Detalhe da pesquisa
1.
Molecular Basis for Inhibition of Heparanases and ß-Glucuronidases by Siastatin B.
J Am Chem Soc
; 146(1): 125-133, 2024 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38118176
2.
The development of a broad-spectrum retaining ß-exo-galactosidase activity-based probe.
Org Biomol Chem
; 21(38): 7813-7820, 2023 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37724332
3.
Design, Synthesis and Structural Analysis of Glucocerebrosidase Imaging Agents.
Chemistry
; 27(66): 16377-16388, 2021 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34570911
4.
Comprehensive structure-activity-relationship of azaindoles as highly potent FLT3 inhibitors.
Bioorg Med Chem
; 27(5): 692-699, 2019 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30661740
5.
Direct Stereoselective Aziridination of Cyclohexenols with 3-Amino-2-(trifluoromethyl)quinazolin-4(3H)-one in the Synthesis of Cyclitol Aziridine Glycosidase Inhibitors.
European J Org Chem
; 2019(6): 1397-1404, 2019 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31787842
6.
Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition.
Proc Natl Acad Sci U S A
; 113(1): 26-33, 2016 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26668358
7.
A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase.
J Am Chem Soc
; 139(40): 14192-14197, 2017 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28937220
8.
Bis-pyridylethenyl benzene as novel backbone for amyloid-ß binding compounds.
Bioorg Med Chem
; 24(23): 6139-6148, 2016 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27838168
9.
Synthesis of 6-Hydroxysphingosine and α-Hydroxy Ceramide Using a Cross-Metathesis Strategy.
J Org Chem
; 80(14): 7258-65, 2015 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26061009
10.
Ultrasensitive in situ visualization of active glucocerebrosidase molecules.
Nat Chem Biol
; 6(12): 907-13, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21079602
11.
A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo.
Chem Biol
; 13(11): 1217-26, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17114003
12.
Chiral disubstituted piperidinyl ureas: a class of dual diacylglycerol lipase-α and ABHD6 inhibitors.
Medchemcomm
; 8(5): 982-988, 2017 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30108813
13.
Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding.
J Med Chem
; 60(1): 428-440, 2017 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27992221
14.
Enantioselective synthesis of adamantylalanine and carboranylalanine and their incorporation into the proteasome inhibitor bortezomib.
Chem Commun (Camb)
; 52(21): 4064-7, 2016 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26894389
15.
Photo-crosslinking of clinically relevant kinases using H89-derived photo-affinity probes.
Mol Biosyst
; 12(6): 1809-17, 2016 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-27138522
16.
In vitro and in vivo comparative and competitive activity-based protein profiling of GH29 α-l-fucosidases.
Chem Sci
; 6(5): 2782-false, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29142681
17.
Synthesis and biological evaluation of 2,3,5-substituted [1,2,4]thiadiazoles as allosteric modulators of adenosine receptors.
J Med Chem
; 47(3): 663-72, 2004 Jan 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-14736246
18.
Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors.
J Med Chem
; 57(21): 9096-104, 2014 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25250725
19.
Incorporation of fluorinated phenylalanine generates highly specific inhibitor of proteasome's chymotrypsin-like sites.
J Med Chem
; 53(5): 2319-23, 2010 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20131905
20.
Synthesis of L-altro-1-deoxynojirimycin, D-allo-1-deoxynojirimycin, and D-galacto-1-deoxynojirimycin from a single chiral cyanohydrin.
Org Lett
; 12(17): 3957-9, 2010 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20690611