Interpatient genetic variability of HIV-1 group O.
AIDS
; 13(1): 41-8, 1999 Jan 14.
Article
em En
| MEDLINE
| ID: mdl-10207543
ABSTRACT
OBJECTIVE:
To analyse the genetic and phylogenetic characteristics of HIV-1 group O viruses. MATERIALS ANDMETHODS:
The env gene, encoding the gp160 glycoprotein, and a partial p24-encoding gag gene fragment of a Cameroonian (CA9) and a Gabonese (VI686) HIV-1 group O virus, isolated from cultured peripheral blood mononuclear cells of symptomatic patients, were sequenced, aligned with other representatives of group O for which the same region has been documented, and genetically and phylogenetically analysed.RESULTS:
Phylogenetic analysis of the env gene (gp160) revealed that CA9, VI686, ANT70, and four Ha strains formed a separate cluster, which was supported by 100% of all bootstrap trees. In addition, these seven isolates were part of the same clade in the p24 phylogeny. VAU and MVP5180 may represent two other subtypes.CONCLUSION:
We have characterized two group O viruses, originating from Cameroon and Gabon, which show a close evolutionary relationship to ANT70 and four Ha strains based on the entire env gene, suggestive of a first group O subgroup, tentatively named the HIV-1 group O env ANT70 clade or subtype.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Variação Genética
/
Infecções por HIV
/
HIV-1
/
Proteína do Núcleo p24 do HIV
/
Proteína gp160 do Envelope de HIV
Limite:
Humans
Idioma:
En
Revista:
AIDS
Assunto da revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Bélgica