Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Bat pluripotent stem cells reveal unusual entanglement between host and viruses.

Déjosez, Marion; Marin, Arturo; Hughes, Graham M; Morales, Ariadna E; Godoy-Parejo, Carlos; Gray, Jonathan L; Qin, Yiren; Singh, Arun A; Xu, Hui; Juste, Javier; Ibáñez, Carlos; White, Kris M; Rosales, Romel; Francoeur, Nancy J; Sebra, Robert P; Alcock, Dominic; Volkert, Thomas L; Puechmaille, Sébastien J; Pastusiak, Andrzej; Frost, Simon D W; Hiller, Michael; Young, Richard A; Teeling, Emma C; García-Sastre, Adolfo; Zwaka, Thomas P.

Cell ; 186(5): 957-974.e28, 2023 03 02.

Artigo em Inglês | MEDLINE | ID: mdl-36812912

2.

SARS-CoV-2 variants evolve convergent strategies to remodel the host response.

Bouhaddou, Mehdi; Reuschl, Ann-Kathrin; Polacco, Benjamin J; Thorne, Lucy G; Ummadi, Manisha R; Ye, Chengjin; Rosales, Romel; Pelin, Adrian; Batra, Jyoti; Jang, Gwendolyn M; Xu, Jiewei; Moen, Jack M; Richards, Alicia L; Zhou, Yuan; Harjai, Bhavya; Stevenson, Erica; Rojc, Ajda; Ragazzini, Roberta; Whelan, Matthew V X; Furnon, Wilhelm; De Lorenzo, Giuditta; Cowton, Vanessa; Syed, Abdullah M; Ciling, Alison; Deutsch, Noa; Pirak, Daniel; Dowgier, Giulia; Mesner, Dejan; Turner, Jane L; McGovern, Briana L; Rodriguez, M Luis; Leiva-Rebollo, Rocio; Dunham, Alistair S; Zhong, Xiaofang; Eckhardt, Manon; Fossati, Andrea; Liotta, Nicholas F; Kehrer, Thomas; Cupic, Anastasija; Rutkowska, Magdalena; Mena, Ignacio; Aslam, Sadaf; Hoffert, Alyssa; Foussard, Helene; Olwal, Charles Ochieng'; Huang, Weiqing; Zwaka, Thomas; Pham, John; Lyons, Molly; Donohue, Laura.

Cell ; 186(21): 4597-4614.e26, 2023 10 12.

Artigo em Inglês | MEDLINE | ID: mdl-37738970

3.

Pluripotency and nuclear reprogramming.

Dejosez, Marion; Zwaka, Thomas P.

Annu Rev Biochem ; 81: 737-65, 2012.

Artigo em Inglês | MEDLINE | ID: mdl-22443931

4.

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.

Riva, Laura; Yuan, Shuofeng; Yin, Xin; Martin-Sancho, Laura; Matsunaga, Naoko; Pache, Lars; Burgstaller-Muehlbacher, Sebastian; De Jesus, Paul D; Teriete, Peter; Hull, Mitchell V; Chang, Max W; Chan, Jasper Fuk-Woo; Cao, Jianli; Poon, Vincent Kwok-Man; Herbert, Kristina M; Cheng, Kuoyuan; Nguyen, Tu-Trinh H; Rubanov, Andrey; Pu, Yuan; Nguyen, Courtney; Choi, Angela; Rathnasinghe, Raveen; Schotsaert, Michael; Miorin, Lisa; Dejosez, Marion; Zwaka, Thomas P; Sit, Ko-Yung; Martinez-Sobrido, Luis; Liu, Wen-Chun; White, Kris M; Chapman, Mackenzie E; Lendy, Emma K; Glynne, Richard J; Albrecht, Randy; Ruppin, Eytan; Mesecar, Andrew D; Johnson, Jeffrey R; Benner, Christopher; Sun, Ren; Schultz, Peter G; Su, Andrew I; García-Sastre, Adolfo; Chatterjee, Arnab K; Yuen, Kwok-Yung; Chanda, Sumit K.

Nature ; 586(7827): 113-119, 2020 10.

Artigo em Inglês | MEDLINE | ID: mdl-32707573

5.

Ronin governs the metabolic capacity of the embryonic lineage for post-implantation development.

Salewskij, Kirill; Gross-Thebing, Theresa; Ing-Simmons, Elizabeth; Duethorn, Binyamin; Rieger, Bettina; Fan, Rui; Chen, Rui; Govindasamy, Niraimathi; Brinkmann, Heike; Kremer, Ludmila; Kuempel-Rink, Nannette; Mildner, Karina; Zeuschner, Dagmar; Stehling, Martin; Dejosez, Marion; Zwaka, Thomas P; Schöler, Hans R; Busch, Karin B; Vaquerizas, Juan M; Bedzhov, Ivan.

EMBO Rep ; 22(11): e53048, 2021 11 04.

Artigo em Inglês | MEDLINE | ID: mdl-34515391

6.

Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells.

Dejosez, Marion; Krumenacker, Joshua S; Zitur, Laura Jo; Passeri, Marco; Chu, Li-Fang; Songyang, Zhou; Thomson, James A; Zwaka, Thomas P.

Cell ; 133(7): 1162-74, 2008 Jun 27.

Artigo em Inglês | MEDLINE | ID: mdl-18585351

7.

Mutations in THAP1/DYT6 reveal that diverse dystonia genes disrupt similar neuronal pathways and functions.

Zakirova, Zuchra; Fanutza, Tomas; Bonet, Justine; Readhead, Ben; Zhang, Weijia; Yi, Zhengzi; Beauvais, Genevieve; Zwaka, Thomas P; Ozelius, Laurie J; Blitzer, Robert D; Gonzalez-Alegre, Pedro; Ehrlich, Michelle E.

PLoS Genet ; 14(1): e1007169, 2018 01.

Artigo em Inglês | MEDLINE | ID: mdl-29364887

8.

Stem cells: The cost of perpetual youth.

Zwaka, Thomas P.

Nature ; 548(7666): 165-166, 2017 08 10.

Artigo em Inglês | MEDLINE | ID: mdl-28746313

9.

Ronin/Hcf-1 binds to a hyperconserved enhancer element and regulates genes involved in the growth of embryonic stem cells.

Dejosez, Marion; Levine, Stuart S; Frampton, Garrett M; Whyte, Warren A; Stratton, Sabrina A; Barton, Michelle C; Gunaratne, Preethi H; Young, Richard A; Zwaka, Thomas P.

Genes Dev ; 24(14): 1479-84, 2010 Jul 15.

Artigo em Inglês | MEDLINE | ID: mdl-20581084

10.

Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT.

Bisson, Joseph A; Mills, Bradley; Paul Helt, Jay-Christian; Zwaka, Thomas P; Cohen, Ethan David.

Dev Biol ; 398(1): 80-96, 2015 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-25482987

11.

GCNF-dependent activation of cyclin D1 expression via repression of Mir302a during ESC differentiation.

Wang, Hongran; Wang, Xiaohong; Archer, Trevor K; Zwaka, Thomas P; Cooney, Austin J.

Stem Cells ; 32(6): 1527-37, 2014 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-24578347

12.

p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells.

Jain, Abhinav K; Allton, Kendra; Iacovino, Michelina; Mahen, Elisabeth; Milczarek, Robert J; Zwaka, Thomas P; Kyba, Michael; Barton, Michelle Craig.

PLoS Biol ; 10(2): e1001268, 2012.

Artigo em Inglês | MEDLINE | ID: mdl-22389628

13.

Epigenetic reprogramming of the germ cell nuclear factor gene is required for proper differentiation of induced pluripotent cells.

Wang, Hongran; Wang, Xiaohong; Xu, Xueping; Zwaka, Thomas P; Cooney, Austin J.

Stem Cells ; 31(12): 2659-66, 2013 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-23495137

14.

Regulatory architecture of housekeeping genes is driven by promoter assemblies.

Dejosez, Marion; Dall'Agnese, Alessandra; Ramamoorthy, Mahesh; Platt, Jesse; Yin, Xing; Hogan, Megan; Brosh, Ran; Weintraub, Abraham S; Hnisz, Denes; Abraham, Brian J; Young, Richard A; Zwaka, Thomas P.

Cell Rep ; 42(5): 112505, 2023 05 30.

Artigo em Inglês | MEDLINE | ID: mdl-37182209

15.

Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection.

Wei, Jin; Patil, Ajinkya; Collings, Clayton K; Alfajaro, Mia Madel; Liang, Yu; Cai, Wesley L; Strine, Madison S; Filler, Renata B; DeWeirdt, Peter C; Hanna, Ruth E; Menasche, Bridget L; Ökten, Arya; Peña-Hernández, Mario A; Klein, Jon; McNamara, Andrew; Rosales, Romel; McGovern, Briana L; Luis Rodriguez, M; García-Sastre, Adolfo; White, Kris M; Qin, Yiren; Doench, John G; Yan, Qin; Iwasaki, Akiko; Zwaka, Thomas P; Qi, Jun; Kadoch, Cigall; Wilen, Craig B.

Nat Genet ; 55(3): 471-483, 2023 03.

Artigo em Inglês | MEDLINE | ID: mdl-36894709

16.

Caspase-3 cleavage links delta-catenin to the novel nuclear protein ZIFCAT.

Gu, Dongmin; Tonthat, Nam Ky; Lee, Moonsup; Ji, Hong; Bhat, Krishna P; Hollingsworth, Faith; Aldape, Kenneth D; Schumacher, Maria A; Zwaka, Thomas P; McCrea, Pierre D.

J Biol Chem ; 286(26): 23178-88, 2011 Jul 01.

Artigo em Inglês | MEDLINE | ID: mdl-21561870

17.

Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral Activity.

Pohl, Marie O; Martin-Sancho, Laura; Ratnayake, Ranjala; White, Kris M; Riva, Laura; Chen, Qi-Yin; Lieber, Gauthier; Busnadiego, Idoia; Yin, Xin; Lin, Samuel; Pu, Yuan; Pache, Lars; Rosales, Romel; Déjosez, Marion; Qin, Yiren; De Jesus, Paul D; Beall, Anne; Yoh, Sunnie; Hale, Benjamin G; Zwaka, Thomas P; Matsunaga, Naoko; García-Sastre, Adolfo; Stertz, Silke; Chanda, Sumit K; Luesch, Hendrik.

ACS Infect Dis ; 8(7): 1265-1279, 2022 07 08.

Artigo em Inglês | MEDLINE | ID: mdl-35766385

18.

The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamsters.

Miorin, Lisa; Mire, Chad E; Ranjbar, Shahin; Hume, Adam J; Huang, Jessie; Crossland, Nicholas A; White, Kris M; Laporte, Manon; Kehrer, Thomas; Haridas, Viraga; Moreno, Elena; Nambu, Aya; Jangra, Sonia; Cupic, Anastasija; Dejosez, Marion; Abo, Kristine A; Tseng, Anna E; Werder, Rhiannon B; Rathnasinghe, Raveen; Mutetwa, Tinaye; Ramos, Irene; de Aja, Julio Sainz; de Alba Rivas, Carolina Garcia; Schotsaert, Michael; Corley, Ronald B; Falvo, James V; Fernandez-Sesma, Ana; Kim, Carla; Rossignol, Jean-François; Wilson, Andrew A; Zwaka, Thomas; Kotton, Darrell N; Mühlberger, Elke; García-Sastre, Adolfo; Goldfeld, Anne E.

bioRxiv ; 2022 Feb 09.

Artigo em Inglês | MEDLINE | ID: mdl-35169796

19.

Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission.

Escalera, Alba; Gonzalez-Reiche, Ana S; Aslam, Sadaf; Mena, Ignacio; Laporte, Manon; Pearl, Rebecca L; Fossati, Andrea; Rathnasinghe, Raveen; Alshammary, Hala; van de Guchte, Adriana; Farrugia, Keith; Qin, Yiren; Bouhaddou, Mehdi; Kehrer, Thomas; Zuliani-Alvarez, Lorena; Meekins, David A; Balaraman, Velmurugan; McDowell, Chester; Richt, Jürgen A; Bajic, Goran; Sordillo, Emilia Mia; Dejosez, Marion; Zwaka, Thomas P; Krogan, Nevan J; Simon, Viviana; Albrecht, Randy A; van Bakel, Harm; García-Sastre, Adolfo; Aydillo, Teresa.

Cell Host Microbe ; 30(3): 373-387.e7, 2022 03 09.

Artigo em Inglês | MEDLINE | ID: mdl-35150638

20.

Breathing chromatin in pluripotent stem cells.