[Postoperative ventral hernia in cancer patients].

Surgical patients with cancer of the stomach, colon and genitals (316) were followed up. Frequencies of postoperative ventral hernia and certain factors of their development were evaluated. It was found that surgical complication occurred in 29.4%, aged 4-192 months. Hernia was mostly registered in gynecological and colorectal cancer patients who had had laparotomy and radiotherapy in their case history. Considering its frequency, postoperative ventral hernia is a serious health problem.

[Average time of cell mitosis in the hematopoietic tissue of rats]. / Sredniaia dlitel'nost' mitoza kletok krovetvornykh tkanei krys.

Rats (Wistar) were irradiated (60Co) with dose of 500 R at the dose-rate of 345 R/min. Using a curve of decrease of the mitotic index in hemopoietic tissue cells after irradiation, an attempt has been made to determine the average time of mitosis. The parameters (latent period, the minimum and average time of mitosis, resp., variance and density distribution type) were introduced in the mathematical equation which relates mitotic index postradiation decrease curve to mitosis time density distribution. It has been found that the actual average time of mitosis for hemopoietic tissues of rats is in the range of 25--27 min 32--33 min and 26--27 min. for thymocytes, promyelocytes--myelocytes and erythroblasts--normoblasts, respectively.

[Effect of phytohemagglutinin on T-lymphocytes isolated from human blood]. / Deistvie fitogemaggliutinina na vydelennye iz krovi cheloveka T-limfotsity.

T--enriched lymphocyte fraction from normal donors was isolated from heparinized peripheral blood on Ficoll-Urotrast gradients. The mitogenic response of T-lymphocytes in culture was 3 times as high as that of unseparated mononuclear cells. The intensity of blast transformation to PHA did not correlate with the increase of T-lymphocytes in culture. These data suggest that cells of not T-origin may be the limiting factor during mitogenic response of T-lymphocytes to PHA.

[Relationship between the detection of circulating antibodies to antigen with a molecular weight of 67 kD and the severity of clinical manifestations of infectious-allergic myocarditis]. / Vzaimosviaz' mezhdu vyiavleniem tsirkuliruiushchikh antitel k antigeny c molekuliarnoi massoi 67 kD i tiazhest'iu klinicheskikh proiavlennii infektsionno-allergicheskogo miokardita.

Infectious allergic myocarditis (IAM) is frequently complicated by signs of congestive heart failure (CHF). IAM patients generally suffer from rhythm and conduction disturbances which can be the leading symptom of the disease in some patients. Slowly progressive immune inflammation in the myocardium makes the differential diagnosis difficult in IAM and dilated cardiomyopathy in which endomyocardial biopsy and cardiospecific immunological examinations of the patient are of great significance. Identification of the autoimmune process in the myocardium and early immunodepressive therapy may arrest the progression of myocardial damage. The purpose of the present study was to examine the relationship between antigen antibodies and clinical manifestations of myocardial damage in IAM.

[The clinical significance of determining the HLA-DR4 antigen in patients with breast cancer]. / Klinicheskoe znachenie opredeleniia antigena HLA-DR4 u bol'nykh rakom molochnoi zhelezy.

A study of HLA phenotype in 151 cases of breast cancer showed an increased occurrence of DR4 antigen (46.8%) as compared to general population (16.3%). Some clinical parameters of DR4-positive and DR4-negative patients were compared. Estradiol receptor-negative tumor was observed in 40% of DR4-positive patients and only in 18.5% of estradiol receptor-negative ones. DR4 positivity was associated with poorer prognosis.

[Selection of the method of plastic surgery of the abdominal wall in ventral hernia]. / Vybor metoda plastiki briushnoi stenki pri ventral'nykh gryzhakh.

Materials on surgical treatment of 365 patients with various types of ventral hernias are discussed. The authors describe original methods of ventroplasty which they developed and approved . The methods comprise duplication of the whole peritoneal-muscular-cicatricial-aponeurotic complex of the abdominal wall by means of a double-row suture passed through all these layers and application of a third reinforcing row of sutures; whenever necessary, the operation is divided into two stages. Preoperative compression training of the abdomen is conducted in cases of a large hernia. Attention is focused on the need to choose the method of plasty for each individual patient, which makes it possible to avoid serious complications and fatal outcomes and produce good results of the treatment. Recurrences in large ventral hernias occurred in 8% of cases.

[Effect of thymocyte autotransplantation on postradiation regeneration of hematopoiesis]. / Vliianie autotransplantatsii timotsitov na postluchevuiu regeneratsiiu krovetvoreniia

Experiments were conducted on Wistar rats irradiated in a dose of 400 R; a study was made of the effect of thymocyte autotransplantation (4-10(8)--8-10(8)) on the restoration of cell number of the bone marrow and the spleen. There was revealed a significant stimulating effect of autotransplantation of thymocytes on the erythroid and granulocytic series in the bone marrow and on the lymphoid one in the spleen during the restoration (the 5 th-- 7 th days) after the irradiation. Irradiation of the thymocyte suspension with gamma-rays in a dose of 10 000 R failed to prevent the effect of autotransplantation on the bone marrow, but decreased its stimulating effect. A conclusion was drawn on the interaction of the administered thymocytes with the stem hemopoietic cell.