Preparation and immunosuppressive activity of 32-(O)-acylated and 32-(O)-thioacylated analogues of ascomycin.
Bioorg Med Chem Lett
; 9(2): 227-32, 1999 Jan 18.
Article
em En
| MEDLINE
| ID: mdl-10021934
ABSTRACT
A series of 32-(O)-acylated and 32-(O)-thioacylated derivatives of the antibiotic ascomycin (1) have been synthesized. These readily accessible analogues exhibit potent immunosuppressive activity in vitro, as measured by an interleukin-2 reporter gene assay and the mixed lymphocyte reaction. Such molecules are expected to have a therapeutic potential in chronic inflammatory diseases of the airways such as asthma.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tacrolimo
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
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