RESUMO
We aimed to investigate the short-term correlation between blood lead levels and oxidative stress generation in coal miners. The study involved 94 male coal miners from the Velenje Coal mine, arranged into four groups: three groups according to the number of consecutive working days, and a fourth control group. Miners who worked for three consecutive days had higher blood levels of lead and 8-isoprostane than the control group (P < 0.001). Correlation between lead and 8-isoprostane was of medium strength (r = 0.512, P < 0.001). Short-term lead environmental exposure can potentially harmful and should be considered when formulating improvements in working processes.
Assuntos
Minas de Carvão , Poluentes Ambientais/toxicidade , Chumbo/sangue , Chumbo/toxicidade , Exposição Ocupacional , Estresse Oxidativo/efeitos dos fármacos , Adulto , Humanos , Isoprostanos/sangue , MasculinoRESUMO
This study was to investigate whether working in conditions of elevated concentrations of mine gases (CO2, CO, CH4, DMS) and dust may result in oxidative stress. Coal miners (n=94) from the Velenje Coal mine who were arranged into control group and three groups according to a number of consecutive working days. 8-isoprostane as a biological marker of oxidative stress was measured in exhaled breath condensate (EBC). Miners who worked for three consecutive days had higher 8-isoprostane values in EBC compared to the control group. Gas/dust concentrations and exposure time of a single/two day shift seem too low to trigger immediate oxidative stress.
Assuntos
Minas de Carvão , Dinoprosta/análogos & derivados , Estresse Oxidativo , Adulto , Biomarcadores/análise , Testes Respiratórios , Carvão Mineral/efeitos adversos , Dinoprosta/análise , Poeira/análise , Humanos , Masculino , Pessoa de Meia-Idade , Mineradores/estatística & dados numéricos , Exposição Ocupacional/análise , Recursos HumanosRESUMO
BACKGROUND: We aimed to investigate the polluted working environment triggers oxidative stress and alter enzymatic antioxidant activity by a short-term interval. METHODS: The experimental study, performed in 2014, involved 94 workers from the Velenje Coalmine in Slovenia, arranged into three groups according to a number of consecutive working days in a mineshaft, supported by a control group. Levels of the antioxidant enzymes (GPx, CAT, SOD) together with TAC (the combined effect of all antioxidants) and 8-isoprostane (a biological marker of oxidative stress/damage) were measured in human plasma. RESULTS: Workers occupationally exposed for three consecutive working days had significantly increased 8-isoprostane biomarker, a parameter of oxidative stress (P<0.001). The antioxidant levels of TAC (P<0.001), CAT (P<0.001) and SOD (P<0.001) were all significantly decreased compared to a control group. CONCLUSION: Workers in polluted working environment had significantly increased oxidative stress and altered antioxidant activity already on a third consecutive working day.