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1.
BMC Infect Dis ; 21(1): 344, 2021 Apr 12.
Artigo em Inglês | MEDLINE | ID: mdl-33845789

RESUMO

BACKGROUND: Ecthyma gangrenosum (EG) is a cutaneous infectious disease characterized by eschar-like skin ulcers typically caused by Pseudomonas aeruginosa. Here, we report a case of relapsing EG in a patient who had returned from a trip to Colombia, thus establishing EG as an important differential diagnosis of tropical diseases, and demonstrating that even long-term antibiotic treatment can result in only partial remission of EG. CASE PRESENTATION: A 77-year-old man with underlying chronic lymphocytic leukemia (CLL) on ibrutinib treatment was admitted because of a superinfected mosquito bite on the left ear and multiple partially necrotic skin lesions disseminated all over the entire body five days after returning from a trip to Colombia. The initial clinical suspicion of a tropical disease (leishmaniosis, systemic mycosis, or others) could not be confirmed. During the diagnostic workup, microbiological cultures of the skin biopsies and bronchoalveolar lavage revealed Pseudomonas aeruginosa, leading to a diagnosis of EG. Initial antibiotic treatment resulted in partial remission. However, the patient had to be re-admitted due to a relapse 3-4 weeks after the first episode. Finally, the patient was successfully treated with a combined approach consisting of antibiotics, recurrent surgical incisions, and administration of immunoglobulins. CONCLUSIONS: In conclusion, EG should be considered as a differential diagnosis in immunosuppressed patients presenting with eschar-like skin ulcers. A combined treatment approach seems to be the best choice to achieve clinical cure and avoid relapse.


Assuntos
Ectima/diagnóstico , Úlcera Cutânea/diagnóstico , Adenina/análogos & derivados , Adenina/uso terapêutico , Administração Intravenosa , Idoso , Antibacterianos/uso terapêutico , Líquido da Lavagem Broncoalveolar/microbiologia , Colômbia , Diagnóstico Diferencial , Ectima/tratamento farmacológico , Ectima/microbiologia , Ectima/cirurgia , Humanos , Hospedeiro Imunocomprometido , Imunoglobulinas/uso terapêutico , Leucemia Linfocítica Crônica de Células B/tratamento farmacológico , Leucemia Linfocítica Crônica de Células B/patologia , Masculino , Piperidinas/uso terapêutico , Pseudomonas aeruginosa/isolamento & purificação , Úlcera Cutânea/microbiologia , Úlcera Cutânea/cirurgia
2.
Transpl Infect Dis ; 21(4): e13131, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31216602

RESUMO

Ecthyma gangrenosum (EG) is a serious bacterial infection in immunocompromised patients. EG in transplant recipients is rarely reported and may go unrecognized, which may delay initiation of appropriate treatment. We report a case of EG in a pediatric heart transplant recipient who was treated successfully with antibiotics and surgical debridement.


Assuntos
Ectima/diagnóstico , Transplante de Coração/efeitos adversos , Infecções por Pseudomonas/diagnóstico , Antibacterianos/uso terapêutico , Pré-Escolar , Desbridamento , Ectima/tratamento farmacológico , Ectima/microbiologia , Ectima/cirurgia , Humanos , Hospedeiro Imunocomprometido , Masculino , Infecções por Pseudomonas/tratamento farmacológico
3.
J Pediatr Hematol Oncol ; 38(1): 53-7, 2016 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25757025

RESUMO

BACKGROUND: Perianal sepsis with ecthyma gangrenosum is a severe and potentially mutilating complication in immunocompromised children. Therapies include antimicrobial treatment, incision and drainage, generous tissue debridement, and skin transplantation. PROCEDURE: We describe 3 children with acute lymphoblastic leukemia having sepsis with Pseudomonas aeruginosa in febrile neutropenia and severe perianal infections treated relatively early with a protective colostomy. Indications for colostomy were nonhealing wounds, and ceaseless pain. RESULTS: All patients showed a rapid reduction of pain. Complete wound healing was seen in 2 patients, and considerable pain reduction and increased quality of life were seen in a third patient during palliative care. CONCLUSIONS: These results suggest that a protective colostomy should be considered early in the management of immunocompromised children with ecthyma gangrenosum.


Assuntos
Canal Anal/patologia , Colostomia/métodos , Leucemia-Linfoma Linfoblástico de Células Precursoras/complicações , Sepse/cirurgia , Pré-Escolar , Ectima/imunologia , Ectima/cirurgia , Neutropenia Febril/etiologia , Humanos , Hospedeiro Imunocomprometido , Masculino , Infecções por Pseudomonas/imunologia , Sepse/imunologia
4.
Ann Chir Plast Esthet ; 57(4): 405-8, 2012 Aug.
Artigo em Francês | MEDLINE | ID: mdl-20724053

RESUMO

Ecthyma gangrenosum is a cutaneous infection, which result from a Pseudomonas aeruginosa septicemia, encountered in most of the case in immunocompromised people. Authors demonstrate the important role of the plastic surgeon in the diagnosis and therapeutic management of the disease in children. An eight-month-old infant has been hospitalized for acute leukaemia. She developed an extensive painful macule in the buttocks and perineal area in a septic context. A multidisciplinary management allowed to set up an adapted antibiotherapy, an early escharrotomy, a protection of the wound by digestive and urine derivation and a reconstruction with wound healing by second intention and split thickness skin graft, which lead to a good quality cure and wound healing at the end of 37 days of evolution. This case demonstrates the importance of the surgical management in the treatment of ecthyma gangrenosum. The wound healing associated with a split thickness skin graft seems to be the less invasive solution in a frail patient and the fastest to re-start the chemotherapy.


Assuntos
Ectima/patologia , Ectima/cirurgia , Procedimentos de Cirurgia Plástica/métodos , Feminino , Gangrena/cirurgia , Humanos , Lactente , Papel do Médico
5.
BMJ Case Rep ; 20162016 Mar 30.
Artigo em Inglês | MEDLINE | ID: mdl-27030458

RESUMO

A 68-year-old woman with a history of breast cancer presented with skin lesions and sternal pain. Clinical examination revealed ulcerative lesions on mastectomy scar and CT scan showed contiguous sternal osteolysis. The main hypothesis was a breast cancer recurrence; however, cutaneous and bone biopsies did not reveal any cancer cells. Skin tissue culture detected Pseudomonas aeruginosa, suggesting ecthyma gangrenosum despite the absence of bacteraemia in our patient and despite her immunocompetence. Surgical treatment was performed, followed by a long course of antibiotherapy.


Assuntos
Ectima/diagnóstico , Infecções por Pseudomonas/diagnóstico , Pele/microbiologia , Idoso , Antibacterianos/uso terapêutico , Neoplasias da Mama , Diagnóstico Diferencial , Ectima/tratamento farmacológico , Ectima/microbiologia , Ectima/cirurgia , Feminino , Humanos , Recidiva Local de Neoplasia , Infecções por Pseudomonas/tratamento farmacológico , Infecções por Pseudomonas/cirurgia , Pseudomonas aeruginosa/isolamento & purificação , Pele/patologia , Resultado do Tratamento
7.
Pediatr Surg Int ; 24(7): 793-7, 2008 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-18427811

RESUMO

Clinical presentation and microbiology profiles of neutropenic paediatric oncology patients presenting with ecthyma gangrenosum (EG) were studied. Surgical strategies deployed for these critically ill children are reported. Between 1994 and 2005, all children with EG were identified. Case notes were reviewed. Hospital course and long-term outcome were documented. Ten patients were identified. Eight had acute lymphoblastic leukaemia, one child had acute myeloid leukaemia and another had rhabdomyosarcoma. Lesions occurred in the perineal region (n = 5), buttocks (n = 2), thigh (n = 2) and the face (n = 1). Seven children had positive blood cultures for Pseudomonas aeruginosa. Surgery included (1) radical debridement, and (2) debridement with covering colostomy for four of those with perianal lesions. Ecthyma gangrenosum is a rapidly spreading and potentially lethal condition. Paediatric oncology patients with neutropenia are at a high risk. Surgical excision is crucial for progressive lesions to prevent mortality.


Assuntos
Desbridamento/métodos , Ectima/cirurgia , Guias de Prática Clínica como Assunto , Leucemia-Linfoma Linfoblástico de Células Precursoras/complicações , Rabdomiossarcoma Alveolar/complicações , Neoplasias de Tecidos Moles/complicações , Adolescente , Criança , Ectima/complicações , Ectima/patologia , Feminino , Seguimentos , Humanos , Masculino , Períneo , Estudos Retrospectivos , Resultado do Tratamento
9.
Dis Colon Rectum ; 42(7): 961-3, 1999 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-10411447

RESUMO

Ecthyma gangrenosum is a cutaneous gangrenous disorder which usually follows Pseudomona aeruginosa infection and is found mainly in immunosuppressed children. We describe a case of a five-year-old female with leukemia with a severe perineal ecthyma gangrenosum resulting in a cloaca-like deformity. One year later a perineoplasty with puborectalis interposition and overlapping external anal sphincteroplasty was successfully performed, achieving satisfactory continence.


Assuntos
Ectima/cirurgia , Períneo/patologia , Períneo/cirurgia , Dermatopatias Infecciosas/cirurgia , Pré-Escolar , Feminino , Humanos , Necrose , Dermatopatias Infecciosas/patologia
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