Biochar imparted constructed wetlands (CWs) for enhanced biodegradation of organic and inorganic pollutants along with its limitation.

The remediation of polluted soil and water stands as a paramount task in safeguarding environmental sustainability and ensuring a dependable water source. Biochar, celebrated for its capacity to enhance soil quality, stimulate plant growth, and adsorb a wide spectrum of contaminants, including organic and inorganic pollutants, within constructed wetlands, emerges as a promising solution. This review article is dedicated to examining the effects of biochar amendments on the efficiency of wastewater purification within constructed wetlands. This comprehensive review entails an extensive investigation of biochar's feedstock selection, production processes, characterization methods, and its application within constructed wetlands. It also encompasses an exploration of the design criteria necessary for the integration of biochar into constructed wetland systems. Moreover, a comprehensive analysis of recent research findings pertains to the role of biochar-based wetlands in the removal of both organic and inorganic pollutants. The principal objectives of this review are to provide novel and thorough perspectives on the conceptualization and implementation of biochar-based constructed wetlands for the treatment of organic and inorganic pollutants. Additionally, it seeks to identify potential directions for future research and application while addressing prevailing gaps in knowledge and limitations. Furthermore, the study delves into the potential limitations and risks associated with employing biochar in environmental remediation. Nevertheless, it is crucial to highlight that there is a significant paucity of data regarding the influence of biochar on the efficiency of wastewater treatment in constructed wetlands, with particular regard to its impact on the removal of both organic and inorganic pollutants.

Variability of green infrastructure performance due to climatic regimes across Sweden.

In the context of increasing urbanization and global warming, there is a growing interest in the implementation of green infrastructure (GI) across different climates and regions. Identifying an appropriate GI design criteria is essential to ensure that the design is tailored to satisfy local environmental requirements. This article aims to compare the hydrological performance of GI facilities in eleven Swedish cities by isolating the effect of climatic conditions using an identical GI design configuration. Long-term simulations based on 23-years of meteorological time-series were used as inputs for the Storm Water Management Model (SWMM) with Low Impact Development (LID) controls representing two types of facilities: a biofilter cell (BC) and a green roof. (GR). Large differences in potential annual and seasonal runoff retention were found between locations, driven mainly by the extent of winter/spring season, and the distribution of precipitation patterns (for BCs) and the sequence of rainy days-dry periods and evapotranspiration rates (for GRs). Winter/spring and summer demonstrated the highest/lowest differences between the seasons, results that suggest that implications for design might be aligned to the spatio-temporal distribution of precipitation patterns, and runoff regimes generated by snowmelt and rain-on-snow events, in locations where snowmelt represent high portion of runoff generation.

Computational modeling of wastewater land application treatment systems to determine strategies to improve carbon and nitrogen removal.

Land application of domestic and food processing wastewater is used due to its low cost, energy use, and maintenance. Design procedures are generally based on empirical relationships that may not account for critical site and waste-specific conditions. A mathematical model was utilized to simulate the complexity of wastewater land application. Multiple scenarios were run to determine system performance as measured by chemical oxygen demand (COD) and the nitrification/denitrification process. The modeling results showed that COD and nitrification occurred within the first 15.4 cm of a sandy loam soil. Increasing the dosing frequency slightly reduced the COD effluent concentration. Complete denitrification does not occur in a typical land application wastewater treatment system. In a domestic wastewater land application system, up to 32% of nitrate can be removed by increasing the dosing frequency and providing more organic carbon. In a food processing wastewater land application system, up to 56% of nitrate can be removed by increasing the dosing frequency and hydraulic and organic loadings. HYDRUS CW2D modeling is a valuable design tool to simulate multiple operation strategies and predict carbon degradation, nitrification, and denitrification. The model result can provide operational strategies to maximize the treatment while minimizing environmental impacts.

Monitoring dynamic spatio-temporal ecological processes optimally.

Population dynamics vary in space and time. Survey designs that ignore these dynamics may be inefficient and fail to capture essential spatio-temporal variability of a process. Alternatively, dynamic survey designs explicitly incorporate knowledge of ecological processes, the associated uncertainty in those processes, and can be optimized with respect to monitoring objectives. We describe a cohesive framework for monitoring a spreading population that explicitly links animal movement models with survey design and monitoring objectives. We apply the framework to develop an optimal survey design for sea otters in Glacier Bay. Sea otters were first detected in Glacier Bay in 1988 and have since increased in both abundance and distribution; abundance estimates increased from 5 otters to >5,000 otters, and they have spread faster than 2.7 km/yr. By explicitly linking animal movement models and survey design, we are able to reduce uncertainty associated with forecasting occupancy, abundance, and distribution compared to other potential random designs. The framework we describe is general, and we outline steps to applying it to novel systems and taxa.

An experimental study of cathodic protection for chloride contaminated reinforced concrete.

Cathodic protection (CP) is being increasingly used on reinforced concrete structures to protect steel reinforcing bars from corrosion in aggressive conditions. Due to the complexity of environmental conditions, the design specifications in national and international standards are still open to discussion to achieve both sufficient and efficient protection for reinforced concrete structures in engineering practices. This paper reports an experimental research to investigate the influence of chloride content on concrete resistivity, rebar corrosion rate and the performance of CP operation using different current densities. It aims to understand the correlation between the chloride content and concrete resistivity together with the CP current requirement, and to investigate the precision of the CP design criteria in standards.

Establishment of new design criteria for GlidCop® X-ray absorbers.

An engineering research program has been conducted at the Advanced Photon Source (APS) in order to determine the thermomechanical conditions that lead to crack formation in GlidCop®, a material commonly used to fabricate X-ray absorbers at X-ray synchrotron facilities. This dispersion-strengthened copper alloy is a proprietary material and detailed technical data of interest to the synchrotron community is limited. The results from the research program have allowed new design criteria to be established for GlidCop® X-ray absorbers based upon the thermomechanically induced fatigue behavior of the material. X-ray power from APS insertion devices was used to expose 30 GlidCop® samples to 10000 thermal loading cycles each under various beam power conditions, and all of the samples were metallurgically examined for crack presence/geometry. In addition, an independent testing facility was hired to measure temperature-dependent mechanical data and uniaxial mechanical fatigue data for numerous GlidCop® samples. Data from these studies support finite element analysis (FEA) simulation and parametric models, allowing the development of a thermal fatigue model and the establishment of new design criteria so that the thermomechanically induced fatigue life of X-ray absorbers may be predicted. It is also demonstrated how the thermal fatigue model can be used as a tool to geometrically optimize X-ray absorber designs.

Decellularized Human Liver Is Too Heterogeneous for Designing a Generic Extracellular Matrix Mimic Hepatic Scaffold.

Decellularized human livers are considered the perfect extracellular matrix (ECM) surrogate because both three-dimensional architecture and biological features of the hepatic microenvironment are thought to be preserved. However, donor human livers are in chronically short supply, both for transplantation or as decellularized scaffolds, and will become even scarcer as life expectancy increases. It is hence of interest to determine the structural and biochemical properties of human hepatic ECM to derive design criteria for engineering biomimetic scaffolds. The intention of this work was to obtain quantitative design specifications for fabricating scaffolds for hepatic tissue engineering using human livers as a template. To this end, hepatic samples from five patients scheduled for hepatic resection were decellularized using a protocol shown to reproducibly conserve matrix composition and microstructure in porcine livers. The decellularization outcome was evaluated through histological and quantitative image analyses to evaluate cell removal, protein, and glycosaminoglycan content per unit area. Applying the same decellularization protocol to human liver samples obtained from five different patients yielded five different outcomes. Only one liver out of five was completely decellularized, while the other four showed different levels of remaining cells and matrix. Moreover, protein and glycosaminoglycan content per unit area after decellularization were also found to be patient- (or donor-) dependent. This donor-to-donor variability of human livers thus precludes their use as templates for engineering a generic "one-size fits all" ECM-mimic hepatic scaffold.

Design Criteria for Architected Materials with Programmable Mechanical Properties Within Theoretical Limit Ranges.

Architected materials comprising periodic arrangements of cells have attracted considerable interest in various fields because of their unconventional properties and versatile functionality. Although some better properties may be exhibited when this homogeneous layout is broken, most such studies rely on a fixed material geometry, which limits the design space for material properties. Here, combining heterogeneous and homogeneous assembly of cells to generate tunable geometries, a hierarchically architected material (HAM) capable of significantly enhancing mechanical properties is proposed. Guided by the theoretical model and 745 752 simulation cases, generic design criteria are introduced, including dual screening for unique mechanical properties and careful assembly of specific spatial layouts, to identify the geometry of materials with extreme properties. Such criteria facilitate the potential for unprecedented properties such as Young's modulus at the theoretical limit and tunable positive and negative Poisson's ratios in an ultra-large range. Therefore, this study opens a new paradigm for materials with extreme mechanical properties.

Functional Chitosan and Its Derivative-Related Drug Delivery Systems for Nano-Therapy: Recent Advances.

In the struggle against diseases, the development of nano-therapy has certainly been a tremendous progression owing to the various superiority, and chitosan is no doubt a kind of prominent biopolymer material with versatility for applications in disease treatments. For the rational construction of chitosan-related nano-biodevices, it is necessary to pay full attention to the material itself, where it is the material properties that guide the design criteria. Additionally, the well-matched preparation methods between material carriers and therapeutic agents draw much attention to the final construction since they seem to be more realistic. In detail, we present a comprehensive overview of recent advances in rational construction of chitosan-related nano-therapies with respect to material-property-oriented design criteria and preparation methods in the current review article, based on the foundation of continuous investigations. Based on this review, a portion of the various uses of chitosan-related nano-biodevices for biomedical applications are specifically discussed. Here, the strategies demonstrate the versatility of chitosan well, and the concept of being simple yet effective is well illustrated and vividly communicated. Altogether, a fresh concept concerning multi-functional chitosan and its derivative-related drug delivery systems for nano-therapy is proposed in this review, and this could be applied to other materials, which seems to be a novel angle.

Challenges and Opportunities in Developing Tracheal Substitutes for the Recovery of Long-Segment Defects.

Tracheal resection and reconstruction procedures are necessary when stenosis, tracheomalacia, tumors, vascular lesions, or tracheal injury cause a tracheal blockage. Replacement with a tracheal substitute is often recommended when the trauma exceeds 50% of the total length of the trachea in adults and 30% in children. Recently, tissue engineering and other advanced techniques have shown promise in fabricating biocompatible tracheal substitutes with physical, morphological, biomechanical, and biological characteristics similar to native trachea. Different polymers and biometals are explored. Even with limited success with tissue-engineered grafts in clinical settings, complete healing of tracheal defects remains a substantial challenge due to low mechanical strength and durability of the graft materials, inadequate re-epithelialization and vascularization, and restenosis. This review has covered a range of reconstructive and regenerative techniques, design criteria, the use of bioprostheses and synthetic grafts for the recovery of tracheal defects, as well as the traditional and cutting-edge methods of their fabrication, surface modification for increased immuno- or biocompatibility, and associated challenges.

Design and Optimization of Tool-Embedded Thin-Film Strain Sensor Substrate Structure.

With the intelligent tool cutting force measurement model as the engineering background, the selection, design, and optimization of the substrate structure of the tool-embedded thin-film strain sensor are studied. The structure of the thin-film strain sensor is studied, and the substrate structure design is divided into function area structure design and connection area structure design. Establishing the substrate structure library of the sensor, we subdivide the library into six layouts of function area infrastructure and five layouts of connection area infrastructure. Taking the sensitivity, fatigue life, and comprehensive mechanical properties of the substrate structure as the design indexes, based on the statics theory, the functional relationship between the structural parameters and the deflection of the six layouts of the substrate function area is established; based on the dynamics theory, the functional relationship between the parameters and the natural frequency of six layouts of the function area is established; based on the coupling of structural statics design theory and dynamics design theory, the evaluation method for the comprehensive performance of the parameters of six layouts of the function area is established. Based on the function area structure, five connection area structures are designed for comprehensive performance analysis. The structural sensitivity of the substrate function area design and optimization is expanded 1.75 times, and the comprehensive performance is expanded 1.53 times. The sensitivity of the connection area design and optimization is expanded 2.3 times, and the comprehensive performance is expanded 1.72 times. The structure is optimized according to the structural stress characteristics, the design, selection, and optimization process of the substrate structure summarized herein, and five design criteria of the substrate structure are proposed.

Rationally-designed Chitosan-based Polymeric Nanomaterials According to Intrinsic Characteristics for Cancer Therapy and Theranostics: A Review.

Chitosan, the only naturally occurring polycationic polysaccharide derived from chitin, has long case been implicated in the designs of nanosystems for diverse biomedical and pharmaceutical applications owing to its exclusive biodegradability, biocompatibility, cationic property, and functional groups. Particularly, some intrinsic characteristics of chitosan equip it with high potential for facile preparation, flexible functionalization, and modification, which circumvent the defects of chitosan and account for extensive attempts in cancer therapy and theranostic. In this review, we first give a classifiable explanation of strategies in fabricating rationally-designed chitosan-based polymeric nanomaterials for cancer therapy, which are categorized by the physical, chemical, and biological intrinsic characteristics of chitosan, respectively. Specifically, examples harnessing the cationic charge of chitosan are clarified, and the accompanied pH-responsive ability functions frequently are also mentioned. Besides, strategies toward the modification of functional groups (amino and hydroxyl groups) in repeated glycosidic units of chitosan and their additional roles are also discussed here. Lastly, the biological superiority of chitosan as an adjuvant or a ligand for glycoprotein and the application of chitosan- based polymeric nanomaterials in theranostic are summarized. Altogether, this review provides a comprehensive overview of recent advances in chitosan-based polymeric nanomaterials for cancer therapy and theranostics from a brand new perspective.

Application of decellularized vascular matrix in small-diameter vascular grafts.

Coronary artery bypass grafting (CABG) remains the most common procedure used in cardiovascular surgery for the treatment of severe coronary atherosclerotic heart disease. In coronary artery bypass grafting, small-diameter vascular grafts can potentially replace the vessels of the patient. The complete retention of the extracellular matrix, superior biocompatibility, and non-immunogenicity of the decellularized vascular matrix are unique advantages of small-diameter tissue-engineered vascular grafts. However, after vascular implantation, the decellularized vascular matrix is also subject to thrombosis and neoplastic endothelial hyperplasia, the two major problems that hinder its clinical application. The keys to improving the long-term patency of the decellularized matrix as vascular grafts include facilitating early endothelialization and avoiding intravascular thrombosis. This review article sequentially introduces six aspects of the decellularized vascular matrix as follows: design criteria of vascular grafts, components of the decellularized vascular matrix, the changing sources of the decellularized vascular matrix, the advantages and shortcomings of decellularization technologies, modification methods and the commercialization progress as well as the application prospects in small-diameter vascular grafts.

Dementia-Friendly Design: A Set of Design Criteria and Design Typologies Supporting Wayfinding.

OBJECTIVES, PURPOSE, OR AIM: This study aims to gain insights into the implementation of theoretical knowledge on dementia-friendly design into practice to (1) identify key design criteria stimulating spatial orientation and wayfinding for seniors with dementia and (2) determine the optimal design for this purpose. BACKGROUND: Spatial orientation problems of seniors with dementia can be counteracted by the design of the physical environment of inpatient care facilities. Research has been conducted about design features supporting wayfinding skills for this target group, however, not on their implementation. METHODS: Fourteen floor plans of the living group of built projects have been evaluated on 14 design criteria supporting wayfinding skills for the target group and measurable in floor plans by the performance of a comparative floorplan analysis and multicriteria assessment. RESULTS: Although one third of the evaluated design criteria are properly implemented, all floor plans of the selected projects had some gaps in fulfilling all design criteria. Five typological floor plans-based on the circulation systems of the cases-were distinguished: one straight corridor structured by two walls, one corridor with corners, two corridors separated from each other by the living room, a continuous loop corridor, and a corridor framed by a wall and interior elements (e.g., cabinets). The majority of the cases was based on a linear system with one straight corridor. CONCLUSIONS: Based on this study, three of the five discovered typological floor plans work well for stimulating wayfinding. Furthermore, special attention need to be given to the configuration of the floor plans, shape, and daylight in the corridor.

Recent advances in low-cost, portable automated resuscitator systems to fight COVID-19.

World is fighting one of its greatest battle against COVID-19 (a highly infectious disease), leading to death of hundreds of thousands of people around the world, with severe patients requiring artificial breathing. To overcome the shortage of ventilators in medical infrastructure, various low-cost, easy to assemble, portable ventilators have been proposed to fight the ongoing pandemic. These mechanical ventilators are made from components that are generally readily available worldwide. Such components are already associated with day-to-day gadgets or items and which do not require specialized manufacturing processes. Various designs have been proposed, focussing on meeting basic requirements for artificial ventilation to fight the ongoing pandemic. But some people are against the usage of these mechanical ventilators in real-life situations, owing to poor reliability and inability of these designs to meet certain clinical requirements. Each design has its own merits and demerits, which need to be addressed for proper designing. Therefore, this article aims to provide readers an overview of various design parameters that needs to be considered while designing portable ventilators, by systematic analysis from available pool of proposed designs. By going through existing literature, we have recognized multiple factors influencing device performance and how these factors need to be considered for efficient device operation.

The Parent-Child Patient Unit (PCPU): Evidence-Based Patient Room Design and Parental Distress in Pediatric Cancer Centers.

Children with cancer are frequently hospitalized during diagnosis and treatment. Since the early 1980s, parents are co-admitted because their presence positively affects children's adjustment to hospitalization and reduces post-traumatic stress. However, the size and overall architectural design of the rooms were never adapted to the doubling of the occupancy rate. Since studies show that many parents experience high levels of distress due to their child's illness, the purpose of this study was to investigate the impact of the architecture of the aged patient rooms on parental distress. A video observation targeted parent-child interaction related to five architectural determinants: (a) function and place of interaction, (b) distance between parent and child, (c) used space, (d) withdrawal, and (e) duration of the interaction. A total of 22 families were included in two Dutch children's hospitals. Results show a significant association between parental distress and three architectural determinants: The less anxious the parents were and the better they estimated their child's well-being, the more distance they created between themselves and their child, and the more space, privacy, and withdrawal options were used. These findings are discussed within a new patient room typology, the parent-child patient unit (PCPU), which reacts to the evident association of parental distress and the design.

Optimizing landfill aeration strategy with a 3-D multiphase model.

In order to reduce the environmental and financial burden for future generations, approaches are needed to shorten aftercare of landfills. Aeration of the waste-body is a promising approach, however, the poor understanding of transport of gas and water through a waste-body makes it difficult to design an effective aeration strategy. The aim of this study is to develop a tool to determine the optimal aeration strategy for landfills. This study presents a comparison of aeration strategies based on the air distribution they generate with a 3-D multiphase model. The implemented theory is based on parameter values obtained from (laboratory) experiments performed under conditions which are similar to those in a full scale landfill. Calibration with field scale gas extraction data from the Dutch pilot site Wieringermeer shows that the model gives a good description of the average gas flow under extraction. Scenario analyses for the case study landfill indicate that injection strategies reach a larger volume fraction of waste with a higher air flow compared with extraction strategies, especially at the bottom of the landfill. Extraction, however, supplies oxygen more homogeneously through-out the waste. An import design criterion is also the distance between the wells. Too large distances lead to ineffective treatment because too large volumes of waste/leachate remain untreated. In addition to the comparison of aeration strategies, an optimal aeration strategy for the pilot site is presented. A combination of (alternating) injection and extraction wells which are maximum 20m apart seems to be the optimal strategy.

Kinetically Limited Phase Formation of Pt-Ir Based Compositionally Complex Thin Films.

The phase formation of PtIrCuAuX (X = Ag, Pd) compositionally complex thin films is investigated to critically appraise the criteria employed to predict the formation of high entropy alloys. The formation of a single-phase high entropy alloy is predicted if the following requirements are fulfilled: 12 J∙K-1 mol-1 ≤ configurational entropy ≤ 17.5 J∙K-1 mol-1, -10 kJ∙mol-1 ≤ enthalpy of mixing ≤ 5 kJ∙mol-1 and atomic size difference ≤ 5%. Equiatomic PtIrCuAuX (X = Ag, Pd) fulfill all of these requirements. Based on X-ray diffraction and energy-dispersive X-ray spectroscopy data, near-equiatomic Pt22Ir23Cu18Au18Pd19 thin films form a single-phase solid solution while near-equiatomic Pt22Ir23Cu20Au17Ag18 thin films exhibit the formation of two phases. The latter observation is clearly in conflict with the design rules for high entropy alloys. However, the observed phase formation can be rationalized by considering bond strengths and differences in activation energy barriers for surface diffusion. Integrated crystal orbital Hamilton population values per bond imply a decrease in bond strength for all the interactions when Pd is substituted by Ag in PtIrCuAuX which lowers the surface diffusion activation energy barrier by 35% on average for each constituent. This enables the surface diffusion-mediated formation of two phases, one rich in Au and Ag and a second phase enriched in Pt and Cu. Hence, phase formation in these systems appears to be governed by the complex interplay between energetics and kinetic limitations rather than by configurational entropy.

Surface topographies of biomimetic superamphiphobic materials: design criteria, fabrication and performance.

Superamphiphobicity is a wetting phenomenon that not only water but also oils or organic solvents with low surface tension exhibit large contact angles above 150° along with low contact angle hysteresis on solid surface. It is well known that both chemical constituent and surface roughness have impacts on the wettability of solid surface. Herein, several fundamental wetting states and design criteria for re-entrant structures are introduced first. Then, various chemical modification materials endowing solid substrates low surface energy are summarized subsequently. Furthermore, roughening processes conferring hierarchical or re-entrant topographic structures on surfaces are classified based on different types of topographies abstracted from the natural oil-repellent creatures (mushroom-like structures) as well as bio-inspired superamphiphobic surfaces (i.e., randomly distributed nanostructures, regularly patterned microstructures and other complex hierarchical structures). Significantly, the impalement pressure and formulated rules of various re-entrant profiles are recommended in detail. At the same time, fabrication, outstanding performances such as mechanical durability, chemical stability are also mentioned according to different types of morphologies. Beyond that, current fabrication obstacles and future prospects are proposed simultaneously in the end.

Putting prototypes in place.

It has recently been proposed that natural concepts are those represented by the cells of an optimally partitioned similarity space. In this proposal, optimal partitioning has been defined in terms of rational design criteria, criteria that a good engineer would adopt if asked to develop a conceptual system. It has been argued, for instance, that convexity should rank high among such criteria. Other criteria concern the possibility of placing prototypes such that they are both similar to the items they represent-each prototype ought to be representative-and dissimilar to each other: the prototypes ought to be contrastive. Parts of this design proposal are already supported by evidence. This paper reports results of a new study meant to address parts still lacking in empirical support. In particular, it presents data concerning color similarity space which indicate that color prototypes are indeed located such that they trade off optimally between being representative and being contrastive.