[Urinary laminin and fibronectin level in children with nephritic syndrome]. / Stezenie lamininy i fibronektyny w moczu dzieci z zespolem nerczycowym.

UNLABELLED: Laminin (LN) and fibronectin (FN) are important extra cellular matrix (ECM) proteins. Disturbance between production and degradation of ECM proteins contributes to renal scarring. The aim of the study was evaluation the levels of urinary LN and FN in children with proteinuria in nephrotic syndrome (NS). MATERIALS AND METHODS: Examinations were conducted on 71 children, 3-15 years old: (A)--44 children with NS (proteinuria above 50 mg/kg b.v./24 hours); (B)--27 children without proteinuria (remission NS). Control group (K)--30 healthy children. Concentration of LN and FN were determined by EIA. RESULTS: In urine of children with NS (A) urinary concentration of LN significantly increased, in comparison to control (K) (p<0.05), but FN was normal (p>0.05). In children with remission of NS (B) urinary concentration of LN was unchanged (p>0.05), but concentration of FN significantly decreased (p<0.05). In renal biopsies majority children of A group presented minimal changes, but majority children of B group presented hyalinization of renal tubules. CONCLUSION: Nephrotic proteinuria disturbs production of LN and increases its urinary excretion, but did not influence on urinary excretion of FN.

IgA nephropathy in a girl with psoriasis and seronegative arthritis.

IgA nephropathy is one of the most common forms of glomerulonephritis, but the coexistence of IgA nephropathy and psoriasis is very rare, especially in children. Herein we report the case of an 8-year-old girl with both psoriasis and IgA nephropathy who responded to treatment with cyclosporine A for both conditions.

[Urinary TGF-beta1 excretion in children with renal cysts]. / Wydalanie TGF-beta1 w moczu dzieci z torbielowatoscia nerek.

UNLABELLED: Autosomal dominant polycystic disease is characterised by abnormal polycystin, protein, which is a component of basement membrane and extracellular matrix. Transforming growth factor (TGF-beta1) is a cytokine, which takes part in development of renal tubule epithelium and stimulates the synthesis of extracellular matrix proteins. The aim of work was the assessment of TGF-beta1 concentration in children with renal polycystic disease. MATERIAL AND METHODS: The examined group (I) consisted of 33 children aged (median 14.7 years, range 4.0-17.9): A--11 children with solitary cyst, B--22 with polycystic renal disease. Control group (C) consisted of 20 healthy children at the same age. The concentration of urinary TGF-b1 was measured using immunoenzymatic ELISA method. The results showed that mean concentration of urinary TGF-beta 1 (121.9 +/- 168 pg/mg cr.) was lower than in group B, in which it was 207.2 +/- 361 pg/mg cr. However the difference was not statistically significant (p>0.05). In both subgroups (A and B) urinary excretion of TGF-beta1 was higher than in control group (C) (p<0.05). In 4 (36%) children from group A and 8 (36%) from group B the urinary concentration of TGF-beta 1 was below the sensitivity of the method. No correlation between TGF-beta 1 and children's age, urinary osmolality and GRF according to Schwartz was found. It was a positive correlation between urinary TGF-betal concentration and total diameter of renal cysts. CONCLUSIONS: TGF-betal takes part in renal cyst formation and increased urinary excretion of TGF-b1 in proportion to the dimension of renal cysts may be an evidence of that fact.

[Reference values of arterial pressure depending on age, assessed by 24-hour ambulatory monitoring]. / Wartosci referencyjne cisnienia tetniczego w zaleznosci od wieku oceniane metoda calodobowego ambulatoryjnego monitorowania.

UNLABELLED: 24-hour blood pressure monitoring has been ever more widely used in children. However, percentile ranks for healthy children have not been prepared yet. The aim of the study was to define percentile ranks of blood pressure measured by ambulatory blood pressure monitoring in healthy children aged 7-17 years depending on sex in children from the Province of Podlasie. The examinations were carried out in a group of 540 children: group I-girls--265, group II boys--275, who were divided into subgroups according to age. Blood pressure was measured by ambulatory blood pressure monitors: BR-102 f. Schiller, Poland LTD and Quiet Tycos, USA according to the principles in force. The results showed that mean systolic blood pressure (RRs) increased with age from 103.2 to 117.7 mm Hg in girls and from 98.8 to 125.6 mm Hg in boys. The differences were statistically significant (p > 0.05). Diastolic blood pressure (RRr) increased less (p > 0.05). Mean systolic blood pressure at night was 9-10% and diastolic pressure 10-11% lower, irrespective of sex. The range of normal blood pressure values (5-95 centile) was established. In group I in the youngest girls the range of RRs was 89-110 mmHg, that of RRr was from 51 to 75 mm Hg while in group II in the youngest boys RRs range was from 95 to 108 mm Hg and RRr--from 52 to 73 mm Hg. In group I and II in the oldest girls and boys the values were higher. The percentile ranks (5-95) were prepared for systolic and diastolic blood pressure based on blood pressure monitoring during 24-hours and separately during activity (day) and resting time (night). CONCLUSIONS: 1. Systolic blood pressure in children aged 7-17 years increases with age more than diastolic blood pressure. 2. Percentile ranks for healthy children aged 7-17 years depending on age, sex and daily time period were established.