RESUMO
PURPOSE: Dural exposure during cholesteatoma surgery can pose a risk of cerebrospinal fluid leakage or residual disease. Therefore, delicate handling of the area surrounding the bone defect in the cranial fossa is required. However, in small-sized defects, preoperative prediction of dural exposure can be challenging. This study aimed to evaluate the diagnostic value of computed tomography (CT) for preoperative prediction of cholesteatoma-related dural exposure in bone discontinuities in the skull base. METHODS: We evaluated serial high-resolution CT images showing bone density discontinuities in the middle cranial fossa (MCF) requiring mastoidectomy for cholesteatoma. The CT and intraoperative findings were analyzed retrospectively. We evaluated the length between the superior margins of the bone density discontinuities using coronal CT planes. Receiver operating characteristic (ROC) curves were constructed to determine the optimal cut-off values. RESULTS: We extracted data from 107 bone density discontinuities, among which 54 (50.5%) showed dural exposure intraoperatively. Discontinuities with dural exposure (n = 54) had significantly greater lengths than did those without (n = 53) (p < 0.001, Wilcoxon rank-sum test). The area under the curve was 0.9780 according to the ROC analysis, and the optimal cut-off value was determined to be 2.99 mm (sensitivity 92.59%; specificity 94.34%). CONCLUSION: A bone density discontinuity length of > 2.99 mm in the MCF on coronal CT plane is a reliable diagnostic marker for cholesteatoma-related dural exposure. Thus, preoperative high-resolution CT analysis can inform optimal surgical preparation and planning before manipulating the area surrounding the osteolytic lesion in the MCF.
Assuntos
Colesteatoma da Orelha Média , Base do Crânio , Humanos , Estudos Retrospectivos , Base do Crânio/diagnóstico por imagem , Base do Crânio/cirurgia , Tomografia Computadorizada por Raios X/métodos , Fossa Craniana Média/cirurgia , Colesteatoma da Orelha Média/diagnóstico por imagem , Colesteatoma da Orelha Média/etiologia , Colesteatoma da Orelha Média/cirurgiaRESUMO
PURPOSE: To analyze the surgical management of cholesteatoma in patients with craniofacial abnormalities, cleft lip/palate by reviewing the institutional experience. The secondary aim was to identify and describe the epidemiological profile of the collected data, and to relate the cleft palate and cholesteatoma. DESIGN AND METHODS: This retrospective chart review includes 97 patients with craniofacial abnormalities and acquired cholesteatoma with anatomopathological proven in 118 ears. The following data were collected from the medical records between 1994 and 2018. RESULTS: The first surgery performed on 76 of the 118 ears (64.4%) was the wall up mastoidectomy, while 42 of the 118 ears (35.5%) received the wall down technique. During the follow-up period of these patients, which ranged from 2 to 29â¯years, with an average of 13.4â¯years (±5.88), 77 wall up (40.3%) and 114 wall down (59.6%) mastoidectomies were performed. This brought the total to 191 mastoidectomy surgeries in 118 ears of 97 patients. Of the wall up mastoidectomies, 65 of the 77 (84.4%) presented with cholesteatoma recurrence. In the wall down mastoidectomies follow up, there were new surgical approaches in 15 of the 114 procedures (13.1%), with 6 patients (5.2%) having anatomopathologically proven cholesteatoma recurrences and 9 (7.8%) having clinical instability for cavity cleaning without identification of disease recurrence. CONCLUSIONS: Early approach with wall down/modified techniques guided by specific indication criteria may be more resolute, prevent multiple procedures, and preserve the bone pathway to facilitate possible future hearing rehabilitation in these patients.
Assuntos
Colesteatoma da Orelha Média/cirurgia , Anormalidades Craniofaciais/complicações , Mastoidectomia/métodos , Adolescente , Adulto , Criança , Pré-Escolar , Colesteatoma da Orelha Média/etiologia , Colesteatoma da Orelha Média/fisiopatologia , Colesteatoma da Orelha Média/reabilitação , Fenda Labial/complicações , Fissura Palatina/complicações , Feminino , Seguimentos , Audição , Humanos , Masculino , Recidiva , Estudos Retrospectivos , Resultado do Tratamento , Adulto JovemRESUMO
PURPOSE: To report our experience of a sequence of events that resulted in an iatrogenic cholesteatoma originating from the external auditory canal (EAC) years after tympanoplasty that had included a tympanomeatal flap. METHODS: Data on the presentation and pathogenesis of iatrogenic cholesteatomas arising from misplaced tympanomeatal flaps during tympanoplasty without mastoidectomy were retrieved from the patients' medical records and analyzed. RESULTS: Five patients were identified with cholesteatomas involving the EAC. They all had recurrent ear infections and varying degrees of conductive hearing loss. Each patient's past surgical history included one or more tympanoplasties in which an ipsilateral tympanomeatal flap had been raised. None had undergone a mastoidectomy. Two patients presented with small cholesteatomas that had developed over an average of 6.5 years after surgery. Three patients had large cholesteatomas that had developed over an average of 33.7 years after surgery. Clinical presentations and imaging studies suggested a misplaced tympanomeatal flap as the most likely source of cholesteatoma. CONCLUSION: Tympanomeatal flap misplacement may cause iatrogenic cholesteatoma formation originating from the EAC during tympanoplasty even without mastoidectomy. These cholesteatomas can grow substantially before becoming symptomatic as they extend to and through the mastoid. They may not affect the sound conduction system until late in the course of the disease. Meticulous replacement of tympanomeatal flaps and exercising a high index of suspicion postoperatively can reduce the incidence of this complication.
Assuntos
Colesteatoma da Orelha Média , Colesteatoma , Timpanoplastia , Colesteatoma/etiologia , Colesteatoma da Orelha Média/etiologia , Colesteatoma da Orelha Média/cirurgia , Humanos , Doença Iatrogênica , Processo Mastoide/cirurgia , Estudos Retrospectivos , Fatores de Tempo , Resultado do Tratamento , Timpanoplastia/efeitos adversosRESUMO
PURPOSE: Congenital cholesteatoma (CC) presents as a white pearl-like lesion behind a normal tympanic membrane (TM), without a history of otorrhea, infection, perforation or previous otologic surgery. Several recent studies provided new data improving this pathology characterization. The aim of this paper is to expand the knowledge about CC and to provide new insights on its pathogenesis. METHODS: The study consisted of two main research parts: (1) systematic review and meta-analysis; (2) medical literature review englobing anatomy, histology, embryology and congenital pathology of the ear. RESULTS: The search strategy identified a total of 636 papers. Seventy retrospective studies were included. A total of 1497 cases were studied and the mean age was 6.58 years, with a male-female ratio of 3:1, 34% were asymptomatic, 26% had hearing loss and 2% had facial dysfunction/paralysis. The overall estimate for antero-superior quadrant involvement was 0.70 [95% confident interval (CI) 0.64-0.76], in the postero-superior quadrant was 0.60 (95% CI 0.52-0.69), in the antero-inferior quadrant was 0.32 (95% CI 0.23-0.41), in the postero-inferior quadrant was 0.38 (95% CI 0.29-0.47), in the attic was 0.53 (95% CI 0.43-0.63) and in the mastoid was 0.33 (95% CI 0.26-0.41). More advanced Potsic stages were present in older patients. The most likely inclusion place seems to be between the pars flaccida and the upper quadrants of the pars tensa. CONCLUSIONS: During the last decades, a substantial improvement in CC diagnosis and management had been achieved. The presented mechanism seems to explain most of middle ear CC.
Assuntos
Colesteatoma da Orelha Média , Orelha Média , Colesteatoma da Orelha Média/congênito , Colesteatoma da Orelha Média/epidemiologia , Colesteatoma da Orelha Média/etiologia , Colesteatoma da Orelha Média/cirurgia , Orelha Média/anormalidades , Orelha Média/anatomia & histologia , Orelha Média/embriologia , Orelha Média/patologia , Humanos , Processo Mastoide , Membrana TimpânicaRESUMO
We have undertaken the analysis of the specific clinical manifestations of acquired cholesteatoma of the middle ear in 437 chronic patients suffering from this pathology. 96.1% of them presented with primarily acquired cholesteatoma of the middle ear (including 53.3% having attic cholesteatoma, 22.8% with sinus cholesteatoma, and 19.9% of tensa retraction cholesteatoma). 3.9% of the patients exhibited a different mechanism of development of cholesteatoma. The secondary acquired mesotympanic cholesteatoma formed in association with the long-term chronic inflammation of the middle ear, concomitant perforation of the tympanic membrane and epithelial invasion from the edge of the tympanic membrane perforation and middle ear cavity. Typmanosclerosis of different degree and localization played an important role in the enhancement of the prevalence of this condition. All types of acquired cholesteatoma were found to extend beyond the point of origin of the disorder. The maximum destruction of the ossicular chain was documented in the patients presenting with sinus cholesteatoma. Those with secondary acquired cholesteatoma showed the worst functional capacity as a result of rigid fixation of the auditory ossicles. The overall cholesteatoma relapse rate (including both residual and recurrent cholesteatoma) was estimated to be 15.6%. It is concluded that the surgical strategy should be chosen on an individual basis for each concrete patient. The long-term observation of the treated patients with the application of the up-to-date radiological techniques is believed to be the indispensable prerequisite for the successful management of the complicated pathology under consideration.
Assuntos
Colesteatoma da Orelha Média , Otite Média/complicações , Procedimentos Cirúrgicos Otológicos/métodos , Perfuração da Membrana Timpânica/complicações , Adulto , Colesteatoma da Orelha Média/diagnóstico , Colesteatoma da Orelha Média/epidemiologia , Colesteatoma da Orelha Média/etiologia , Colesteatoma da Orelha Média/cirurgia , Técnicas de Diagnóstico Otológico , Endoscopia/métodos , Feminino , Humanos , Masculino , Seleção de Pacientes , Prevalência , Estudos Retrospectivos , Federação Russa/epidemiologiaRESUMO
PURPOSE: This study aims to report the postoperative complications and management of cochlear implantation in pediatric patients at our institution. All procedures were carried out by a single surgeon utilizing minimally invasive techniques. The impact of past surgical history of tympanostomy tubes was also reviewed to access association with postoperative complications. MATERIALS AND METHODS: All children receiving cochlear implants at our institution between April 2003 and October 2014 were reviewed. Complications were grouped into "major" and "minor" depending on degree of management and "immediate," "early," and "delayed" depending on time of presentation. RESULTS: In our series, 248 cochlear implants were placed into 141 children. The mean age at time of surgery was 4.8 years. The overall complication rate per ear was 16.5%, 5.2% being major and 11.3% being minor complications. Complications arose in the first 30 days following surgery in 8.4% of patients, with acute otitis media being the most common. A history of tympanostomy tubes did not impact complication rate. Excluding device failures, major complication rate was 2.4%. Hematoma was not encountered, and delayed seroma occurred in one patient. CONCLUSION: Minimally invasive cochlear implantation carries a low complication rate. The most common major complication was intrinsic device failure, and the most common minor complication was acute otitis media. Past medical history of chronic otitis media with tympanostomy tube placement prior to cochlear implantation did not have a statistically significant impact on postoperative complication rates. Given the rarity of hematomas and seromas, pressure dressings appear to be unnecessary with this approach.
Assuntos
Implante Coclear/métodos , Complicações Pós-Operatórias , Adolescente , Criança , Pré-Escolar , Colesteatoma da Orelha Média/etiologia , Falha de Equipamento , Feminino , Humanos , Lactente , Masculino , Ventilação da Orelha Média , Otite Média/etiologia , Estudos RetrospectivosRESUMO
This study examined the differences between congenital cholesteatoma (CC) and acquired cholesteatomas (AC) in children by comparing clinical features and treatment courses. This was a retrospective study which retrospectively evaluated 127 children with middle ear cholesteatomas using medical records from January 1999 to December 2012 in the Department of Otolaryngology, Niigata University Hospital. The study comprised 69 and 58 cases of CC and AC, respectively. The main outcome measures include patient backgrounds, the opportunities for consultations, mastoid cell development, intraoperative finding of stapes, surgical procedure and number of surgeries. The average age at operation was 6.4 and 9.8 years in CC and AC, respectively. AC was more prevalent in boys. Mastoid development was better in CC than in AC. We adopted a two-stage operation in 17 cases (25 %) of CC and in 22 cases (38 %) of AC. The repeat surgery rate was 11.6 % in CC and 27.6 % in AC. Three times as many operations were required for three cases (4.3 %) of CC and 10 cases (17.2 %) of AC. The lesions in AC were more difficult to control. In the treatment of pediatric middle ear cholesteatoma, we had to keep the outcome in mind.
Assuntos
Colesteatoma da Orelha Média/etiologia , Colesteatoma da Orelha Média/patologia , Colesteatoma/congênito , Criança , Pré-Escolar , Colesteatoma/etiologia , Colesteatoma/patologia , Colesteatoma/cirurgia , Colesteatoma da Orelha Média/cirurgia , Feminino , Humanos , Lactente , Masculino , Processo Mastoide/patologia , Reoperação , Estudos Retrospectivos , Estribo/patologia , Resultado do TratamentoRESUMO
Introduction: The treatment for head and neck cancer with radiotherapy can cause different alterations of the auditory system. We report two cases of chronic otitis of the external and middle ear secondary to osteoradionecrosis of the temporal bone. This article aims to report the experience of the surgical approach in such condition. Cases report: The first patient was treated with radiotherapy in his childhood for a cerebellar tumor. He developed years later a cholesteatoma which invaded the mastoid cavities through a destruction of the external auditory canal. The second was treated for a malignant parotid tumour 15 years before by surgery and radiotherapy. She developed a chronic otorrhea with a partial destruction of the bony external auditory canal. Both patients were treated by surgery with reconstruction including bone, cartilage, fascia and skin grafts. The outcome was good in both cases. Osteoradionecrosis of the temporal bone is a rare but serious complication of radiotherapy for head and neck cancer. This complication can occur even many years after the treatment. Our two cases demonstrate a way to solve this pathology. A long term supervision with regular cares is essential in order to get a good healing. Due to the improvement of the radiation therapy we could expect less complications of this type in the future.
Assuntos
Colesteatoma da Orelha Média/etiologia , Osteorradionecrose/etiologia , Radioterapia/efeitos adversos , Osso Temporal/patologia , Adulto , Neoplasias Cerebelares/radioterapia , Colesteatoma da Orelha Média/cirurgia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Osteorradionecrose/cirurgia , Neoplasias Parotídeas/radioterapia , Osso Temporal/cirurgiaRESUMO
AIM: Girls with Turner syndrome are prone to cholesteatoma, a serious suppurative middle ear disease. We aimed to confirm its high prevalence in Turner syndrome, identify risk factors and suggest possible strategies for earlier detection. METHODS: We reviewed 179 girls with Turner syndrome between 1989 and 2012 to identify cases of cholesteatoma. RESULTS: Seven girls (3.9%) had cholesteatoma (index girls) and each was compared with three age-matched girls without cholesteatoma (comparison girls). All the index girls had either the 45,X or 45,X/46X,i(Xq) karyotypes. Nine ears were initially affected, with three recurrences in two girls. Median age at first cholesteatoma presentation was 11.9 years (range: 7.5-15.2), with otorrhoea for three (range: one to seven) months in all 12 affected ears. Index girls had a significantly higher proportion of previous recurrent acute (p = 0.007) and chronic otitis media (p = 0.008), chronic perforation (p = 0.038) aural polyps (p < 0.0001) and tympanic membrane retraction (p = 0.0001) than comparison girls. CONCLUSION: Cholesteatoma has a high prevalence in Turner syndrome. Risk factors include 45,X and 46,XiXq karyotypes; a history of chronic otitis media, tympanic membrane retraction and persistent otorrhoea; and older age. Earlier recognition of ear disease is needed and otoscopy training for paediatricians caring for Turner syndrome patients may be beneficial.
Assuntos
Colesteatoma da Orelha Média/etiologia , Síndrome de Turner/complicações , Adolescente , Audiologia , Criança , Colesteatoma da Orelha Média/diagnóstico , Colesteatoma da Orelha Média/epidemiologia , Colesteatoma da Orelha Média/cirurgia , Feminino , Humanos , Incidência , Cariótipo , Otoscopia , Estudos Retrospectivos , Escócia/epidemiologia , Síndrome de Turner/diagnósticoRESUMO
Cochlear implant candidates with mastoid cavity present a significant challenge to safe cochlear implantation because of possible spread of infection to the inner ear as well as an increased risk of electrode array extrusion. Closure of the external auditory canal is one of the several surgical techniques utilized to block the potential entry routes for infection and to protect the implanted device. The main concern after external auditory canal closure is the risk of developing a cholesteatoma, which can lead to an asymptomatic erosion of the temporal bone and/or cochlear implant failure. In this study we present the results of very long-term (mean 12 years) clinical and radiological follow-up in 12 patients who underwent external auditory canal closure associated with mastoid and Eustachian tube obliteration to facilitate cochlear implantation. To date, with a mean ± SD follow-up of 12 ± 4.7 years (range 5-21 years), the only complication experienced was the breakdown of the EAC closure in one patient, successfully treated by performing a rotation skin flap. The results of this study confirmed that external auditory canal closure is a reliable technique in cochlear implantation after radical mastoidectomy provided that a rigorous surgical technique is performed. A right balance between the need to reduce costs and to avoid unnecessary doses of radiation to patients and the task of a radiological surveillance may be represented by performing computed tomography 12-18 months postoperatively and then, only if clinically warranted.
Assuntos
Implante Coclear , Meato Acústico Externo , Processo Mastoide/cirurgia , Procedimentos Cirúrgicos Otológicos/efeitos adversos , Complicações Pós-Operatórias/prevenção & controle , Adulto , Colesteatoma da Orelha Média/etiologia , Colesteatoma da Orelha Média/prevenção & controle , Implante Coclear/efeitos adversos , Implante Coclear/métodos , Meato Acústico Externo/fisiopatologia , Meato Acústico Externo/cirurgia , Orelha Interna/diagnóstico por imagem , Orelha Interna/fisiopatologia , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Procedimentos Cirúrgicos Otológicos/métodos , Estudos Retrospectivos , Tempo , Tomografia Computadorizada por Raios X/métodos , Timpanoplastia/efeitos adversos , Timpanoplastia/métodosRESUMO
OBJECTIVES: One of theories concerning the origins of cholesteatoma, is the barotraumatic etiology. It suggests blast perforation of the tympanic membrane, and secondary implantation of epithelium in the tympanic cavity, as a cause of middle ear cholesteatoma. We report a case of cholesteatoma after spontaneous healing of a tympanic membrane perforation by blast, and revue the literature about this etiology of cholesteatoma. CASE REPORT: We report the case of a 38 year-old man with a history of bilateral blast injury trauma 4 years earlier. The blast caused a bilateral tympanic perforation. The right tympanic membrane healed spontaneously and a left tympanic perforation remained. A cholesteatoma was encountered on the right side, behind a scared tympanic membrane, during preoperative imaging study for surgery for the left side. The literature describes an incidence of 3 to 12% cholesteatoma after blast injury, rarely behind a closed tympanic membrane. We discuss the best imaging methods to detect cholesteatoma in these cases. CONCLUSIONS: After a blast injury, a cholesteatoma may arise behind a spontaneously healed tympanic membrane. For this reason, spontaneous healing of the perforation does not mean the end of the follow-up. It is essential to plan a follow-up with imaging test one year after the blast trauma. We consider that in cases of traumatic tympanic membrane perforations due to blast injury with spontaneous healing of the perforation, HRCT scan offers a better diagnostic performance and a higher spatial resolution for cholesteatoma detection (as it relates to an aerated mastoid and tympanic cavity) than DW MRI. Furthermore, it is available in the great majority of health centers.
Assuntos
Traumatismos por Explosões/complicações , Colesteatoma da Orelha Média/etiologia , Colesteatoma da Orelha Média/cirurgia , Perfuração da Membrana Timpânica/etiologia , Adulto , Colesteatoma da Orelha Média/diagnóstico , Humanos , Masculino , Resultado do Tratamento , Perfuração da Membrana Timpânica/complicaçõesRESUMO
OBJECTIVES: Myospherulosis is a foreign body reaction induced by the application of oil-based ointments. Myospherulosis in the ear is extremely rare. Only 4 cases have been described, all of which occurred after (repeated) mastoid surgery. METHODS: We present a case of persistent otorrhea and conductive hearing loss caused by myospherulosis in the middle ear following tympanoplasty. RESULTS: The patient underwent revision middle ear surgery with removal of abnormally thick, pale tissue in the middle ear. Histology showed a foreign body reaction with signs of myospherulosis. CONCLUSIONS: Myospherulosis is a very rare complication of the use of oil-based ointments. Surgeons should be aware that these products might cause a foreign body reaction leading to myospherulosis. In patients who have chronic otorrhea after previous mastoid or middle ear surgery, myospherulosis should be considered in the differential diagnosis.
Assuntos
Colesteatoma da Orelha Média/complicações , Reação a Corpo Estranho/etiologia , Bases para Pomadas/efeitos adversos , Otite Média Supurativa/tratamento farmacológico , Timpanoplastia/efeitos adversos , Adulto , Colesteatoma da Orelha Média/etiologia , Colesteatoma da Orelha Média/patologia , Colesteatoma da Orelha Média/terapia , Doença Crônica , Diagnóstico Diferencial , Feminino , Reação a Corpo Estranho/complicações , Reação a Corpo Estranho/patologia , Reação a Corpo Estranho/terapia , Perda Auditiva Condutiva/etiologia , Humanos , Otite Média Supurativa/etiologia , Resultado do TratamentoRESUMO
The objectives of the study are to evaluate the feasibility, results and complications of the endoscopic transcanal cartilaginous myringoplasty. Thirty patients with a tympanic membrane perforation underwent a transcanal endoscopic cartilaginous myringoplasty, between June 2008 and January 2010. Three patients had a residual perforation at 2 months after surgery. At 1 year, the perforation was closed for 29 patients (96 %). There was no case of blunting, lateralization of the tympanic membrane or ossicular injury. Two patients had an iatrogenic superficial cholesteatoma in the tympanic membrane. There was no significant postoperative worsening of sensorineural hearing loss. The preoperative Air Bone Gap (ABG) was not correlated with the size or site of TMP. The evolution of ABG postoperatively was not significant. The statistical analysis was performed by the Student's t test. The endoscopic transcanal cartilaginous myringoplasty is a minimally invasive, effective and reliable procedure in the management of the tympanic membrane perforations.
Assuntos
Cartilagem/transplante , Miringoplastia/métodos , Cirurgia Endoscópica por Orifício Natural/métodos , Perfuração da Membrana Timpânica/cirurgia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Colesteatoma da Orelha Média/etiologia , Estudos de Coortes , Estudos de Viabilidade , Testes Auditivos , Humanos , Pessoa de Meia-Idade , Miringoplastia/efeitos adversos , Cirurgia Endoscópica por Orifício Natural/efeitos adversos , Resultado do Tratamento , Adulto JovemRESUMO
OBJECTIVE: To compare the incidence and the histopathological aspect of spontaneous and two induced Mongolian gerbils' models of cholesteatoma: External Auditory Canal (EAC) obliteration model and the Auditory Tube (AT) cauterization model. METHODS: Fifty-four ears of 27 animals were divided into EAC obliteration, AT cauterization, and control groups and histologically assessed for cholesteatoma incidence and classification at intervals of 2, 4, 8, and 16 weeks. RESULTS: Cholesteatoma was diagnosed in 30 of the 53 ears evaluated with a significantly higher incidence in groups that received some type of intervention (p<0.0001). It was not possible to histologically distinguish cholesteatomas of the same stage between the study groups. CONCLUSION: Although we observed a significant increase in cholesteatoma incidence with the two methods used when compared to the control group, all developed cholesteatomas were apparently identical from a histological point of view.
Assuntos
Colesteatoma da Orelha Média , Colesteatoma , Otopatias , Tuba Auditiva , Animais , Modelos Animais de Doenças , Colesteatoma/complicações , Colesteatoma/patologia , Orelha , Otopatias/etiologia , Meato Acústico Externo/patologia , Gerbillinae , Colesteatoma da Orelha Média/etiologia , Colesteatoma da Orelha Média/patologiaRESUMO
This report describes a French bulldog and a pug that presented to the authors' hospital following total ear canal ablation (TECA) and lateral bulla osteotomy (LBO), with signs of recurring otitis media and difficulty opening their mouths. The bulldog also had unilateral facial paralysis and sensory deficits of the trigeminal nerve on the ipsilateral side. Computed tomography and MRI scans suggested cholesteatoma in the bulldog, but showed only slight enlargement of the bulla in the pug. Histopathologic examination of samples yielded cholesteatoma in both cases. The authors suspect that development of the cholesteatomas was linked to the TECA/LBO surgery in both cases. Cholesteatomas may occur more frequently than currently thought. Even if only slight changes of the bulla wall are detected on CT, early-stage cholesteatoma should be considered. The narrow anatomic conditions in brachycephalic dogs possibly predispose such breeds to develop cholesteatoma after middle ear surgery because complete removal of all inflammatory and epithelial tissue can be more difficult than in other breeds. To the authors' knowledge, this is the first report of an aural cholesteatoma causing sensory deficits of the trigeminal nerve.
Assuntos
Colesteatoma da Orelha Média/veterinária , Doenças do Cão/diagnóstico , Osteotomia/veterinária , Otite Média/veterinária , Animais , Colesteatoma da Orelha Média/diagnóstico , Colesteatoma da Orelha Média/etiologia , Doenças do Cão/etiologia , Doenças do Cão/cirurgia , Cães , Orelha Média/cirurgia , Masculino , Osteotomia/efeitos adversos , Otite Média/cirurgia , Complicações Pós-Operatórias/veterinária , Resultado do TratamentoRESUMO
Osteoma in the external auditory canal (EAC) is an uncommon benign tumor. The association of a cholesteatoma with an osteoma of EAC is extremely rare. We report a case of a 26-year-old woman with an osteoma of the left EAC that was complicated by a cholesteatoma in the EAC between the osteoma and left tympanic membrane. Surgical removal of the osteoma and cholesteatoma proved successful by postauricular approach. The follow up without recurrence is 24 months. Osteoma of the EAC is a solitary, unilateral, and slow-growing bony benign tumor. The foremost differential diagnosis is exostose that is multiple and bilateral. Cholesteatoma of the EAC is uncommon. Its basic pathogenesis is a chronic occlusion of the EAC. Surgical treatment avoids complications related to local aggressiveness of cholesteatoma.
Assuntos
Neoplasias Ósseas/complicações , Colesteatoma da Orelha Média/etiologia , Meato Acústico Externo/patologia , Neoplasias da Orelha/complicações , Osteoma/complicações , Adulto , Neoplasias Ósseas/diagnóstico , Neoplasias Ósseas/patologia , Neoplasias Ósseas/cirurgia , Colesteatoma da Orelha Média/diagnóstico , Colesteatoma da Orelha Média/cirurgia , Meato Acústico Externo/cirurgia , Neoplasias da Orelha/diagnóstico , Neoplasias da Orelha/patologia , Neoplasias da Orelha/cirurgia , Feminino , Humanos , Osteoma/diagnóstico , Osteoma/patologia , Osteoma/cirurgiaRESUMO
The most important literature data concerning retraction pockets (RP) of the tympanic membrane and their currently accepted classification are presented. The objective of the present work was to develop criteria for the objective estimation of the dynamic state of the tympanic retraction pockets in children presenting with non-perforating forms of otitis media. A total of 138 children suffering from exudative otitis media were available for observation; retraction pockets were found in the majority of these patients. Otomicroscopic characteristics of various RP species are described. A diagnostic approach to the observation of the dynamic state of the tympanic retraction pockets is proposed. The presence of the retraction pockets of the tympanic membrane is considered to be a risk factor of the development of cholesteatoma and chronic purulent pathology of the middle ear in the children. Deep retraction pockets without a controllable bottom and attic cholesteatomas were identified in 16 (11.6%) and 6 (4.3%) of the examined children respectively. They were treated by means of sparing otosurgery.
Assuntos
Colesteatoma da Orelha Média/patologia , Otite Média/complicações , Otite Média/diagnóstico , Membrana Timpânica/patologia , Adolescente , Criança , Pré-Escolar , Colesteatoma da Orelha Média/etiologia , Diagnóstico Precoce , Humanos , Lactente , Otite Média/etiologia , Fatores de Risco , Membrana Timpânica/anormalidadesRESUMO
Middle ear cholesteatoma is characterized by enhanced proliferation of epithelial cells with aberrant morphological characteristics. To investigate the origin of the cholesteatoma cells, we analyzed spontaneously occurring cholesteatomas associated with a new transplantation model in Mongolian gerbils (gerbils). Cholesteatomas were induced in gerbils with a transplanted tympanic membrane by using the external auditory canal (EAC) ligation method. After the pars flaccida of the tympanic membranes were completely removed from male gerbils, corresponding portions of tympanic membranes of female gerbils were transplanted to the area of defect, and then we ligated the EAC (hybrid-model group). As a control group, the EAC of normal male and female gerbils was ligated without myringoplasty. In all ears of each group, the induced cholesteatomas were seen. In situ PCR was then performed to detect the mouse X chromosome-linked phosphoglycerate kinase-1 (pgk-1) gene on the paraffin sections. One pgk-1 spot in the epithelial nuclei was detected in male cholesteatoma, and two pgk-1 spots were detected in female cholesteatoma, respectively. On the other hand, in the hybrid-model group, we detected not only one but also two pgk-1 spots in the epithelial nuclei of cholesteatoma. These results strengthened the evidence that the origin of epithelial cells in cholesteatoma is the tympanic membrane in this model, but not the residential middle ear epithelial cells or the skin of the EAC.
Assuntos
Colesteatoma da Orelha Média , Modelos Animais de Doenças , Gerbillinae , Animais , Colesteatoma da Orelha Média/etiologia , Colesteatoma da Orelha Média/patologia , Meato Acústico Externo/cirurgia , Células Epiteliais/metabolismo , Feminino , Masculino , Camundongos , Fosfoglicerato Quinase/genética , Reação em Cadeia da Polimerase , Membrana Timpânica/patologia , Membrana Timpânica/transplanteRESUMO
OBJECTIVE: The purpose of this article is to explore the factors that contribute to the occurrence of cholesteatoma. We studied the size of the mastoid air cells and the tympanic cavity using high-resolution CT. MATERIALS AND METHODS: Temporal bone CT scans of consecutive patients with unilateral cholesteatoma and healthy control subjects were retrospectively analyzed. We compared the total volume and the greatest cross-sectional area of the cavities of the combined mastoid air cells and tympanic cavity between the affected and unaffected sides in patients with cholesteatoma and in the control subjects. We also compared separately the measured volumes of the cavities of the mastoid air cells and tympanic cavity between the unaffected side of the patients with cholesteatoma and the control subjects. RESULTS: One hundred temporal bones of 50 patients with cholesteatoma and 50 control subjects were included. Both the volume and the cross-sectional area of the cavities of the combined mastoid air cells and tympanic cavity in the affected side of the patients with cholesteatoma were significantly smaller than those in the unaffected side (p < 0.001). Moreover, both the volume and the cross-sectional area of the cavities of the combined mastoid air cells and tympanic cavity in both affected and unaffected sides of patients with cholesteatoma were significantly smaller than those in control subjects (p < 0.001). The volume of the cavities of the mastoid air cells in the unaffected side of patients with cholesteatoma was smaller than that of the control subjects (p < 0.001). In contrast, no significant difference was found in the tympanic cavity volume between the unaffected side and the control subjects. CONCLUSION: Our results were consistent with the hypothesized contribution of mastoid air cell underdevelopment to the occurrence of cholesteatoma. A small tympanic cavity is less likely to contribute to the occurrence of cholesteatoma.
Assuntos
Colesteatoma da Orelha Média/etiologia , Colesteatoma da Orelha Média/patologia , Orelha Média/patologia , Processo Mastoide/patologia , Tomografia Computadorizada por Raios X , Adulto , Idoso , Idoso de 80 Anos ou mais , Colesteatoma da Orelha Média/diagnóstico por imagem , Estudos de Coortes , Orelha Média/diagnóstico por imagem , Feminino , Humanos , Masculino , Processo Mastoide/diagnóstico por imagem , Pessoa de Meia-Idade , Tamanho do Órgão , Estudos Retrospectivos , Fatores de Risco , Adulto JovemRESUMO
OBJECTIVE: Cleft palate increases the risk of chronic middle ear disease and hearing loss. The goal of this report was to determine which of two palate surgeries and which timing of palate surgery were associated with better otologic and audiologic outcomes in children with unilateral cleft lip and palate at 5 to 6 years of age. DESIGN: Subjects were randomly assigned to the von Langenbeck with intravelar veloplasty or Furlow palate repair, to palate surgery at 9 to 12 months or 15 to 18 months of age, and to the Spina or Millard lip repair. SETTING: Centralized, tertiary care craniofacial treatment center. PATIENTS: A total of 673 infants with unilateral cleft lip and palate. INTERVENTIONS: Palate and lip were repaired using established techniques. Serial otoscopic and audiometric evaluations were performed. MAIN OUTCOME MEASURES: Hearing and otoscopic findings at 5 to 6 years old. RESULTS: There were 370 children available for analysis. Hearing and need for tympanostomy tube placement did not differ by palatoplasty, age at palatoplasty, cheiloplasty, or surgeon. Risk of developing cholesteatoma or perforation was higher with Millard cheiloplasty (odds ratio â=â 5.1, 95% confidence interval â=â 1.44 to 18.11, p â=â .012). Type and age at palatoplasty were not significantly associated with either the rate of developing these sequelae or the rate of achieving bilaterally normal hearing and ear examinations. CONCLUSIONS: Type of palatoplasty did not influence otologic and audiologic outcomes in 5- to 6-year-olds with unilateral cleft lip and palate. The potential influence of lip repair on otologic outcomes warrants further investigation.