RESUMO
OBJECTIVES: The purpose of the present study was to assess the process of late regional remodeling and the changes in regional diastolic function at the base and apex of the left ventricle in patients with chronic systolic dysfunction. BACKGROUND: Remodeling has been suggested to play an important role in the progression of left ventricular dysfunction and heart failure. However, the regional difference in the process of late remodeling and its relation to diastolic function remain unclear. METHODS: In 32 patients with previous myocardial infarction and left ventricular ejection fraction < or = 35%, left ventricular hemodynamic and angiographic data were studied before and 1 year after randomization to conventional therapy with placebo (n = 12) or enalapril, 10 mg twice daily (n = 20). Left ventricular regional wall dynamics were analyzed in the basal and apical regions by the area method. RESULTS: In the placebo group, left ventricular end-diastolic and end-systolic regional areas increased significantly over time at the base but were unchanged at the apex. At the base, the diastolic left ventricular pressure-regional area relation shifted rightward and the regional stiffness constant decreased (6.9 +/- 4.3 to 5.0 +/- 3.1 x 10(-3) mm-2, p < 0.05), indicating an increase in regional distensibility. At the apex, however, the diastolic pressure-regional area relation shifted upward slightly, and the regional stiffness constant increased from 11.5 +/- 4.4 to 14.4 +/- 5.6 x 10(-3) mm-2 (p = 0.08). The regional peak filling rate was maintained at the base but decreased at the apex (1,014 +/- 436 to 762 +/- 306 mm2/s, p < 0.05); further, the changes in regional peak filling rate during follow-up were inversely related to the changes in the regional stiffness constant (r = -0.78, p < 0.001) at the apex. In contrast, in the enalapril group, end-diastolic and end-systolic regional areas significantly decreased over time both at the base and at the apex. Diastolic pressure-regional area relations shifted leftward, but the regional stiffness constant and regional peak filling rate did not change significantly either at the base or at the apex. CONCLUSIONS: These findings suggest that in patients with severe systolic left ventricular dysfunction, there was a regional difference in the process of late remodeling between the base and apex of the left ventricle, which was associated with nonuniform changes in regional diastolic function in the placebo group. The data also suggest that the nonuniform progression of regional remodeling and diastolic dysfunction was prevented by long-term enalapril treatment.
Assuntos
Enalapril/uso terapêutico , Hemodinâmica/efeitos dos fármacos , Infarto do Miocárdio/tratamento farmacológico , Infarto do Miocárdio/fisiopatologia , Função Ventricular Esquerda/efeitos dos fármacos , Cateterismo Cardíaco , Diástole/efeitos dos fármacos , Enalapril/farmacologia , Feminino , Seguimentos , Imagem do Acúmulo Cardíaco de Comporta , Insuficiência Cardíaca/etiologia , Humanos , Masculino , Pessoa de Meia-Idade , Infarto do Miocárdio/complicações , Infarto do Miocárdio/diagnóstico , Placebos , Índice de Gravidade de Doença , Sístole , Fatores de TempoRESUMO
OBJECTIVES: This study sought to assess the hemodynamic and cardiac effects of two dose levels of mibefradil in patients with varying degrees of ischemic left ventricular dysfunction. BACKGROUND: Mibefradil is a new, selective T-type and L-type calcium channel blocking agent. Because L-type channel blockade may depress myocardial performance, an invasive hemodynamic study was performed to assess the safety of this agent. METHODS: We performed an open label study, examining the effects of two intravenous doses of mibefradil, selected to produce plasma levels comparable to those measured after oral administration of 50 mg (dose 1: 400 ng/ml) or 100 mg (dose 2: 800 ng/ml) of the drug. Variables studied included the indexes of left ventricular function and neurohormone levels. Patients were stratified according to ejection fraction (EF) (> or = 40%, n = 26; < 40%, n = 24) and the presence (n = 15) or absence (n = 35) of heart failure. RESULTS: In patients with preserved systolic function, dose 1 had no clinically significant hemodynamic effects, but dose 2 decreased mean aortic pressure and systemic vascular resistance (-8.5 mm Hg, -12%, both p < 0.01) and also reduced end-systolic stress and volume, thus improving EF (52% to 58%, p < 0.01). Heart rate tended to decrease. In patients with depressed EF, heart rate decreased significantly with both doses. The effects of dose 1 mimicked those observed after dose 2 in patients with preserved EF. Dose 2 (plasma levels 1,052 +/- 284 ng/ml) still decreased left ventricular systolic wall stress and improved EF (24.0% to 28.5%, p < 0.05) but also significantly depressed the maximal first derivative of left ventricular pressure. Examination of individual pressure-volume loops in two patients with heart failure showed a clear rightward shift of the loop despite a decrease in systolic pressure, suggesting negative inotropy. Neurohormone levels were unchanged at both dose levels and in all subgroups. CONCLUSIONS: Intravenous mibefradil was well tolerated and produced an overall favorable cardiovascular response. However, high plasma concentrations might produce myocardial depression in patients with heart failure, and caution should be exerted in this setting.
Assuntos
Benzimidazóis/administração & dosagem , Bloqueadores dos Canais de Cálcio/administração & dosagem , Coração/efeitos dos fármacos , Tetra-Hidronaftalenos/administração & dosagem , Disfunção Ventricular Esquerda/fisiopatologia , Adulto , Idoso , Relação Dose-Resposta a Droga , Feminino , Hemodinâmica/efeitos dos fármacos , Humanos , Masculino , Mibefradil , Pessoa de Meia-Idade , Norepinefrina/sangue , Renina/sangueRESUMO
OBJECTIVES: The aim of this study was to assess the cardiovascular effects of BAY y 5959, a calcium promoter modulating myocardial calcium channels, in the presence or absence of congestive heart failure. BACKGROUND: There is still a clinical need for short-term administration of intravenous positive inotropes. BAY y 5959 was developed as a new approach to increase myocardial performance by selectively enhancing calcium influx in the myocytes. METHODS: Forty-one patients (21 without and 20 with congestive heart failure) were studied in an open label, dose-ranging study. Hemodynamic variables (including left ventricular [LV] angiography) and plasma samples were obtained at baseline and after 20 min of intravenous infusion of BAY y 5959 at doses ranging from 0.25 to 4.5 microg/kg body weight per min. RESULTS: In both study groups, BAY y 5959 produced dose-dependent increases in the indexes of inotropic state, without affecting isovolumetric relaxation rate. The magnitude of the response was comparable in patients with or without heart failure (average 38% increase in maximal first derivative of LV pressure [dP/dt max] at plasma levels of 100 microg/liter). BAY y 5959 also induced mild but statistically significant bradycardia and significantly decreased end-systolic volume while producing a leftward shift of the pressure-volume loop. Mean aortic pressure was unaffected at doses up to 3.0 microg/kg per min, and cardiac index improved in patients with heart failure at doses of 2.0 microg/kg per min (+23%, p < 0.05). However, at a dose of 4.5 microg/kg per min, mean aortic pressure and LV systolic wall stress increased, suggesting systemic vasoconstriction. The QT interval was also prolonged significantly at most doses. CONCLUSIONS: BAY y 5959 exhibits positive inotropic effects in patients with and without heart failure. The optimal response--combining bradycardia, reduced preload and improved cardiac output--appeared to be achieved at a dose of approximately 2.0 microg/kg per min. The impact of QT prolongation with regard to potential antiarrhythmic or proarrhythmic effects is unclear at this time.
Assuntos
Agonistas dos Canais de Cálcio/uso terapêutico , Cardiotônicos/uso terapêutico , Di-Hidropiridinas/uso terapêutico , Eletrocardiografia/efeitos dos fármacos , Insuficiência Cardíaca/tratamento farmacológico , Hemodinâmica/efeitos dos fármacos , Agonistas dos Canais de Cálcio/administração & dosagem , Cardiotônicos/administração & dosagem , Estudos de Casos e Controles , Di-Hidropiridinas/administração & dosagem , Relação Dose-Resposta a Droga , Feminino , Insuficiência Cardíaca/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Contração Miocárdica/efeitos dos fármacos , Estimulação Química , Disfunção Ventricular Esquerda/tratamento farmacológico , Disfunção Ventricular Esquerda/fisiopatologiaRESUMO
Right ventricular adaptation to changes in pulmonary input impedance was studied in open-chest dogs. When identical increases in pulmonary vascular resistance are imposed by two different manoeuvres (lung inflation and clamping of the left pulmonary artery), external power and pressure-time integral of the right ventricle at similar filling pressure are always greater during clamping than during inflation. Further studies demonstrate that, at equal increases in pulmonary input impedance modulus at 0 Hz, the clamping produces a greater change in the sum of the first three harmonics of impedance than the inflation (respectively +77% and -10% vs control modulus; -82% and +8% vs control phase). These impedance changes could explain the different behaviour of the right ventricle either by better matching of the ventricular internal impedance or by functional modification of the outflow tract.
Assuntos
Coração/fisiologia , Circulação Pulmonar , Resistência Vascular , Animais , Pressão Sanguínea , Circulação Coronária , Cães , Artéria Pulmonar/fisiologia , Função VentricularRESUMO
To assess myocardial contractility in patients with hypertrophic cardiomyopathy (HC), force-velocity-length relations were analyzed during left ventricular (LV) ejection. LV pressure, volume and wall stress data in 15 patients with HC were analyzed and compared with values from 32 normal subjects. Patients with HC had a greater LV mass than did normal subjects (272 versus 96 g/m2, p less than 0.001), elevated LV end-diastolic pressure (17.5 versus 9.8 mm Hg, p less than 0.01) and impaired LV relaxation compared with those of normal subjects. Patients with HC also had a greater ejection fraction (84 +/- 7 versus 74 +/- 8%, p less than 0.01) and mean velocity of shortening than did normal subjects. However, in patients with HC, end-systolic stress (60 +/- 29 versus 187 +/- 61 kdyne/cm2, p less than 0.001) was significantly lower. End-systolic volume and stress data were linearly related in normal subjects (r = 0.88), and values from patients with HC fell either within the lowest part of the 95% confidence interval of this normal relation or outside it in the zone of depressed contractility (11 patients with HC). In addition, the slopes of the relations between end-systolic wall stress and ejection fraction or mean velocity of shortening were abnormal in patients with HC; the slope of the stress-volume trajectory during late ejection was also depressed in 12 patients with HC (average slope 2.6 versus 5.5 kdyne/cm5/m2, p less than 0.001). Thus, there is no evidence of a hypercontractile state in patients with HC; their high values of ejection phase indexes may be explained by a reduction in myocardial afterload.
Assuntos
Cardiomiopatia Hipertrófica/fisiopatologia , Contração Miocárdica , Adolescente , Adulto , Cardiomiopatia Hipertrófica/diagnóstico por imagem , Angiografia Coronária , Feminino , Ventrículos do Coração/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Volume SistólicoRESUMO
Left ventricular (LV) diastolic filling is impaired in hearts with healed myocardial infarction. Possible hemodynamic parameters related to impaired LV filling include left atrial pressure, time constant of isovolumic relaxation, chamber stiffness and wall motion asynchrony. Previous studies demonstrated univariate correlations between each of these parameters and LV filling. The current study was designed to compare relative importance of these parameters in patients with a myocardial infarction. Left ventriculograms with simultaneous LV pressure measurement were analyzed in 15 patients with a myocardial infarction and in 10 control subjects. Every frame of the left ventriculogram was divided into 8 segments and the volume of each segment was obtained frame-by-frame by planimetry and area-length method. Asynchrony was quantitated as the sum of areas of discrepancy between each segmental and global volume-time curve. Patients with myocardial infarction had greater asynchrony (20 +/- 2 vs 10 +/- 1%, p < 0.01), greater atrial filling fraction (46 +/- 4 vs 35 +/- 5%, p < 0.05) and slower peak early filling rate (2.5 +/- 0.1 vs 4.1 +/- 0.4 end-diastolic volume/s, p < 0.01) than the control subjects. Multiple regression analyses with hemodynamic variables (asynchrony, LV pressure at mitral valve opening, time constant of LV isovolumic pressure decrease and LV chamber stiffness constant) showed that asynchrony and LV pressure at mitral valve opening were significant determinants of LV filling in patients with myocardial infarction, whereas LV pressure at mitral valve opening was the only significant determinant in control subjects.
Assuntos
Contração Miocárdica , Infarto do Miocárdio/fisiopatologia , Função Ventricular Esquerda , Análise de Variância , Diástole , Eletrocardiografia/estatística & dados numéricos , Ventrículos do Coração/fisiopatologia , Hemodinâmica , Humanos , Pessoa de Meia-Idade , Infarto do Miocárdio/epidemiologia , Análise de Regressão , Fatores de TempoRESUMO
This study assesses the effects of dofetilide, a new selective Ikr blocker with class III properties, on left ventricular function and hemodynamics of heart failure and compares these effects with those of placebo and amiodarone. Because available antiarrhythmic drugs may depress myocardial performance, an invasive hemodynamic study was performed to assess the safety of this agent. Hemodynamic and angiographic data were obtained at baseline and after 30 minutes of double-blind infusion of dofetilide (8 microg/kg; n = 12), placebo (n = 12), or amiodarone (5 mg/kg; n = 6) in heart failure patients (New York Heart Association class II or III, ejection fraction <35%). Intravenous dofetilide preserved the inotropic indexes and the end-systolic volume index despite a slight but significant decrease in heart rate, whereas intravenous amiodarone increased end-diastolic and end-systolic volume indexes. Amiodarone induced a negative inotropic effect illustrated by a rightward shift of the pressure-volume loop and a reduction in pressure-derived indexes of contractility. Intravenous dofetilide acutely prolonged QT interval more than intravenous amiodarone; however, dofetilide did not slow the overall relaxation rate and reduced QT dispersion. In an acute setting, compared with intravenous amiodarone, intravenous dofetilide preserves cardiac function offering a hemodynamic advantage to treat arrhythmias in patients with impaired left ventricular function.
Assuntos
Antiarrítmicos/administração & dosagem , Insuficiência Cardíaca/tratamento farmacológico , Hemodinâmica/efeitos dos fármacos , Fenetilaminas/administração & dosagem , Sulfonamidas/administração & dosagem , Função Ventricular Esquerda/efeitos dos fármacos , Adulto , Idoso , Amiodarona/administração & dosagem , Amiodarona/efeitos adversos , Antiarrítmicos/efeitos adversos , Método Duplo-Cego , Eletrocardiografia/efeitos dos fármacos , Feminino , Humanos , Infusões Intravenosas , Síndrome do QT Longo/induzido quimicamente , Síndrome do QT Longo/diagnóstico , Masculino , Pessoa de Meia-Idade , Contração Miocárdica/efeitos dos fármacos , Fenetilaminas/efeitos adversos , Sulfonamidas/efeitos adversosRESUMO
A method for calculation of the blood volume from the internal carotid and vertebral arteries to the internal jugular veins [total cerebral blood volume (TCBV)] was validated. This was achieved noninvasively in anesthetized rats from the time-activity curve recorded over the head after [99mTc]pertechnetate (Tc) intravenous bolus injection. Tc had the advantage over many other tracers in that it rapidly and evenly distributed in blood cells and plasma. Tc was found to behave in the head according to a two-parallel-compartment model containing a fast cerebral compartment and a slow extracerebral compartment. This model was mathematically described by a sum of two lagged normal density curves (LNDC) that fitted the head curve adequately. Responses of the LNDC parameters to flow and volume variations were first tested on a hydraulic setup. TCBV was calculated from the LNDC parameters of the cerebral fast compartment and the simultaneously determined cardiac output. In normocapnic rats, TCBV amounted to 49 +/- 7 (SD) microliters/g, distributed approximately two-thirds in the extra-parenchymal and one-third in the intraparenchymal cerebral vasculatures.
Assuntos
Volume Sanguíneo/fisiologia , Circulação Cerebrovascular/fisiologia , Animais , Encéfalo/irrigação sanguínea , Feminino , Cabeça/irrigação sanguínea , Cinética , Meninges/irrigação sanguínea , Modelos Biológicos , Ratos , Ratos Sprague-Dawley , Pertecnetato Tc 99m de SódioRESUMO
To assess local myocardial relaxation abnormalities in patients with coronary artery disease, local myocardial left ventricular wall stress was computed in nine normal subjects and in 22 patients with coronary artery disease. In normal left ventricles, the rate of decrease in isovolumic local stress was not significantly different from the rate of decrease in isovolumic pressure, and the residual wall stress at the end of isovolumic relaxation was uniformly low. In patients with coronary artery disease, the residual wall stress was increased both in infarcted areas and in non-infarcted areas perfused by stenosed arteries (43 +/- 31 and 30 +/- 19 kdyne/cm2, respectively, vs 9 +/- 5 kdyne/cm2 in normal areas; p less than .001). The rate of decrease in local stress in infarcted areas paralleled the rate of decrease in pressure (48 vs 49 msec; NS), but in ischemic areas the rate of decrease in stress was significantly slower than the rate of decrease in pressure (69 +/- 35 vs 48 +/- 15 msec; p less than .05). It is concluded that in patients with coronary artery disease, indexes based only on the analysis of decreases in isovolumic pressure underestimate the severity of local impairments in relaxation rate and cannot be used to predict the level of residual diastolic wall stress.
Assuntos
Doença das Coronárias/fisiopatologia , Ventrículos do Coração/fisiopatologia , Adulto , Idoso , Ventrículos do Coração/efeitos dos fármacos , Humanos , Pessoa de Meia-Idade , Relaxamento Muscular , Nicardipino , Nifedipino/análogos & derivados , Nifedipino/farmacologiaRESUMO
The changes in sodium and water balances during the first 4 days after an uncomplicated transmural myocardial infarction (MI) were determined in forty patients. The sodium balance was positive 4 days after MI in 80% of the patients but negative in 20%. Neither in anterior (n = 23) nor in inferior (n = 17) MI were rank correlations found between the haemodynamic parameters (cardiac index, mean arterial pressure, mean right atrial or pulmonary capillary pressures, right or left ventricular work indices) and sodium balance. However, the sodium balances correlated with the total creatine kinase (CK) release in anterior MI after 1 day (r = 0.60; P less than 0.002) and after 4 days (r = 0.65; P less than 0.001) but not in inferior MI. Furthermore, in anterior and inferior MI matched for their CK release, the sodium handling was different both after 1 day (-70 in anterior v. +44 mmol (24 h)-1 in inferior MI; P less than 0.001) and after 4 days (-36 v. +147 mmol (72 h)-1; P less than 0.01), a difference unexplained by differences in medical management or in sodium intake. Finally, sodium balance correlated with the changes in left ventricular stroke work index (LVSWI) observed during this period (r = 0.48, P less than 0.001), LVSWI being more stable when sodium balance was more positive. In conclusion, sodium balance after uncomplicated acute MI is related to MI location, to the size of anterior MI, and cannot be predicted from initial haemodynamics. Finally, the relation between LVSWI stability and positive sodium balance suggests that arbitrary sodium restrictions or diuretics might be deleterious to the haemodynamics after uncomplicated myocardial infarction.
Assuntos
Creatina Quinase/sangue , Coração/fisiopatologia , Infarto do Miocárdio/fisiopatologia , Sódio/metabolismo , Equilíbrio Hidroeletrolítico , Adulto , Idoso , Pressão Sanguínea , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Infarto do Miocárdio/patologia , Sódio/sangueRESUMO
Impaired left ventricular diastolic dysfunction is common in patients with ischaemic heart failure. The beta 1-adrenoceptor partial agonist xamoterol was compared with pindolol, a beta-adrenoceptor blocker with intrinsic sympathomimetic activity, in a haemodynamic study in 17 patients with ischaemic heart disease. Pindolol caused left ventricular end-diastolic pressure, wall stress and T1 to rise, whereas xamoterol produced improvements in all three parameters. These results suggest that xamoterol may be of greater benefit to patients in heart failure.
Assuntos
Agonistas Adrenérgicos beta/farmacologia , Doença das Coronárias/fisiopatologia , Coração/efeitos dos fármacos , Pindolol/farmacologia , Propanolaminas/farmacologia , Pressão Sanguínea/efeitos dos fármacos , Diástole , Feminino , Frequência Cardíaca/efeitos dos fármacos , Humanos , Masculino , XamoterolRESUMO
To assess the effects of nisoldipine on chronically underperfused myocardial areas ("hibernating myocardium"), the global and regional left ventricular (LV) function was analyzed before and after 2 months of double-blind monotherapy with nisoldipine (10 mg twice daily) or placebo in 17 patients with a previous anterior myocardial infarction. The baseline LV ejection fraction ranged from 34 to 51%, and no patient had heart failure. Compared to placebo, nisoldipine significantly lowered the LV systolic pressure and end-diastolic pressure (-3 vs. +6 mmHg with placebo; p < 0.01) and the LV pressure at the time of mitral valve opening (-2.0 +/- 3.4 vs. +3.5 +/- 3.0 mm Hg; p < 0.01). Despite this reduction in driving pressure, the global LV early peak filling rate improved only with nisoldipine and this improvement was related to a selective increase in the expansion rate of the anterior areas, from 1,010 +/- 360 to 1,339 +/- 496 mm2/s (p < 0.001). The time to regional peak filling rate (-8%; p < 0.01), the asynchrony of diastolic wall motion, and the regional ejection fraction (33 +/- 10 to 38 +/- 12%; p < 0.001) also improved in the anterior areas with nisoldipine but not with placebo. In contrast, in the inferior control zones, the regional ejection fraction and filling rate remained unchanged, both when compared to baseline and to placebo. In conclusion, prolonged nisoldipine therapy had no significant effect on the normal myocardium but improved systolic and diastolic function in hypokinetic areas.(ABSTRACT TRUNCATED AT 250 WORDS)
Assuntos
Contração Miocárdica/efeitos dos fármacos , Infarto do Miocárdio/tratamento farmacológico , Nisoldipino/uso terapêutico , Função Ventricular Esquerda/efeitos dos fármacos , Método Duplo-Cego , Frequência Cardíaca/efeitos dos fármacos , Humanos , Infarto do Miocárdio/fisiopatologia , Nisoldipino/administração & dosagem , Nisoldipino/farmacologiaRESUMO
BACKGROUND: The changes in myocardial performance responsible for the progression from a stage of asymptomatic left ventricular dysfunction toward overt congestive heart failure are still poorly understood. Accordingly, using invasive methods, we examined the differences in baseline left ventricular function between a subgroup of patients enrolled in the treatment arm (presence of congestive heart failure) and in the prevention arm (asymptomatic patients) of the Studies of Left Ventricular Dysfunction. METHODS AND RESULTS: High-fidelity left ventricular pressures and frame-by-frame angiographic volumes were simultaneously obtained under baseline conditions in 65 patients with left ventricular ejection fraction < or = 35%. Sixteen patients had New York Heart Association congestive heart failure (class II or III), whereas the remaining 49 patients had no clinical signs of heart failure and did not receive therapy for this syndrome. A second set of data was obtained an average of 12.4 months later in 42 patients. The group with heart failure had significantly greater end-diastolic and end-systolic volumes than the asymptomatic group (both p < 0.001), but the stroke index at rest was similar in both groups. Accordingly, ejection fraction was significantly lower in the heart failure group (19.6 +/- 7.0% versus 26.3 +/- 7.2%; p < 0.02). Left ventricular end-diastolic pressure was greater and peak +dP/dt was lower in heart failure patients, but the difference did not reach statistical significance after Bonferroni correction for multiple comparisons. Moreover, the individual end-systolic stress/end-systolic volume data of the heart failure patients fell within the 95% confidence interval of the relation observed in the patients without heart failure both at baseline and after 1 year of follow-up irrespective of their changes in functional status. It was also noted that during follow-up, the changes in end-diastolic and end-systolic volumes correlated linearly, as if both dimensions always shifted in parallel, whereas alterations in contractility primarily influence end-systolic volume. CONCLUSIONS: These observations are compatible with the hypothesis that a depression in the mechanical performance of the viable myocardial areas is not the major determinant for the progression from asymptomatic to symptomatic left ventricular dysfunction. Abnormalities in left ventricular diastolic distensibility, on the other hand, might underlie the progressive ventricular dilation and create a vicious cycle through the afterload mismatch.
Assuntos
Insuficiência Cardíaca/etiologia , Coração/fisiologia , Função Ventricular Esquerda , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Seguimentos , Insuficiência Cardíaca/prevenção & controle , Insuficiência Cardíaca/terapia , Humanos , Masculino , Pessoa de Meia-Idade , Valores de ReferênciaRESUMO
The aim of this study was to clarify the mechanisms responsible for the increase in early filling rate observed during oral nisoldipine therapy in patients with ischaemic left ventricular (LV) dysfunction. For that purpose, the global and regional LV function was analysed before and after 2 months of double-blind monotherapy with nisoldipine (10 mg twice daily) or a placebo, in 17 patients with a previous anterior myocardial infarction. The baseline LV ejection fraction ranged from 34-51% and no patient had heart failure. Compared to the placebo, nisoldipine significantly lowered LV systolic pressure and end-diastolic pressure (-3 mmHg vs +6 with the placebo; P less than 0.01) and the LV pressure at the time of mitral opening (-2.0 +/- 3.4 mmHg vs +3.5 +/- 3.0; P less than 0.01). Despite this reduction in driving pressure, the global LV early peak filling rate improved with nisoldipine only and this improvement was related to a selective increase in expansion rate of the anterior areas, from 1010 +/- 360 to 1339 +/- 496 mm2.s-1 (P less than 0.001). The time to regional peak filling rate (-8%; P less than 0.01), the asynchrony of diastolic wall motion and the regional ejection fraction (33 +/- 10 to 38 +/- 12%; P less than 0.001) also improved in the anterior areas with nisoldipine but not with the placebo. In contrast, in the inferior, control zones, the regional ejection fraction and filling rate remained unchanged, both when compared to baseline and to the placebo.(ABSTRACT TRUNCATED AT 250 WORDS)
Assuntos
Hemodinâmica/efeitos dos fármacos , Infarto do Miocárdio/tratamento farmacológico , Nisoldipino/administração & dosagem , Função Ventricular Esquerda/efeitos dos fármacos , Adulto , Idoso , Cateterismo Cardíaco/instrumentação , Relação Dose-Resposta a Droga , Método Duplo-Cego , Feminino , Hemodinâmica/fisiologia , Humanos , Masculino , Pessoa de Meia-Idade , Contração Miocárdica/efeitos dos fármacos , Contração Miocárdica/fisiologia , Infarto do Miocárdio/fisiopatologia , Processamento de Sinais Assistido por Computador/instrumentação , Função Ventricular Esquerda/fisiologiaRESUMO
The relation between global left ventricular function at rest (evaluated during cardiac catheterization) and exercise capacity was examined in a group of 33 untreated patients with a previous anterior myocardial infarction. The resting ejection fraction (range, 24-68%) correlated poorly with exercise duration (r = 0.47) and did not separate patients with a depressed exercise capacity (exercise duration less than 500 seconds: group A, n = 18) from patients with preserved exercise tolerance (group B, n = 15). The resting left ventricular end-diastolic and end-systolic volume indexes were comparable in groups A and B, but the diastolic pressure-volume relation was shifted upward, and the mean left ventricular pressure during diastolic filling was higher in group A than in group B (19 +/- 8 versus 14 +/- 4 mm Hg; p less than 0.02). The heart rate at maximal exercise was similar in both groups (160 +/- 16 versus 160 +/- 17 beats/min; NS), but heart rate was higher at any given level of exercise in group A than in group B. When 12 patients of group A were treated with xamoterol, a beta 1-adrenoceptor partial agonist, their exercise duration increased by 20 +/- 14% (p less than 0.001), and their maximal exercise heart rate decreased from 158 +/- 16 to 143 +/- 11 beats/min (p less than 0.001). This improved exercise capacity was accompanied by a downward shift of the resting diastolic left ventricular pressure-volume relation and by a decrease in mean left ventricular pressure during diastolic filling.(ABSTRACT TRUNCATED AT 250 WORDS)
Assuntos
Agonistas Adrenérgicos beta/uso terapêutico , Antagonistas Adrenérgicos beta/uso terapêutico , Doença das Coronárias/fisiopatologia , Exercício Físico , Coração/fisiopatologia , Adulto , Doença das Coronárias/tratamento farmacológico , Diástole , Teste de Esforço , Feminino , Coração/efeitos dos fármacos , Ventrículos do Coração , Humanos , Masculino , Pessoa de Meia-Idade , Resistência Física , Propanolaminas/uso terapêutico , Descanso , Fatores de Tempo , XamoterolRESUMO
The effects of the slow calcium channel blocker nicardipine on the synchrony of left ventricular filling were examined in eight patients with angina pectoris. Left ventriculography was performed at baseline (after pretreatment with propranolol to minimize reflex changes) and was repeated after the intravenous administration of 2.5 mg nicardipine. Regional peak filling rate and time to peak filling rate were determined in eight ventricular segments before and after nicardipine. At baseline, the time from the R wave to the regional peak filling rate was 380-680 msec, and there were a large number of segments with depressed peak filling rate (p less than 0.001, vs. distribution of regional peak filling rate in normal subjects using a Kolmogorov-Smirnov test), indicating both asynchrony of filling (p less than 0.001, vs. distribution of time to peak filling rate in normal subjects) and nonhomogeneity of diastolic distensibility. Nicardipine administration significantly reduced the distribution of the time to peak filling rate (p less than 0.001) and increased regional peak filling rate (p less than 0.001) in a large subset of segments. Segments with normal values of peak filling rate at baseline, however, frequently did not improve or even decreased their peak filling rate. The changes in global left ventricular filling rate after drug administration also correlated with the number of segments improved after nicardipine. It is concluded that intravenous nicardipine improves the synchrony of diastolic filling in patients with angina pectoris.(ABSTRACT TRUNCATED AT 250 WORDS)
Assuntos
Angina Pectoris/tratamento farmacológico , Contração Miocárdica/efeitos dos fármacos , Nicardipino/uso terapêutico , Débito Cardíaco/fisiologia , Cineangiografia , Eletrocardiografia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pré-Medicação , PropranololRESUMO
The effects of the intravenous administration of the angiotensin converting enzyme inhibitor benazeprilat on left ventricular function were examined in 18 patients with ischemic heart disease. Twenty minutes after drug infusion (0.3-10 mg), heart rate (78 +/- 17 to 71 +/- 16 beats/min, p less than 0.0003), left ventricular systolic pressure (-9 mm Hg, p less than 0.0004), and plasma norepinephrine concentration all decreased significantly. The isovolumic indexes of inotropic state also decreased slightly (-10% in dP/dtmax, p less than 0.001), whereas the ejection fraction (39 +/- 16% to 41 +/- 16%, p less than 0.08) and the end-systolic volume (-6%, p less than 0.04) tended to improve, probably because of the afterload reduction (-13% in mean systolic wall stress, p less than 0.05). After benazeprilat administration, the left ventricular end-diastolic pressure was unchanged at the group level, but there was a consistent downward shift of the diastolic pressure-volume relation during rapid filling, and the mean diastolic wall stress decreased from 99 +/- 73 to 69 +/- 42 kdyne/cm2 (p less than 0.007). These data indicate that the acute administration of benazeprilat has a dual action on left ventricular pump function, which is that the negative inotropic effect of bradycardia and reduced sympathetic drive are compensated by afterload reduction. The drug also improved left ventricular diastolic distensibility and significantly reduced wall stress during diastole. The beneficial effects on diastolic function were noted both in patients with mild left ventricular dysfunction and in patients with heart failure.