Indoor phthalate exposure and contributions to total intake among pregnant women in the SELMA study.

Phthalates are widely used in consumer products. Exposure to phthalates can lead to adverse health effects in humans, with early-life exposure being of particular concern. Phthalate exposure occurs mainly through ingestion, inhalation, and dermal absorption. However, our understanding of the relative importance of different exposure routes is incomplete. This study estimated the intake of five phthalates from the residential indoor environment for 455 Swedish pregnant women in the SELMA study using phthalate mass fraction in indoor dust and compares these to total daily phthalate intakes back-calculated from phthalate metabolite concentrations in the women's urine. Steady-state models were used to estimate indoor air phthalate concentrations from dust measurements. Intakes from residential dust and air made meaningful contributions to total daily intakes of more volatile di-ethyl phthalate (DEP), di-n-butyl phthalate (DnBP), and di-iso-butyl phthalate (DiBP) (11% of total DEP intake and 28% of total DnBP and DiBP intake combined). Dermal absorption from air was the dominant pathway contributing to the indoor environmental exposure. Residential exposure to less volatile phthalates made minor contributions to total intake. These results suggest that reducing the presence of low molecular weight phthalates in the residential indoor environment can meaningfully reduce phthalate intake among pregnant women.

Examining the role of total organic carbon and black carbon in the fate of legacy persistent organic pollutants (POPs) in indoor dust from Nepal: Implication on human health.

Despite the fact that the consumption and import of legacy persistent organic pollutants (POPs) have been stopped in Nepal since 2001, they are still of worry for human prosperity and the environment because of their persistence behavior and constant release from sources that are presently being used. The essential objective of this study was to assess the concentration and spatial distribution of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in residential dust from Nepal keeping in mind the end goal to evaluate the importance of total organic carbon (TOC) and black carbon (BC) in the fate of legacy POPs. Additionally, health risk exposure via dust ingestion and dermal absorption was estimated to evaluate the significance of dust media for human exposure. Results demonstrated that ∑OCPs in dust was 37 times greater than ∑PCBs. DDT was mostly dominated in the dust, and contributed 90% of the ∑OCPs, while hexa-CBs predominated among PCBs and represented 34% of ∑PCBs. Birgunj and Biratnagar had a relatively higher level of ∑OCPs and ∑PCBs than those of Kathmandu and Pokhara. TOC and BC showed a poor connection with OCPs, recommending little or no role. However, PCB in the dust, especially low congeners was strongly linked with TOC but not BC indicating the significant role of TOC. The daily risk exposure estimation indicated dermal absorption through dust as the principal means of OCPs/PCBs intake to both adult and children population. These estimated exposures were 2-4 orders of magnitude inferior to their corresponding reference dose showing insignificant risk.

Organophosphate flame retardants in the indoor air and dust in cars in Japan.

The concentrations of organophosphate flame retardants (OPFRs) in the indoor air and dust were measured in 25 unoccupied cars in Japan. In the indoor air of the cars, most OPFRs were neither detected nor found at a concentration lower than the method quantification limit. The highest concentration (1500 ng m-3) was obtained for tris(1-chloro-2-propyl) phosphate (TCIPP). By contrast, many OPFRs were detected in the dust samples collected from the interior of the cars. TCIPP and tris(2-ethylhexyl) phosphate (TEHP) were present at the highest concentrations at 390 µg g-1 (in dust from car seats) and 640 µg g-1 (in dust from car floor mats), respectively. The highest median concentrations (35 µg g-1 for car seats, 53 µg g-1 for car floor mats) were obtained for tris(2-butoxyethyl) phosphate (TBOEP). According to the results of our exposure assessment, the typical exposures to OPFRs via inhalation in car cabins ranged from 9.0×10-4 to 7.8×10-1 ng kg-bw-1 day-1. The typical exposures to OPFRs via dust ingestion ranged from 9.2×10-4 to 8.8×10-1 ng kg-bw-1 day-1. We compared these results with the ref-erence doses for OPFRs and found that, based on cur-rent information about the toxicities of OPFRs, exposure to OPFRs in car cabins via inhalation and dust ingestion is unlikely to have adverse human health effects.

Brominated flame retardants in food and environmental samples from a production area in China: concentrations and human exposure assessment.

Human exposure to brominated flame retardants (BFRs: decabromodiphenyl ether (BDE209), decabromodiphenyl ethane (DBDPE), hexabromobenzene (HBB), pentabromoethylbenzene (PBEB), pentabromotoluene (PBT), 1,2,3,4,5-pentabromobenzene (PBBz), and 2,3,5,6-tetrabromo-p-xylene (TBX)) in a brominated flame retardant production area (Weifang, Shandong Province, China) was estimated. Thirty food samples, 14 air samples, and 13 indoor dust samples were analyzed. BDE209 and DBDPE were the dominant BFRs in all samples. Higher alternative brominated flame retardant (including DBDPE, HBB, PBEB, PBT, PBBz, and TBX) concentrations were found in vegetables than in fish and meat; thus, plant-original foods might be important alternative BFR sources in the study area. The BDE209 and alternative BFR concentrations in air were 1.5×10(4) to 2.2×10(5) and 620 to 3.6×10(4) pg/m3, respectively. Mean total BFR exposures through the diet, inhalation, and indoor dust ingestion were 570, 3000, and 69 ng/d, respectively (16, 82, and 2% of total intake, respectively). Inhalation was the dominant BFR source except for DBDPE, for which diet dominated. BDE209 contributed 85% of the total BFR intake in the study area.

Biocide and other semi-volatile organic compound concentrations in settled indoor dust of CRESPI daycare centers and implication for public health.

This study investigates the presence of biocides and other semi-volatile organic compounds (SVOCs) in cleaning products used in daycare centers and health impact through ingestion of settled dust by young children. In Paris metropolitan area, 106 daycares area were investigated between 2019-2022. Fifteen substances were analyzed in settled indoor dust by gas chromatography-tandem mass spectrometry. Detection rates and concentrations ranged from 5 to 100%, and

Methodologies for the collection of parameters to estimate dust/soil ingestion for young children.

Background: Heavy metals, pesticides and a host of contaminants found in dust and soil pose a health risk to young children through ingestion. Dust/soil ingestion rates for young children can be estimated using micro-level activity time series (MLATS) as model inputs. MLATS allow for the generation of frequency and duration of children's contact activities, along with sequential contact patterns. Models using MLATS consider contact types, and transfer dynamics to assign mechanisms of contact and appropriate exposure factors for cumulative estimates of ingestion rates. Objective: The objective of this study is to describe field implementation, data needs, advanced field collection, laboratory methodologies, and challenges for integrating into and updating a previously validated physical-stochastic MLATS-based model framework called the Child-Specific Aggregate Cumulative Human Exposure and Dose (CACHED) model. The manuscript focuses on describing the methods implemented in the current study. Methods: This current multidisciplinary study (Dust Ingestion childRen sTudy [DIRT]) was implemented across three US regions: Tucson, Arizona; Miami, Florida and Greensboro, North Carolina. Four hundred and fifty participants were recruited between August 2021 to June 2023 to complete a 4-part household survey, of which 100 also participated in a field study. Discussion: The field study focused on videotaping children's natural play using advanced unattended 360° cameras mounted for participants' tracking and ultimately conversion to MLATS. Additionally, children's hand rinses were collected before and after recording, along with indoor dust and outdoor soil, followed by advanced mass analysis. The gathered data will be used to quantify dust/soil ingestion by region, sociodemographic variables, age groups (from 6 months to 6 years), and other variables for indoor/outdoor settings within an adapted version of the CACHED model framework. Significance: New innovative approaches for the estimation of dust/soil ingestion rates can potentially improve modeling and quantification of children's risks to contaminants from dust exposure.

A comparative study on contamination profiles of liquid crystal monomers (LCMs) between outdoor and indoor dusts, and the assessment of health risk of human exposure.

Liquid crystal monomers (LCMs) are ubiquitous in various environmental samples, which has led to increasing concerns regarding their potential health risks to humans and wildlife. However, the comparison of the contamination patterns of LCMs between indoor and outdoor environments has rarely been studied. In this study, 35 LCMs were investigated in n = 55 dust samples collected from indoor (n = 20) and outdoor (n = 35) spaces in Yulin, Northwest China. The LCMs were widely detected in indoor and outdoor dusts; the total concentrations of LCMs ranged from 48.6 to 396 ng/g (median: 153 ng/g), and from not detectable to 388 ng/g (median: 56.4 ng/g) in indoor and outdoor dusts, respectively. The concentration levels of ΣLCMs in indoor dusts were significantly higher than those in outdoor dusts (p < 0.05). For each microenvironment, the ranking order of LCM concentrations was dormitory (mean: 202 ng/g) > teaching building (182 ng/g) > campus road (150 ng/g) > urban road (107 ng/g) > laboratory building (91.0 ng/g) > pedestrian street (20.1 ng/g). The mean estimated daily intake values of Σ35LCMs for adults were 2.48 × 10-2 and 1.37 × 10-3 ng/g BW/day in indoor and outdoor dusts, respectively. The hazard quotients of individual LCMs and hazard indices of all analytes were considerably less than one, indicating little health risk for humans via dust ingestion.

In vitro modeling of the post-ingestion mobilization and bioaccessibility of pesticides sorbed to soil and house dust.

Soils and dusts can act as sinks for semivolatile lipophilic organic compounds and children ingest relatively large amounts of both soils and dusts. Following intake, sorbed chemicals may desorb (mobilize) and become available for intestinal absorption (bioaccessible). When chemicals are not degraded in the digestive tract, mobilization can approximate bioaccessibility. Alternatively, when gastrointestinal degradation of mobilized chemicals does occur, it can be useful to separate mobilization from bioaccessibility. In this study we used synthetic digestive fluids in a sequential, three-compartment (saliva, gastric, and intestinal) in vitro assay to construct mobilization and bioaccessibility models for 16 pesticides (log Kow 2.5-6.8) sorbed to 32 characterized soils and house dusts. To address the potential loss of mobilized pesticides due to absorption, the assays were repeated using a solid phase sorbent (tenax) added to the digestive fluid immediately after addition of the intestinal fluid components. We found that pesticide mobilization was predicted by pesticide log Kow and the carbon content of the soils and dusts. Pesticide loss measurably reduced the bioaccessibility of most pesticides, and bioaccessibility was largely predicted by log Kow and pesticide loss rate constants. Introduction of the sink increased mobilization by x̄ = 4 ± 6% (soil) and x̄ = 9 ± 7% (dust) while bioaccessibility increases were x̄ = 41 ± 21% (soil) and x̄ = 24 ± 12% (dust). The physicochemical properties of the soils, dusts, and pesticides used in this study successfully predicted the in vitro mobilization and bioaccessibility of the pesticides. This suggests that modeling of pesticide mobilization and bioaccessibility could reduce uncertainty in exposure and risk assessments.

Innovative non-targeted screening approach using High-resolution mass spectrometry for the screening of organic chemicals and identification of specific tracers of soil and dust exposure in children.

Environmental contamination through direct contact, ingestion and inhalation are common routes of children's exposure to chemicals, in which through indoor and outdoor activities associated with common hand-to-mouth, touching objects, and behavioral tendencies, children can be susceptible and vulnerable to organic contaminants in the environment. The objectives of this study were the screening and identification of a wide range of organic contaminants in indoor dust, soil, food, drinking water, and urine matrices (N = 439), prioritizing chemicals to assess children's environmental exposure, and selection of unique tracers of soil and dust ingestion in young children by non-targeted analysis (NTA) using Q-Exactive Orbitrap followed data processing by the Compound Discoverer (v3.3, SP2). Chemical features were first prioritized based on their predominant abundance (peak area>500,000), detection frequency (in >50% of the samples), available information on their uses and potential toxicological effects. Specific tracers of soil and dust exposure in children were selected in this study including Tripropyl citrate and 4-Dodecylbenzenesulfonic acid. The criteria for selection of the tracers were based on their higher abundance, detection frequency, unique functional uses, measurable amounts in urine (suitable biomarker), and with information on gastrointestinal absorption, metabolism, and excretion, and were further confirmed by authentic standards. We are proposing for the first time suitable unique tracers for dust ingestion by children.

Microplastics: Human exposure assessment through air, water, and food.

BACKGROUND: Microplastics (MP) are plastic particles with dimension up to 5 mm. Due to their persistence, global spread across different ecosystems and potential human health effects, they have gained increasing attention during the last decade. However, the extent of human exposure to MP through different pathways and their intake have not been elucidated. OBJECTIVES: The objective of this review is to provide an overview on the pathways of exposure to MP through inhalation, ingestion, and dermal contact considering data from the open bibliography on MP in air, dust, food, water and drinks. METHODS: A bibliographic search on Scopus and PubMed was conducted using keywords on MP in outdoor and indoor air, indoor dust, food including beverages and water and human intake (n = 521). Articles were sorted by their title and abstract (n = 213), and only studies reporting MP identification and quantification techniques were further considered (n = 168). A total of 115 articles that include quality assurance and quality control (QA/QC) procedures are finally discussed in the present review. Based on MP concentration data available in literature, we estimated the potential inhaled dose (ID), dust intake (DI), the estimated daily intake (EDI) via food and beverages. Finally, the total daily intake (TDI) considering both inhalation and ingestion routes are provided for adults, infants and newborns. RESULTS: The concentrations of MP in outdoor and indoor air, dust, and in food and water are provided according to the bibliography. Human exposure to MP through dust ingestion, inhalation of air and food/drinks consumption revealed that indoor air and drinking waters were the main sources of MP. CONCLUSIONS: This study reveals that humans are constantly exposed to MP, and that the indoor environment and the food and water we ingest decisively contribute to MP intake. Additionally, we highlight that infants and newborns are exposed to high MP concentrations and further studies are needed to evaluate the presence and risk of MP in this vulnerable age-population.

Bioaccessible metals in dust materials from non-sulfide Zn deposit and related hydrometallurgical operation.

Mining and processing of ores in arid (desert) areas generates high amounts of dust, which might be enriched in potentially harmful elements. We studied dust fractions of ores, soils, and technological materials from mining and related hydrometallurgical operation at former Skorpion Zinc non-sulfide Zn deposit in southern Namibia (closed and placed under maintenance in 2020). Chemical and mineralogical investigation was combined with oral bioaccessibility testing of fine dust fractions (<48 µm and <10 µm) in simulated gastric fluid (SGF) to assess potential risk of intake of metallic contaminants (Cd, Cu, Pb, Zn) for staff operating in the area. The bulk metals concentrations were largely variable and ranked as follows: soils < tailings â‰ª Skorpion ores < imported ores and dross used for feed ore blending. Maximum contaminant concentrations in the original granular materials were 927 mg Cd/kg, 9150 mg Cu/kg, 50 g Pb/kg and 706 g Zn/kg, respectively, and generally increased as a function of decreasing grain size. The highest bioaccessible concentrations of Cd and Pb yielded imported ores from Taiwan and Turkey and, together with the milled dross, these samples also exhibited the highest Zn bioaccessibilities. The exposure estimates calculated for a worker (weighing 70 kg) in this mining/ore processing operation at a dust ingestion rate of 100 mg/day indicated that most dust samples (soils, tailings, Skorpion ores) exhibited metals intake values far below tolerable daily intake limits. The overall health risk was limited in all mining and ore processing areas except for the ore blending area, where imported ores and recycled dross enriched in bioaccessible Cd, Pb and/or Zn were used for the ore blending. Safety measures required by the mine operator (wearing of masks by the operating staff) helped to prevent the staff's exposure to potentially contaminated dust even in this blending ore area.

Novel Brominated Flame Retardants in Dust from E-Waste-Dismantling Workplace in Central China: Contamination Status and Human Exposure Assessment.

Novel brominated flame retardants (NBFRs) have been widely used as alternatives to legacy BFRs. However, information on the contamination status and human exposure risks of electronic waste (e-waste)-derived NBFRs in the e-waste workplace is limited. In this study, six NBFRs and the legacy BFRs, hexabromocyclododecanes (HBCDs), were analyzed in 50 dust samples from an e-waste-dismantling workplace in Central China. The dust concentration of NBFRs in e-waste-dismantling workshops (median, 157−169 ng/g) was found to be significantly higher than those in an outdoor environment (17.3 ng/g) (p < 0.01). Differently, the highest median concentration of HBCDs was found in dust from the dismantling workshop for cellphones and computers (367 ng/g) among studied areas. The bis(2-ethylhexyl)-3,4,5,6-tetrabromo-phthalate (BEHTBP) was the predominant compound, which contributed 66.0−88.0% of measured NBFR concentrations. NBFRs might originate from plastic and rubber materials in wastes based on the correlation and principal component analysis. Moreover, the total estimated daily intakes (average scenario) of NBFRs were calculated at 2.64 × 10−2 ng/kg bw/d and 2.91× 10−2 ng/kg bw/d for the male and female dismantling workers, respectively, via dust ingestion, inhalation, and dermal contact pathways, which were lower than the reference dose values, and thus indicated a limited human exposure risk for NBFRs at the current level. Although the dust concentrations and daily intakes of NBFRs were still lower than those of other emerging pollutants (e.g., organophosphate and nitrogenous flame retardants) measured in the same sampling set, the elevated levels of NBFRs suggested the progressive BFR replacement process in China, which deserves more attention regarding their adverse effects on both the environment and human health.

Organohalogenated flame retardants and organophosphate esters from home and preschool dust in Sweden: Pollution characteristics, indoor sources and intake assessment.

This study analysed settled dust samples in Sweden to assess children's combined exposure to 39 organohalogenated flame retardants (HFRs) and 11 organophosphate esters (OPEs) from homes and preschools. >94 % of the targeted compounds were present in dust, indicating widespread use of HFRs and OPEs in Swedish homes and preschools. Dust ingestion was the primary exposure pathway for most analytes, except BDE-209 and DBDPE, where dermal contact was predominant. Children's estimated intakes of ∑emerging HFRs and ∑legacy HFRs from homes were 1-4 times higher than from preschools, highlighting higher exposure risk for HFRs in homes compared to preschools. In a worst-case scenario, intakes of tris(2-butoxyethyl) phosphate (TBOEP) were 6 and 94 times lower than the reference dose for children in Sweden, indicating a potential concern if exposure from other routes like inhalation and diet is as high. The study also found significant positive correlations between dust concentrations of some PBDEs and emerging HFRs and the total number of foam mattresses and beds/m2, the number of foam-containing sofas/m2, and the number of TVs/m2 in the microenvironment, indicating these products as the main source of those compounds. Additionally, younger preschool building ages were found to be linked to higher ΣOPE concentrations in preschool dust, suggesting higher ΣOPE exposure. The comparison with earlier Swedish studies indicates decreasing dust concentrations for some banned and restricted legacy HFRs and OPEs but increasing trends for several emerging HFRs and several unrestricted OPEs. Therefore, the study concludes that emerging HFRs and OPEs are replacing legacy HFRs in products and building materials in homes and preschools, possibly leading to increased exposure of children.

Model-based predictions of soil and dust ingestion rates for U.S. adults using the stochastic human exposure and dose simulation soil and dust model.

BACKGROUND: Adults can be exposed to chemicals through incidental ingestion of soil and dust, either through hobbies, occupations, or behaviors that increase contact with soil or dust (e.g., cleaning or renovating). However, few data describing these ingestion rates are available. OBJECTIVE: Our objective was to use the Stochastic Human Exposure and Dose Simulation Soil and Dust (SHEDS-Soil/Dust) model to estimate distributions of soil and dust ingestion rates for adults (≥21 years old) with varying degrees of soil and dust contact. METHODS: We parameterized SHEDS-Soil/Dust to estimate soil and dust ingestion rates for several categories of adults: adults in the general population; adults with moderate (higher) soil exposure (represented by hobbyists, such as gardeners, with increased soil contact); adults with high soil exposure (represented by occupationally exposed individuals, such as landscapers); and individuals who have high dust exposure (e.g., are in contact with very dusty indoor environments). RESULTS: Total soil plus dust ingestion for adults in the general population was 7 mg/day. Hobbyists or adults with moderate soil exposure averaged 33 mg/day and occupationally exposed individuals averaged 123 mg/day. Total soil plus dust ingestion for adults in the high dust exposure scenario was 25 mg/day. Results were driven by time spent in contact with soil and, thus, warmer seasons (e.g., summer) were associated with higher ingestion rates than colder seasons (e.g., winter). SIGNIFICANCE: These results provide modeled estimates of soil and dust ingestion rates for adults for use in decision making using real-world exposure considerations. These modeled estimates suggest that soil and dust ingestion is a potential concern for adults who spend a higher amount of time interacting with either soil or dusty environments. IMPACT STATEMENT: The parameterization of real-world scenarios within the application of SHEDS-Soil/Dust model to predict soil and dust ingestion rates for adults provides estimates of soil and dust ingestion rates useful for refining population-based risk assessments. These data illuminate drivers of exposure useful for both risk management decisions and designing future studies to improve existing tracer methodologies.

Estimation of Children's Soil and Dust Ingestion Rates and Health Risk at E-Waste Dismantling Area.

Due to environmental health concerns, exposure to heavy metals and related adverse effects in electronic waste (e-waste) dismantling areas have attracted considerable interest in the recent years. However, little information is available about the Soil/Dust Ingestion Rates (SIR) of heavy metals for children living in such sites. This study estimated the soil ingestion of 66 children from e-waste disassembly areas by collecting and analyzing selected tracer elements in matched samples of their consumed food, feces, and urine, as well as soil samples from their play areas. The concentrations of tracer elements (including Al, Ba, Ce, Mn, Sc, Ti, Y, and V) in these samples were analyzed. The SIR was estimated to be 148.3 mg/day (median) and 383.3 mg/day (95th percentile) based on the Best Tracer Method (BTM). These values are somewhat higher than those observed in America, Canada, and other parts of China. Health risk assessments showed that Cr presented the greatest carcinogenic risk, at more than 10-6 in this typical polluted area, while As was second. These findings provide important insights into the exposure risks of heavy metals in e-waste dismantling sites and emphasize the health risk caused by Cr and As.

Occurrence, Distribution, and Human Exposure of Emerging Liquid Crystal Monomers (LCMs) in Indoor and Outdoor Dust: A Nationwide Study.

Liquid crystal monomers (LCMs) are a class of emerging, persistent, bioaccumulative, and toxic organic pollutants. They are detected in various environmental matrixes that are associated with electronic waste (e-waste) dismantling. However, their occurrence and distribution in indoor and outdoor dust on a national scale remain unknown. In this study, a dedicated target analysis quantified a broad range of 60 LCMs in dust samples collected across China. The LCMs were frequently detected in indoor (n = 48) and outdoor dust (n = 97; 37 sampled concomitantly with indoors dust) from dwellings, and indoor dust from cybercafés (n = 34) and phone repair stores (n = 22), with median concentrations of 41.6, 94.7, 106, and 171 ng/g, respectively. No significant spatial difference was observed for the concentrations of the total LCMs among distinct geographical regions (p > 0.05). The median daily intake values of the total LCMs via dust ingestion, dermal contact, and inhalation were estimated at 1.50 × 10-2, 2.90 × 10-2, and 8.57 × 10-6 ng/kg BW/day for adults and 1.47 × 10-1, 1.22 × 10-1, and 2.18 × 10-5 ng/kg BW/day for children, respectively. These estimates suggested higher exposure risks for children and indicated that dust ingestion and dermal contact significantly contribute to the human intake of LCMs. The microenvironmental pollution levels of LCMs together with the potential exposure risks associated with some of these chemicals are of concern for human health.

Risk assessment of PBDEs and PCBs in dust from an e-waste recycling area of China.

Polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) are widely used in outdated electronic and electrical products. In the present study, dust samples from houses, kindergartens, and roads were collected in Guiyu, where informal e-waste recycling activities have been sustained since the 1980s. Haojiang was chosen as a reference site without e-waste pollution. A total of 20 PBDE congeners and 18 PCB congeners was measured. Concentrations of total PBDEs and PCBs in dust samples from Guiyu were significantly higher than those from Haojiang. In Guiyu, kindergarten dust had the highest concentration of PCBs in these three typical environments, whereas the concentration of PBDEs showed no significant difference. Concentrations of PBDEs in Haojiang house dust were found significantly higher than other two environmental dusts. According to the questionnaires, we found that factors such as shoe cabinets, electrical products, and potted plants might affect PBDE and PCB concentrations in house dust. Daily intake of PBDEs and PCBs via dust ingestion was estimated after correction by their house, kindergarten, and road dust concentrations. The mean estimated daily intake (EDI) of PBDEs for Guiyu children was far lower than the oral reference dose recommended by the environmental protection agency (EPA). The Guiyu children seem to have a higher trend of daily intakes of PCBs although their EDIs not being calculated accurately due to the low detection rate. Child exposure to PBDEs via dust ingestion in Guiyu was 36 times higher than those in Haojiang. This indicates that children from e-waste-polluted areas stay in surroundings with heavy burdens of PBDEs, even PCBs. The risk to their health from contaminants is a severe concern.

Occurrence of novel organophosphate esters derived from organophosphite antioxidants in an e-waste dismantling area: Associations between hand wipes and dust.

Electronic waste (e-waste) is a well-known source of plastic additives in the environment. However, the e-waste-related occupational exposure to organophosphite antioxidants (OPAs) and the relevant oxidation products-novel organophosphate esters (NOPEs)-via different pathways is still unknown. In this study, six OPAs and three NOPEs were measured in 116 dust and 43 hand-wipe samples from an e-waste dismantling area in Central China. The median concentrations of ΣOPAs and ΣNOPEs were 188 and 13,900 ng·g-1 in workshop dust and 5,250 ng·m-2 and 53,600 ng·m-2 on workers' hands, respectively. The increasing concentrations of dust in the form of triphenyl phosphate (TPHP) (p < 0.01) and tris(2,4-di-tert-butylphenyl) phosphate (AO168 = O) (p < 0.05) were strongly associated with the corresponding concentration on workers' hands. Furthermore, men had significantly lower levels of NOPEs on their hands than did women (p < 0.01). Moreover, the hand wipe levels of AO168 = O (41,600 ng·m-2) was significantly higher than that of the typical OPE (TPHP, 7370 ng·m-2), and the hand-to-mouth contact (ΣOPAs, 9.48 ng·kg bw-1·day-1; ΣNOPEs, 109 ng·kg bw-1·day-1) was a more significant and integrated pathway than dust ingestion (ΣOPAs, 0.10 ng·kg bw-1·day-1; ΣNOPEs, 5.01 ng·kg bw-1·day-1) of e-waste related occupational exposure to these "new" chemicals.

Preliminary results on polybrominated diphenyl ether contamination status in Croatian households and insights into children's exposure.

Polybrominated diphenyl ether (PBDE) congeners were analyzed in house dust samples collected in Croatian households. ∑PBDEs ranged between 1.1 ng g-1 dust and 17662.4 ng g-1 dust with BDE-99 being the most dominant congener accounting for approximately 60 %. The estimated daily intake (EDI) for toddlers as the most vulnerable population group ranged from 0.003 to 55.04 and from 0.01 to 110.07 ng kg-1 bw day-1 in the central and worst case scenario, respectively. The EDI calculated for the dominant BDE-99 in the sample with the highest ∑PBDE was in the worst case scenario 68.99 ng kg-1 bw day-1, which was quite close to the reference dose of 100 ng kg-1 bw day-1.

Traditional and emerging organophosphate esters (OPEs) in indoor dust of Nanjing, eastern China: Occurrence, human exposure, and risk assessment.

Here, fifteen OPEs were investigated in n = 50 floor dust samples collected from six types of indoor spaces in Nanjing, eastern China, in the year 2018. Ten OPEs, including tris(2-chloroethyl) phosphate (TCEP), tris(2-chloroisopropyl) phosphate (TCIPP), tris(1,3-dichloro-isopropyl) phosphate (TDCIPP), tris(2-ethylhexyl) phosphate (TEHP), tris(2-butoxyethyl) phosphate (TBOEP), 2-ethylhexyl-diphenyl phosphate (EHDPP), triphenyl phosphate (TPHP), tris(methyl-phenyl) phosphate (TMPP), 4-biphenylyl diphenyl phosphate (4-BPDP) and tris(2-biphenylyl) phosphate (TBPP), were detected in at least one of the analyzed samples (>method limits of quantification). Regardless of indoor spaces, EHDPP (34% of Σ8OPEs, mean: 1.43 µg/g) and TDCIPP (19%, 0.81 µg/g) were the ascendant OPEs in indoor floor dust. 4-BPDP and TBPP were detectable in indoor floor dust samples, but at relatively low detection frequencies with 2% and 10%, respectively. Various indoor microenvironments exhibited different pollution characteristics of OPEs. Floor dust collected from electronic product maintenance centers contained the richest OPE contaminants with highest mean Σ8OPEs concentration of 7.92 µg/g. On the basis of measured Σ10OPEs concentrations in dust sample, we estimated daily intake via floor dust ingestion to be 1.37, 0.75 and 1.24 ng/kg BW/day for electronic engineers, undergraduates, and graduate students under mean-exposure scenario, respectively. Overall, our study reported the occurrence of 4-BPDP and TBPP in environmental samples for the first time, and demonstrated that indoor floor dust ingestion exposure does values were far less than reference dosage values of oral toxicity proposed by United States Environmental Protection Agency (USEPA) Integrated Risk Information System.