Exclusion of the apoE gene in autosomal dominant retinitis pigmentosa.
Vision Res
; 38(24): 3829-31, 1998 Dec.
Article
em En
| MEDLINE
| ID: mdl-10211375
ABSTRACT
Our purpose was to search for mutations in the apolipoprotein E (apoE) gene and to evaluate the role of apoE polymorphisms in the occurrence of autosomal dominant retinitis pigmentosa (ADRP). The ApoE gene coding sequence was analyzed in 51 unrelated patients affected with ADRP. A screening for mutations by SSCP and an analysis of the apoE polymorphisms were performed using PCR and restriction enzymatic digestion. No abnormal patterns of migration were observed by SSCP analysis. No significant statistical difference was seen between our ADRP population and the French general population for apoE allele frequency. From these results we report that the apoE gene does not seems to be involved in our ADRP population.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apolipoproteínas E
/
Retinose Pigmentar
Limite:
Humans
Idioma:
En
Revista:
Vision Res
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
França