Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

ADAR1 edits the SenZ and SenZ-ability of RNA.

Zillinger, Thomas; Bartok, Eva.

Immunity ; 54(9): 1909-1911, 2021 09 14.

Artigo em Inglês | MEDLINE | ID: mdl-34525334

2.

SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA.

Maharana, Shovamayee; Kretschmer, Stefanie; Hunger, Susan; Yan, Xiao; Kuster, David; Traikov, Sofia; Zillinger, Thomas; Gentzel, Marc; Elangovan, Shobha; Dasgupta, Padmanava; Chappidi, Nagaraja; Lucas, Nadja; Maser, Katharina Isabell; Maatz, Henrike; Rapp, Alexander; Marchand, Virginie; Chang, Young-Tae; Motorin, Yuri; Hubner, Norbert; Hartmann, Gunther; Hyman, Anthony A; Alberti, Simon; Lee-Kirsch, Min Ae.

Mol Cell ; 82(19): 3712-3728.e10, 2022 10 06.

Artigo em Inglês | MEDLINE | ID: mdl-36150385

3.

Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2.

Ostendorf, Thomas; Zillinger, Thomas; Andryka, Katarzyna; Schlee-Guimaraes, Thais Marina; Schmitz, Saskia; Marx, Samira; Bayrak, Kübra; Linke, Rebecca; Salgert, Sarah; Wegner, Julia; Grasser, Tatjana; Bauersachs, Sonja; Soltesz, Leon; Hübner, Marc P; Nastaly, Maximilian; Coch, Christoph; Kettwig, Matthias; Roehl, Ingo; Henneke, Marco; Hoerauf, Achim; Barchet, Winfried; Gärtner, Jutta; Schlee, Martin; Hartmann, Gunther; Bartok, Eva.

Immunity ; 52(4): 591-605.e6, 2020 04 14.

Artigo em Inglês | MEDLINE | ID: mdl-32294405

4.

Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.

Gao, Pu; Ascano, Manuel; Wu, Yang; Barchet, Winfried; Gaffney, Barbara L; Zillinger, Thomas; Serganov, Artem A; Liu, Yizhou; Jones, Roger A; Hartmann, Gunther; Tuschl, Thomas; Patel, Dinshaw J.

Cell ; 153(5): 1094-107, 2013 May 23.

Artigo em Inglês | MEDLINE | ID: mdl-23647843

5.

Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA.

Gao, Pu; Ascano, Manuel; Zillinger, Thomas; Wang, Weiyi; Dai, Peihong; Serganov, Artem A; Gaffney, Barbara L; Shuman, Stewart; Jones, Roger A; Deng, Liang; Hartmann, Gunther; Barchet, Winfried; Tuschl, Thomas; Patel, Dinshaw J.

Cell ; 154(4): 748-62, 2013 Aug 15.

Artigo em Inglês | MEDLINE | ID: mdl-23910378

6.

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA.

Herzner, Anna-Maria; Hagmann, Cristina Amparo; Goldeck, Marion; Wolter, Steven; Kübler, Kirsten; Wittmann, Sabine; Gramberg, Thomas; Andreeva, Liudmila; Hopfner, Karl-Peter; Mertens, Christina; Zillinger, Thomas; Jin, Tengchuan; Xiao, Tsan Sam; Bartok, Eva; Coch, Christoph; Ackermann, Damian; Hornung, Veit; Ludwig, Janos; Barchet, Winfried; Hartmann, Gunther; Schlee, Martin.

Nat Immunol ; 16(10): 1025-33, 2015 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-26343537

7.

A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA.

de Regt, Ann Kristin; Anand, Kanchan; Ciupka, Katrin; Bender, Felix; Gatterdam, Karl; Putschli, Bastian; Fusshöller, David; Hilbig, Daniel; Kirchhoff, Alexander; Hunkler, Charlotte; Wolter, Steven; Grünewald, Agathe; Wallerath, Christina; Schuberth-Wagner, Christine; Ludwig, Janos; Paeschke, Katrin; Bartok, Eva; Hagelueken, Gregor; Hartmann, Gunther; Zillinger, Thomas; Geyer, Matthias; Schlee, Martin.

Nucleic Acids Res ; 51(21): 11893-11910, 2023 Nov 27.

Artigo em Inglês | MEDLINE | ID: mdl-37831086

8.

Varicella zoster virus-induced autophagy in human neuronal and hematopoietic cells exerts antiviral activity.

Heinz, Johanna L; Hinke, Daniëla M; Maimaitili, Muyesier; Wang, Jiayi; Sabli, Ira K D; Thomsen, Michelle; Farahani, Ensieh; Ren, Fanghui; Hu, Lili; Zillinger, Thomas; Grahn, Anna; von Hofsten, Joanna; Verjans, Georges M G M; Paludan, Søren R; Viejo-Borbolla, Abel; Sancho-Shimizu, Vanessa; Mogensen, Trine H.

J Med Virol ; 96(6): e29690, 2024 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-38804180

9.

Exonuclease TREX1 also Has a Sweet Tooth.

Barchet, Winfried; Zillinger, Thomas.

Immunity ; 43(3): 411-3, 2015 Sep 15.

Artigo em Inglês | MEDLINE | ID: mdl-26377892

10.

A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2'O-Methylated Self RNA.

Schuberth-Wagner, Christine; Ludwig, Janos; Bruder, Ann Kristin; Herzner, Anna-Maria; Zillinger, Thomas; Goldeck, Marion; Schmidt, Tobias; Schmid-Burgk, Jonathan L; Kerber, Romy; Wolter, Steven; Stümpel, Jan-Philip; Roth, Andreas; Bartok, Eva; Drosten, Christian; Coch, Christoph; Hornung, Veit; Barchet, Winfried; Kümmerer, Beate M; Hartmann, Gunther; Schlee, Martin.

Immunity ; 43(1): 41-51, 2015 Jul 21.

Artigo em Inglês | MEDLINE | ID: mdl-26187414

11.

C-terminal variants in CDC42 drive type I interferon-dependent autoinflammation in NOCARH syndrome reversible by ruxolitinib.

Kapp, Friedrich G; Kretschmer, Stefanie; Beckmann, Cora C A; Wäsch, Lena; Molitor, Anne; Carapito, Raphaël; Schubert, Mario; Lucas, Nadja; Conrad, Solène; Poignant, Sylvaine; Isidor, Bertrand; Rohlfs, Meino; Kisaarslan, Aysenur Paç; Schanze, Denny; Zenker, Martin; Schmitt-Graeff, Annette; Strahm, Brigitte; Peters, Anke; Yoshimi, Ayami; Driever, Wolfgang; Zillinger, Thomas; Günther, Claudia; Maharana, Shovamayee; Guan, Kaomei; Klein, Christoph; Ehl, Stephan; Niemeyer, Charlotte M; Unal, Ekrem; Bahram, Seiamak; Hauck, Fabian; Lee-Kirsch, Min Ae; Speckmann, Carsten.

Clin Immunol ; 256: 109777, 2023 11.

Artigo em Inglês | MEDLINE | ID: mdl-37741518

12.

Induction of Interferon-Stimulated Genes Correlates with Reduced Growth of Influenza A Virus in Lungs after RIG-I Agonist Treatment of Ferrets.

Schwab, Lara S U; Londrigan, Sarah L; Brooks, Andrew G; Hurt, Aeron C; Sahu, Anshupa; Deng, Yi-Mo; Moselen, Jean; Coch, Christoph; Zillinger, Thomas; Hartmann, Gunther; Reading, Patrick C.

J Virol ; 96(16): e0055922, 2022 08 24.

Artigo em Inglês | MEDLINE | ID: mdl-35916513

13.

Absence of cGAS-mediated type I IFN responses in HIV-1-infected T cells.

Elsner, Carina; Ponnurangam, Aparna; Kazmierski, Julia; Zillinger, Thomas; Jansen, Jenny; Todt, Daniel; Döhner, Katinka; Xu, Shuting; Ducroux, Aurélie; Kriedemann, Nils; Malassa, Angelina; Larsen, Pia-Katharina; Hartmann, Gunther; Barchet, Winfried; Steinmann, Eike; Kalinke, Ulrich; Sodeik, Beate; Goffinet, Christine.

Proc Natl Acad Sci U S A ; 117(32): 19475-19486, 2020 08 11.

Artigo em Inglês | MEDLINE | ID: mdl-32709741

14.

Retinoic Acid-Inducible Gene I Activation Inhibits Human Respiratory Syncytial Virus Replication in Mammalian Cells and in Mouse and Ferret Models of Infection.

Schwab, Lara S U; Farrukee, Rubaiyea; Eléouët, Jean-François; Rameix-Welti, Marie-Anne; Londrigan, Sarah L; Brooks, Andrew G; Hurt, Aeron C; Coch, Christoph; Zillinger, Thomas; Hartmann, Gunther; Reading, Patrick C.

J Infect Dis ; 226(12): 2079-2088, 2022 12 13.

Artigo em Inglês | MEDLINE | ID: mdl-35861054

15.

Recessive NLRC4-Autoinflammatory Disease Reveals an Ulcerative Colitis Locus.

Steiner, Annemarie; Reygaerts, Thomas; Pontillo, Alessandra; Ceccherini, Isabella; Moecking, Jonas; Moghaddas, Fiona; Davidson, Sophia; Caroli, Francesco; Grossi, Alice; Castro, Fabio Fernandes Morato; Kalil, Jorge; Gohr, Florian N; Schmidt, Florian I; Bartok, Eva; Zillinger, Thomas; Hartmann, Gunther; Geyer, Matthias; Gattorno, Marco; Mendonça, Leonardo Oliveira; Masters, Seth L.

J Clin Immunol ; 42(2): 325-335, 2022 02.

Artigo em Inglês | MEDLINE | ID: mdl-34783940

16.

Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing.

Gehrke, Nadine; Mertens, Christina; Zillinger, Thomas; Wenzel, Jörg; Bald, Tobias; Zahn, Sabine; Tüting, Thomas; Hartmann, Gunther; Barchet, Winfried.

Immunity ; 39(3): 482-95, 2013 Sep 19.

Artigo em Inglês | MEDLINE | ID: mdl-23993650

17.

Characterization of Endogenous SERINC5 Protein as Anti-HIV-1 Factor.

Passos, Vânia; Zillinger, Thomas; Casartelli, Nicoletta; Wachs, Amelie S; Xu, Shuting; Malassa, Angelina; Steppich, Katja; Schilling, Hildegard; Franz, Sergej; Todt, Daniel; Steinmann, Eike; Sutter, Kathrin; Dittmer, Ulf; Bohne, Jens; Schwartz, Olivier; Barchet, Winfried; Goffinet, Christine.

J Virol ; 93(24)2019 12 15.

Artigo em Inglês | MEDLINE | ID: mdl-31597782

18.

SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue.

Kmiec, Dorota; Akbil, Bengisu; Ananth, Swetha; Hotter, Dominik; Sparrer, Konstantin M J; Stürzel, Christina M; Trautz, Birthe; Ayouba, Ahidjo; Peeters, Martine; Yao, Zhong; Stagljar, Igor; Passos, Vânia; Zillinger, Thomas; Goffinet, Christine; Sauter, Daniel; Fackler, Oliver T; Kirchhoff, Frank.

PLoS Pathog ; 14(8): e1007269, 2018 08.

Artigo em Inglês | MEDLINE | ID: mdl-30125328

19.

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5'-diphosphates.

Goubau, Delphine; Schlee, Martin; Deddouche, Safia; Pruijssers, Andrea J; Zillinger, Thomas; Goldeck, Marion; Schuberth, Christine; Van der Veen, Annemarthe G; Fujimura, Tsutomu; Rehwinkel, Jan; Iskarpatyoti, Jason A; Barchet, Winfried; Ludwig, Janos; Dermody, Terence S; Hartmann, Gunther; Reis e Sousa, Caetano.

Nature ; 514(7522): 372-375, 2014 10 16.

Artigo em Inglês | MEDLINE | ID: mdl-25119032

20.

Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes.

Steinhagen, Folkert; Zillinger, Thomas; Peukert, Konrad; Fox, Mario; Thudium, Marcus; Barchet, Winfried; Putensen, Christian; Klinman, Dennis; Latz, Eicke; Bode, Christian.

Eur J Immunol ; 48(4): 605-611, 2018 04.

Artigo em Inglês | MEDLINE | ID: mdl-29215161

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