Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Crystal Structures and Nuclear Magnetic Resonance Studies of the Apo Form of the c-MYC:MAX bHLHZip Complex Reveal a Helical Basic Region in the Absence of DNA.

Sammak, Susan; Hamdani, Najoua; Gorrec, Fabrice; Allen, Mark D; Freund, Stefan M V; Bycroft, Mark; Zinzalla, Giovanna.

Biochemistry ; 58(29): 3144-3154, 2019 07 23.

Artigo em Inglês | MEDLINE | ID: mdl-31260268

2.

A New Way Forward in Cancer Drug Discovery: Inhibiting the SWI/SNF Chromatin Remodelling Complex.

Zinzalla, Giovanna.

Chembiochem ; 17(8): 677-82, 2016 Apr 15.

Artigo em Inglês | MEDLINE | ID: mdl-26684344

3.

Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry.

Heidelberger, Sibylle; Zinzalla, Giovanna; Antonow, Dyeison; Essex, Samantha; Basu, B Piku; Palmer, Jonathan; Husby, Jarmila; Jackson, Paul J M; Rahman, Khondaker M; Wilderspin, Andrew F; Zloh, Mire; Thurston, David E.

Bioorg Med Chem Lett ; 23(16): 4719-22, 2013 Aug 15.

Artigo em Inglês | MEDLINE | ID: mdl-23810499

4.

Small-molecule inhibition of c-MYC:MAX leucine zipper formation is revealed by ion mobility mass spectrometry.

Harvey, Sophie R; Porrini, Massimiliano; Stachl, Christiane; MacMillan, Derek; Zinzalla, Giovanna; Barran, Perdita E.

J Am Chem Soc ; 134(47): 19384-92, 2012 Nov 28.

Artigo em Inglês | MEDLINE | ID: mdl-23106332

5.

Molecular dynamics studies of the STAT3 homodimer:DNA complex: relationships between STAT3 mutations and protein-DNA recognition.

Husby, Jarmila; Todd, Alan K; Haider, Shozeb M; Zinzalla, Giovanna; Thurston, David E; Neidle, Stephen.

J Chem Inf Model ; 52(5): 1179-92, 2012 May 25.

Artigo em Inglês | MEDLINE | ID: mdl-22500887

6.

Biophysical and Structural Methods to Study the bHLHZip Region of Human c-MYC.

Zinzalla, Giovanna.

Methods Mol Biol ; 2318: 21-43, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-34019285

7.

SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site.

Allen, Mark D; Freund, Stefan M V; Bycroft, Mark; Zinzalla, Giovanna.

Commun Biol ; 4(1): 528, 2021 05 05.

Artigo em Inglês | MEDLINE | ID: mdl-33953332

8.

A novel small-molecule inhibitor of IL-6 signalling.

Zinzalla, Giovanna; Haque, Mohammad R; Basu, B Piku; Anderson, John; Kaye, Samantha L; Haider, Shozeb; Hasan, Fyeza; Antonow, Dyeison; Essex, Samantha; Rahman, Khondaker M; Palmer, Jonathan; Morgenstern, Daniel; Wilderspin, Andrew F; Neidle, Stephen; Thurston, David E.

Bioorg Med Chem Lett ; 20(23): 7029-32, 2010 Dec 01.

Artigo em Inglês | MEDLINE | ID: mdl-21030257

9.

Facile nucleophilic substitution at the C3a tertiary carbon of the 3a-bromohexahydropyrrolo[2,3-b]indole scaffold.

Villanueva-Margalef, Isabel; Thurston, David E; Zinzalla, Giovanna.

Org Biomol Chem ; 8(23): 5294-303, 2010 Dec 07.

Artigo em Inglês | MEDLINE | ID: mdl-20856944

10.

Structure of the BRK domain of the SWI/SNF chromatin remodeling complex subunit BRG1 reveals a potential role in protein-protein interactions.

Allen, Mark D; Bycroft, Mark; Zinzalla, Giovanna.

Protein Sci ; 29(4): 1047-1053, 2020 04.

Artigo em Inglês | MEDLINE | ID: mdl-31909846

11.

The structure of INI1/hSNF5 RPT1 and its interactions with the c-MYC:MAX heterodimer provide insights into the interplay between MYC and the SWI/SNF chromatin remodeling complex.

Sammak, Susan; Allen, Mark D; Hamdani, Najoua; Bycroft, Mark; Zinzalla, Giovanna.

FEBS J ; 285(22): 4165-4180, 2018 11.

Artigo em Inglês | MEDLINE | ID: mdl-30222246

12.

A selective high affinity MYC-binding compound inhibits MYC:MAX interaction and MYC-dependent tumor cell proliferation.

Castell, Alina; Yan, Qinzi; Fawkner, Karin; Hydbring, Per; Zhang, Fan; Verschut, Vasiliki; Franco, Marcela; Zakaria, Siti Mariam; Bazzar, Wesam; Goodwin, Jacob; Zinzalla, Giovanna; Larsson, Lars-Gunnar.

Sci Rep ; 8(1): 10064, 2018 07 03.

Artigo em Inglês | MEDLINE | ID: mdl-29968736

13.

Targeting protein-protein interactions (PPIs) of transcription factors: Challenges of intrinsically disordered proteins (IDPs) and regions (IDRs).

Sammak, Susan; Zinzalla, Giovanna.

Prog Biophys Mol Biol ; 119(1): 41-6, 2015 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-26126425

14.

The SWI/SNF Subunit INI1 Contains an N-Terminal Winged Helix DNA Binding Domain that Is a Target for Mutations in Schwannomatosis.

Allen, Mark D; Freund, Stefan M V; Zinzalla, Giovanna; Bycroft, Mark.

Structure ; 23(7): 1344-9, 2015 Jul 07.

Artigo em Inglês | MEDLINE | ID: mdl-26073604

15.

Synthesis of chiral chromium tricarbonyl labeled thymine PNA monomers via the Ugi reaction.

Baldoli, Clara; Maiorana, Stefano; Licandro, Emanuela; Zinzalla, Giovanna; Perdicchia, Dario.

Org Lett ; 4(24): 4341-4, 2002 Nov 28.

Artigo em Inglês | MEDLINE | ID: mdl-12443093

16.

Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography.

Nkansah, Edwin; Shah, Rahi; Collie, Gavin W; Parkinson, Gary N; Palmer, Jonathan; Rahman, Khondaker M; Bui, Tam T; Drake, Alex F; Husby, Jarmila; Neidle, Stephen; Zinzalla, Giovanna; Thurston, David E; Wilderspin, Andrew F.

FEBS Lett ; 587(7): 833-9, 2013 Apr 02.

Artigo em Inglês | MEDLINE | ID: mdl-23434585

17.

Chemical variation of natural-product-like scaffolds: design, synthesis, and biological activity of fused bicyclic acetal derivatives.

Milroy, Lech-Gustav; Zinzalla, Giovanna; Prencipe, Giuseppe; Michel, Patrick; Ley, Steven V; Gunaratnam, Mekala; Beltran, Monica; Neidle, Stephen.

Angew Chem Int Ed Engl ; 46(14): 2493-6, 2007.

Artigo em Inglês | MEDLINE | ID: mdl-17318936

18.

Targeting MYC: is it getting any easier?

Zinzalla, Giovanna.

Future Med Chem ; 8(16): 1899-1902, 2016 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-27652613

19.

Paving the way to targeting HECT ubiquitin ligases.

Zinzalla, Giovanna.

Future Med Chem ; 7(16): 2107-11, 2015.

Artigo em Inglês | MEDLINE | ID: mdl-26510616

20.

Facile oxidation of electron-poor benzo[b]thiophenes to the corresponding sulfones with an aqueous solution of H2O2 and P2O5.

Antonow, Dyeison; Marrafa, Teresa; Dawood, Irfaan; Ahmed, Tauheed; Haque, Mohammad R; Thurston, David E; Zinzalla, Giovanna.

Chem Commun (Camb) ; 46(13): 2289-91, 2010 Apr 07.

Artigo em Inglês | MEDLINE | ID: mdl-20234935

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Crystal Structures and Nuclear Magnetic Resonance Studies of the Apo Form of the c-MYC:MAX bHLHZip Complex Reveal a Helical Basic Region in the Absence of DNA.

A New Way Forward in Cancer Drug Discovery: Inhibiting the SWI/SNF Chromatin Remodelling Complex.

Investigation of the protein alkylation sites of the STAT3:STAT3 inhibitor Stattic by mass spectrometry.

Small-molecule inhibition of c-MYC:MAX leucine zipper formation is revealed by ion mobility mass spectrometry.

Molecular dynamics studies of the STAT3 homodimer:DNA complex: relationships between STAT3 mutations and protein-DNA recognition.

Biophysical and Structural Methods to Study the bHLHZip Region of Human c-MYC.

SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site.

A novel small-molecule inhibitor of IL-6 signalling.

Facile nucleophilic substitution at the C3a tertiary carbon of the 3a-bromohexahydropyrrolo[2,3-b]indole scaffold.

Structure of the BRK domain of the SWI/SNF chromatin remodeling complex subunit BRG1 reveals a potential role in protein-protein interactions.

The structure of INI1/hSNF5 RPT1 and its interactions with the c-MYC:MAX heterodimer provide insights into the interplay between MYC and the SWI/SNF chromatin remodeling complex.

A selective high affinity MYC-binding compound inhibits MYC:MAX interaction and MYC-dependent tumor cell proliferation.

Targeting protein-protein interactions (PPIs) of transcription factors: Challenges of intrinsically disordered proteins (IDPs) and regions (IDRs).

The SWI/SNF Subunit INI1 Contains an N-Terminal Winged Helix DNA Binding Domain that Is a Target for Mutations in Schwannomatosis.

Synthesis of chiral chromium tricarbonyl labeled thymine PNA monomers via the Ugi reaction.

Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography.

Chemical variation of natural-product-like scaffolds: design, synthesis, and biological activity of fused bicyclic acetal derivatives.

Targeting MYC: is it getting any easier?

Paving the way to targeting HECT ubiquitin ligases.

Facile oxidation of electron-poor benzo[b]thiophenes to the corresponding sulfones with an aqueous solution of H2O2 and P2O5.