Detalhe da pesquisa
1.
Anti-CD45 PBD-based antibody-drug conjugates are effective targeted conditioning agents for gene therapy and stem cell transplant.
Mol Ther
; 2024 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38549377
2.
The use of recovery animals in nonclinical safety assessment studies with monoclonal antibodies: further 3Rs opportunities remain.
Regul Toxicol Pharmacol
; 138: 105339, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-36649820
3.
Re-evaluating the need for chronic toxicity studies with therapeutic monoclonal antibodies, using a weight of evidence approach.
Regul Toxicol Pharmacol
; 138: 105329, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-36592682
4.
Opportunities for use of one species for longer-term toxicology testing during drug development: A cross-industry evaluation.
Regul Toxicol Pharmacol
; 113: 104624, 2020 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-32126256
5.
Monoclonal antibody targeting of fibroblast growth factor receptor 1c causes cardiac valvulopathy in rats.
Toxicol Appl Pharmacol
; 355: 147-155, 2018 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30008375
6.
The future trajectory of adverse outcome pathways: a commentary.
Arch Toxicol
; 92(4): 1657-1661, 2018 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-29549413
7.
Non-clinical Safety Evaluation of Biotherapeutics - Challenges, Opportunities and new Insights.
Regul Toxicol Pharmacol
; 80S: S1-S14, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27578450
8.
Nonclinical safety testing of biopharmaceuticals--Addressing current challenges of these novel and emerging therapies.
Regul Toxicol Pharmacol
; 73(1): 265-75, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26219199
9.
New challenges and opportunities in nonclinical safety testing of biologics.
Regul Toxicol Pharmacol
; 69(2): 226-33, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24755365
10.
Recommendations from a global cross-company data sharing initiative on the incorporation of recovery phase animals in safety assessment studies to support first-in-human clinical trials.
Regul Toxicol Pharmacol
; 70(1): 413-29, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25078890
11.
Characterization of a novel potency endpoint for the evaluation of immune checkpoint blockade in humanized mice.
Front Immunol
; 14: 1107848, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36936963
12.
The design of chronic toxicology studies of monoclonal antibodies: implications for the reduction in use of non-human primates.
Regul Toxicol Pharmacol
; 62(2): 347-54, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22100994
13.
Use of human splenocytes in an innovative humanised mouse model for prediction of immunotherapy-induced cytokine release syndrome.
Clin Transl Immunology
; 9(11): e1202, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33173582
14.
Potent Immune Modulation by MEDI6383, an Engineered Human OX40 Ligand IgG4P Fc Fusion Protein.
Mol Cancer Ther
; 17(5): 1024-1038, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29545330
15.
MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential.
Oncoimmunology
; 6(3): e1280645, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28405505
16.
Bacterial toxins as versatile delivery vehicles.
Curr Opin Drug Discov Devel
; 5(2): 269-78, 2002 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-11926133
17.
Current challenges and opportunities in nonclinical safety testing of biologics.
Drug Discov Today
; 18(23-24): 1138-43, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23942260
18.
Challenges and approaches for the development of safer immunomodulatory biologics.
Nat Rev Drug Discov
; 12(4): 306-24, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23535934
19.
Monoclonal antibody therapeutics: history and future.
Curr Opin Pharmacol
; 12(5): 615-22, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22920732
20.
Cholera toxin: a paradigm for multi-functional engagement of cellular mechanisms (Review).
Mol Membr Biol
; 21(2): 77-92, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15204437