Internalization of growth factor-receptor complexes under the influence of antibodies initiates cell apoptosis in vitro.
Eur J Cell Biol
; 78(3): 194-8, 1999 Mar.
Article
em En
| MEDLINE
| ID: mdl-10219569
ABSTRACT
Antibodies against growth factors like IGF1, IGF2, aFGF, bFGF and, to a certain extent, TGF alpha and EGF were shown to cause apoptosis of normal and tumorigenic cells while apoptotic cell death could be prevented neither by single growth factors nor by serum. Antibodies to growth factors caused apoptosis by interacting with growth factors bound to their receptors on the cell surface. The phenomenon is likely to be associated with active internalization of growth factor receptors loaded with ligands. Apparently these activated receptors are essential for cell survival and their disappearance from the cell surface initiates apoptosis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Substâncias de Crescimento
/
Apoptose
/
Receptores de Fatores de Crescimento
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Eur J Cell Biol
Ano de publicação:
1999
Tipo de documento:
Article