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1.
Eur Arch Otorhinolaryngol ; 281(8): 4121-4131, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-38564010

RESUMO

PURPOSE: Cochlear implantation is a prevalent remedy for severe-to-profound hearing loss. Optimising outcomes and hearing preservation, and minimising insertion trauma, require precise electrode placement. Objective monitoring during the insertion process can provide valuable insights and enhance surgical precision. This study assesses the feasibility and performance of an impedance-based method for monitoring electrode insertion, compared to the surgeon's feedback. METHODS: The study utilised the Insertion Monitoring Tool (IMT) research software, allowing for real-time measurement of impedance and evoked compound action potential (eCAP) during electrode insertion in 20 patient implantations. This enabled an impedance-based method to continuously assess the status of each electrode during the insertion process. The feasibility and performance was evaluated and compared to the surgeon's feedback approach. eCAP measurements focused merely on feasibility without searching specific responses. RESULTS: The IMT demonstrated feasibility in measuring real-time impedances and eCAP during the insertion of the electrode array. The impedance-based method exhibited potential for accurately monitoring the insertion depth with a high success rate. However, further development is needed to improve the number of usable contacts. CONCLUSIONS: Objective monitoring with the impedance-based method shows promise as a valuable tool to enhance the precision of cochlear implant electrode insertion respecting insertion distance estimation. The IMT research software proved feasible in recording real-time impedances and eCAP during electrode insertion. While this impedance-based method exhibits high success rates, further improvements are required to optimise the number of usable contacts. This study highlights the potential of objective monitoring techniques to enhance cochlear implantation outcomes.


Assuntos
Implante Coclear , Implantes Cocleares , Impedância Elétrica , Estudos de Viabilidade , Humanos , Implante Coclear/métodos , Masculino , Feminino , Pessoa de Meia-Idade , Adulto , Idoso , Criança , Pré-Escolar , Adolescente , Eletrodos Implantados , Potenciais Evocados Auditivos/fisiologia , Adulto Jovem , Monitorização Intraoperatória/métodos , Monitorização Intraoperatória/instrumentação
2.
Int J Audiol ; 62(12): 1137-1144, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36193989

RESUMO

OBJECTIVE: Shorter and thinner electrodes were developed for preserving residual hearing after cochlear implantation by minimising trauma. As trauma is regarded as one of the causes of fibrous tissue formation after implantation, and increase in impedance is considered to be connected to fibrous tissue formation, the aim of the current study was to evaluate impedance development after implantation of Hybrid-L electrodes. DESIGN: Impedance values were retrospectively collected from our clinical database and evaluated for all active contacts and basal, middle and apical contacts separately for up to 10 years. STUDY SAMPLES: All 137 adult patients received a Hybrid-L electrode and had to be implanted for at least 1 year. RESULTS: On average impedances increased to 13 kOhm before first fitting and dropped to 5-7 kOhm under electrical stimulation with lower values measured on apical contacts. Mean values remained stable over years, but variability increased. Values before first fitting were independent of age at implantation whereas lower values were found later in patients of higher age at implantation. CONCLUSION: Despite smaller contacts, impedance values after start of electrical stimulation were comparable to published values of Contour electrodes. This might suggest less tissue growth with the Hybrid-L electrode array.


Assuntos
Implante Coclear , Implantes Cocleares , Adulto , Humanos , Estudos Retrospectivos , Impedância Elétrica , Eletrodos , Audição , Eletrodos Implantados
3.
Eur Arch Otorhinolaryngol ; 277(8): 2235-2241, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32447497

RESUMO

PURPOSE: To evaluate the impact of sequential second CI on the electrophysiological parameters of the initial CI. METHODS: Totally, 30 children who received sequential CIs between January and July 2018 were included in the study. All patients received the same brand of CI (Advanced Bionics, HIRES 90K Advantage 1J). Of 16 CI electrodes, 3rd (E3), 7th (E7) and 11th (E11), and 15th (E15) electrodes which were corresponding to the apical, middle, and basal cochlea were used in the measurements. The tNRI, electrode impedance and M levels were recorded as the contralateral CI was switched off and on, respectively. RESULTS: As the second CI was switched off, the impedance, tNRI and M values of initial CI 1st, 3rd and 6th months were not significantly different (p > 0.05). There was a significant difference between the impedance, tNRI and M values of initial CI as the second CI was switched on (p < 0.05). CONCLUSION: Activation of the sequential second CI leads to a decrease in the tNRI and M levels of the initial CI. This condition can increase the efficiency obtained by CIs. However, these changes should be remembered during CI programming.


Assuntos
Implante Coclear , Implantes Cocleares , Impedância Elétrica , Potenciais de Ação , Limiar Auditivo , Criança , Humanos
4.
Vestn Otorinolaringol ; 85(5): 29-32, 2020.
Artigo em Russo | MEDLINE | ID: mdl-33140930

RESUMO

To determine the electrode impedance dynamics changes in the postoperative period after cochlear implantation as well as the time of their stabilization. MATERIAL AND METHODS: 75 patients with a bilateral sensorineural deafness aged from 1 to 4 years (average age - 1.5 years) were included in the study. 50 patients were implanted with Nucleus cochlear implants (Cochlear - Australia) and other 25 patients - with Advanced Bionics implants (Switzerland). RESULTS: The impedance dynamics analysis in two groups of patients implanted with «Cochlear¼ and «Advanced Bionics¼ cochlear implants demonstrated that statistically significant decrease in impedance (p<0.05) was observed after the beginning of electrical stimulation and the reduction of postoperative inflammatory process in the inner ear. The stabilization of the impedance levels in both groups of patients was obtained in 3-6 months after the switch-on of speech processor.


Assuntos
Implante Coclear , Implantes Cocleares , Surdez , Perda Auditiva Neurossensorial , Criança , Pré-Escolar , Cóclea , Impedância Elétrica , Perda Auditiva Neurossensorial/diagnóstico , Perda Auditiva Neurossensorial/cirurgia , Humanos , Lactente
5.
Eur Biophys J ; 48(8): 711-719, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31529144

RESUMO

Electrical impedance measurements of biological tissue have many potential applications and tetrapolar impedance measurement (TPIM) with four electrodes is traditionally used which eliminates high skin contact impedance. A linear array of four electrodes for TPIM on the horizontal plane of a cylindrical volume conductor of diameter D, where the length of the array is πD/2 with potential electrodes near the centre of the array, will give a high sensitivity near the surface which reduces rapidly with depth. A recently proposed six-electrode variation of TPIM uses an additional pair of potential electrodes on the opposite side of the volume conductor in the same horizontal plane around the circumference, with the expectation that the sensitivity of the deeper regions will thereby be enhanced. The present work carries out a finite element simulation (using COMSOL) and an experimental phantom study (saline phantom) to quantitatively evaluate the improvement obtained by this new method. The new configuration doubled the sensitivity at the central region, which was reasonably uniform over a wider zone, gradually increasing towards the potential electrodes on both sides. This would be useful for a range of biological studies of deep body organs such as lungs, stomach, and bladder. where the respective external body shapes may be approximated by an oval cylinder and where electrical impedance techniques have shown promise.


Assuntos
Análise de Elementos Finitos , Imagens de Fantasmas , Impedância Elétrica , Eletrodos , Humanos
6.
J Korean Med Sci ; 33(21): e154, 2018 May 21.
Artigo em Inglês | MEDLINE | ID: mdl-29780294

RESUMO

BACKGROUND: One of the key issues in electroencephalogram (EEG) monitoring is accurate signal acquisition with less cumbersome electrodes. In this study, the L2 phase electro-deposited nanoporous platinum (L2-ePt) electrode is introduced, which is a new type of electrode that utilizes a stable nanoporous platinum surface to reduce the skin-electrode impedance. METHODS: L2-ePt electrodes were fabricated using electro-deposition technique. Then, the effect of the nanoporous surface on the surface roughness and the electrode impedance were observed from the L2-ePt electrodes and the flat platinum (FlatPt) electrode. The skin-electrode impedances of the L2-ePt electrodes, a gold cup electrode, and the FlatPt electrode were evaluated when placed on the hairy occipital area of the head in ten subjects. For the validation of using the L2-ePt electrode, a correlational analysis of the alpha rhythms was performed in the same subjects for simultaneous EEG recordings using the L2-ePt and clinically-used EEG electrodes. RESULTS: The results indicated that the L2-ePt electrode with a roughness factor of 200 had the lowest mean impedance performance. Moreover, the proposed L2-ePt electrode showed a significantly lower mean skin-electrode impedance than the FlatPt electrode. Finally, the EEG signal quality recorded by the L2-ePt electrode (r = 0.94) was comparable to that of the clinically-used gold cup electrode. CONCLUSION: Based on these results, the proposed L2-ePt electrode is suitable for use in various high-quality EEG applications.


Assuntos
Eletroencefalografia/métodos , Nanoporos , Platina/química , Eletrodos Implantados , Eletroencefalografia/instrumentação , Modelos Biológicos , Propriedades de Superfície
7.
Platelets ; 27(8): 751-757, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-27164510

RESUMO

Coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) is frequently associated with low platelet count (PC) and disturbed platelet function (PF). While PC is easy to measure, PF is more difficult to assess. Moreover, the time-related platelet dysfunction and recovery after CPB is not fully elucidated. Platelet dysfunction could lead to bleeding but also to coronary graft failure. Laboratory tests could provide more insights into PF after CABG. The aim of the current study was to investigate the time-related PF induced by CPB. Blood samples of 20 patients with a preoperative PC of more than 250 × 109/L were collected before incision, after weaning from CPB, and 24 h postoperative. Platelet contribution to coagulation was quantified by PLTEM (calculated by means of EXTEM and FIBTEM results). PF was assessed by multiple electrode impedance aggregometry (MEIA) in whole blood and by light transmission aggregometry (LTA) in platelet-rich plasma after stimulation with arachidonic acid (AA), adenosine diphosphate, collagen, and thrombin-receptor-activating peptide. LTA and MEIA analysis demonstrated significant platelet dysfunction after CPB, with partial recovery within 24 h after surgery. AA-induced platelet aggregation increased to higher levels within 24 h after surgery compared to baseline values as measured by LTA. PLTEM maximum clot firmness remained unchanged throughout the study. Correlation analyses revealed that MEIA and rotational thromboelastometry (ROTEM), but not LTA, were dependent on PC and hematocrit. No correlations were found between LTA, MEIA, ROTEM, PC, and clinical outcome parameters. Our results demonstrate a reversible platelet dysfunction recovering within 24 h after CPB. Interestingly, AA-induced platelet aggregation increases to higher levels during the first 24 h postoperatively, which might be important for early initiation of antiplatelet therapy after CABG. MEIA as POC test is able to detect platelet dysfunction during cardiac surgery with a PC of ≥150 × 109/L.


Assuntos
Ponte Cardiopulmonar/efeitos adversos , Doença da Artéria Coronariana/sangue , Contagem de Plaquetas , Idoso , Testes de Coagulação Sanguínea , Ponte de Artéria Coronária/efeitos adversos , Doença da Artéria Coronariana/cirurgia , Feminino , Hematócrito , Humanos , Masculino , Pessoa de Meia-Idade , Agregação Plaquetária , Testes de Função Plaquetária , Período Pós-Operatório , Tromboelastografia , Trombose/sangue , Trombose/diagnóstico , Resultado do Tratamento
8.
Int J Audiol ; 54(7): 453-60, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-25766491

RESUMO

OBJECTIVE: This study assessed the prevalence of electrode failures and electrode impedance measures in Nucleus cochlear implants around initial activation (an average of 16 days after surgery) and after 8 to 12 years of device use. DESIGN: Retrospective data from the Melbourne Cochlear Implant Clinic was collated and analysed. STUDY SAMPLE: Included in this study were 232 adults, all of whom were implanted at the clinic between March 1998 and August 2005. RESULTS: Overall 0.5% of electrodes failed over the entire test period, with 5.6% of devices showing one or more electrode failure. The majority of these failures were recorded by initial activation. The numbers of electrode failures have decreased over time with array type, such that no failures were recorded with the currently available Contour Advance array. Array type was shown to affect electrode impedance at both time points, with the Contour and Contour Advance arrays having significantly higher absolute values than the Banded array. However, the Banded array had significantly higher area-normalized impedances at initial and final measures than the Contour and Contour Advance array. CONCLUSIONS: A relatively low incidence of electrode failures were recorded for the Nucleus devices of these recipients. Electrode impedance dropped for all array types after 8 to 12 years of device use.


Assuntos
Implante Coclear/instrumentação , Implantes Cocleares , Eletrodos Implantados/estatística & dados numéricos , Falha de Prótese , Adulto , Impedância Elétrica , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Tempo , Vitória
9.
J Neurosci Methods ; 404: 110058, 2024 04.
Artigo em Inglês | MEDLINE | ID: mdl-38215949

RESUMO

Implantable neural stimulation is becoming increasingly popular for treating neurologically impaired patients, restoring neural functions which would otherwise be lost due to diseases or injuries. The charge balance of the stimulus pulses is of paramount importance for the long-term safety of the electrode-tissue interface. This paper presents a novel neurostimulator integrated circuit in which two novel charge balancing schemes are proposed. One is based on acquiring the access resistance part (RS) of the inter-electrode impedance. Thanks to its adaptive anodic phase, the RS-based charge balance circuit does not require an additional discharge phase, achieving faster charge balance than most existing stimulator ICs. The other scheme is based on acquiring the double-layer capacitance part (CDL) of the inter-electrode impedance and the entire charge balancing process (inc. monitoring, computation and compensation) is performed in the analog domain. This is in sharp contrast to the existing electrode-impedance-aware charge balancing schemes which require ADCs and compute the net charge in the digital domain. Hence the new impedance-aware charge-balancing scheme is faster and more power friendly. The impedance-aware stimulator ASIC has been implemented using X-FAB's 180-nm CMOS process. The post-layout simulation results suggest a good charge balance is achieved as the voltage deviation from the electrode offset voltage on the electrode after the charge compensation reduces to 2.64 mV and -1.39 mV under the RS-based and CDL-based charge balancing schemes, respectively. The additional power overhead due to the proposed CDL-based charge balancer circuit is 2.46 µW at a stimulation rate of 400 Hz.


Assuntos
Impedância Elétrica , Humanos , Eletrodos , Simulação por Computador
10.
J Electr Bioimpedance ; 15(1): 85-88, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-38962505

RESUMO

There are various methods for cell growth monitoring. However, most of these methods have drawbacks, such as being invasive, not providing real-time results, or being costly. In this study, we present an alternate method of cell growth monitoring, which is low-cost, non-invasive, real-time, and uses Electrical Impedance Spectro-scopy (EIS). In this work, commercially available culture plates were fitted with custom tetrapolar electrodes, and mouse cells were cultured on them. The variation of culture media impedance, resulting from cell growth, proliferation and other metabolic activities, was recorded over a period of seven days. The results demonstrated an initial increase in impedance corresponding with the cell growth phase, followed by a decrease during the cell death (apoptosis) phase, as confirmed by microscope images. Overall, the results show that our method to monitor cell growth using tetrapolar electrodes is promising and can be further refined for related applications.

11.
J Clin Med ; 13(11)2024 Jun 03.
Artigo em Inglês | MEDLINE | ID: mdl-38893010

RESUMO

Objectives: The growing adoption of cochlear implants (CIs) necessitates understanding the factors influencing long-term performance and improved outcomes. This work investigated the long-term effect of early activation of CIs on electrode impedance in a large sample of CI users at different time points. Methods: A retrospective study on 915 ears from CI patients who were implanted between 2015 and 2020. According to their CI audio processor activation time, the patients were categorized into early activation (activated 1 day after surgery, n = 481) and classical activation (activated 4 weeks after surgery, n = 434) groups. Then, the impact of the activation times on the electrode impedance values, along the electrode array contacts, at different time points up to two years was studied and analyzed. Results: The early activation group demonstrated lower impedance values across all the electrode array sections compared to the classical activation at 1 month, 1 year, and 2 years post-implantation. At 1 month, early activation was associated with a reduction of 0.34 kΩ, 0.46 kΩ, and 0.37 kΩ in the apical, middle, and basal sections, respectively. These differences persisted at subsequent intervals. Conclusions: Early activation leads to sustained reductions in the electrode impedance compared to classical activation (CA), suggesting that earlier activation might positively affect long-term CI outcomes.

12.
Turk Arch Otorhinolaryngol ; 61(3): 103-108, 2023 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-38020414

RESUMO

Objective: This study investigated the impact of different local corticosteroid applications on impedance measurements in patients with cochlear implants. Methods: The study was designed as a controlled, randomized, and prospective study in which 34 consecutive patients who had undergone cochlear implant surgery were divided into three groups. The first group received intracochlear dexamethasone, in the second group the middle ear cavity was filled with dexamethasone, and the third group did not receive dexamethasone. Intraoperative, postoperative 1st week, 1st month, 3rd month, 6th-month neural response telemetry, and impedances were measured. The measurements were compared by electrode groups representing the different regions of cochlea like basal (1-7), middle (8-13), and apical (14-22) regions. Results: The intergroup analysis showed no statistically significant differences in impedance measurements of the basal, middle, and apical regions (p>0.05). However, the impedances were lower in the two dexamethasone groups, especially in the basal and middle parts. Sixth month impedances were also lower in the dexamethasone groups. There was apparent stability in the impedance of the basal region with the intracochlear application during the first week. Conclusion: Local dexamethasone applications had a potentially positive impact on the impedance of the basal and middle regions. Patients had lower impedances than the control group during follow-up and at the endpoint. The increase in the apical region may indicate that dexamethasone was not reaching the apical zone in local applications.

13.
Ear Nose Throat J ; 102(5): NP229-NP231, 2023 May.
Artigo em Inglês | MEDLINE | ID: mdl-33734884

RESUMO

Hearing loss in older people can cause communication impairments, decreased quality of life, social isolation, depression, and dementia. Cochlear implant surgery is an effective treatment for older patients with hearing loss who cannot achieve satisfactory audiologic outcomes with hearing aids. However, older people have an increased risk of heart disease and often take medications that affect heart rhythm. Herein, we report a case of an 80-year-old woman who underwent cardioversion at 50J after cochlear implant surgery. Electrical impedance before and after cardioversion showed only minor changes without abnormality, and the cochlear implant functioned well. We believe that the electronic circuits of the cochlear implant may have been relatively tolerant to the electrical shock from the external defibrillator. Typically, cardioversion should be avoided in cochlear implant recipients because it may damage the implant. If cardioversion cannot be avoided, we strongly recommend starting cardioversion at the lowest energy level (50 J) and removing the sound processor of the implant during the procedure.


Assuntos
Flutter Atrial , Implantes Cocleares , Surdez , Perda Auditiva , Feminino , Humanos , Idoso , Idoso de 80 Anos ou mais , Cardioversão Elétrica/efeitos adversos , Cardioversão Elétrica/métodos , Flutter Atrial/etiologia , Qualidade de Vida , Arritmias Cardíacas/etiologia , Perda Auditiva/etiologia
14.
J Neurosurg Case Lessons ; 6(12)2023 Sep 18.
Artigo em Inglês | MEDLINE | ID: mdl-37756484

RESUMO

BACKGROUND: Deep brain stimulation (DBS) is a well-established neurosurgical intervention for a growing number of neurological and psychiatric diseases. Patients who are affected by Parkinson's disease may benefit from DBS of either the subthalamic nucleus or the globus pallidus internus. Patients who undergo DBS often notice a significant reduction in their clinical symptoms; however, the procedure is not without risks. Multicenter studies have reported postoperative complications such as hardware infection, intracranial hemorrhage, and perielectrode edema. OBSERVATIONS: The authors report a case of a perielectrode cyst managed conservatively. Tracking the impedance trend was a novel approach to monitor for changes within the cyst and to herald a clinical change in the patient. Perielectrode cystic formation can be a transient process that resolves spontaneously or with conservative, nonoperative management, and all diagnostic information is valuable in making clinical decisions. LESSONS: Impedance values have provided an appropriate estimation of this patient's clinical picture. The authors suggest treatment of edema and a cyst after DBS lead implantation through conservative management and observation, avoiding the removal of hardware if a patient's clinical picture is either stable or improving and forgoing additional clinical imaging if the impedance values are trending in an appropriate direction.

15.
Cochlear Implants Int ; : 1-10, 2023 Dec 11.
Artigo em Inglês | MEDLINE | ID: mdl-38081181

RESUMO

OBJECTIVES: Electrode impedance measurements from cochlear implants (CI) reflect the status of the electrode array as well as the surrounding cochlear environment, and could provide a clinical index of functional changes with the CI. The goals of this study were to examine (1) the impact of electrode array type on electrode impedance, and (2) the relationship between electrode impedance and short-term hearing preservation and speech recognition outcomes. METHODS: Retrospective study of 115 adult hearing preservation CI recipients of a slim modiolar or slim straight array. Common ground electrode impedances, pre- and post-operative hearing thresholds and CNC word recognition scores were retrieved. RESULTS: Electrode impedances were significantly higher for recipients of the straight electrode array. Within individuals, electrode impedances were stable after the first week post-activation. However, increased standard deviation of electrode impedances was associated with greater loss of low frequency hearing at initial activation, and with poorer speech recognition at 6 months post-implantation. CONCLUSIONS: Results demonstrate that electrode impedances depend on the type of implanted array. Findings also suggest that there may be a role for the variability in electrode impedance across electrodes as an indicator of changes in the intracochlear environment that contribute to outcomes with a CI.

16.
Biosensors (Basel) ; 13(7)2023 Jul 13.
Artigo em Inglês | MEDLINE | ID: mdl-37504127

RESUMO

Biopotential electrodes play an integral role within smart wearables and clothing in capturing vital signals like electrocardiogram (ECG), electromyogram (EMG), and electroencephalogram (EEG). This study focuses on dry e-textile electrodes (E1-E6) and a laser-cut knit electrode (E7), to assess their impedance characteristics under varying contact forces and moisture conditions. Synthetic perspiration was applied using a moisture management tester and impedance was measured before and after exposure, followed by a 24 h controlled drying period. Concurrently, the signal-to-noise ratio (SNR) of the dry electrode was evaluated during ECG data collection on a healthy participant. Our findings revealed that, prior to moisture exposure, the impedance of electrodes E7, E5, and E2 was below 200 ohm, dropping to below 120 ohm post-exposure. Embroidered electrodes E6 and E4 exhibited an over 25% decrease in mean impedance after moisture exposure, indicating the impact of stitch design and moisture on impedance. Following the controlled drying, certain electrodes (E1, E2, E3, and E4) experienced an over 30% increase in mean impedance. Overall, knit electrode E7, and embroidered electrodes E2 and E6, demonstrated superior performance in terms of impedance, moisture retention, and ECG signal quality, revealing promising avenues for future biopotential electrode designs.


Assuntos
Eletrocardiografia , Têxteis , Humanos , Impedância Elétrica , Eletrodos
17.
Cochlear Implants Int ; 24(2): 65-72, 2023 03.
Artigo em Inglês | MEDLINE | ID: mdl-37354550

RESUMO

INTRODUCTION: Intra-operative Switch ON (IOSO) is a novel clinical approach of activating the cochlear implant during the surgery adopted at our cochlear implantation center.We compared the electrode impedances in two conditions of Switch ON of cochlear implants; IOSO and post-operative Switch ON (POSO, 21st day of surgery). METHODS: Electrode impedances of 185 cochlear implants, 93 of whom received IOSO and 92 POSO, recorded over 10 years were analyzed retrospectively. RESULTS: Electrode impedances of IOSO group were significantly lower than POSO group at Switch ON and 3rd, 6th, 9th, and 12th months post cochlear implantation. In IOSO group, 3rd month's electrode impedances were high when compared to electrode impedances at Switch ON. Beyond the 3rd months, electrode impedance remained unchanged. In POSO group, there were no significant differences in electrode impedances between any measurement schedule. CONCLUSIONS: To our knowledge, this is the first study to investigate in detail the electrode impedances of the two above-said conditions of Switch ON in the process of cochlear implantation. This study concludes that timing of CI Switch ON has a significant effect on the electrode impedances. These results may affect the choice of cochlear implant Switch ON timing.


Assuntos
Implante Coclear , Implantes Cocleares , Humanos , Criança , Implante Coclear/métodos , Impedância Elétrica , Estudos Retrospectivos , Período Pós-Operatório
18.
J Med Eng Technol ; 47(4): 201-216, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37910047

RESUMO

A first-level textile-based electrocardiogram (ECG) monitoring system referred to as "CardioS" (cardiac sensor) for continuous health monitoring applications is proposed in this study to address the demand for resource-constrained environments. and the signal quality assessment of a wireless CardioS was studied. The CardioS consists of a Lead-I ECG signal recorded wirelessly using silver-plated nylon woven (Ag-NyW) dry textile electrodes to compare the results of wired wearable Ag-NyW textile electrode-based ECG acquisition system and CardioS. The effect of prolonged usage of Ag-NyW dry electrodes on electrode impedance was tested in the current work. In addition, electrode half-cell potential was measured to validate the range of Ag-NyW dry electrodes for ECG signal acquisition. Further, the quality of signals recorded by the proposed wireless CardioS framework was evaluated and compared with clinical disposable (Ag-AgCl Gel) electrodes. The signal quality was assessed in terms of mean magnitude coherence spectra, signal cross-correlation, signal-to-noise-band ratio (Sband/Nband), crest factor, low and high band powers and power spectral density. The experimental results showed that the impedance was increased by 2.5-54.6% after six weeks of continuous usage. This increased impedance was less than 1 MΩ/cm2, as reported in the literature. The half-cell potential of the Ag-NyW textile electrode obtained was 80 mV, sufficient to acquire the ECG signal from the human body. All the fidelity parameters measured by Ag-NyW textile electrodes were correlated with standard disposable electrodes. The cardiologists validated all the measurements and confirmed that the proposed framework exhibited good performance for ECG signal acquisition from the five healthy subjects. As a result of its low-cost architecture, the proposed CardioS framework can be used in resource-constrained environments for ECG monitoring.


Assuntos
Eletrocardiografia , Têxteis , Humanos , Eletrocardiografia/métodos , Impedância Elétrica , Monitorização Fisiológica , Prata , Eletrodos
19.
Biomed Tech (Berl) ; 67(1): 33-42, 2022 Feb 23.
Artigo em Inglês | MEDLINE | ID: mdl-35007412

RESUMO

Decoding the cellular network interaction of neurons and glial cells are important in the development of new therapies for diseases of the central nervous system (CNS). Electrophysiological in vivo studies in mice will help to understand the highly complex network. In this paper, the optimization of epidural liquid crystal polymer (LCP) electrodes for different platinum electroplating parameters are presented and compared. Constant current and pulsed current electroplating varied in strength and duration was used to decrease the electrode impedance and to increase the charge storage capacity (CSCC). In best cases, both methods generated similar results with an impedance reduction of about 99%. However, electroplating with pulsed currents was less parameter-dependent than the electroplating with constant current. The use of ultrasound was essential to generate platinum coatings without plating defects. Electrode model parameters extracted from the electrode impedance reflected the increase in surface porosity due to the electroplating processes.


Assuntos
Galvanoplastia , Platina , Animais , Impedância Elétrica , Eletrodos , Ouro , Camundongos , Polímeros
20.
Front Neurol ; 13: 1042408, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36468071

RESUMO

Recent technological advances in cochlear implant (CI) telemetry have enabled, for the first time, CI users to perform cochlear health (CH) measurements through self-assessment for prolonged periods of time. This is important to better understand the influence of CH on CI outcomes, and to assess the safety and efficacy of future novel treatments for deafness that will be administered as adjunctive therapies to cochlear implantation. We evaluated the feasibility of using a CI to assess CH and examined patterns of electrode impedances, electrically-evoked compound action potentials (eCAPs) and electrocochleography (ECochGs), over time, in a group of adult CI recipients. Fifteen subjects were trained to use the Active Insertion Monitoring tablet by Advanced Bionics, at home for 12 weeks to independently record impedances twice daily, eCAPs once weekly and ECochGs daily in the first week, and weekly thereafter. Participants also completed behavioral hearing and speech assessments. Group level measurement compliance was 98.9% for impedances, 100% for eCAPs and 99.6% for ECochGs. Electrode impedances remained stable over time, with only minimal variation observed. Morning impedances were significantly higher than evening measurements, and impedances increased toward the base of the cochlea. eCAP thresholds were also highly repeatable, with all subjects showing 100% measurement consistency at, at least one electrode. Just over half of all subjects showed consistently absent thresholds at one or more electrodes, potentially suggesting the existence of cochlear dead regions. All subjects met UK NICE guidelines for cochlear implantation, so were expected to have little residual hearing. ECochG thresholds were, unsurprisingly, highly erratic and did not correlate with audiometric thresholds, though lower ECochG thresholds showed more repeatability over time than higher thresholds. We conclude that it is feasible for CI users to independently record CH measurements using their CI, and electrode impedances and eCAPs are promising measurements for objectively assessing CH.

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