Detalhe da pesquisa
1.
Mining scientific advice reports on cell-based products: Insight into the nonclinical development program.
Br J Clin Pharmacol
; 87(6): 2465-2474, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32790909
2.
Towards a mechanism-based approach for the prediction of nongenotoxic carcinogenic potential of agrochemicals.
Crit Rev Toxicol
; 50(9): 725-739, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33236972
3.
A cross-sector call to improve carcinogenicity risk assessment through use of genomic methodologies.
Regul Toxicol Pharmacol
; 110: 104526, 2020 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-31726190
4.
A comprehensive view on mechanistic approaches for cancer risk assessment of non-genotoxic agrochemicals.
Regul Toxicol Pharmacol
; 118: 104789, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-33035627
5.
Evaluation of Juvenile Animal Studies for Pediatric CNS-Targeted Compounds: A Regulatory Perspective.
Int J Toxicol
; 38(6): 456-475, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31662008
6.
Is current risk assessment of non-genotoxic carcinogens protective?
Crit Rev Toxicol
; 48(6): 500-511, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29745287
7.
EMA commentary on the ICH guideline for testing for carcinogenicity of pharmaceuticals.
Br J Clin Pharmacol
; 89(8): 2341-2348, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37265032
8.
Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production.
Breast Cancer Res
; 19(1): 14, 2017 02 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28173837
9.
Prediction of thyroid C-cell carcinogenicity after chronic administration of GLP1-R agonists in rodents.
Toxicol Appl Pharmacol
; 320: 51-59, 2017 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28213092
10.
Comparing rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on systemic dose and developmental effects.
Crit Rev Toxicol
; 47(5): 402-414, 2017 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-27766926
11.
Critical analysis of carcinogenicity study outcomes. Relationship with pharmacological properties.
Crit Rev Toxicol
; 46(7): 587-614, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27116466
12.
An integrative test strategy for cancer hazard identification.
Crit Rev Toxicol
; 46(7): 615-39, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27142259
13.
Comparison of rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on the nature and severity of developmental effects.
Crit Rev Toxicol
; 46(10): 900-910, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27848393
14.
Animal-free applications in the development of cell-based therapies.
Br J Clin Pharmacol
; 87(6): 2425-2427, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32935350
15.
Prediction of carcinogenic potential of chemicals using repeated-dose (13-week) toxicity data.
Regul Toxicol Pharmacol
; 81: 242-249, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27614137
16.
Regulatory Acceptance of Alternative Methods in the Development and Approval of Pharmaceuticals.
Adv Exp Med Biol
; 856: 33-64, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27671719
17.
Alternative signaling network activation through different insulin receptor family members caused by pro-mitogenic antidiabetic insulin analogues in human mammary epithelial cells.
Breast Cancer Res
; 17: 97, 2015 Jul 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26187749
18.
Mammary gland tumor promotion by chronic administration of IGF1 and the insulin analogue AspB10 in the p53R270H/âºWAPCre mouse model.
Breast Cancer Res
; 17: 14, 2015 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-25848982
19.
Treatment with insulin (analogues) and breast cancer risk in diabetics; a systematic review and meta-analysis of in vitro, animal and human evidence.
Breast Cancer Res
; 17: 100, 2015 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26242987
20.
Knowledge sharing to facilitate regulatory decision-making in regard to alternatives to animal testing: Report of an EPAA workshop.
Regul Toxicol Pharmacol
; 73(1): 210-26, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26188116