Spoligotypes of Mycobacterium tuberculosis complex isolates from patients residents of 11 states of Brazil
Gomes, Harrison Magdinier; Elias, Atina Ribeiro; Oelemann, Maranibia Aparecida Cardoso; Pereira, Márcia Aparecida da Silva; Montes, Fátima Fandinho Onofre; Marsico, Ana Grazia; Kritski, Afrânio Lineu; Anjos Filho, Luciano dos; Caldas, Paulo C; Possuelo, Lia Gonçalves; Cafrune, Patrícia; Rossetti, Maria Lúcia; Lucena, Norma; Saad, Maria Helena Feres; Cavalcanti, Hebe Rodrigues; Leite, Clarisse Queico Fujimura; Brito, Rossana Coimbra de; Lopes, Maria Luiza; Lima, Karla; Souza, Maisa; Trindade, Rita de Cássia; Zozio, Thierry; Sola, Christophe.
Infect Genet Evol
; 12(4): 649-656, 2012. ilus, tab
Artigo
em Inglês
| BVS DIP, FIOCRUZ | ID: dip-3284
One of the high tuberculosis (TB) incidence countries in the world, Brazil is characterized by considerable differences in TB incidence on regional and state level. In the present study, we describe Brazilian spoligotypes of 1991 Mycobacterium tuberculosis complex (MTC) clinical isolates from patients residents of 11 states from different regions of the country, diagnosed between 1996 and 2005. By performing spoligotyping on a large number of M. tuberculosis clinical isolates, one of the main objectives of this study was to determine the major genotype families causing TB in Brazil and to verify the region-associated genotype distribution. We observed a total of 577 distinct spoligopatterns, 12.6 per cent of these corresponded to orphan patterns while 87.4 per cent belonged to 326 shared-types (SITs). Among the latter, 86 SITs (isolated from 178 patients) had been observed for the first time in this study, the most frequent being SIT2517 which belonged to the T3-ETH lineage and was exclusively found among patients residents of Belém, the capital of the state of Pará (n = 8 isolates). Irrespective of shared-type labeling, a total of 19.5 per cent strains were unique (unclustered) in our study as opposed to 80.5 per cent clustered isolates (189 clusters, size range from 2 to 205 isolates)...(AU)
Biblioteca responsável:
BR275.1
Localização: BR275.1; PCIEC2012
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