Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Autonomous B-cell receptor signaling and genetic aberrations in chronic lymphocytic leukemia-phenotype monoclonal B lymphocytosis in siblings of patients with chronic lymphocytic leukemia.

Quinten, Edwin; Sepúlveda-Yáñez, Julieta H; Koning, Marvyn T; Eken, Janneke A; Pfeifer, Dietmar; Nteleah, Valeri; De Groen, Ruben A L; Saravia, Diego Alvarez; Knijnenburg, Jeroen; Stuivenberg-Bleijswijk, Hedwig E; Pantic, Milena; Agathangelidis, Andreas; Keppler-Hafkemeyer, Andrea; Van Bergen, Cornelis A M; Uribe-Paredes, Roberto; Stamatopoulos, Kostas; Vermaat, Joost S P; Zirlik, Katja; Navarrete, Marcelo A; Jumaa, Hassan; Veelken, Hendrik.

Haematologica ; 109(3): 824-834, 2024 Mar 01.

Artigo em Inglês | MEDLINE | ID: mdl-37439337

2.

Conditional survival to assess prognosis in patients with chronic lymphocytic leukemia.

Schlosser, Pascal; Schiwitza, Annett; Klaus, Jonas; Hieke-Schulz, Stefanie; Szic, Katarzyna Szarc Vel; Duyster, Justus; Trepel, Martin; Zirlik, Katja; Schumacher, Martin; Claus, Rainer.

Ann Hematol ; 103(5): 1613-1622, 2024 May.

Artigo em Inglês | MEDLINE | ID: mdl-38308707

3.

Microenvironmental stromal cells abrogate NF-κB inhibitor-induced apoptosis in chronic lymphocytic leukemia.

Simon-Gabriel, Carl Philipp; Foerster, Katharina; Saleem, Shifa; Bleckmann, Dorothee; Benkisser-Petersen, Marco; Thornton, Nicolas; Umezawa, Kazuo; Decker, Sarah; Burger, Meike; Veelken, Hendrik; Claus, Rainer; Dierks, Christine; Duyster, Justus; Zirlik, Katja.

Haematologica ; 103(1): 136-147, 2018 01.

Artigo em Inglês | MEDLINE | ID: mdl-29122993

4.

Idelalisib.

Zirlik, Katja; Veelken, Hendrik.

Recent Results Cancer Res ; 212: 243-264, 2018.

Artigo em Inglês | MEDLINE | ID: mdl-30069634

5.

Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling.

Dühren-von Minden, Marcus; Übelhart, Rudolf; Schneider, Dunja; Wossning, Thomas; Bach, Martina P; Buchner, Maike; Hofmann, Daniel; Surova, Elena; Follo, Marie; Köhler, Fabian; Wardemann, Hedda; Zirlik, Katja; Veelken, Hendrik; Jumaa, Hassan.

Nature ; 489(7415): 309-12, 2012 Sep 13.

Artigo em Inglês | MEDLINE | ID: mdl-22885698

6.

Lectins from opportunistic bacteria interact with acquired variable-region glycans of surface immunoglobulin in follicular lymphoma.

Schneider, Dunja; Dühren-von Minden, Marcus; Alkhatib, Alabbas; Setz, Corinna; van Bergen, Cornelis A M; Benkißer-Petersen, Marco; Wilhelm, Isabel; Villringer, Sarah; Krysov, Sergey; Packham, Graham; Zirlik, Katja; Römer, Winfried; Buske, Christian; Stevenson, Freda K; Veelken, Hendrik; Jumaa, Hassan.

Blood ; 125(21): 3287-96, 2015 May 21.

Artigo em Inglês | MEDLINE | ID: mdl-25784678

7.

Histopathological regression after neoadjuvant docetaxel, oxaliplatin, fluorouracil, and leucovorin versus epirubicin, cisplatin, and fluorouracil or capecitabine in patients with resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4-AIO): results from the phase 2 part of a multicentre, open-label, randomised phase 2/3 trial.

Al-Batran, Salah-Eddin; Hofheinz, Ralf D; Pauligk, Claudia; Kopp, Hans-Georg; Haag, Georg Martin; Luley, Kim Barbara; Meiler, Johannes; Homann, Nils; Lorenzen, Sylvie; Schmalenberg, Harald; Probst, Stephan; Koenigsmann, Michael; Egger, Matthias; Prasnikar, Nicole; Caca, Karel; Trojan, Jörg; Martens, Uwe M; Block, Andreas; Fischbach, Wolfgang; Mahlberg, Rolf; Clemens, Michael; Illerhaus, Gerald; Zirlik, Katja; Behringer, Dirk M; Schmiegel, Wolff; Pohl, Michael; Heike, Michael; Ronellenfitsch, Ulrich; Schuler, Martin; Bechstein, Wolf O; Königsrainer, Alfred; Gaiser, Timo; Schirmacher, Peter; Hozaeel, Wael; Reichart, Alexander; Goetze, Thorsten O; Sievert, Mark; Jäger, Elke; Mönig, Stefan; Tannapfel, Andrea.

Lancet Oncol ; 17(12): 1697-1708, 2016 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-27776843

8.

MDSCs: the final frontier of the microenvironment in CLL?

Zirlik, Katja.

Blood ; 124(5): 666-8, 2014 Jul 31.

Artigo em Inglês | MEDLINE | ID: mdl-25082859

9.

BCR and chemokine responses upon anti-IgM and anti-IgD stimulation in chronic lymphocytic leukaemia.

Haerzschel, Andrea; Catusse, Julie; Hutterer, Evelyn; Paunovic, Manuela; Zirlik, Katja; Eibel, Hermann; Krenn, Peter W; Hartmann, Tanja N; Burger, Meike.

Ann Hematol ; 95(12): 1979-1988, 2016 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-27542958

10.

Premature terminal differentiation protects from deregulated lymphocyte activation by ITK-Syk.

Bach, Martina P; Hug, Eva; Werner, Markus; Holch, Julian; Sprissler, Clara; Pechloff, Konstanze; Zirlik, Katja; Zeiser, Robert; Dierks, Christine; Ruland, Jürgen; Jumaa, Hassan.

J Immunol ; 192(3): 1024-33, 2014 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-24376268

11.

Insulin-like growth factor-1 receptor (IGF1R) as a novel target in chronic lymphocytic leukemia.

Yaktapour, Niuscha; Übelhart, Rudolf; Schüler, Julia; Aumann, Konrad; Dierks, Christine; Burger, Meike; Pfeifer, Dietmar; Jumaa, Hassan; Veelken, Hendrik; Brummer, Tilman; Zirlik, Katja.

Blood ; 122(9): 1621-33, 2013 Aug 29.

Artigo em Inglês | MEDLINE | ID: mdl-23863897

12.

Sphingosine-1-phosphate receptors control B-cell migration through signaling components associated with primary immunodeficiencies, chronic lymphocytic leukemia, and multiple sclerosis.

Sic, Heiko; Kraus, Helene; Madl, Josef; Flittner, Karl-Andreas; von Münchow, Audrey Lilly; Pieper, Kathrin; Rizzi, Marta; Kienzler, Anne-Kathrin; Ayata, Korcan; Rauer, Sebastian; Kleuser, Burkhard; Salzer, Ulrich; Burger, Meike; Zirlik, Katja; Lougaris, Vassilios; Plebani, Alessandro; Römer, Winfried; Loeffler, Christoph; Scaramuzza, Samantha; Villa, Anna; Noguchi, Emiko; Grimbacher, Bodo; Eibel, Hermann.

J Allergy Clin Immunol ; 134(2): 420-8, 2014 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-24679343

13.

Multidimensional scaling analysis identifies pathological and prognostically relevant profiles of circulating T-cells in chronic lymphocytic leukemia.

Rissiek, Anne; Schulze, Christian; Bacher, Ulrike; Schieferdecker, Aneta; Thiele, Benjamin; Jacholkowski, Anita; Flammiger, Anna; Horn, Christiane; Haag, Friedrich; Tiegs, Gisa; Zirlik, Katja; Trepel, Martin; Tolosa, Eva; Binder, Mascha.

Int J Cancer ; 135(10): 2370-9, 2014 Nov 15.

Artigo em Inglês | MEDLINE | ID: mdl-24723150

14.

Trisomy 12 and elevated GLI1 and PTCH1 transcript levels are biomarkers for Hedgehog-inhibitor responsiveness in CLL.

Decker, Sarah; Zirlik, Katja; Djebatchie, Lauritte; Hartmann, David; Ihorst, Gabriele; Schmitt-Graeff, Annette; Herchenbach, Dieter; Jumaa, Hassan; Warmuth, Markus; Veelken, Hendrik; Dierks, Christine.

Blood ; 119(4): 997-1007, 2012 Jan 26.

Artigo em Inglês | MEDLINE | ID: mdl-22130798

15.

Multimodal treatment of locally advanced esophageal adenocarcinoma: which regimen should we choose? Outcome analysis of perioperative chemotherapy versus neoadjuvant chemoradiation in 105 patients.

Hoeppner, Jens; Zirlik, Katja; Brunner, Thomas; Bronsert, Peter; Kulemann, Birte; Sick, Olivia; Marjanovic, Goran; Hopt, Ulrich Theodor; Makowiec, Frank.

J Surg Oncol ; 109(3): 287-93, 2014 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-24277235

16.

Essential role of stromally induced hedgehog signaling in B-cell malignancies.

Dierks, Christine; Grbic, Jovana; Zirlik, Katja; Beigi, Ronak; Englund, Nathan P; Guo, Gui-Rong; Veelken, Hendrik; Engelhardt, Monika; Mertelsmann, Roland; Kelleher, Joseph F; Schultz, Peter; Warmuth, Markus.

Nat Med ; 13(8): 944-51, 2007 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-17632527

17.

The cumulative amount of serum-free light chain is a strong prognosticator in chronic lymphocytic leukemia.

Morabito, Fortunato; De Filippi, Rosaria; Laurenti, Luca; Zirlik, Katja; Recchia, Anna Grazia; Gentile, Massimo; Morelli, Emanuela; Vigna, Ernesto; Gigliotti, Vincenzo; Calemma, Rosa; Amoroso, Barbara; Neri, Antonino; Cutrona, Giovanna; Ferrarini, Manlio; Molica, Stefano; Del Poeta, Giovanni; Tripodo, Claudio; Pinto, Antonio.

Blood ; 118(24): 6353-61, 2011 Dec 08.

Artigo em Inglês | MEDLINE | ID: mdl-21998207

18.

Predictive value of the CLL-IPI in CLL patients receiving chemo-immunotherapy as first-line treatment.

Gentile, Massimo; Shanafelt, Tait D; Mauro, Francesca Romana; Reda, Gianluigi; Rossi, Davide; Laurenti, Luca; Del Principe, Maria Ilaria; Cutrona, Giovanna; Angeletti, Ilaria; Coscia, Marta; Herishanu, Yair; Chiarenza, Annalisa; Molica, Stefano; Ciolli, Stefania; Goldschmidt, Neta; Angrilli, Francesco; Giordano, Annamaria; Rago, Angela; Bairey, Osnat; Tripepi, Giovanni; Chaffee, Kari G; Sameer, Parikh A; Vigna, Ernesto; Zirlik, Katja; Shvidel, Lev; Innocenti, Idanna; Recchia, Anna Grazia; Di Raimondo, Francesco; Del Poeta, Giovanni; Cortelezzi, Agostino; Neri, Antonino; Ferrarini, Manlio; Gaidano, Gianluca; Kay, Neil E; Polliack, Aaron; Foà, Robin; Morabito, Fortunato.

Eur J Haematol ; 2018 Jul 24.

Artigo em Inglês | MEDLINE | ID: mdl-30039576

19.

Comparative analysis of predicted HLA binding of immunoglobulin idiotype sequences indicates T cell-mediated immunosurveillance in follicular lymphoma.

Strothmeyer, Anna-Maria; Papaioannou, Dimitrios; Dühren-von Minden, Marcus; Navarrete, Marcelo; Zirlik, Katja; Heining-Mikesch, Kristina; Veelken, Hendrik.

Blood ; 116(10): 1734-6, 2010 Sep 09.

Artigo em Inglês | MEDLINE | ID: mdl-20522710

20.

Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia.

Buchner, Maike; Baer, Constance; Prinz, Gabriele; Dierks, Christine; Burger, Meike; Zenz, Thorsten; Stilgenbauer, Stephan; Jumaa, Hassan; Veelken, Hendrik; Zirlik, Katja.

Blood ; 115(22): 4497-506, 2010 Jun 03.

Artigo em Inglês | MEDLINE | ID: mdl-20335218

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