Detalhe da pesquisa
1.
Combinatorial targeting of G-protein-coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug-induced liver injury.
Hepatology
; 78(1): 26-44, 2023 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36107019
2.
Atorvastatin protects against liver and vascular damage in a model of diet induced steatohepatitis by resetting FXR and GPBAR1 signaling.
FASEB J
; 36(1): e22060, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34862975
3.
The bile acid activated receptors GPBAR1 and FXR exert antagonistic effects on autophagy.
FASEB J
; 35(1): e21271, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33368684
4.
The Bile Acid Receptor GPBAR1 Modulates CCL2/CCR2 Signaling at the Liver Sinusoidal/Macrophage Interface and Reverses Acetaminophen-Induced Liver Toxicity.
J Immunol
; 204(9): 2535-2551, 2020 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32213564
5.
Obeticholic Acid: An Update of Its Pharmacological Activities in Liver Disorders.
Handb Exp Pharmacol
; 256: 283-295, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31201552
6.
Bile acids serve as endogenous antagonists of the Leukemia inhibitory factor (LIF) receptor in oncogenesis.
Biochem Pharmacol
; 223: 116134, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38494064
7.
Modeling Inflammatory Bowel Disease by Intestinal Organoids.
Recent Adv Inflamm Allergy Drug Discov
; 17(1): 39-53, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36411558
8.
Combinatorial therapy with BAR502 and UDCA resets FXR and GPBAR1 signaling and reverses liver histopathology in a model of NASH.
Sci Rep
; 13(1): 1602, 2023 01 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36709356
9.
Correction to "Discovery of a Novel Class of Dual GPBAR1 Agonists-RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders".
ACS Omega
; 8(47): 45163, 2023 Nov 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38046314
10.
Discovery of a Novel Class of Dual GPBAR1 Agonists-RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders.
ACS Omega
; 8(6): 5983-5994, 2023 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36816679
11.
Discovery of BAR502, as potent steroidal antagonist of leukemia inhibitory factor receptor for the treatment of pancreatic adenocarcinoma.
Front Oncol
; 13: 1140730, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36998446
12.
Defective Bile Acid Signaling Promotes Vascular Dysfunction, Supporting a Role for G-Protein Bile Acid Receptor 1/Farnesoid X Receptor Agonism and Statins in the Treatment of Nonalcoholic Fatty Liver Disease.
J Am Heart Assoc
; 12(23): e031241, 2023 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37996988
13.
The leukemia inhibitory factor regulates fibroblast growth factor receptor 4 transcription in gastric cancer.
Cell Oncol (Dordr)
; 2023 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37945798
14.
Activation of GPBAR1 attenuates vascular inflammation and atherosclerosis in a mouse model of NAFLD-related cardiovascular disease.
Biochem Pharmacol
; 218: 115900, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37926268
15.
Organoids as ex vivo culture system to investigate infection-host interaction in gastric pre-carcinogenesis.
Recent Adv Inflamm Allergy Drug Discov
; 2022 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34986780
16.
Discovery of a Potent and Orally Active Dual GPBAR1/CysLT1R Modulator for the Treatment of Metabolic Fatty Liver Disease.
Front Pharmacol
; 13: 858137, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35559268
17.
Next-Generation Sequencing Analysis of Gastric Cancer Identifies the Leukemia Inhibitory Factor Receptor as a Driving Factor in Gastric Cancer Progression and as a Predictor of Poor Prognosis.
Front Oncol
; 12: 939969, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35847866
18.
GLP-1 Mediates Regulation of Colonic ACE2 Expression by the Bile Acid Receptor GPBAR1 in Inflammation.
Cells
; 11(7)2022 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35406751
19.
Beneficial effects of UDCA and norUDCA in a rodent model of steatosis are linked to modulation of GPBAR1/FXR signaling.
Biochim Biophys Acta Mol Cell Biol Lipids
; 1867(11): 159218, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35985473
20.
Repositioning Mifepristone as a Leukaemia Inhibitory Factor Receptor Antagonist for the Treatment of Pancreatic Adenocarcinoma.
Cells
; 11(21)2022 11 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36359879