Antiovulatory faculty of the flower of Malvaviscus conzattii.
Phytother Res
; 13(2): 169-71, 1999 Mar.
Article
em En
| MEDLINE
| ID: mdl-10190196
ABSTRACT
The methanol extract of the flowers of Malvaviscus conzattii was orally administered in cycling unilaterally ovariectomized (ULO) rats at a dose level of 1 g/kg body wt/day for one or two cycles. The effect of the extract on the length of the cycle and ULO-induced compensatory ovulation and hypertrophy of the remaining ovary was assessed on the first oestrus following completion of treatment. Although no adverse influence was observed on either of the parameters, the cycle length was significantly prolonged and both the compensatory phenomena underwent significant inhibition after treatment of the extract for two consecutive cycles. In another experiment, the extract was found to be ineffective in preventing exogenous gonadotropin(s)-induced ovulation in immature and sub-adult rats. It is, therefore, suggested that the extract might have interfered with the synthesis and/or release of gonadotropin(s) from the pituitary while the ovarian utilization of gonadotropin(s) remained unaffected. The LD50 of the extract was found to be 20 g/kg body wt.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ovário
/
Ovulação
/
Estro
/
Anticoncepcionais Femininos
/
Malvaceae
Limite:
Animals
Idioma:
En
Revista:
Phytother Res
Assunto da revista:
TERAPIAS COMPLEMENTARES
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Índia