Competence of the human host as a reservoir for Leishmania chagasi
Costa, Carlos H. N; Gomes, Régis B. B; Silva, Mauro R. B.; Garcez, Lourdes M.; Ramos, Patrícia K. S.; Santos, Regina S; Shaw, Jeffrey J.; Davi, John R; Maguire, James H.
J Infect Dis
; 182(3): 997-1000, 2000. tab
Artigo
em Inglês
| BVS DIP, FIOCRUZ | ID: dip-1992
The faiJure of control programs for visceralleishmaniasis (VL) that depend on elimination of infected dogs suggests that other reservoir hosts may participate in the transmission cycle. To determine whether persons infected with Leishmania chagasi can infect the vector sand fty,laboratory-reared Lutzomyia longipalpis were allowed to feed on Brazilian subjects with active, cured, and asymptomatic VL and on asymptomatic residents ofhouses ofpersons with active VL. Of 3747 insects that had fed, 26 acquired infection from 11 of the 44 persons with active VL, but none acquired infection from the 137 asymptomatic persons. Among persons <4 yearsold with active VL, a history of diarrhea and higher peripheral blood neutrophiJ counts were independent predictors of infectivity. Further experiments using larger numbers of insects are necessary to evaluate the reservoir competence of persons with asymptomatic infections, who represent a large segment of the population of several Brazilian cities...(AU)
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BR275.1
Localização: BR275.1; PCIEC2000
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