Pharmacokinetic-pharmacodynamic modeling of metoprolol stereoisomers in spontaneously hypertensive rat.
Zhongguo Yao Li Xue Bao
; 18(2): 104-8, 1997 Mar.
Article
em En
| MEDLINE
| ID: mdl-10072957
ABSTRACT
AIM:
To study the combined pharmacokinetic-pharmacodynamic (PK-PD) model of metoprolol stereoisomers, and compare their inhibitory effects on cardiovascular system in the spontaneously hypertensive rats (SHR).METHODS:
The drug concentration in plasma was measured by the reversed phase HPLC and the drug effects were recorded by polygraph. The pharmacokinetic parameters and the PK-PD model parameters were calculated.RESULTS:
The plasma concentration-time profiles were adequately described by two-compartment model. Differences of Vd between (+)-Met and (-)-Met were found. The relationships between effects and concentration of effect compartment were represented by the sigmoid-Emax model. The Css50 of Vmax, dp/dtmax, and HR inhibitory effects of (+)-Met were larger than those of (-)-Met.CONCLUSION:
Stereo-selective drug distribution and different potencies of the inhibitory effects of (+)-Met and (-)-Met existed in SHR.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antagonistas Adrenérgicos beta
/
Metoprolol
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Zhongguo Yao Li Xue Bao
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
China