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Stat Med ; 43(3): 452-474, 2024 02 10.
Artigo em Inglês | MEDLINE | ID: mdl-38037270

RESUMO

In clustered randomized controlled trials (RCTs), sample recruitment is often conducted after cluster randomization. This timing can lead to recruitment bias if access to the intervention affects the composition of study-eligible cluster entrants and study consenters. This article develops a potential outcomes framework in such settings that yields a causal estimand that pertains to the always-recruited in either research condition. A consistent inverse probability weighting (IPW) estimator is developed using data on recruits only, and a generalized estimating equations approach is used to obtain robust clustered SE estimators that adjust for estimation error in the IPW weights. A simple data collection strategy is discussed to improve the predictive accuracy of the logit propensity score models. Simulations show that the IPW estimator achieves nominal confidence interval coverage under the assumed identification conditions. An empirical application demonstrates the methods using data from an RCT testing the effects of a behavioral health intervention in schools. An R program for estimation is available for download.


Assuntos
Viés , Ensaios Clínicos Controlados Aleatórios como Assunto , Humanos , Causalidade , Simulação por Computador , Modelos Logísticos , Pontuação de Propensão
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