylglutaryl-CoA synthase-based probe for the discovery of the acyltransferase-less type I polyketide synthases.
Environ Microbiol
; 21(11): 4270-4282, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31435987
19.
Streptomycin-induced ribosome engineering complemented with fermentation optimization for enhanced production of 10-membered enediynes tiancimycin-A and tiancimycin-D.
Biotechnol Bioeng
; 116(6): 1304-1314, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30712262
20.
Recycling of Chinese herb residues by endophytic and probiotic fungus Aspergillus cristatus CB10002 for the production of medicinal valuable anthraquinones.
Microb Cell Fact
; 18(1): 102, 2019 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31164126