RESUMO
Between 19 April and 23 June 2015, 52 laboratory-confirmed cases of Middle East Respiratory Syndrome due to coronavirus (MERS) were reported from Al-Ahssa region, eastern Saudi Arabia. The first seven cases occurred in one family; these were followed by 45 cases in three public hospitals. The objectives of this investigation were to describe the epidemiological characteristic of the cluster and identify potential risk factors and control measures to be instituted to prevent further occurrence of MERS. We obtained the medical records of all confirmed cases, interviewed the members of the affected household and reviewed the actions taken by the health authorities. All the cases were connected. The index case was a 62-year-old man with a history of close contact with dromedary camels; three of the seven infected family members and 18 people in hospitals died (case-fatality rate, 40.4%). The median incubation period was about 6 days. The cluster of cases appeared to be due to high exposure to MERS, delayed diagnosis, inadequate risk communication and inadequate compliance of hospital health workers and visitors with infection prevention and control measures.
Assuntos
Infecções por Coronavirus/epidemiologia , Surtos de Doenças , Coronavírus da Síndrome Respiratória do Oriente Médio/isolamento & purificação , Humanos , Incidência , Entrevistas como Assunto , Auditoria Médica , Pesquisa Qualitativa , Arábia Saudita/epidemiologiaRESUMO
The viral haemorrhagic fevers (VHF) are a growing public health threat in the Eastern Mediterranean Region. Nearly all of them are of zoonotic origin. VHF often cause outbreaks with high fatalities and, except for yellow fever, currently there are no specific treatment or vaccination options available. In response to this growing threat, the Regional Office for the Eastern Mediterranean of the World Health Organization convened a technical consultation in Tehran on 27-30 November 2011 to review the current gaps in prevention and control of VHF outbreaks in the Region. The meeting recommended a number of strategic public health approaches for prevention and control of VHF outbreaks through synergizing effective collaboration between the human and animal health sectors on areas that involve better preparedness, early detection and rapid response. Implementation of these approaches would require working together with vision, commitment and a sense of purpose involving partnerships and cooperation from all relevant sectors.
Assuntos
Controle de Doenças Transmissíveis/métodos , Febres Hemorrágicas Virais/epidemiologia , Febres Hemorrágicas Virais/prevenção & controle , Saúde Pública , Animais , Vetores Artrópodes , Técnicas e Procedimentos Diagnósticos , Surtos de Doenças/prevenção & controle , Comportamentos Relacionados com a Saúde , Humanos , Oriente Médio/epidemiologia , Controle de Pragas/métodos , Vigilância de Evento Sentinela , Organização Mundial da SaúdeRESUMO
A cross-sectional study, a follow-up study and an evaluation of impact of community-based distribution of vitamin A capsules (200,000 IU) were conducted in Omdurman (Sudan) between November, 1988, and March, 1989. In the cross-sectional survey 1441 children less than 5 years of age participated, which established the baseline values for plasma retinol-binding protein. During the follow-up period 290 cases of diarrhea occurred. Low concentrations of plasma retinol-binding protein (less than 1.85 mg/dl) proved to be a risk factor for diarrhea, especially in girls. The relative risk increased after the second year of life. Children who received vitamin A supplementation before commencement of the study had a lower incidence of diarrhea. The protective effect of vitamin A supplementation was greater in girls (relative risk, 0.297; 95% confidence interval, 0.240 to 0.368) than in boys (relative risk, 0.404; 95% confidence interval, 0.352 to 0.464).
Assuntos
Diarreia/etiologia , Deficiência de Vitamina A/complicações , Pré-Escolar , Estudos Transversais , Feminino , Humanos , Lactente , Masculino , Estudos Prospectivos , Proteínas de Ligação ao Retinol/análise , Proteínas Plasmáticas de Ligação ao Retinol , Fatores de Risco , Estudos Soroepidemiológicos , Sudão/epidemiologia , Deficiência de Vitamina A/epidemiologiaRESUMO
This short review summarizes all the published and unpublished reports on vitamin A deficiency in the Sudan in the last four decades. Different local terms used by people to indicate vitamin A deficiency were enlisted. There is evidence that vitamin A deficiency is a public health problem in eastern Sudan and among communities from western and southern Sudan living around Greater Khartoum, who were displaced from their homelands because of drought, famine conditions and civil unrest. There are reports indicative of vitamin A deficiency problem in the central and the far western provinces. There were no reports from the northern provinces. The need for a surveillance system was discussed.
PIP: Vitamin A deficiency is a world wide health problem following protein energy malnutrition. Recently, data have indicated the interrelationship between vitamin A deficiency and childhood respiratory infections, diarrhea, and measles. Medical articles and reports from the Sudanese Ministry of Health and the Helen Keller International were reviewed covering 4 decades to assess the extent of vitamin A deficiency. In a study of 1265 people over 3 years old in the Gezira area the incidence of deficiency was higher in children especially girls. Keratomalacia was higher in children especially girls. Keratomalacia was restricted to infants who were emaciated and marasmic with poor eyesight. The cause was neglected gastrointestinal derangement rather than vitamin A intake. In another study of 3461 children under 5 in 69 villages and 4 rural towns in eastern Sudan there was significant prevalence twice as high among girls than boys with a peak in the 2nd 1.2 of the 3rd year of life probably attributable to a staple of sorghum and avoidance of green leafy vegetables. A survey in western Sudan indicated focal distribution of the deficiency, and as a result of the drought of 1983-84 children may have become blind. A survey of children under 5 in a displaced community around the city of Omdurman using the sensitive plasma retinol-binding protein test to detect the deficiency showed that only 3 children out of 1441 had the protein level equal to or more than 3 mcg/dl, the normal level. Clinical signs of vitamin A deficiency were not manifest, however, mothers of 2.7% of boys and 5.8% of girls said that their children's eyesight was weak at night. Periodic surveys, health education, and vitamin A supplementation are needed.
Assuntos
Vigilância da População/métodos , Deficiência de Vitamina A/epidemiologia , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Prevalência , Fatores de Risco , Sudão/epidemiologia , Deficiência de Vitamina A/prevenção & controleRESUMO
The annual pilgrimage to Makkah (Mecca), Hajj, is a very stressful endeavour and requires strenuous physical effort, especially for the diabetic, the elderly and persons with other chronic illnesses. To identify the complications and to assess the needs of the Omani diabetics during Hajj (DOH), a special diabetes clinic was established in the camping site of Omani pilgrims (Hajjees) in Mina, where all Omani Hajjees convene for three days. The socio-demographic characteristics, the diabetes profile and the knowledge about complications of diabetes of all DOH were ascertained; their random blood sugar (RBS) was tested. Of 10,800 Omani who performed the Hajj in 1996, the 169 Hajjees with diabetes mellitus (prevalence rate 16 per 1000) included four per cent insulin dependent (IDDM), seven per cent on dietary control, and 89% on oral hypoglycaemic agents. Almost all DOH (98%) were medically examined before their departure for Hajj. All Hajjees with IDDM and 96% on oral hypoglycaemic agents brought their medicines with them. During the Hajj period, 2.4% of DOH had RBS < 75 mg/dl, 14% 75-110 mg/dl, and 49% were hyperglycaemic (RBS > 200 mg/dL). About half of the DOH (48%) knew the clinical presentation of hyperglycaemia, a fourth (24%) about symptoms of hypoglycaemia. Only 9.5% were trained to test themselves for blood sugar. The median age of DOH was 54 years (inter-quartile range 50-62). Some 7.5% females and 4.9% of males were obese (body mass index > 30). Forty seven (28%) of the DOH had other coronary heart diseases, hypertension or both. DOH moved between Holy places (four journeys; 5-15 km long) on foot (40%), by car or bus (31%), or both (29%). All DOH except one were not wearing protective shoes, 70% did not have identification wrist bands that show their diabetic status and regimen for treatment. Four per cent lost their way during Hajj, four per cent suffered from heat exhaustion, three per cent had cut wounds, 1.2% had pneumonia, and two per cent went into coma. There is a need for a special health education programme and for special services for the diabetics during Hajj. Hajjees should learn about symptoms and signs of hypoglycaemia, were protective shoes and identifying wrist bands. Specialised services for the diabetics would alleviate a lot of the stress during Hajj among the diabetics.
Assuntos
Diabetes Mellitus/etnologia , Diabetes Mellitus/prevenção & controle , Islamismo , Viagem/estatística & dados numéricos , Adulto , Instituições de Assistência Ambulatorial , Acampamento , Diabetes Mellitus/sangue , Feminino , Nível de Saúde , Humanos , Masculino , Pessoa de Meia-Idade , Omã/etnologia , Prevalência , Arábia Saudita , Fatores Socioeconômicos , Inquéritos e QuestionáriosRESUMO
OBJECTIVE: To identify the factors that influence transmission of bacillary dysentry (BD) within families during a propagated outbreak of bacillary dysentery. DESIGN: A retrospective cohort study. SETTING: Eighteen neighbouring villages in rural Gizan, southwestern Saudi Arabia. SUBJECTS: Two hundred and thirty three cases of BD were identified among seventy nine families. RESULTS: Secondary cases of BD occurred in 57 of 79 families with a primary case of BD. The secondary attack rate per cent (AR%) within families ranged between 7.7% and 80%. Age of primary cases did not correlate with degree of secondary AR% in exposed families (p > 0.04; p > 0.05); however, within households, the age of the first secondary cases (median = two years) was usually less than the age of the primary case (median = six years). Children under five years of age constituted 43% of secondary cases. The median interval between successive cases within a house ranged from three and seven days. Two hundred and twenty cases (94.4%) gave history of close contact within another case of BD. Cases of BD were exposed to close relatives with BD (79.1%), neighbours (11.4%), and friends (9.5%). Risk factors influencing the spread of BD within families included two rooms or fewer per house (OR = 4.3, 9.5% CI 1.3-14.3), family size of five or more (p = 0.012, two-tailed Fisher's exact test), and presence of more than two persons per room (OR = 11.2, 95% CI 3.1-42.4). CONCLUSION: Person-to-person secondary transmission can amplify the spread of bacillary dysentery within households and neighbouring villages. Crowding was a risk factor that amplified transmission of BD within families.
Assuntos
Surtos de Doenças/estatística & dados numéricos , Disenteria Bacilar/epidemiologia , Disenteria Bacilar/transmissão , Família , Shigella dysenteriae , Adolescente , Adulto , Distribuição por Idade , Criança , Pré-Escolar , Aglomeração , Disenteria Bacilar/microbiologia , Características da Família , Feminino , Humanos , Lactente , Masculino , Vigilância da População , Estudos Retrospectivos , Fatores de Risco , Arábia Saudita/epidemiologia , Distribuição por Sexo , Fatores de TempoRESUMO
Blood samples (100-160 microliters) were obtained from 1360 children by a finger prick in heparinized collection tubes, and an LC-Partigen retinol-binding protein (RBP) kit was used for quantification of RBP in the plasma. Only three boys and two girls had plasma RBP that was equal to or more than 3.0 mg/dL, a recommended cut-off point for normal values. The mean +/- SD) plasma RBP levels were at 1.150 +/- 0.613 mg/dL for boys (N = 689) and 1.233 +/- 0.572 mg/dL for girls (N = 671). The difference between boys and girls was statistically significant (p < 0.001). None of the children included in this study had eye signs of vitamin A deficiency. Two hundred eighty-two children (19.6%) received vitamin A supplements (200,000 IU) before the beginning of the study. The mean +/- SD for plasma RBP for children who received vitamin A supplement were 1.159 +/- .762 mg/dL for boys and 1.151 +/- 0.470 mg/dL for girls. The observed discrepancy between the biochemical and clinical manifestations of vitamin A deficiency was discussed.
Assuntos
Proteínas de Ligação ao Retinol/análise , Fatores Etários , Estatura , Peso Corporal , Pré-Escolar , Diarreia/sangue , Diarreia/etiologia , Oftalmopatias/diagnóstico , Feminino , Transtornos do Crescimento/etiologia , Humanos , Lactente , Masculino , Distúrbios Nutricionais/complicações , Kit de Reagentes para Diagnóstico , Proteínas Plasmáticas de Ligação ao Retinol , Fatores Sexuais , Sudão , Vitamina A/sangue , Vitamina A/uso terapêutico , Deficiência de Vitamina A/sangue , Deficiência de Vitamina A/complicações , Deficiência de Vitamina A/prevenção & controleRESUMO
In June 1992, 19 cases of typhoid fever were reported from the town of Al-Mudhnab town (population 10,000) in the Qassim region of central Saudi Arabia. Ten of the cases were females (53%), and these were clustered by onset in a 15-day period. Cases in boys followed the girls and were more dispersed over time. Cases included 14 school-age children, four pre-school children, and the wife of a girls' school bus driver. The attack rates (AR) did not differ between boys' and girls' schools and ranged from 5.5 to 15.87 per 1,000 in six different schools. All patients except one lived within two blocks in one quarter of the town. Typhoid fever was associated with attending a school potluck dinner (OR = 5.31; 95% CI 1.02, 28.85) or eating food prepared for that dinner (OR = 6.95; 95%; CI 1.40, 36.61). Cake with cream topping from the dinner was kept overnight at room temperature and served to girls on the bus the next day. The OR of eating leftover cake on the school bus and becoming ill was 11.04 (95%; CI 1.59, 95.27). The localization of this outbreak by time and place and by the age groups affected, supports the conclusion that the outbreak was foodborne. The most likely food was cream topping on the cake. Lessons on proper food handling and storage should be included in home economics classes.
Assuntos
Surtos de Doenças , Microbiologia de Alimentos , Intoxicação Alimentar por Salmonella/etiologia , Salmonella typhi , Adolescente , Estudos de Casos e Controles , Criança , Intervalos de Confiança , Feminino , Humanos , Masculino , Razão de Chances , Intoxicação Alimentar por Salmonella/epidemiologia , Arábia Saudita/epidemiologia , Conglomerados Espaço-Temporais , EstudantesRESUMO
Full text is available as a scanned copy of the original print version.
RESUMO
Full text is available as a scanned copy of the original print version.
RESUMO
Between 19 April and 23 June 2015, 52 laboratory-confirmed cases of Middle East Respiratory Syndrome due to coronavirus [MERS] were reported from Al-Ahssa region, eastern Saudi Arabia. The first seven cases occurred in one family; these were followed by 45 cases in three public hospitals. The objectives of this investigation were to describe the epidemiological characteristic of the cluster and identify potential risk factors and control measures to be instituted to prevent further occurrence of MERS. We obtained the medical records of all confirmed cases, interviewed the members of the affected household and reviewed the actions taken by the health authorities. All the cases were connected. The index case was a 62-year-old man with a history of close contact with dromedary camels; three of the seven infected family members and 18 people in hospitals died [case-fatality rate, 40.4%]. The median incubation period was about 6 days. The cluster of cases appeared to be due to high exposure to MERS, delayed diagnosis, inadequate risk communication and inadequate compliance of hospital health workers and visitors with infection prevention and control measures
Entre le 19 avril et le 23 juin 2015, 52 cas confirmés en laboratoire de syndrome respiratoire du Moyen-Orient [MERS] causé par le coronavirus ont été notifiés dans la région d'Al-Ahssa, partie orientale de l'Arabie saoudite. Les sept premiers cas sont survenus dans une seule famille ; ils ont été suivis de 45 cas déclarés dans trois hôpitaux publics. Cette investigation avait pour objectifs de détailler les caractéristiques épidémiologiques de ce groupe de cas et d'identifier les facteurs de risque potentiels ainsi que les mesures de lutte à mettre en place afin d'empêcher la survenue de nouveaux cas de MERS. Nous avons consulté les dossiers médicaux de l'ensemble des cas confirmés, avons interrogé les membres des foyers touchés et passé en revue les interventions entreprises par les autorités sanitaires. Tous les cas étaient reliés entre eux. Le cas indicateur était un homme de 62 ans ayant eu des contacts étroits avec des dromadaires ; trois des sept membres infectés de la famille et 18 patients hospitalisés sont décédés [taux de létalité : 40,4%]. La période d'incubation médiane était d'environ 6 jours. Le groupe de cas était vraisemblablement dû à une forte exposition au MERS, associée à un diagnostic tardif, une communication sur les risques inappropriée et une mauvaise observance des mesures de prévention et de lutte contre les infections par les personnels de santé de l'hôpital et les visiteurs
Assuntos
Doenças Transmissíveis , Infecções por Coronavirus , Coronavírus da Síndrome Respiratória do Oriente Médio , Pessoal de Saúde , Arábia SauditaAssuntos
Diarreia/etiologia , Bem-Estar Materno , Adolescente , Adulto , Criança , Pré-Escolar , Estudos Transversais , Diarreia Infantil/epidemiologia , Diarreia Infantil/etiologia , Feminino , Giardíase/transmissão , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Prevalência , Estudos Prospectivos , Fatores de Risco , Sudão/epidemiologiaAssuntos
Deficiência de Vitamina A/epidemiologia , Pré-Escolar , Estudos Transversais , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , População Rural , SudãoRESUMO
In May 1996, an outbreak of gastroenteritis occurred among customers who bought dinner from a restaurant that specialised in fried chicken in Abha city, south-west Saudi Arabia. The median incubation period was 10 hours (range: 3 to 27 hours). Of the 10 food items served, only mayonnaise (RR 2.52; 95% CI 1.71-3.73) and minced garlic (RR 1.20; 95% CI 1.02-1.41) were associated with cases. Salmonella enterica was isolated from 124 (84%) of the 159 persons with symptoms of food poisoning, and 91 (73%) were serogroup Enteritidis, phage type B 14. Mayonnaise was prepared in the restaurant using a regular blender. Minced garlic was prepared with the same blender immediately after making the mayonnaise. Unsafe storage of the mayonnaise at room temperature for a median of 6 hours could have resulted in overgrowth of bacteria and a high infective dose of bacteria per serving.
Assuntos
Surtos de Doenças , Ovos/intoxicação , Intoxicação Alimentar por Salmonella/epidemiologia , Adolescente , Adulto , Criança , Pré-Escolar , Estudos de Coortes , Ovos/microbiologia , Feminino , Manipulação de Alimentos , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Salmonella enterica/isolamento & purificação , Arábia Saudita/epidemiologia , Temperatura , Fatores de TempoRESUMO
In May 1992, 81 bacteriologically confirmed cases of typhoid fever (TF) were identified in all districts of Tabuk City in northwestern Saudi Arabia. Attack rates (AR) in residential districts ranged from 0.9-10.3 per 10,000. Confirmed cases included 9 workers in the city's referral hospital, King Khalid Hospital (AR 140/10,000), 2 in families of medical staff, 57 in the community (AR 4.4/10,000) and 13 in a local military cantonment (AR 0.8/10,000). The outbreak began with the onset of TF in the three areas within 5 days, continued for 7 weeks, and ended 2 weeks after chlorination began. Among water sources, the odds ratio (OR) was highest (2.6; 95% confidence interval [CI] 1.25-5.39) for water purchased from reverse osmosis (RO) plants, especially RO plants supplied by one well (ASUW) (OR = 7.05; 95% CI 2.51-20.7). The aquifer for ASUW lay partially beneath a depression where city sewage collected. Unchlorinated water samples from ASUW 1 month after the outbreak ended yielded coliforms. ASUW probably became contaminated with Salmonella typhi when KKH demand overtaxed the aquifer and drew in surface water. Membranes in RO plants using this unchlorinated well water could then become fouled with S. typhi. RO plants, which are common throughout Saudi Arabia, need close monitoring. Water for RO must be prechlorinated to prevent microbiologic fouling of the membranes.
Assuntos
Surtos de Doenças , Febre Tifoide/epidemiologia , Purificação da Água/métodos , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Arábia Saudita/epidemiologia , Purificação da Água/normasRESUMO
During March and April of 1992, the health surveillance system began detecting increasing numbers of cases of meningococcal disease (MCD) in the Islamic holy city of Makkah (Mecca). We identified 102 bacteriologically confirmed cases (CC) and 80 suspected cases (SC) of MCD. Neisseria meningitidis was identified as Group A, III-1 clone. The ratio of male:female cases was 2.9:1. All age groups of males were affected. There was only one case among women aged 10-30; 50% of the adult female cases were 55 or older. The case-fatality ratio (CFR) was 14.7% among CC. Pakistanis, who comprised about one-third of the CC, had a CFR of 26.7%. Fifty-nine percent of CC were religious visitors. CC in residents were most common in persons living near the Holy Mosque (Haram), where the carriage rate reached 86%. A mass vaccination program against MCD was instituted, using AC bivalent meningococcal vaccine (MCV). An abrupt drop, from a mean of 15 CC per week to 2 CC per week (only in visitors), coincided with vaccinating 600,000 persons over 2 weeks. Makkah residents who had been vaccinated against MCD were less likely to have contracted MCD (OR = 0.17, 95% CI: 0.06-0.50). MCV was of no significant protective value if it had been administered 5 years before the outbreak. The main reason for not being vaccinated as stated by both cases (71%) and controls (45%) was not knowing about the disease. The age and sex differences probably relate to differences in exposures to crowded conditions. Health education should illuminate the seriousness of the disease and the importance of vaccination.
Assuntos
Surtos de Doenças , Meningite Meningocócica/epidemiologia , Adolescente , Adulto , Distribuição por Idade , Idoso , Bacteriemia/microbiologia , Vacinas Bacterianas , Criança , Pré-Escolar , Surtos de Doenças/prevenção & controle , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Meningite Meningocócica/etiologia , Meningite Meningocócica/prevenção & controle , Vacinas Meningocócicas , Pessoa de Meia-Idade , Neisseria meningitidis/isolamento & purificação , Vigilância da População , Arábia Saudita/epidemiologia , Distribuição por Sexo , VacinaçãoRESUMO
We studied case-fatality rates (CFRs) among cases of meningococcal disease (MCD) admitted to Makkah (Saudi Arabia) hospitals during the period 1988-97. Of 483 cases, 431 (89.2%) were due to strains of serogroup A, 31 (6.4%) to serogroup W135, 16 (3.3%) to serogroup C, and 5 (10%) to serogroup B. Eighty-one patients died (case fatality rate (CFR)) 16.8%, 95% CI 13.5%, 20.4%). The CFR in infections due to serogroup A strains was 14.8%, and for other serogroups it was 32.7% (95% CI 20.3%, 47.1%). The CFR of MCD due to N. meningitidis serogroup A increased steadily with age (P<0.05). Seeking first medical help at a foreign Hajj medical mission and being treated in a non-specialized hospital were associated with a higher case fatality rate.